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The map label for this gene is ahpC [C]

Identifier: 227080910

GI number: 227080910

Start: 744116

End: 744739

Strand: Reverse

Name: ahpC [C]

Synonym: VCM66_0689

Alternate gene names: 227080910

Gene position: 744739-744116 (Counterclockwise)

Preceding gene: 227080912

Following gene: 227080909

Centisome position: 25.75

GC content: 46.15

Gene sequence:

>624_bases
TTGCTTAGGAGCAAAAAAATGGTACTAGTTGGTCGCAAAGCCCCTGATTTTACTGCAGCTGCTGTTCTTGGTAACGGTGA
AATCGTTGATAACTTCAACTTCGCAGAATTTACAAAAGGTAAGAAAGCGGTTGTTTTCTTCTACCCACTAGACTTCACTT
TCGTTTGCCCATCTGAACTGATTGCATTCGACAACCGTTACGAAGACTTCCTTGCTAAAGGTGTAGAAGTGATCGGTGTT
TCTATCGACTCTCAGTTCTCTCACAACGCATGGCGTAACACTGCTGTTGAAAACGGCGGTATCGGTCAAGTGAAATACCC
ACTGGTTGCAGACGTTAAACACGAAATCTGTAAAGCTTACGATGTTGAGCACCCAGAAGCTGGCGTGGCTTTCCGTGGTT
CATTCCTGATCGACGAAGAAGGCATGGTTCGTCACCAAGTAGTGAACGATCTGCCACTGGGTCGTAACATCGACGAAATG
CTACGTATGGTTGATGCACTGAACTTCCACCAAACTCACGGTGAAGTGTGCCCAGCACAATGGGAAGCAGGCAAAGCAGG
TATGGAAGCATCTCCAAAAGGCGTTGCAGCATTCCTGTCTCAATACTCTGCTGACCTAAAATAA

Upstream 100 bases:

>100_bases
ATTAATTCATTTTTTACTTTGTCTACTTTGTACTATATTTCTCCTCGTTATTCACGGACTGAATTATGAACTCAACGCAC
ATAGTTCAGTACTTACAAAA

Downstream 100 bases:

>100_bases
GACTCTTAACCCCGCGCTCAACACGGGTGGTTGGAAATAATAAAGCGAAAACGCTACGCCAATCAGTTAAGAAGTAAAGT
CATCAAAAGCCCAAAGCACT

Product: antioxidant, AhpC/Tsa family

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MLRSKKMVLVGRKAPDFTAAAVLGNGEIVDNFNFAEFTKGKKAVVFFYPLDFTFVCPSELIAFDNRYEDFLAKGVEVIGV
SIDSQFSHNAWRNTAVENGGIGQVKYPLVADVKHEICKAYDVEHPEAGVAFRGSFLIDEEGMVRHQVVNDLPLGRNIDEM
LRMVDALNFHQTHGEVCPAQWEAGKAGMEASPKGVAAFLSQYSADLK

Sequences:

>Translated_207_residues
MLRSKKMVLVGRKAPDFTAAAVLGNGEIVDNFNFAEFTKGKKAVVFFYPLDFTFVCPSELIAFDNRYEDFLAKGVEVIGV
SIDSQFSHNAWRNTAVENGGIGQVKYPLVADVKHEICKAYDVEHPEAGVAFRGSFLIDEEGMVRHQVVNDLPLGRNIDEM
LRMVDALNFHQTHGEVCPAQWEAGKAGMEASPKGVAAFLSQYSADLK
>Mature_207_residues
MLRSKKMVLVGRKAPDFTAAAVLGNGEIVDNFNFAEFTKGKKAVVFFYPLDFTFVCPSELIAFDNRYEDFLAKGVEVIGV
SIDSQFSHNAWRNTAVENGGIGQVKYPLVADVKHEICKAYDVEHPEAGVAFRGSFLIDEEGMVRHQVVNDLPLGRNIDEM
LRMVDALNFHQTHGEVCPAQWEAGKAGMEASPKGVAAFLSQYSADLK

