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The map label for this gene is norM [H]

Identifier: 227081783

GI number: 227081783

Start: 1702922

End: 1704298

Strand: Reverse

Name: norM [H]

Synonym: VCM66_1570

Alternate gene names: 227081783

Gene position: 1704298-1702922 (Counterclockwise)

Preceding gene: 227081785

Following gene: 227081782

Centisome position: 58.92

GC content: 50.47

Gene sequence:

>1377_bases
GTGTCTGTTGTCTCTCAAGTTTTATCCCACATGAGAGGGGATTTCTTCCGCCGCTTGATCGCGATTGCTCTGCCGATCAC
GCTACAAAATATCATGTTCTCCAGCCGCGGTTTGGTCGATGTGCTAATGCTCGGTCAACTGGGAGAGGCCGAAATTGCCG
CAGTAGGTGTCGCGGCACGAGCGACCTTTGTGACTACGATCATGCTGGTGGGCGTGACCACAGGCGGCGCACTGCTCACG
GCGCAATATTGGGGCGCGGGCGATCGCAAAGGTGTGCGTGAAAGTACGGCACTGACTTGGTTAGTCTCTAACTTCTTTGC
CTTTTTCACGGTATTGCTGTTCCTGTTTTTCCCACAGCAAATCATGTCGTTAACGACCGATTCGGAGCAAGTTAATGCGC
TGGGTAGTCAATATCTGATCATCACCTCGTTCACTATGTTTGCGGTGGCTTGTGTCAGCAGTATGGCAGTCGGACTTCGC
GCGATGCACAAGCCCGGGGTAAGCACGTTTTTCAGCGGTATCGGCATTGTGTCTAACGTGGTACTGAACTGGATCTTAAT
TTTCGGTAAATTTGGATTCCCAGCGATGGGTATTCAAGGGGCGGCGATTGCCACCGTGTTGAGTGGCGCGATTGAAATTG
CTTGTTTGTACAGTTACTTGTATGGCAAAAAACATTTGATGGCCTTTGGCTGGCAAGACATCAAAGCGGTAATTGATTGG
CCGAAAATTAGCCGTTTTCTACGTTTGTCATTACCCACCACCTTTAACTTTCTGATCTGGGCTGCCGGTTTATTTACCTA
CCACGCTATCATGGGGCAGACGGGGGTTCAGGGGCTTGCTGCGCTATCCGTCATGACTCCGGTTGAATCGATTTCCCTGA
GTTTACTGATTGGCATGTCTACTGCGGCGGCCGTCTTGGTGGGCAATCAACTTGGCGCGAAAAACTATGAAGCGGTGTAC
TACCAAGCGATAGGTGTAACCGCATGCAGTGTGCTGGTCGGTATTGTTGTCGCGATTGGTCTGTATCTGGTGCAAATTCC
GGTGCTTGGTGCGTTTACGGCGTTAACGCCTGAAACGCGCGAGTTATCAGAAAAATTCATGCTGATCTTGTGTTTAGGTA
TCGTGCTGCGTTCATTCCCGATGACCGCGATCGTTGGCGTGTTGCGCGCGGGCGGCGATGTAAAATTCTGTCTCGGCCAA
GACATCGTCGCGCAGTGGTGTATTGGTATCCCGTTAGCCGCCTTTGCTGCGCTAGTGTTAAAGGTCGAACCGGAGTGGAT
TTACCTGCTGTTTTTGACTGAAGAAGTGGTGAAGTGGTTTGGCTCACTACATCGCATGAAAAGCAAGAAGTGGATGAAGA
ATTTGATTGAAAATTAG

Upstream 100 bases:

>100_bases
TGCTTATGCGTGCGTGAGTATAATAGCGGCTGTTTTTTCTGCCTACTCTGTCCTTAACCTTAACAGGTAATAGGGAGTCC
TCACACTTTGGAGTGATACT

Downstream 100 bases:

