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The map label for this gene is tyrR [H]

Identifier: 227081479

GI number: 227081479

Start: 1347414

End: 1348955

Strand: Direct

Name: tyrR [H]

Synonym: VCM66_1263

Alternate gene names: 227081479

Gene position: 1347414-1348955 (Clockwise)

Preceding gene: 227081478

Following gene: 227081480

Centisome position: 46.58

GC content: 48.83

Gene sequence:

>1542_bases
GTGCGTCTTGAAGTCCTCTGTGAAGACCGATTAGGTCTGACTCGCGAGTTACTGGATATTCTCGCCTCCAAAAGCATCGA
TCTGCGAGGGATCGAAATCGATGTGATCGGTATTATTTACCTCAATTGTCCTGATATTGATTTTGAAACCTTCAGTGAAC
TGATGGCGGAAATTCGCCGCATTCCCGGGGTGAAAGATGTCCGTAAAATCCAGTTCATGCCGATTGAACGGCACAACACC
GAATTGATTTCTCTGCTCAATAACTTGCCTGATGCGGTATTGGCGATCAACCTCAAAGGCGCGGTGGATATGGCTAACCA
CGCTGCGGCTGCATTGTTCAATCGTGAAGAATCCAGCATGATCGGCCAGCAAATTTCAGCCTTGATGCCCGTCTTCAACT
TCACACGTTGGCTGGAAGGCAGTAAGTCTCGTCTGCGTGAAGATGTGGTCTTGGATGGACTGGATTATGTGATGGAAATC
ATGCCCGTTTACATTTCGAGCGATGCCAAACAATCCACCTTAGCCAGCGCGATGATGATGTTACGTGCTGCGAATGCGGG
ATTGACTAGCACAACTCAAATCCCACTACAGAGCAACTTAGGCTTTGAACATTTTGTGGGTGTTTCGAATCGACACAAAA
GCCTGATGAGCCAAGCGAAAAAATTGGCCATGCTTGATCAACCTCTGCTGATTGAAGGGGAAACCGGCACAGGTAAAGAG
ATGCTCGCTAAGGCGTGCCATAACCGTTCGGATCGTTCTTCTGCACCCTTTTTGGTTCTGAGTTGCGCTTCGATGCCGGA
TGATGTGGCCGAAACCGAATTGTTTGGTCATGCGCCGGGATCTTTTAACCATCAACAAGGTCATAAAGGGATTTTTGAGC
AAGCCAATGGTGGCACTGTATTTCTGGATGAAATTGGTGAAATGAGTCCACATTTGCAAATTAAGCTGCTGCGCTTTTTG
CAAGATGGCACTTTCCGTCGTGTCGGGGAGGAGCATGAAATCCACGTGGATGTGCGTGTGATTGCCTCCACGCGTCATAA
TTTAGCGGATTTGGCCGAGTCGCGCCGTTTTCGGGAGGACCTGTTCTACCGCCTCAATGTCTTGACGCTGCGTATTCCAC
CTCTGCGTGAACGCCCAAGTGATGTACAGCCGCTGCTTGAACTCTTCATCACCAAACACTGTAACAAGTTGGGCATGCTC
AAACCTAAGTTGACCGACGATCTGCTGGATAAACTCAGTCAGTATCAGTGGCCGGGCAATATGCGCCAACTGGACAATAT
GGTGCTGCGTGCCTTAACTGAAATTGAAGGGGATGTGCTGGGTATTGAACCGTTCCACCTACCGCAAGTGGACAGCGTAA
GTTCTGCGCCTAGTATCAACCTCGATGGTTCGCTCGACGACATCATGAAGGAGTACGAATCGCAAGTGTTGGATCGTCTG
TTCCAATCTTTTCCTTCCAGTCGTAAGTTGGCGAAAAGACTCAATGTTTCTCACACGTCGATCGCGAATAAGCTGAGGGA
TTATGGAATAAGGAAGCGCTGA

Upstream 100 bases:

>100_bases
GAAACTGCGATCCGTTATCACGGATCGCTTGACGCCGATCTGGGCTTGGGCGAAACTACTGTCAACTTTTCGTGACACTT
TCAAACAGGATCCTATTAAA

Downstream 100 bases:

