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The map label for this gene is cry2

Identifier: 227081563

GI number: 227081563

Start: 1440604

End: 1442118

Strand: Direct

Name: cry2

Synonym: VCM66_1347

Alternate gene names: 227081563

Gene position: 1440604-1442118 (Clockwise)

Preceding gene: 227081562

Following gene: 227081564

Centisome position: 49.8

GC content: 53.4

Gene sequence:

>1515_bases
ATGGAAAAGATCAATCTGGTATGGCTCAAACGCGACCTAAGGCTGACCGATCACGCGCCATTACAAGCGGCGTTAACTTC
GGGGCGACCGACGTTACTACTCTATCTGTTTGAGCCAATGCTGCTTGGCGATGCGCATTACAGCGAACGACACTGGCGCT
TTGTGTGGCAATCATTGCAAGCCATCAATCGTGATTTGGCGCAGAGTAAAGGGGAGGTGTTGATCGTCACATCCGATTGG
CAAACCTGCTTTGCACGTATTGCTGAGCGCTACGCCATTGAGGCGATTTATTCTCATCAAGAAGTCGGTTTAGCCTGCAC
TTTTCAGCGCGATCTTGCGCTGGCGCAGTGGTGCCAGCAACACGACATCGTCTGGCATGAGTTTCCTTATGCCGCCGTGA
TCCGCGGCGCGCAAACCCGTAAAAATTGGGATGAGCATTGGCAGCAAGTGATGCGCTCCCCTTGCTGCGATCCTGATTTA
ACACGCGCCAATTGGCTGAAGCTGGATGCCGCAACACTTGGTTTGCGCAGCGATATCCCTGCCACATGGCAGAGTAAACA
AGCGGGCATGCAAACTGGCGGCAGTGATATGGCGTGGGCGACGCTGGAGGATTTTTTCGCGCGTCGAGGGCGAGAGTATT
ACCGCTCCATTTCAAGTCCGAGCTTAGCGCGCCACGCGTGCTCGCGGATGTCGCCTTATCTTGCGTGGGGGAATATCTCA
CTGCGGGAGATGTATCAAACTTTGCTCAAACACTGGTCGGTAGCGGGATTTCGCCGCAGCCTGATTGCGCTTTCATCACG
TCTGCATTGGCACTGTCACTTTATCCAAAAATTTGAATCAGAATGTGAGATGGAGTTTCGCTGCGTCAACCGCGCTTATG
ATTCACTCTTACAGCAATCAAGCGATGCCCCCGCCGCGCAGTTAGCGGCTTGGCAAACTGGGCACACCGGCATTCCACTG
GTCGATGCCTGTATGCGTTGCTTAATTCAAACCGGATACCTCAATTTTCGCATGCGCGCGATGTTGGTGAGCGTGTTAAC
TCATCATATGAATGTGGATTGGCGAGCGGGCGTGACTTATTTGGCGCAACTGTTCCTCGATTTTGAACCGGGCATTCATT
ATCCGCAGTTTCAAATGCAAGCAGGGGTCACGGGTACCAATACTATCCGCATTTATAACCCGACCAAGCAAGCACAAGAG
CATGACAGCGAAGGGCAGTTTATTCACAAATGGGTGCCAGAGTTGGCGCAAGTGCCTGTACCGCTGCTCTTTGAACCCTG
GCTGATGACACCGCTTGAAGCGCAGATGTATCAAGTACCGCTTGAGAGCCCTTACCTCAAGCCGGTGATGGATTTGGAAG
CCAGTGCCAAGCAAGCACGGGATCGCTTATGGCAGTGGCAGAAACTGCCTGCGGTACAAGCCGAAGCGATGCGTATCCTC
GCGCGCCATGTGCGGCAAGCTAAACCGAGAACTTCGCCGCGCCAACCCAACAAGCGTCAACCGGAGATGGATTAA

Upstream 100 bases:

>100_bases
CAGAAAGTGAGGTAATAGAAAGAGAAGCGATAGATAGAACACGGGAGCGATCTTTTCCTCTTCTGTCGCGTACAAACGGC
AGAGAAAACAAGGAAAGAGT

Downstream 100 bases:

>100_bases
CACGGCTTTGCGAGTTTTGCATCGCGCCAAGCCAAGCTAGCCAAGACCCGTAAGCTTTGCTAGTCTTAGCGGCACATCAG
GAAGTGAGGACGACCTCACC

Product: putative deoxyribodipyrimidine photolyase

Products: 2 pyrimidine residues (in DNA) [C]

