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The map label for this gene is lolC [H]

Identifier: 227082014

GI number: 227082014

Start: 1965498

End: 1966718

Strand: Reverse

Name: lolC [H]

Synonym: VCM66_1808

Alternate gene names: 227082014

Gene position: 1966718-1965498 (Counterclockwise)

Preceding gene: 227082020

Following gene: 227082013

Centisome position: 67.99

GC content: 51.68

Gene sequence:

>1221_bases
ATGGTTGGATTTATGTTTCATCCGATTTCGGCTTTTATTGGTTTGCGCTATTTGCGCGGCCGCTCAGGGGATCGTTTTAG
CCGCTTTGTCTCTTATATGTCGACGGCGGGGATCACGATCGGTGTGATGTCGCTAGTTACTGTTTTATCGGTGATGAACG
GTTTTGAGGCGCAGCTTAAGTCACGCATTCTTGGGGTGTTACCTCAAGCGGTTGTCACCGAAGCCGCAGGCAAAACCACC
CTCAGCGCAACGCCCCCAGATTTTGTCACGGCATTATCGACTCAGCGCCCACCAGAGCCGTTAGTGCGCAGTGACGCGGT
GGTGCAAAGTGCCTCGCAACTGGCTGCGGGTTTGTTGATTGGTATCGAGCCACAACAAAATGATCCGATTGAGCAACACC
TGATTGCAGGTCGGGTAACGGCTTTGCAAGCGGGCGAGTATCAACTCTTTCTTGGGCATCTTCTTGCGCGCAGTTTGAAT
GTCACCGTGGGTGATAAAGTGCGTTTGATGGTGACAGAAGCGAGCCAATTTACCCCGTTGGGCCGTTTGCCCAGTCAGCG
AAACTTTACGGTAGCGGGAATTTTTAATACCGGTTCGGATGTGGATGGGCAACTCATGGTGACTCATCTGCGCGATGCGG
CCAAGCTATTGCGCTATGATGCACAGACCATTTCAGGTTGGCGGCTATTTTTTGATGACCCGTTTGTGGTCAGTCAGCTT
GCCGAACAGCCATTGCCGCAAGATTGGCAATGGAGCGACTGGCGTGAGCAGCGCGGTGAACTGTTTCAAGCGGTACGTAT
GGAAAAGAACATGATGGGGCTGATGCTCGGACTTATCGTTGGGGTGGCTGCGTTTAATATTATTTCTGCGCTGATCATGG
TGGTGATGGAGAAGCAGGCTGAGGTGGCGATTTTAAAAACCCAAGGCATGCAGTCACAACATGTGCTGGCGATTTTCATG
GTACAAGGCGCCAGCAGCGGTGTGATTGGTGCGCTGGTTGGTGGTTTACTTGGCGTGCTGTTGGCGGCCAATTTAAATAG
CCTGATGGAAGCCTTAGGTGTTGCCCTTTTTTCGGTGGGTGGCAGTTTGCCAGTGGCGATTGATCCGCTGCAGATTGTCC
TCGTTATTGTTCTTGCGATTGTATTAAGTCTGTTGGCAACGCTGTTTCCAGCCTATCGCGCATCTTCTGTTCAACCCGCT
GAGGCGTTACGTTATGAATAA

Upstream 100 bases:

>100_bases
CTTGTTATGGGTGTGAAATAAACGTTCTCTTACACAGATTTGATAAAGAAAAACTACAACCGCGCAGGGATTCTCGCTAC
ATTAACGCCATTCTCTTCCT

Downstream 100 bases:

>100_bases
CCTTTTACGTTGTCATCAGGTTTGCAAAACCTATCAAGAAGGGGAGTTGCAAACTCAGGTTCTTAAAGGGGTGAGTTTTG
AGCTAAAACGCGGTGAGTTG

Product: Lipoprotein-releasing system transmembrane protein lolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MVGFMFHPISAFIGLRYLRGRSGDRFSRFVSYMSTAGITIGVMSLVTVLSVMNGFEAQLKSRILGVLPQAVVTEAAGKTT
LSATPPDFVTALSTQRPPEPLVRSDAVVQSASQLAAGLLIGIEPQQNDPIEQHLIAGRVTALQAGEYQLFLGHLLARSLN
VTVGDKVRLMVTEASQFTPLGRLPSQRNFTVAGIFNTGSDVDGQLMVTHLRDAAKLLRYDAQTISGWRLFFDDPFVVSQL
AEQPLPQDWQWSDWREQRGELFQAVRMEKNMMGLMLGLIVGVAAFNIISALIMVVMEKQAEVAILKTQGMQSQHVLAIFM
VQGASSGVIGALVGGLLGVLLAANLNSLMEALGVALFSVGGSLPVAIDPLQIVLVIVLAIVLSLLATLFPAYRASSVQPA
EALRYE