>100_bases
TGAATGGATTAAACAGCGAATGCCATTTCTATCAAACCGATGGTGACATTGTTGTACGCTGCGCGCAAATCAACGACGCC
GAGCGTTTAAGCCAGTATTT

Product: transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MRLEVLCEDRLGLTRELLDILASKSIDLRGIEIDVIGIIYLNCPDIDFETFSELMAEIRRIPGVKDVRKIQFMPIERHNT
ELISLLNNLPDAVLAINLKGAVDMANHAAAALFNREESSMIGQQISALMPVFNFTRWLEGSKSRLREDVVLDGLDYVMEI
MPVYISSDAKQSTLASAMMMLRAANAGLTSTTQIPLQSNLGFEHFVGVSNRHKSLMSQAKKLAMLDQPLLIEGETGTGKE
MLAKACHNRSDRSSAPFLVLSCASMPDDVAETELFGHAPGSFNHQQGHKGIFEQANGGTVFLDEIGEMSPHLQIKLLRFL
QDGTFRRVGEEHEIHVDVRVIASTRHNLADLAESRRFREDLFYRLNVLTLRIPPLRERPSDVQPLLELFITKHCNKLGML
KPKLTDDLLDKLSQYQWPGNMRQLDNMVLRALTEIEGDVLGIEPFHLPQVDSVSSAPSINLDGSLDDIMKEYESQVLDRL
FQSFPSSRKLAKRLNVSHTSIANKLRDYGIRKR

Sequences:

>Translated_513_residues
MRLEVLCEDRLGLTRELLDILASKSIDLRGIEIDVIGIIYLNCPDIDFETFSELMAEIRRIPGVKDVRKIQFMPIERHNT
ELISLLNNLPDAVLAINLKGAVDMANHAAAALFNREESSMIGQQISALMPVFNFTRWLEGSKSRLREDVVLDGLDYVMEI
MPVYISSDAKQSTLASAMMMLRAANAGLTSTTQIPLQSNLGFEHFVGVSNRHKSLMSQAKKLAMLDQPLLIEGETGTGKE
MLAKACHNRSDRSSAPFLVLSCASMPDDVAETELFGHAPGSFNHQQGHKGIFEQANGGTVFLDEIGEMSPHLQIKLLRFL
QDGTFRRVGEEHEIHVDVRVIASTRHNLADLAESRRFREDLFYRLNVLTLRIPPLRERPSDVQPLLELFITKHCNKLGML
KPKLTDDLLDKLSQYQWPGNMRQLDNMVLRALTEIEGDVLGIEPFHLPQVDSVSSAPSINLDGSLDDIMKEYESQVLDRL
FQSFPSSRKLAKRLNVSHTSIANKLRDYGIRKR
>Mature_513_residues
MRLEVLCEDRLGLTRELLDILASKSIDLRGIEIDVIGIIYLNCPDIDFETFSELMAEIRRIPGVKDVRKIQFMPIERHNT
ELISLLNNLPDAVLAINLKGAVDMANHAAAALFNREESSMIGQQISALMPVFNFTRWLEGSKSRLREDVVLDGLDYVMEI
MPVYISSDAKQSTLASAMMMLRAANAGLTSTTQIPLQSNLGFEHFVGVSNRHKSLMSQAKKLAMLDQPLLIEGETGTGKE
MLAKACHNRSDRSSAPFLVLSCASMPDDVAETELFGHAPGSFNHQQGHKGIFEQANGGTVFLDEIGEMSPHLQIKLLRFL
QDGTFRRVGEEHEIHVDVRVIASTRHNLADLAESRRFREDLFYRLNVLTLRIPPLRERPSDVQPLLELFITKHCNKLGML
KPKLTDDLLDKLSQYQWPGNMRQLDNMVLRALTEIEGDVLGIEPFHLPQVDSVSSAPSINLDGSLDDIMKEYESQVLDRL
FQSFPSSRKLAKRLNVSHTSIANKLRDYGIRKR