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=194, Percent_Identity=46.3917525773196, Blast_Score=190, Evalue=9e-49,
Organism=Homo sapiens, GI4505591, Length=192, Percent_Identity=45.8333333333333, Blast_Score=186, Evalue=8e-48,
Organism=Homo sapiens, GI32455266, Length=192, Percent_Identity=45.8333333333333, Blast_Score=186, Evalue=8e-48,
Organism=Homo sapiens, GI32455264, Length=192, Percent_Identity=45.8333333333333, Blast_Score=186, Evalue=8e-48,
Organism=Homo sapiens, GI5453549, Length=192, Percent_Identity=42.7083333333333, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI5802974, Length=183, Percent_Identity=46.448087431694, Blast_Score=175, Evalue=2e-44,
Organism=Homo sapiens, GI32483377, Length=180, Percent_Identity=46.6666666666667, Blast_Score=174, Evalue=5e-44,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=56.0975609756098, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1786822, Length=186, Percent_Identity=34.4086021505376, Blast_Score=119, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193204376, Length=202, Percent_Identity=43.5643564356436, Blast_Score=180, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI32565831, Length=194, Percent_Identity=44.3298969072165, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17554494, Length=168, Percent_Identity=47.6190476190476, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25153706, Length=185, Percent_Identity=25.4054054054054, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=182, Percent_Identity=41.2087912087912, Blast_Score=154, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6320661, Length=184, Percent_Identity=38.5869565217391, Blast_Score=144, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6319407, Length=183, Percent_Identity=27.8688524590164, Blast_Score=85, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24656348, Length=193, Percent_Identity=45.0777202072539, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17864676, Length=193, Percent_Identity=45.0777202072539, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17738015, Length=189, Percent_Identity=45.5026455026455, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17157991, Length=186, Percent_Identity=45.1612903225806, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24641739, Length=186, Percent_Identity=45.1612903225806, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21357347, Length=189, Percent_Identity=41.7989417989418, Blast_Score=164, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24581278, Length=191, Percent_Identity=29.8429319371728, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17975518, Length=189, Percent_Identity=27.5132275132275, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24652434, Length=189, Percent_Identity=27.5132275132275, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24652436, Length=189, Percent_Identity=27.5132275132275, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22862; Mature: 22862

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSKKMVLVGRKAPDFTAAAVLGNGEIVDNFNFAEFTKGKKAVVFFYPLDFTFVCPSEL
CCCCCCEEEEECCCCCCEEEEEECCCEEEECCCHHHHCCCCEEEEEEEECCEEEECCHHH
IAFDNRYEDFLAKGVEVIGVSIDSQFSHNAWRNTAVENGGIGQVKYPLVADVKHEICKAY
HHHCCHHHHHHHCCEEEEEEEECCCCCCCHHHCCCCCCCCCCEEECCHHHHHHHHHHHHH
DVEHPEAGVAFRGSFLIDEEGMVRHQVVNDLPLGRNIDEMLRMVDALNFHQTHGEVCPAQ
CCCCCCCCEEEECEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
WEAGKAGMEASPKGVAAFLSQYSADLK
CCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLRSKKMVLVGRKAPDFTAAAVLGNGEIVDNFNFAEFTKGKKAVVFFYPLDFTFVCPSEL
CCCCCCEEEEECCCCCCEEEEEECCCEEEECCCHHHHCCCCEEEEEEEECCEEEECCHHH
IAFDNRYEDFLAKGVEVIGVSIDSQFSHNAWRNTAVENGGIGQVKYPLVADVKHEICKAY
HHHCCHHHHHHHCCEEEEEEEECCCCCCCHHHCCCCCCCCCCEEECCHHHHHHHHHHHHH
DVEHPEAGVAFRGSFLIDEEGMVRHQVVNDLPLGRNIDEMLRMVDALNFHQTHGEVCPAQ
CCCCCCCCEEEECEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
WEAGKAGMEASPKGVAAFLSQYSADLK
CCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]