Sequences:

>Translated_406_residues
MVGFMFHPISAFIGLRYLRGRSGDRFSRFVSYMSTAGITIGVMSLVTVLSVMNGFEAQLKSRILGVLPQAVVTEAAGKTT
LSATPPDFVTALSTQRPPEPLVRSDAVVQSASQLAAGLLIGIEPQQNDPIEQHLIAGRVTALQAGEYQLFLGHLLARSLN
VTVGDKVRLMVTEASQFTPLGRLPSQRNFTVAGIFNTGSDVDGQLMVTHLRDAAKLLRYDAQTISGWRLFFDDPFVVSQL
AEQPLPQDWQWSDWREQRGELFQAVRMEKNMMGLMLGLIVGVAAFNIISALIMVVMEKQAEVAILKTQGMQSQHVLAIFM
VQGASSGVIGALVGGLLGVLLAANLNSLMEALGVALFSVGGSLPVAIDPLQIVLVIVLAIVLSLLATLFPAYRASSVQPA
EALRYE
>Mature_406_residues
MVGFMFHPISAFIGLRYLRGRSGDRFSRFVSYMSTAGITIGVMSLVTVLSVMNGFEAQLKSRILGVLPQAVVTEAAGKTT
LSATPPDFVTALSTQRPPEPLVRSDAVVQSASQLAAGLLIGIEPQQNDPIEQHLIAGRVTALQAGEYQLFLGHLLARSLN
VTVGDKVRLMVTEASQFTPLGRLPSQRNFTVAGIFNTGSDVDGQLMVTHLRDAAKLLRYDAQTISGWRLFFDDPFVVSQL
AEQPLPQDWQWSDWREQRGELFQAVRMEKNMMGLMLGLIVGVAAFNIISALIMVVMEKQAEVAILKTQGMQSQHVLAIFM
VQGASSGVIGALVGGLLGVLLAANLNSLMEALGVALFSVGGSLPVAIDPLQIVLVIVLAIVLSLLATLFPAYRASSVQPA
EALRYE

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=402, Percent_Identity=52.9850746268657, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1787362, Length=417, Percent_Identity=31.1750599520384, Blast_Score=145, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 43748; Mature: 43748

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGFMFHPISAFIGLRYLRGRSGDRFSRFVSYMSTAGITIGVMSLVTVLSVMNGFEAQLK
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHH
SRILGVLPQAVVTEAAGKTTLSATPPDFVTALSTQRPPEPLVRSDAVVQSASQLAAGLLI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEE
GIEPQQNDPIEQHLIAGRVTALQAGEYQLFLGHLLARSLNVTVGDKVRLMVTEASQFTPL
ECCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCEECCCEEEEEECCCCCCCC
GRLPSQRNFTVAGIFNTGSDVDGQLMVTHLRDAAKLLRYDAQTISGWRLFFDDPFVVSQL
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHH
AEQPLPQDWQWSDWREQRGELFQAVRMEKNMMGLMLGLIVGVAAFNIISALIMVVMEKQA
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EVAILKTQGMQSQHVLAIFMVQGASSGVIGALVGGLLGVLLAANLNSLMEALGVALFSVG
CEEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSLPVAIDPLQIVLVIVLAIVLSLLATLFPAYRASSVQPAEALRYE
CCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC
>Mature Secondary Structure
MVGFMFHPISAFIGLRYLRGRSGDRFSRFVSYMSTAGITIGVMSLVTVLSVMNGFEAQLK
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHH
SRILGVLPQAVVTEAAGKTTLSATPPDFVTALSTQRPPEPLVRSDAVVQSASQLAAGLLI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEE
GIEPQQNDPIEQHLIAGRVTALQAGEYQLFLGHLLARSLNVTVGDKVRLMVTEASQFTPL
ECCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCEECCCEEEEEECCCCCCCC
GRLPSQRNFTVAGIFNTGSDVDGQLMVTHLRDAAKLLRYDAQTISGWRLFFDDPFVVSQL
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHH
AEQPLPQDWQWSDWREQRGELFQAVRMEKNMMGLMLGLIVGVAAFNIISALIMVVMEKQA
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EVAILKTQGMQSQHVLAIFMVQGASSGVIGALVGGLLGVLLAANLNSLMEALGVALFSVG
CEEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSLPVAIDPLQIVLVIVLAIVLSLLATLFPAYRASSVQPAEALRYE
CCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]