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The map label for this gene is hemH [H]

Identifier: 227081161

GI number: 227081161

Start: 1008688

End: 1009662

Strand: Direct

Name: hemH [H]

Synonym: VCM66_0943

Alternate gene names: 227081161

Gene position: 1008688-1009662 (Clockwise)

Preceding gene: 227081160

Following gene: 227081163

Centisome position: 34.87

GC content: 47.28

Gene sequence:

>975_bases
TTGAAGGAAGCCATGAATAATCATAAAAAACTTGGCATTTTGCTTGCCAACTTAGGTACTCCGCAAGCGCCAACCTCTCA
AGCGGTAAAAGCGTTTTTGAGCCAATTTCTGCATGATCAGCGAGTGGTAGACATGAGTCGTTGGTTATGGTGCCCCCTTT
TACATGGCATTATCTTGCCAACGCGATCGCCTAAGGTGGCTAAGCTGTATCAATCAATCTGGATGGATGAGGGATCGCCT
TTGATGGTCTACTCTCGACGTCAACGCGATAAATTGGCAGAGCTTAGCCAACGGCCTGTTGAGCTAGGGATGACCTACGG
AGAGCCGAGTTTATTGGAGGGTGTACGCAAGTTGCAGCAACAAGGTGTTGAACAGATAGTGGTGCTGCCGCTTTATCCGC
AATATTCCGCGACGACAACGGCGGCGGTGTTTGATGGTCTCGCCAAAGCGTTGCGTCAGTTACCTGTAGTCCCTGAATTG
CACTTTATTCGTGATTATCATGACCATCCACTCTATATCCAAGCCCTCGCGAAAAGCGTTCGTGCTTCATGGCAACAACA
TGGACAAGGTGATCTGTTACTCTGCTCTTACCATGGTATTCCCAAACGTTATGCGCAAAATGGCGATATCTACCCAGAGC
ATTGCCTAAAAACCACAGAGTTATTGGCTCAAGCATTAGGATTGCCTCAAGATAAAGTCATGATGACTTACCAATCTCAG
TTTGGTAAGGAAGAGTGGCTGCAGCCATACACGGACAAGACGATGGAAGCGCTTCCTCGCCAAGGCATTAAAAAGCTTGA
TGTTATTTGCCCTGCCTTTTCAGTGGACTGCTTAGAAACGCTGGAAGAAATTGCTGAGCAGAACCAAGAAATCTTTTTGC
ACAGTGGTGGCGAAGCGTTCCACTATGTTCCCTGTTTGAATGACAGTCAGAGCCATATTGAGCTGATGGCCGCGCTGGTT
AAAGTCGATTGTTAA

Upstream 100 bases:

>100_bases
TGCTGATTGCATTGATAGGTGAAATAAAGCGGCAGTAAAGCCGCTTTTTTTATAAACTTTTTACCAGAAAGAGACGTAAT
AACGTATTCAACAGTGCATT

Downstream 100 bases:

>100_bases
GCTCCAATGTGAGCGAGTCATCCATAAAGCAGCCATACAAAAACAGCGCCTCATTCGGCGCTGTTTTCAGTTTCACGGGG
CGTATTTATGATTCAATCTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKEAMNNHKKLGILLANLGTPQAPTSQAVKAFLSQFLHDQRVVDMSRWLWCPLLHGIILPTRSPKVAKLYQSIWMDEGSP
LMVYSRRQRDKLAELSQRPVELGMTYGEPSLLEGVRKLQQQGVEQIVVLPLYPQYSATTTAAVFDGLAKALRQLPVVPEL
HFIRDYHDHPLYIQALAKSVRASWQQHGQGDLLLCSYHGIPKRYAQNGDIYPEHCLKTTELLAQALGLPQDKVMMTYQSQ
FGKEEWLQPYTDKTMEALPRQGIKKLDVICPAFSVDCLETLEEIAEQNQEIFLHSGGEAFHYVPCLNDSQSHIELMAALV
KVDC