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=515, Percent_Identity=52.2330097087379, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1789087, Length=318, Percent_Identity=36.7924528301887, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI87082117, Length=334, Percent_Identity=37.4251497005988, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1788550, Length=324, Percent_Identity=35.8024691358025, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1789233, Length=322, Percent_Identity=34.1614906832298, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1790437, Length=389, Percent_Identity=34.4473007712082, Blast_Score=195, Evalue=7e-51,
Organism=Escherichia coli, GI1790299, Length=206, Percent_Identity=47.5728155339806, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI87082152, Length=288, Percent_Identity=39.9305555555556, Blast_Score=188, Evalue=9e-49,
Organism=Escherichia coli, GI1788905, Length=215, Percent_Identity=41.8604651162791, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87081872, Length=305, Percent_Identity=35.4098360655738, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1786524, Length=219, Percent_Identity=43.8356164383562, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789828, Length=240, Percent_Identity=32.5, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87081858, Length=495, Percent_Identity=25.2525252525253, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57755; Mature: 57755

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVLCEDRLGLTRELLDILASKSIDLRGIEIDVIGIIYLNCPDIDFETFSELMAEIRR
CCEEEEECCCCCHHHHHHHHHHCCCCCEECEEEEEEEEEEEECCCCCHHHHHHHHHHHHH
IPGVKDVRKIQFMPIERHNTELISLLNNLPDAVLAINLKGAVDMANHAAAALFNREESSM
CCCCCHHHHEEEEECCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCHHHHH
IGQQISALMPVFNFTRWLEGSKSRLREDVVLDGLDYVMEIMPVYISSDAKQSTLASAMMM
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LRAANAGLTSTTQIPLQSNLGFEHFVGVSNRHKSLMSQAKKLAMLDQPLLIEGETGTGKE
HHHHCCCCCCCEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
MLAKACHNRSDRSSAPFLVLSCASMPDDVAETELFGHAPGSFNHQQGHKGIFEQANGGTV
HHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCEE
FLDEIGEMSPHLQIKLLRFLQDGTFRRVGEEHEIHVDVRVIASTRHNLADLAESRRFRED
EEEHHCCCCCCHHHHHHHHHHCCHHHHCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHH
LFYRLNVLTLRIPPLRERPSDVQPLLELFITKHCNKLGMLKPKLTDDLLDKLSQYQWPGN
HHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
MRQLDNMVLRALTEIEGDVLGIEPFHLPQVDSVSSAPSINLDGSLDDIMKEYESQVLDRL
HHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FQSFPSSRKLAKRLNVSHTSIANKLRDYGIRKR
HHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRLEVLCEDRLGLTRELLDILASKSIDLRGIEIDVIGIIYLNCPDIDFETFSELMAEIRR
CCEEEEECCCCCHHHHHHHHHHCCCCCEECEEEEEEEEEEEECCCCCHHHHHHHHHHHHH
IPGVKDVRKIQFMPIERHNTELISLLNNLPDAVLAINLKGAVDMANHAAAALFNREESSM
CCCCCHHHHEEEEECCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCHHHHH
IGQQISALMPVFNFTRWLEGSKSRLREDVVLDGLDYVMEIMPVYISSDAKQSTLASAMMM
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LRAANAGLTSTTQIPLQSNLGFEHFVGVSNRHKSLMSQAKKLAMLDQPLLIEGETGTGKE
HHHHCCCCCCCEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
MLAKACHNRSDRSSAPFLVLSCASMPDDVAETELFGHAPGSFNHQQGHKGIFEQANGGTV
HHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCEE
FLDEIGEMSPHLQIKLLRFLQDGTFRRVGEEHEIHVDVRVIASTRHNLADLAESRRFRED
EEEHHCCCCCCHHHHHHHHHHCCHHHHCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHH
LFYRLNVLTLRIPPLRERPSDVQPLLELFITKHCNKLGMLKPKLTDDLLDKLSQYQWPGN
HHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
MRQLDNMVLRALTEIEGDVLGIEPFHLPQVDSVSSAPSINLDGSLDDIMKEYESQVLDRL
HHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
FQSFPSSRKLAKRLNVSHTSIANKLRDYGIRKR
HHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]