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The map label for this gene is gabT [H]

Identifier: 227812990

GI number: 227812990

Start: 332516

End: 333952

Strand: Direct

Name: gabT [H]

Synonym: BAMEG_0384

Alternate gene names: 227812990

Gene position: 332516-333952 (Clockwise)

Preceding gene: 227812989

Following gene: 227812991

Centisome position: 6.36

GC content: 38.9

Gene sequence:

>1437_bases
TTGGAAAAGAATGTTGGCATACATTTTGCAATAAAAAGAGAAAACAATGTAAAGAAAAGGATGGGGTACGTAATGAATAC
AAAAAAATTTGCTAAAGTAAATGAACAAATTCCTGGACCGAAAGCAGCGTCTTTACTAGAACGCCGCCAAAATATAGTAC
CAAAAGGAGTAAGTAACGGCATCCCAACGTTTGTACAATCTGCAAACGGTGCTCTTGTAACAGATGTTGATGGCAATCAG
TACATTGATTTCGCTGGAGCGATAGGAACAATTAACGTAGGGCATTGTCACCCAGCTGTTAAAGAAGCGCTCCATAAACA
AGTAGATCAATACATCCATACGGGCTTTAATGTCATGATGTATGAGCCATATATTGAATTAGCAGAAAAACTTGCGGCAT
TAGCACCAGGAAGTTTTGATAAGCAAGTACTATTTTTAAATAGTGGTGCAGAAGCAGTTGAGAATGCGGTGAAAATCGCT
CGTAAATATACAAAAAGACCTGGCATTATCGCTTTTTCTAAAGGTTTCCACGGACGTACATTAATGACAATGACGATGAC
AAGTAAAGTAAAACCATATAAATTTGGATTTGGCCCATTTGCTCCAGAAGTATATAAAGCGCCATTCCCTTATGAATATC
GTTGCCCAGAAGGATTAACGGAAGAGCAGTATGATGACTTTATGATTGAAGAGTTTAAGAATTTCTTCATATCAGAAGTA
GCACCAGAAACGATTGCAGCCGTTGTAATGGAACCTGTTCAAGGGGAAGGTGGATTTATCGTCCCAAGTAAGAAGTTTGC
GCAAGAAGTACGCAATATTTGTTCAGAACACGGCATCTTATTTGTAGCGGATGAAATTCAAACAGGATTTAGCCGTACAG
GAAAATATTTTGCCATTGATCATTATGATGTCGTTCCGGATTTAATTACGGTATCTAAATCATTAGGTGCTGGTGTACCA
ATTAGTGGTGTTATTGGGCGCAAGGAAATTATGAATGAGTCTGCACCAGGAGAGCTTGGGGGAACGTATGCGGGAAGCCC
GCTAGGATGTGCGGCAGCATTAGCAGTACTTGATGTAATAGAAAAAGAGAATTTAAATGATAGAGCGATAGAATTAGGAA
AAGTTGTAATGAACCGATTCGAAGAGATGAAAAATAAATATAATTGCATCGGTGATGTGCGCGGTTTAGGAGCAATGTGT
GCATTCGAGCTCGTTCAAGACCGTAAGACGAAAACACCTGATAAAACGTTAACAGCTAATTTGTGCACAGAAGCAAACAA
ACGCGGCCTACTTCTACTATCAGCAGGAACATACGGTAATGTTATTCGTGTACTAATGCCGCTAGTTATTACAGATGAGC
AACTGGAAGAAGGATTAACAATTATTGAAGAATCATTGCAAATTTGTTATGAGAAAGCAAATACTGCCCGTGTTTAA

Upstream 100 bases:

>100_bases
GGAAAGTCTAATGTGTAAGAAAAATAAGTCTATAAAGACTCTTAATGAGTCTTTATAGACTTATTTTTTATGGCGAAATA
GAAGGTGTGTAGGATGAATA

Downstream 100 bases:

>100_bases
AAGTTAAATAAATAGCAAACATTCTAGCTGACTCTATATAAAATGCAGAAAATTCACTTTATAATAAAGGTAGTGAAGTG
AATCGATGGATTGGAAGTTA

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MEKNVGIHFAIKRENNVKKRMGYVMNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSNGIPTFVQSANGALVTDVDGNQ
YIDFAGAIGTINVGHCHPAVKEALHKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKIA
RKYTKRPGIIAFSKGFHGRTLMTMTMTSKVKPYKFGFGPFAPEVYKAPFPYEYRCPEGLTEEQYDDFMIEEFKNFFISEV
APETIAAVVMEPVQGEGGFIVPSKKFAQEVRNICSEHGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVP
ISGVIGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDVIEKENLNDRAIELGKVVMNRFEEMKNKYNCIGDVRGLGAMC
AFELVQDRKTKTPDKTLTANLCTEANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQICYEKANTARV

Sequences:

>Translated_478_residues
MEKNVGIHFAIKRENNVKKRMGYVMNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSNGIPTFVQSANGALVTDVDGNQ
YIDFAGAIGTINVGHCHPAVKEALHKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKIA
RKYTKRPGIIAFSKGFHGRTLMTMTMTSKVKPYKFGFGPFAPEVYKAPFPYEYRCPEGLTEEQYDDFMIEEFKNFFISEV
APETIAAVVMEPVQGEGGFIVPSKKFAQEVRNICSEHGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVP
ISGVIGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDVIEKENLNDRAIELGKVVMNRFEEMKNKYNCIGDVRGLGAMC
AFELVQDRKTKTPDKTLTANLCTEANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQICYEKANTARV
>Mature_478_residues
MEKNVGIHFAIKRENNVKKRMGYVMNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSNGIPTFVQSANGALVTDVDGNQ
YIDFAGAIGTINVGHCHPAVKEALHKQVDQYIHTGFNVMMYEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKIA
RKYTKRPGIIAFSKGFHGRTLMTMTMTSKVKPYKFGFGPFAPEVYKAPFPYEYRCPEGLTEEQYDDFMIEEFKNFFISEV
APETIAAVVMEPVQGEGGFIVPSKKFAQEVRNICSEHGILFVADEIQTGFSRTGKYFAIDHYDVVPDLITVSKSLGAGVP
ISGVIGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDVIEKENLNDRAIELGKVVMNRFEEMKNKYNCIGDVRGLGAMC
AFELVQDRKTKTPDKTLTANLCTEANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQICYEKANTARV

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=419, Percent_Identity=35.3221957040573, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=32.2352941176471, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI37574042, Length=423, Percent_Identity=31.6784869976359, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI24119277, Length=424, Percent_Identity=31.6037735849057, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI226442709, Length=392, Percent_Identity=32.1428571428571, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI284507298, Length=330, Percent_Identity=36.0606060606061, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI226442705, Length=423, Percent_Identity=30.9692671394799, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI188536080, Length=467, Percent_Identity=25.9100642398287, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI38679950, Length=467, Percent_Identity=25.9100642398287, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI38679946, Length=467, Percent_Identity=25.9100642398287, Blast_Score=152, Evalue=9e-37,
Organism=Escherichia coli, GI1789016, Length=430, Percent_Identity=47.4418604651163, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=47.8571428571429, Blast_Score=394, Evalue=1e-110,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=34.0050377833753, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788044, Length=396, Percent_Identity=34.0909090909091, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI145693181, Length=424, Percent_Identity=33.7264150943396, Blast_Score=202, Evalue=6e-53,
Organism=Escherichia coli, GI1786349, Length=345, Percent_Identity=31.0144927536232, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI1786991, Length=424, Percent_Identity=27.3584905660377, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71992977, Length=447, Percent_Identity=31.3199105145414, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI32564660, Length=419, Percent_Identity=32.2195704057279, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI25144271, Length=415, Percent_Identity=30.1204819277108, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI25144274, Length=298, Percent_Identity=29.1946308724832, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17541228, Length=471, Percent_Identity=25.0530785562633, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71981843, Length=161, Percent_Identity=31.055900621118, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=422, Percent_Identity=33.175355450237, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6324432, Length=415, Percent_Identity=32.289156626506, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321456, Length=431, Percent_Identity=25.5220417633411, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=449, Percent_Identity=24.9443207126949, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI161085790, Length=451, Percent_Identity=31.7073170731707, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI28574759, Length=429, Percent_Identity=32.4009324009324, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI21357415, Length=469, Percent_Identity=30.7036247334755, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21356575, Length=418, Percent_Identity=32.0574162679426, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI281366494, Length=450, Percent_Identity=26, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24667139, Length=450, Percent_Identity=26, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24667143, Length=450, Percent_Identity=26, Blast_Score=118, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 52552; Mature: 52552

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKNVGIHFAIKRENNVKKRMGYVMNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSNG
CCCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCC
IPTFVQSANGALVTDVDGNQYIDFAGAIGTINVGHCHPAVKEALHKQVDQYIHTGFNVMM
CCHHHHCCCCCEEEECCCCCEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCEEEE
YEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGRT
ECHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCE
LMTMTMTSKVKPYKFGFGPFAPEVYKAPFPYEYRCPEGLTEEQYDDFMIEEFKNFFISEV
EEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
APETIAAVVMEPVQGEGGFIVPSKKFAQEVRNICSEHGILFVADEIQTGFSRTGKYFAID
CHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHCCCCEEEEE
HYDVVPDLITVSKSLGAGVPISGVIGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDVI
CHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
EKENLNDRAIELGKVVMNRFEEMKNKYNCIGDVRGLGAMCAFELVQDRKTKTPDKTLTAN
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LCTEANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQICYEKANTARV
HHHCCCCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEKNVGIHFAIKRENNVKKRMGYVMNTKKFAKVNEQIPGPKAASLLERRQNIVPKGVSNG
CCCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCC
IPTFVQSANGALVTDVDGNQYIDFAGAIGTINVGHCHPAVKEALHKQVDQYIHTGFNVMM
CCHHHHCCCCCEEEECCCCCEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCEEEE
YEPYIELAEKLAALAPGSFDKQVLFLNSGAEAVENAVKIARKYTKRPGIIAFSKGFHGRT
ECHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCE
LMTMTMTSKVKPYKFGFGPFAPEVYKAPFPYEYRCPEGLTEEQYDDFMIEEFKNFFISEV
EEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
APETIAAVVMEPVQGEGGFIVPSKKFAQEVRNICSEHGILFVADEIQTGFSRTGKYFAID
CHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHCCCCEEEEE
HYDVVPDLITVSKSLGAGVPISGVIGRKEIMNESAPGELGGTYAGSPLGCAAALAVLDVI
CHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
EKENLNDRAIELGKVVMNRFEEMKNKYNCIGDVRGLGAMCAFELVQDRKTKTPDKTLTAN
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LCTEANKRGLLLLSAGTYGNVIRVLMPLVITDEQLEEGLTIIEESLQICYEKANTARV
HHHCCCCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]