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The map label for this gene is trpR [H]

Identifier: 227080881

GI number: 227080881

Start: 707790

End: 708146

Strand: Direct

Name: trpR [H]

Synonym: VCM66_0659

Alternate gene names: 227080881

Gene position: 707790-708146 (Clockwise)

Preceding gene: 227080880

Following gene: 227080887

Centisome position: 24.47

GC content: 50.42

Gene sequence:

>357_bases
TTGCTGCACTACAATAGGCCGGTGTATCACTTAACGAGTACAACTATGGTACAGCAACCTTCTTTTAGTGAGTGGCAGCA
AGTGTTGGATCTGGTTAAGCAAGCCGTGCAGCAAGAGCAGCACGAAATGCTACTGACCATGTTGATGACGCCGGATGAGC
GTGAAGCATTAGTCGCTCGAGTGAATATTGTGCATGAGCTGCTGCAAGGCGAGCTCTCTCAGCGCCAAATAAGCCAAATG
CTTGGGGTCGGGATTGCAACCATCACGCGTGGTTCGAATGAGCTCAAGTCACGGAGTGAAGATGAGAAAGCGGCATTAGC
TCAACTGCTTATGCCGCCTCCATCCTCAGAAGCCTAA

Upstream 100 bases:

>100_bases
GAACATTTTGATGTTTGAAACCTACTATCGGGATTTGATGGGCGTACAAGGCCGCTTCTTGAATGAGCATGAGTTAAATA
CAAAGTATTGATTCCTCAAC

Downstream 100 bases:

>100_bases
TGACATCACTGGCTAAGCCGAGTGTTTTTTGAAGAACTCGATGAGTTGAAGTGAATGAGAGCTTCAACTCATACTCACTA
AGCTGATGGATAATGTTCTG

Product: Trp operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 118; Mature: 118

Protein sequence:

>118_residues
MLHYNRPVYHLTSTTMVQQPSFSEWQQVLDLVKQAVQQEQHEMLLTMLMTPDEREALVARVNIVHELLQGELSQRQISQM
LGVGIATITRGSNELKSRSEDEKAALAQLLMPPPSSEA

Sequences:

>Translated_118_residues
MLHYNRPVYHLTSTTMVQQPSFSEWQQVLDLVKQAVQQEQHEMLLTMLMTPDEREALVARVNIVHELLQGELSQRQISQM
LGVGIATITRGSNELKSRSEDEKAALAQLLMPPPSSEA
>Mature_118_residues
MLHYNRPVYHLTSTTMVQQPSFSEWQQVLDLVKQAVQQEQHEMLLTMLMTPDEREALVARVNIVHELLQGELSQRQISQM
LGVGIATITRGSNELKSRSEDEKAALAQLLMPPPSSEA

Specific function: This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription [H]

COG id: COG2973

COG function: function code K; Trp operon repressor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpR family [H]

Homologues:

Organism=Escherichia coli, GI1790854, Length=91, Percent_Identity=52.7472527472528, Blast_Score=84, Evalue=2e-18,

Paralogues:

None

Copy number: 250-750 50-300 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000831
- InterPro:   IPR013335
- InterPro:   IPR010921
- ProDom:   PD012582 [H]

Pfam domain/function: PF01371 Trp_repressor [H]

EC number: NA

Molecular weight: Translated: 13354; Mature: 13354

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHYNRPVYHLTSTTMVQQPSFSEWQQVLDLVKQAVQQEQHEMLLTMLMTPDEREALVAR
CCCCCCCEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VNIVHELLQGELSQRQISQMLGVGIATITRGSNELKSRSEDEKAALAQLLMPPPSSEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLHYNRPVYHLTSTTMVQQPSFSEWQQVLDLVKQAVQQEQHEMLLTMLMTPDEREALVAR
CCCCCCCEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VNIVHELLQGELSQRQISQMLGVGIATITRGSNELKSRSEDEKAALAQLLMPPPSSEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]