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The map label for this gene is drrB [H]

Identifier: 227813730

GI number: 227813730

Start: 1026885

End: 1027634

Strand: Direct

Name: drrB [H]

Synonym: BAMEG_1134

Alternate gene names: 227813730

Gene position: 1026885-1027634 (Clockwise)

Preceding gene: 227813729

Following gene: 227813731

Centisome position: 19.63

GC content: 41.6

Gene sequence:

>750_bases
ATGAAAAGCAAAACAGGTGTATTACTTGGGCGCTTAATGCGCAATATTATGCGTAGTCCAGATACAATTATTACGGTAGC
GATTACACCGATTATGATGATGCTATTGTTTGTATACGTATTTGGCGGCGCAATACAAACAGGAACAGATAACTATGTCA
ATTATTTATTGCCGGGAATTTTGCTAATGGCTATCGCATCTGGTGTCGCTTACACTTCTGTACGATTATTTACGGATGTA
AAGAGTGGGCTTATGGCACGTTTCATTACGATGCCTATTAAGCGCTCATCGATATTATGGGCTCACGTTTTAACCTCTCT
TGTTGCGAATGTACTTACTATCTTAGTTGTTATTCTTGTTGCGCTCTTAATGGGTTTCCGTTCCAGTGCGAATATTCTAG
ATTGGCTTGGAGTAGCTGGGATACTAGGGATGTTTACGTTAGCACTAACATGGTTGGCTATCATTCCAGGGCTGACGGCA
AAGTCTATGGAAGGGGCGACAGCCTACTCGTACCCACTCGTTTTTCTTCCATTTATTAGTTCAGCCTTTGTACCTACCGA
AACGATGCCGAAAATTGTTCGTGTATTTGCTGAAAACCAGCCTGTAACTTCAATCGTGAATGCGGTTCGTGCTCTTTTAT
ATGAAGGAACTGTTGGAAACGATATTTGGATTGCGCTCACTTGGTGCGTAGGGATCATGATCATCTCTTACTTTTTCGCT
AGTAAAGCATTTAAACGCCAGATAGGGTAA

Upstream 100 bases:

>100_bases
GAAAGAGATGTTCCCGCCAGCAAAAGTAGAGTATATCGAGAAGCAGCCGACATTGGAAGAAATATTCCTTGCGATCATTG
GCAAAAAGGAGGAGATGTAA

Downstream 100 bases:

>100_bases
GTGAATGAAATCATCCGGAATAATATATTTTTTTGAAAAAGCACGGGAAGATTTTCCGTGCTTTAATAATACATTCATAC
TTCCCTTAATTGTAGTAGTT

Product: ABC transporter, efflux permease protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MKSKTGVLLGRLMRNIMRSPDTIITVAITPIMMMLLFVYVFGGAIQTGTDNYVNYLLPGILLMAIASGVAYTSVRLFTDV
KSGLMARFITMPIKRSSILWAHVLTSLVANVLTILVVILVALLMGFRSSANILDWLGVAGILGMFTLALTWLAIIPGLTA
KSMEGATAYSYPLVFLPFISSAFVPTETMPKIVRVFAENQPVTSIVNAVRALLYEGTVGNDIWIALTWCVGIMIISYFFA
SKAFKRQIG

Sequences:

>Translated_249_residues
MKSKTGVLLGRLMRNIMRSPDTIITVAITPIMMMLLFVYVFGGAIQTGTDNYVNYLLPGILLMAIASGVAYTSVRLFTDV
KSGLMARFITMPIKRSSILWAHVLTSLVANVLTILVVILVALLMGFRSSANILDWLGVAGILGMFTLALTWLAIIPGLTA
KSMEGATAYSYPLVFLPFISSAFVPTETMPKIVRVFAENQPVTSIVNAVRALLYEGTVGNDIWIALTWCVGIMIISYFFA
SKAFKRQIG
>Mature_249_residues
MKSKTGVLLGRLMRNIMRSPDTIITVAITPIMMMLLFVYVFGGAIQTGTDNYVNYLLPGILLMAIASGVAYTSVRLFTDV
KSGLMARFITMPIKRSSILWAHVLTSLVANVLTILVVILVALLMGFRSSANILDWLGVAGILGMFTLALTWLAIIPGLTA
KSMEGATAYSYPLVFLPFISSAFVPTETMPKIVRVFAENQPVTSIVNAVRALLYEGTVGNDIWIALTWCVGIMIISYFFA
SKAFKRQIG

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 27186; Mature: 27186

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKTGVLLGRLMRNIMRSPDTIITVAITPIMMMLLFVYVFGGAIQTGTDNYVNYLLPGI
CCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LLMAIASGVAYTSVRLFTDVKSGLMARFITMPIKRSSILWAHVLTSLVANVLTILVVILV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLMGFRSSANILDWLGVAGILGMFTLALTWLAIIPGLTAKSMEGATAYSYPLVFLPFIS
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHH
SAFVPTETMPKIVRVFAENQPVTSIVNAVRALLYEGTVGNDIWIALTWCVGIMIISYFFA
HCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SKAFKRQIG
HHHHHHCCC
>Mature Secondary Structure
MKSKTGVLLGRLMRNIMRSPDTIITVAITPIMMMLLFVYVFGGAIQTGTDNYVNYLLPGI
CCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LLMAIASGVAYTSVRLFTDVKSGLMARFITMPIKRSSILWAHVLTSLVANVLTILVVILV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLMGFRSSANILDWLGVAGILGMFTLALTWLAIIPGLTAKSMEGATAYSYPLVFLPFIS
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHH
SAFVPTETMPKIVRVFAENQPVTSIVNAVRALLYEGTVGNDIWIALTWCVGIMIISYFFA
HCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
SKAFKRQIG
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]