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The map label for this gene is rtxC

Identifier: 227081622

GI number: 227081622

Start: 1507105

End: 1507566

Strand: Direct

Name: rtxC

Synonym: VCM66_1406

Alternate gene names: 227081622

Gene position: 1507105-1507566 (Clockwise)

Preceding gene: 227081621

Following gene: 227081623

Centisome position: 52.1

GC content: 49.13

Gene sequence:

>462_bases
ATGTCTATTACACATCAACCTGCAAATCTCACATTAGCGCAAATACAACAGATGATAGGTGGTGTGATGCTGCTCAGCCA
GCATTCGCCGCTTCATCGTCGTTATGTGGTTGCAGAATGGCTGCAACGCATTCTGCCTGCGTTTGAGCTAAACCAGTTTT
GCTATTACGAAGATGAGCATGGGCGTCCAATTGCCTTTTGTAATTGGGCGTTTGTCTCTGAGCAGATCCGAGATGAGCTG
CTTTCTGGTGTGCGCGAAATATCTCCATCCGACTGGCGTTCGGGCCAGCAAATCTACATTCCAGAGATGATTGCTCCATT
CGGGCATGGTCGCGAGGTCGTCAATGATCTTCGTCGTCGTGTATTTCTTCCGTGGCAGGGGCAGAAAGTCTGTACTGTCC
GCGGCAAGGTGGATGCTCAAAATGACCGCTGTATCCGAAAGGTGCAGTGGTTTTCTATTTAA

Upstream 100 bases:

>100_bases
GCAAATTCAGCAGAAGACGCCGCCGCGGAAGAGAAAACCGCAGCGAAGAAACGTCCTGCTCAGGTGAAAAAGTAACCGCG
CATCGGTTGATACTGGGCAC

Downstream 100 bases:

>100_bases
TCCCTAAAAGAAGAGTTTGGCTTATGGGAAAACCATTTTGGAGAAGTGTTGAATACTTCTTCACAGGAAACTATTCCGCC
GACGATGGAAACAACAACAT

Product: RTX toxin activating protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MSITHQPANLTLAQIQQMIGGVMLLSQHSPLHRRYVVAEWLQRILPAFELNQFCYYEDEHGRPIAFCNWAFVSEQIRDEL
LSGVREISPSDWRSGQQIYIPEMIAPFGHGREVVNDLRRRVFLPWQGQKVCTVRGKVDAQNDRCIRKVQWFSI

Sequences:

>Translated_153_residues
MSITHQPANLTLAQIQQMIGGVMLLSQHSPLHRRYVVAEWLQRILPAFELNQFCYYEDEHGRPIAFCNWAFVSEQIRDEL
LSGVREISPSDWRSGQQIYIPEMIAPFGHGREVVNDLRRRVFLPWQGQKVCTVRGKVDAQNDRCIRKVQWFSI
>Mature_152_residues
SITHQPANLTLAQIQQMIGGVMLLSQHSPLHRRYVVAEWLQRILPAFELNQFCYYEDEHGRPIAFCNWAFVSEQIRDELL
SGVREISPSDWRSGQQIYIPEMIAPFGHGREVVNDLRRRVFLPWQGQKVCTVRGKVDAQNDRCIRKVQWFSI

Specific function: Involved in fatty acylation of the protoxin (rtxA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP

COG id: COG2994

COG function: function code O; ACP:hemolysin acyltransferase (hemolysin-activating protein)

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RTX toxin acyltransferase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RTXC_VIBCH (Q9X4W3)

Other databases:

- EMBL:   AF119150
- EMBL:   AE003852
- PIR:   B82199
- RefSeq:   NP_231093.1
- GeneID:   2613956
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC1450
- TIGR:   VC_1450
- HOGENOM:   HBG284064
- OMA:   EWQQRIL
- ProtClustDB:   CLSK874384
- GO:   GO:0005737
- GO:   GO:0019835
- InterPro:   IPR003996
- PRINTS:   PR01489

Pfam domain/function: PF02794 HlyC

EC number: NA

Molecular weight: Translated: 17895; Mature: 17764

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: ACT_SITE 32-32

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITHQPANLTLAQIQQMIGGVMLLSQHSPLHRRYVVAEWLQRILPAFELNQFCYYEDEH
CCCCCCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GRPIAFCNWAFVSEQIRDELLSGVREISPSDWRSGQQIYIPEMIAPFGHGREVVNDLRRR
CCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHCCCCCCHHHHHHHHHH
VFLPWQGQKVCTVRGKVDAQNDRCIRKVQWFSI
EECCCCCCEEEEEECCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SITHQPANLTLAQIQQMIGGVMLLSQHSPLHRRYVVAEWLQRILPAFELNQFCYYEDEH
CCCCCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GRPIAFCNWAFVSEQIRDELLSGVREISPSDWRSGQQIYIPEMIAPFGHGREVVNDLRRR
CCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHCCCCCCHHHHHHHHHH
VFLPWQGQKVCTVRGKVDAQNDRCIRKVQWFSI
EECCCCCCEEEEEECCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9927695; 10952301