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The map label for this gene is uvrY [H]

Identifier: 227081385

GI number: 227081385

Start: 1248014

End: 1248658

Strand: Direct

Name: uvrY [H]

Synonym: VCM66_1168

Alternate gene names: 227081385

Gene position: 1248014-1248658 (Clockwise)

Preceding gene: 227081383

Following gene: 227081386

Centisome position: 43.15

GC content: 47.44

Gene sequence:

>645_bases
TTGATTAGTGTTTTCCTTGTAGATGATCACGAGCTGGTTCGCACAGGGATACGACGTATTATTGAAGACGTCCGTGGAAT
GAAAGTAGCAGGGGAAGCTGACAGCAGTGAAGAAGCAGTAAAATGGTGCCGTACTAACCATGCGGATGTCATTTTAATGG
ATATGAACATGCCGGGTATTGGTGGCTTGGAAGCAACCAAGAAGCTGTTGCGTGTTAATCCGGACATTAAAATTATCGTA
TTGACGGTACATACCGAAAATCCGTTCCCAACCAAAGTGATGCAAGCGGGTGCCGCAGGTTATCTCACGAAGGGCGCGGC
ACCGGATGAAATGGTCAATGCGATCCGTATCGTTCACAGCGGTCAGCGTTACATTTCTCCAGAAATTGCGCAGCAAATGG
CGTTGAGTCAGTTTTCGCCCGCCTCTGAAAATCCTTTTGCTGATCTCTCCGAGCGTGAATTGCAGATCATGTTAATGATC
ACCAAAGGCCAGAAGGTGACGGACATTTCCGAACAGCTCAGTTTGAGCCCGAAAACCGTCAACAGCTACCGCTACCGTTT
GTTCGCCAAGCTGAATATCAACGGTGATGTGGAATTAACCCACTTAGCTATCCGACACGGGATCTTAGATACTGAGAAGT
TATAG

Upstream 100 bases:

>100_bases
TTCACGGGAGAAAAGTTGCCCGCGTTGGTTTGGGGTAGCTTCGCTGTAATCCACTGTCTCGGTGGGTGCAGAGCCAATAG
ATAAGTGTGGAGATACAAGT

Downstream 100 bases:

>100_bases
TGTCGACACAGTTTGATTCTGCCCCTTTTCTTAAGACAGTCACCAACCAGCCCGGCGTATACCGAATGTATAACGCTGAG
GCTGAAGTGATTTATGTCGG

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MISVFLVDDHELVRTGIRRIIEDVRGMKVAGEADSSEEAVKWCRTNHADVILMDMNMPGIGGLEATKKLLRVNPDIKIIV
LTVHTENPFPTKVMQAGAAGYLTKGAAPDEMVNAIRIVHSGQRYISPEIAQQMALSQFSPASENPFADLSERELQIMLMI
TKGQKVTDISEQLSLSPKTVNSYRYRLFAKLNINGDVELTHLAIRHGILDTEKL

Sequences:

>Translated_214_residues
MISVFLVDDHELVRTGIRRIIEDVRGMKVAGEADSSEEAVKWCRTNHADVILMDMNMPGIGGLEATKKLLRVNPDIKIIV
LTVHTENPFPTKVMQAGAAGYLTKGAAPDEMVNAIRIVHSGQRYISPEIAQQMALSQFSPASENPFADLSERELQIMLMI
TKGQKVTDISEQLSLSPKTVNSYRYRLFAKLNINGDVELTHLAIRHGILDTEKL
>Mature_214_residues
MISVFLVDDHELVRTGIRRIIEDVRGMKVAGEADSSEEAVKWCRTNHADVILMDMNMPGIGGLEATKKLLRVNPDIKIIV
LTVHTENPFPTKVMQAGAAGYLTKGAAPDEMVNAIRIVHSGQRYISPEIAQQMALSQFSPASENPFADLSERELQIMLMI
TKGQKVTDISEQLSLSPKTVNSYRYRLFAKLNINGDVELTHLAIRHGILDTEKL

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=215, Percent_Identity=75.3488372093023, Blast_Score=346, Evalue=8e-97,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=34, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1788521, Length=203, Percent_Identity=33.4975369458128, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786747, Length=201, Percent_Identity=25.3731343283582, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1788546, Length=205, Percent_Identity=26.8292682926829, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788712, Length=210, Percent_Identity=24.2857142857143, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=28.4153005464481, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23782; Mature: 23782

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVFLVDDHELVRTGIRRIIEDVRGMKVAGEADSSEEAVKWCRTNHADVILMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCC
GGLEATKKLLRVNPDIKIIVLTVHTENPFPTKVMQAGAAGYLTKGAAPDEMVNAIRIVHS
CCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
GQRYISPEIAQQMALSQFSPASENPFADLSERELQIMLMITKGQKVTDISEQLSLSPKTV
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCEEECHHHHHCCCCCHH
NSYRYRLFAKLNINGDVELTHLAIRHGILDTEKL
CCEEEEEEEEEECCCCEEEEHHHHHHCCCCCCCC
>Mature Secondary Structure
MISVFLVDDHELVRTGIRRIIEDVRGMKVAGEADSSEEAVKWCRTNHADVILMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCC
GGLEATKKLLRVNPDIKIIVLTVHTENPFPTKVMQAGAAGYLTKGAAPDEMVNAIRIVHS
CCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
GQRYISPEIAQQMALSQFSPASENPFADLSERELQIMLMITKGQKVTDISEQLSLSPKTV
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCEEECHHHHHCCCCCHH
NSYRYRLFAKLNINGDVELTHLAIRHGILDTEKL
CCEEEEEEEEEECCCCEEEEHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]