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MEKINLVWLKRDLRLTDHAPLQAALTSGRPTLLLYLFEPMLLGDAHYSERHWRFVWQSLQAINRDLAQSKGEVLIVTSDW
QTCFARIAERYAIEAIYSHQEVGLACTFQRDLALAQWCQQHDIVWHEFPYAAVIRGAQTRKNWDEHWQQVMRSPCCDPDL
TRANWLKLDAATLGLRSDIPATWQSKQAGMQTGGSDMAWATLEDFFARRGREYYRSISSPSLARHACSRMSPYLAWGNIS
LREMYQTLLKHWSVAGFRRSLIALSSRLHWHCHFIQKFESECEMEFRCVNRAYDSLLQQSSDAPAAQLAAWQTGHTGIPL
VDACMRCLIQTGYLNFRMRAMLVSVLTHHMNVDWRAGVTYLAQLFLDFEPGIHYPQFQMQAGVTGTNTIRIYNPTKQAQE
HDSEGQFIHKWVPELAQVPVPLLFEPWLMTPLEAQMYQVPLESPYLKPVMDLEASAKQARDRLWQWQKLPAVQAEAMRIL
ARHVRQAKPRTSPRQPNKRQPEMD

Sequences:

>Translated_504_residues
MEKINLVWLKRDLRLTDHAPLQAALTSGRPTLLLYLFEPMLLGDAHYSERHWRFVWQSLQAINRDLAQSKGEVLIVTSDW
QTCFARIAERYAIEAIYSHQEVGLACTFQRDLALAQWCQQHDIVWHEFPYAAVIRGAQTRKNWDEHWQQVMRSPCCDPDL
TRANWLKLDAATLGLRSDIPATWQSKQAGMQTGGSDMAWATLEDFFARRGREYYRSISSPSLARHACSRMSPYLAWGNIS
LREMYQTLLKHWSVAGFRRSLIALSSRLHWHCHFIQKFESECEMEFRCVNRAYDSLLQQSSDAPAAQLAAWQTGHTGIPL
VDACMRCLIQTGYLNFRMRAMLVSVLTHHMNVDWRAGVTYLAQLFLDFEPGIHYPQFQMQAGVTGTNTIRIYNPTKQAQE
HDSEGQFIHKWVPELAQVPVPLLFEPWLMTPLEAQMYQVPLESPYLKPVMDLEASAKQARDRLWQWQKLPAVQAEAMRIL
ARHVRQAKPRTSPRQPNKRQPEMD
>Mature_504_residues
MEKINLVWLKRDLRLTDHAPLQAALTSGRPTLLLYLFEPMLLGDAHYSERHWRFVWQSLQAINRDLAQSKGEVLIVTSDW
QTCFARIAERYAIEAIYSHQEVGLACTFQRDLALAQWCQQHDIVWHEFPYAAVIRGAQTRKNWDEHWQQVMRSPCCDPDL
TRANWLKLDAATLGLRSDIPATWQSKQAGMQTGGSDMAWATLEDFFARRGREYYRSISSPSLARHACSRMSPYLAWGNIS
LREMYQTLLKHWSVAGFRRSLIALSSRLHWHCHFIQKFESECEMEFRCVNRAYDSLLQQSSDAPAAQLAAWQTGHTGIPL
VDACMRCLIQTGYLNFRMRAMLVSVLTHHMNVDWRAGVTYLAQLFLDFEPGIHYPQFQMQAGVTGTNTIRIYNPTKQAQE
HDSEGQFIHKWVPELAQVPVPLLFEPWLMTPLEAQMYQVPLESPYLKPVMDLEASAKQARDRLWQWQKLPAVQAEAMRIL
ARHVRQAKPRTSPRQPNKRQPEMD

Specific function: Has no photolyase activity

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain

Homologues:

Organism=Homo sapiens, GI188536100, Length=505, Percent_Identity=20.5940594059406, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI188536103, Length=291, Percent_Identity=23.0240549828179, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1786926, Length=451, Percent_Identity=27.0509977827051, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324962, Length=235, Percent_Identity=26.8085106382979, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137248, Length=506, Percent_Identity=20.9486166007905, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585455, Length=506, Percent_Identity=20.9486166007905, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648152, Length=505, Percent_Identity=22.3762376237624, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CRY2_VIBCH (Q9KS67)