Sequences:

>Translated_324_residues
MKEAMNNHKKLGILLANLGTPQAPTSQAVKAFLSQFLHDQRVVDMSRWLWCPLLHGIILPTRSPKVAKLYQSIWMDEGSP
LMVYSRRQRDKLAELSQRPVELGMTYGEPSLLEGVRKLQQQGVEQIVVLPLYPQYSATTTAAVFDGLAKALRQLPVVPEL
HFIRDYHDHPLYIQALAKSVRASWQQHGQGDLLLCSYHGIPKRYAQNGDIYPEHCLKTTELLAQALGLPQDKVMMTYQSQ
FGKEEWLQPYTDKTMEALPRQGIKKLDVICPAFSVDCLETLEEIAEQNQEIFLHSGGEAFHYVPCLNDSQSHIELMAALV
KVDC
>Mature_324_residues
MKEAMNNHKKLGILLANLGTPQAPTSQAVKAFLSQFLHDQRVVDMSRWLWCPLLHGIILPTRSPKVAKLYQSIWMDEGSP
LMVYSRRQRDKLAELSQRPVELGMTYGEPSLLEGVRKLQQQGVEQIVVLPLYPQYSATTTAAVFDGLAKALRQLPVVPEL
HFIRDYHDHPLYIQALAKSVRASWQQHGQGDLLLCSYHGIPKRYAQNGDIYPEHCLKTTELLAQALGLPQDKVMMTYQSQ
FGKEEWLQPYTDKTMEALPRQGIKKLDVICPAFSVDCLETLEEIAEQNQEIFLHSGGEAFHYVPCLNDSQSHIELMAALV
KVDC

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=326, Percent_Identity=23.9263803680982, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI60499021, Length=326, Percent_Identity=23.9263803680982, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1786681, Length=312, Percent_Identity=59.6153846153846, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6324750, Length=340, Percent_Identity=26.4705882352941, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17864156, Length=329, Percent_Identity=25.531914893617, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24651774, Length=264, Percent_Identity=25.3787878787879, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36708; Mature: 36708

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEAMNNHKKLGILLANLGTPQAPTSQAVKAFLSQFLHDQRVVDMSRWLWCPLLHGIILP
CCCCHHCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TRSPKVAKLYQSIWMDEGSPLMVYSRRQRDKLAELSQRPVELGMTYGEPSLLEGVRKLQQ
CCCCHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
QGVEQIVVLPLYPQYSATTTAAVFDGLAKALRQLPVVPELHFIRDYHDHPLYIQALAKSV
CCHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHH
RASWQQHGQGDLLLCSYHGIPKRYAQNGDIYPEHCLKTTELLAQALGLPQDKVMMTYQSQ
HHHHHHCCCCCEEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
FGKEEWLQPYTDKTMEALPRQGIKKLDVICPAFSVDCLETLEEIAEQNQEIFLHSGGEAF
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCEE
HYVPCLNDSQSHIELMAALVKVDC
EEECCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKEAMNNHKKLGILLANLGTPQAPTSQAVKAFLSQFLHDQRVVDMSRWLWCPLLHGIILP
CCCCHHCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TRSPKVAKLYQSIWMDEGSPLMVYSRRQRDKLAELSQRPVELGMTYGEPSLLEGVRKLQQ
CCCCHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
QGVEQIVVLPLYPQYSATTTAAVFDGLAKALRQLPVVPELHFIRDYHDHPLYIQALAKSV
CCHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHH
RASWQQHGQGDLLLCSYHGIPKRYAQNGDIYPEHCLKTTELLAQALGLPQDKVMMTYQSQ
HHHHHHCCCCCEEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
FGKEEWLQPYTDKTMEALPRQGIKKLDVICPAFSVDCLETLEEIAEQNQEIFLHSGGEAF
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCEE
HYVPCLNDSQSHIELMAALVKVDC
EEECCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]