Click here to switch to the map view.

The map label for this gene is ribA [H]

Identifier: 227081435

GI number: 227081435

Start: 1294462

End: 1295112

Strand: Direct

Name: ribA [H]

Synonym: VCM66_1218

Alternate gene names: 227081435

Gene position: 1294462-1295112 (Clockwise)

Preceding gene: 227081434

Following gene: 227081436

Centisome position: 44.75

GC content: 45.47

Gene sequence:

>651_bases
ATGCAAATGTTGAGAAACGTGCATCCCGTTACAGAAATTCAAGTGAGTGCAAACATGGCGGAAGTAAGAGCCAGAGTCGA
TTTTAAAGTCGGTGCGAAAAGCAATATTGACGCAGAAATCCTGTCATTTCATGGACTGCAATCAGACAAAGAACACGTTG
CAGTGATTTTCAAATCAGCGGATACCACCCAAGAAGCCCCGCTTGTGCGTATGCACTCGGAGTGTTTAACGGGCGATGTT
TTCCATTCGTCTCGTTGTGACTGTGGTGAGCAGCTAGAAGAAACCATTACTCGCATGGGGCAGTCAGGCGGCATCATTCT
GTATTTACGTCAAGAAGGGCGAGGTATTGGTCTGTACAACAAGATTGATGCGTATCGCTTGCAAAGTCAGGGTATGAATA
CTTATGAAGCCAATAATCACCTCGGTTTTGGGGATGATCTGCGTGACTTTACGGAAGCCGCACAAATGCTACAAGCCTTG
GGGGTGAAGAAGATCCGTTTGGTGACGAACAATCCGAAAAAGATCCGTGAGTTACAAGAACATGGCATTGAGATTGTCGA
GGTGGTTCATACCTCGGCACACATCAAAGACGGTAATGAAAATTACCTGAAAGCCAAAGTTTCTCACGGTAAGCATCAAC
TCAAACTGTAA

Upstream 100 bases:

>100_bases
AGGCATTTGTTATAACATAACAATTTAAGCCTTCGAGTGATCTTTTCTTTGAAAAAAGGGGTATGAGCCCTCATAGTTAG
GTCACTAGTAGAGACAAGTT

Downstream 100 bases:

>100_bases
CCTTCAGTTTTATAAATAGATTCGCGTTGCTGCCGATAATATCGCATGTTATTAAACCCCACACTTGTGGGGTTTTTTGT
GTGTTCAGGTTGAAAAAAAA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MQMLRNVHPVTEIQVSANMAEVRARVDFKVGAKSNIDAEILSFHGLQSDKEHVAVIFKSADTTQEAPLVRMHSECLTGDV
FHSSRCDCGEQLEETITRMGQSGGIILYLRQEGRGIGLYNKIDAYRLQSQGMNTYEANNHLGFGDDLRDFTEAAQMLQAL
GVKKIRLVTNNPKKIRELQEHGIEIVEVVHTSAHIKDGNENYLKAKVSHGKHQLKL

Sequences:

>Translated_216_residues
MQMLRNVHPVTEIQVSANMAEVRARVDFKVGAKSNIDAEILSFHGLQSDKEHVAVIFKSADTTQEAPLVRMHSECLTGDV
FHSSRCDCGEQLEETITRMGQSGGIILYLRQEGRGIGLYNKIDAYRLQSQGMNTYEANNHLGFGDDLRDFTEAAQMLQAL
GVKKIRLVTNNPKKIRELQEHGIEIVEVVHTSAHIKDGNENYLKAKVSHGKHQLKL
>Mature_216_residues
MQMLRNVHPVTEIQVSANMAEVRARVDFKVGAKSNIDAEILSFHGLQSDKEHVAVIFKSADTTQEAPLVRMHSECLTGDV
FHSSRCDCGEQLEETITRMGQSGGIILYLRQEGRGIGLYNKIDAYRLQSQGMNTYEANNHLGFGDDLRDFTEAAQMLQAL
GVKKIRLVTNNPKKIRELQEHGIEIVEVVHTSAHIKDGNENYLKAKVSHGKHQLKL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=180, Percent_Identity=50, Blast_Score=164, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6319438, Length=185, Percent_Identity=40, Blast_Score=109, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 24208; Mature: 24208

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMLRNVHPVTEIQVSANMAEVRARVDFKVGAKSNIDAEILSFHGLQSDKEHVAVIFKSA
CCCHHHCCCCEEEEECCCHHHHHHHHEEEECCCCCCCHHHHHHCCCCCCCCEEEEEEECC
DTTQEAPLVRMHSECLTGDVFHSSRCDCGEQLEETITRMGQSGGIILYLRQEGRGIGLYN
CCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHH
KIDAYRLQSQGMNTYEANNHLGFGDDLRDFTEAAQMLQALGVKKIRLVTNNPKKIRELQE
HHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHH
HGIEIVEVVHTSAHIKDGNENYLKAKVSHGKHQLKL
CCHHEEEHHHHHHCCCCCCCCEEEEEECCCCEECCC
>Mature Secondary Structure
MQMLRNVHPVTEIQVSANMAEVRARVDFKVGAKSNIDAEILSFHGLQSDKEHVAVIFKSA
CCCHHHCCCCEEEEECCCHHHHHHHHEEEECCCCCCCHHHHHHCCCCCCCCEEEEEEECC
DTTQEAPLVRMHSECLTGDVFHSSRCDCGEQLEETITRMGQSGGIILYLRQEGRGIGLYN
CCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHH
KIDAYRLQSQGMNTYEANNHLGFGDDLRDFTEAAQMLQALGVKKIRLVTNNPKKIRELQE
HHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHH
HGIEIVEVVHTSAHIKDGNENYLKAKVSHGKHQLKL
CCHHEEEHHHHHHCCCCCCCCEEEEEECCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]