Other databases:

- EMBL:   AE003852
- PIR:   A82205
- RefSeq:   NP_231036.1
- ProteinModelPortal:   Q9KS67
- SMR:   Q9KS67
- GeneID:   2614024
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC1392
- TIGR:   VC_1392
- HOGENOM:   HBG693486
- OMA:   YNPIKQG
- ProtClustDB:   CLSK874352
- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00147

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7; SSF52425 DNA_photolyase_N; SSF48173 Photolyase_FAD-bd/Cryptochr_C

EC number: 4.1.99.3 [C]

Molecular weight: Translated: 58437; Mature: 58437

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKINLVWLKRDLRLTDHAPLQAALTSGRPTLLLYLFEPMLLGDAHYSERHWRFVWQSLQ
CCCEEEEEEEECCCCCCCCCHHHHHHCCCCEEEEEEHHHHHHCCCCCCHHHHHHHHHHHH
AINRDLAQSKGEVLIVTSDWQTCFARIAERYAIEAIYSHQEVGLACTFQRDLALAQWCQQ
HHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHH
HDIVWHEFPYAAVIRGAQTRKNWDEHWQQVMRSPCCDPDLTRANWLKLDAATLGLRSDIP
CCCEEECCCHHHHHCCCHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHCCCCCCC
ATWQSKQAGMQTGGSDMAWATLEDFFARRGREYYRSISSPSLARHACSRMSPYLAWGNIS
CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEECCCC
LREMYQTLLKHWSVAGFRRSLIALSSRLHWHCHFIQKFESECEMEFRCVNRAYDSLLQQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SDAPAAQLAAWQTGHTGIPLVDACMRCLIQTGYLNFRMRAMLVSVLTHHMNVDWRAGVTY
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
LAQLFLDFEPGIHYPQFQMQAGVTGTNTIRIYNPTKQAQEHDSEGQFIHKWVPELAQVPV
HHHHHHHCCCCCCCCCHHEECCCCCCCEEEEECCHHHHHCCCCCCCHHHHHHHHHHHCCC
PLLFEPWLMTPLEAQMYQVPLESPYLKPVMDLEASAKQARDRLWQWQKLPAVQAEAMRIL
CCEECCHHCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ARHVRQAKPRTSPRQPNKRQPEMD
HHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEKINLVWLKRDLRLTDHAPLQAALTSGRPTLLLYLFEPMLLGDAHYSERHWRFVWQSLQ
CCCEEEEEEEECCCCCCCCCHHHHHHCCCCEEEEEEHHHHHHCCCCCCHHHHHHHHHHHH
AINRDLAQSKGEVLIVTSDWQTCFARIAERYAIEAIYSHQEVGLACTFQRDLALAQWCQQ
HHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHH
HDIVWHEFPYAAVIRGAQTRKNWDEHWQQVMRSPCCDPDLTRANWLKLDAATLGLRSDIP
CCCEEECCCHHHHHCCCHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHCCCCCCC
ATWQSKQAGMQTGGSDMAWATLEDFFARRGREYYRSISSPSLARHACSRMSPYLAWGNIS
CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEECCCC
LREMYQTLLKHWSVAGFRRSLIALSSRLHWHCHFIQKFESECEMEFRCVNRAYDSLLQQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SDAPAAQLAAWQTGHTGIPLVDACMRCLIQTGYLNFRMRAMLVSVLTHHMNVDWRAGVTY
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
LAQLFLDFEPGIHYPQFQMQAGVTGTNTIRIYNPTKQAQEHDSEGQFIHKWVPELAQVPV
HHHHHHHCCCCCCCCCHHEECCCCCCCEEEEECCHHHHHCCCCCCCHHHHHHHHHHHCCC
PLLFEPWLMTPLEAQMYQVPLESPYLKPVMDLEASAKQARDRLWQWQKLPAVQAEAMRIL
CCEECCHHCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ARHVRQAKPRTSPRQPNKRQPEMD
HHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: ATP; FADH2; Flavin; pterin [C]

Metal ions: NA

Kcat value (1/min): 2.4 [C]

Specific activity: NA

Km value (mM): NA

Substrates: cyclobutadipyrimidine (in DNA) [C]

Specific reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) [C]

General reaction: C-C-bond cleavage [C]

Inhibitor: yeast DNA [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301