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The map label for this gene is hoxA [H]

Identifier: 227081328

GI number: 227081328

Start: 1183856

End: 1184401

Strand: Reverse

Name: hoxA [H]

Synonym: VCM66_1111

Alternate gene names: 227081328

Gene position: 1184401-1183856 (Counterclockwise)

Preceding gene: 227081329

Following gene: 227081327

Centisome position: 40.95

GC content: 47.44

Gene sequence:

>546_bases
GTGGCTGCCTTTAATGGTATCCGCACCCACCTTGGCAAGGAGCAAGCCATGAACAAATTTTTGATTTTATGTGTGGATGA
CGAACGAGAAGTGCTCGACAGTGTGGTGCAAGATCTCGACTGTTTTGAAGAGCATTTCATTATTGAAGCGGCCGAATCGG
TTGCGGAAGCGAAATCCGTGATTGAGGATTATCGCCAAGAAGCGATCCCCCTCGCCCTGATCCTGTGTGATCACATCATG
CCGGAGCAGACTGGCATTCAATTTCTTATTGAGCTCAACCAAGAAGCCGATACCACCCGCACACGCAAGATGTTACTCAC
AGGCCAAGCGGGGCTGGAAGATACCGTACAAGCCGTTAACCATGCCAGTTTACACTTTTACATCGCTAAGCCTTGGCATG
GAGAACAACTGCGCCAAGCCGTAAAAGAGCAATTGACTCATTACGTGATTGAGAACGAAGAGGACTTAATGCCTTGGATT
CAAATTCTCGATGCAGAAAAAATTCTAAATGCGATCGCCGCTAAAAGAATGAGCTTTGGCGAATAG

Upstream 100 bases:

>100_bases
GTCTTGGGATTGGCCTATCTGTCTGTCAACAGATCATTATGCAACATCAAGGTTGGATTGATGTCGACTCCCAACCTAAC
CACTACACCACCATGACGGT

Downstream 100 bases:

>100_bases
GGAATTTGGCACTCTAATTGCTTAAATTTCATATGAACGACAAAACTCTGACATTTTTTGATAGTAGCTTGATACATCAA
TGCTTTATGATGTCAAACCA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MAAFNGIRTHLGKEQAMNKFLILCVDDEREVLDSVVQDLDCFEEHFIIEAAESVAEAKSVIEDYRQEAIPLALILCDHIM
PEQTGIQFLIELNQEADTTRTRKMLLTGQAGLEDTVQAVNHASLHFYIAKPWHGEQLRQAVKEQLTHYVIENEEDLMPWI
QILDAEKILNAIAAKRMSFGE

Sequences:

>Translated_181_residues
MAAFNGIRTHLGKEQAMNKFLILCVDDEREVLDSVVQDLDCFEEHFIIEAAESVAEAKSVIEDYRQEAIPLALILCDHIM
PEQTGIQFLIELNQEADTTRTRKMLLTGQAGLEDTVQAVNHASLHFYIAKPWHGEQLRQAVKEQLTHYVIENEEDLMPWI
QILDAEKILNAIAAKRMSFGE
>Mature_180_residues
AAFNGIRTHLGKEQAMNKFLILCVDDEREVLDSVVQDLDCFEEHFIIEAAESVAEAKSVIEDYRQEAIPLALILCDHIMP
EQTGIQFLIELNQEADTTRTRKMLLTGQAGLEDTVQAVNHASLHFYIAKPWHGEQLRQAVKEQLTHYVIENEEDLMPWIQ
ILDAEKILNAIAAKRMSFGE

Specific function: Probable member of the two-component regulatory system involved in the regulation of the hydrogenase activity. HoxA is probably phosphorylated by a sensory component (which could be hoxX) and then acts in conjunction with sigma-54 as a transcriptional act

COG id: COG0784

COG function: function code T; FOG: CheY-like receiver

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 20620; Mature: 20489

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAFNGIRTHLGKEQAMNKFLILCVDDEREVLDSVVQDLDCFEEHFIIEAAESVAEAKSV
CCCCHHHHHHCCHHHHHCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEDYRQEAIPLALILCDHIMPEQTGIQFLIELNQEADTTRTRKMLLTGQAGLEDTVQAVN
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEECCCCCHHHHHHHHHCCCCCHHHHHHHHH
HASLHFYIAKPWHGEQLRQAVKEQLTHYVIENEEDLMPWIQILDAEKILNAIAAKRMSFG
HCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
E
C
>Mature Secondary Structure 
AAFNGIRTHLGKEQAMNKFLILCVDDEREVLDSVVQDLDCFEEHFIIEAAESVAEAKSV
CCCHHHHHHCCHHHHHCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEDYRQEAIPLALILCDHIMPEQTGIQFLIELNQEADTTRTRKMLLTGQAGLEDTVQAVN
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEECCCCCHHHHHHHHHCCCCCHHHHHHHHH
HASLHFYIAKPWHGEQLRQAVKEQLTHYVIENEEDLMPWIQILDAEKILNAIAAKRMSFG
HCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2001989; 12948488 [H]