>100_bases
ACACTCATCGTTCGATTGGTGCAAATTAATGCATATAGTGTGATCTGCTAGCCAAAATACTTTCTCCGCTTAGGGTTTTG
GTGTAGATTCTGTGTCCGGT

Product: hypothetical protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSVVSQVLSHMRGDFFRRLIAIALPITLQNIMFSSRGLVDVLMLGQLGEAEIAAVGVAARATFVTTIMLVGVTTGGALLT
AQYWGAGDRKGVRESTALTWLVSNFFAFFTVLLFLFFPQQIMSLTTDSEQVNALGSQYLIITSFTMFAVACVSSMAVGLR
AMHKPGVSTFFSGIGIVSNVVLNWILIFGKFGFPAMGIQGAAIATVLSGAIEIACLYSYLYGKKHLMAFGWQDIKAVIDW
PKISRFLRLSLPTTFNFLIWAAGLFTYHAIMGQTGVQGLAALSVMTPVESISLSLLIGMSTAAAVLVGNQLGAKNYEAVY
YQAIGVTACSVLVGIVVAIGLYLVQIPVLGAFTALTPETRELSEKFMLILCLGIVLRSFPMTAIVGVLRAGGDVKFCLGQ
DIVAQWCIGIPLAAFAALVLKVEPEWIYLLFLTEEVVKWFGSLHRMKSKKWMKNLIEN

Sequences:

>Translated_458_residues
MSVVSQVLSHMRGDFFRRLIAIALPITLQNIMFSSRGLVDVLMLGQLGEAEIAAVGVAARATFVTTIMLVGVTTGGALLT
AQYWGAGDRKGVRESTALTWLVSNFFAFFTVLLFLFFPQQIMSLTTDSEQVNALGSQYLIITSFTMFAVACVSSMAVGLR
AMHKPGVSTFFSGIGIVSNVVLNWILIFGKFGFPAMGIQGAAIATVLSGAIEIACLYSYLYGKKHLMAFGWQDIKAVIDW
PKISRFLRLSLPTTFNFLIWAAGLFTYHAIMGQTGVQGLAALSVMTPVESISLSLLIGMSTAAAVLVGNQLGAKNYEAVY
YQAIGVTACSVLVGIVVAIGLYLVQIPVLGAFTALTPETRELSEKFMLILCLGIVLRSFPMTAIVGVLRAGGDVKFCLGQ
DIVAQWCIGIPLAAFAALVLKVEPEWIYLLFLTEEVVKWFGSLHRMKSKKWMKNLIEN
>Mature_457_residues
SVVSQVLSHMRGDFFRRLIAIALPITLQNIMFSSRGLVDVLMLGQLGEAEIAAVGVAARATFVTTIMLVGVTTGGALLTA
QYWGAGDRKGVRESTALTWLVSNFFAFFTVLLFLFFPQQIMSLTTDSEQVNALGSQYLIITSFTMFAVACVSSMAVGLRA
MHKPGVSTFFSGIGIVSNVVLNWILIFGKFGFPAMGIQGAAIATVLSGAIEIACLYSYLYGKKHLMAFGWQDIKAVIDWP
KISRFLRLSLPTTFNFLIWAAGLFTYHAIMGQTGVQGLAALSVMTPVESISLSLLIGMSTAAAVLVGNQLGAKNYEAVYY
QAIGVTACSVLVGIVVAIGLYLVQIPVLGAFTALTPETRELSEKFMLILCLGIVLRSFPMTAIVGVLRAGGDVKFCLGQD
IVAQWCIGIPLAAFAALVLKVEPEWIYLLFLTEEVVKWFGSLHRMKSKKWMKNLIEN

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=306, Percent_Identity=22.2222222222222, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI48994890, Length=423, Percent_Identity=23.4042553191489, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49629; Mature: 49498

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVVSQVLSHMRGDFFRRLIAIALPITLQNIMFSSRGLVDVLMLGQLGEAEIAAVGVAAR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHH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EECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]