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The map label for this gene is cvrA [H]

Identifier: 227080870

GI number: 227080870

Start: 693340

End: 695139

Strand: Direct

Name: cvrA [H]

Synonym: VCM66_0647

Alternate gene names: 227080870

Gene position: 693340-695139 (Clockwise)

Preceding gene: 227080869

Following gene: 227080873

Centisome position: 23.97

GC content: 50.89

Gene sequence:

>1800_bases
ATGATGCACGAAGAGTCTATTGCTCTGACTATCGCTGCGGTTGGCGTAGTCGGTTTAGGATGTCAGTGGTTAGCCTGGCG
GTTACGTCTGCCAGCCATCTTATTTTTGCTGTTGGCGGGGATTTTAGCTGGCCCAGTATTTGGGGTGTTAAACCCGGAAG
CCCTGATGGGTGATTTGCTCTTTCCGCTTGTTTCACTTGCCGTGGCGGTGATTTTGTTTGAAGGCAGTCTCACTCTAAAT
TTCAAAGAGATCCGCGGCGTCAGTAATACAGTGTGGAGCATTGTCACGGTTGGCGCACTCGTCTCATGGGGGATCACCAG
CACGGCTGCGCATTGGTTGCTTGGCTTTGAATGGCCGTTAGCACTGATGTTTGGCAGTTTGACTGTGGTCACGGGCCCAA
CCGTGATTGTGCCTTTGCTGCGCACAGTACGCCCAACCGCACGTTTAGCGAATATTCTGCGTTGGGAGGGGATTTTAATC
GACCCACTTGGTGCACTGTTTGTGGTCATGGTGTATGAATTTATCGTATCCAGCAGCCATGCTCATAGCCTAGAAGTGTT
TAGCCTGATTTTATTGGTCGGTTTTTCCATTGGTATCGCTTCTGGAGTAGCGGTGGCGGCGGTACTGCGTAGAGGCCTGT
TGCCGGAGTACTTGCAGCCGTTTGCGGTGCTGAGTGTTGTGCTCGGTGTGTTTGCTGCGTCTAATGCCTTGGAGTCCGAA
TCTGGCCTACTGACAGTGACAGTCATGGGGATGTGGCTGGCGAATGCCAAAGGGGTCAATATTCAGCACATCTTGCACTT
TAAAGAGCACTTAACGATTTTGCTGATCACAGGGCTGTTTATTCTGCTCGCGGCGCGGATTGAAGTGGCGGATTTCCAAG
CGTTGGGCTGGAGCGCCTTGGGGCTGTTTGTGGTGATGCAACTGCTGGCTCGCCCTGCGTCTATCTTCATTTCAACGTTG
CGCAGCACGCTCAATGTTCGTGAAAAAGCCTTTTTAGCTTGGGTGGCTCCGCGCGGGATTGTGGCCGCTTCGATCTCTTC
TCTGTTTGCCATCAAATTGATGGAGTTTGGCATCGCTGATGCCAAGCTATTAGTGCCGCTGACCTTTATGGTGATCATTG
GCACTGTCGTGCTGCAAAGTGCGACTGCTCGACCAATGGCGTTGGCATTGAAAGTGTCTGAACCTGCGCCGAAAGGCTTC
TTGATCATCGGTGCCAATGATGTGGCGCGTCAGGTCGGTTTAGCGATCGCTAAGTACGATTGTCGAGTGGTGGTGACGGA
TTCCAACTGGGACTACATTCGCCAAGCAAGAATGACCGGGCTTGAGCACTATTACGGCAACCCGATTTCCAGCCATGCCG
AGGATTACCTTAATTTGATTGGGATTGGGCATGTGTTAGCTCTGAGCCCTGACAAACACTTCAACATCATGGCCTGTATG
CAGTTTTTATCGGATTTTGGCGATAAGCGTGTGTTTTGCCTCAACGATAATCCAACCAATAACGTCAGTGAAAAGCATCT
CGTCGCTCAGGAATATCATGGCTTGCCGTTTCTAGGTGGTGAAGTGAGTTACAAAAAACTGGCGAGTTTGGTCGGCCAAG
GTGCGGAAGTGAAGCACACCAAATTGAGCGAAAACTTCACTTATCAGGATTATCAGCAAATCCACAAAGAGAGTTTTGTT
TTGCCGCTGTTTTCAGTCGACAGTCGTGGGCGGGTGCAGATGTGTCAGGATGTGGCGAGTTTTGCGCCGAAAGAGGGCGA
AATTGTCGTGTCTCTGATCAAAAGTCACGAGAGCCCATAG

Upstream 100 bases:

>100_bases
TTATGAAGGGATTTGTGAAGGTACAGAGCAGGCGCAGCGTTTTCGTATGGAGTGGCAACGCGGTTGGAATGAGTACAATC
AATAACCGATAAGAGGTGCA

Downstream 100 bases:

>100_bases
GGCTCTCGTTTTGCTCTGGCTAATTACTCTTCGTGCTCTTCCATGGCGCGGCGTAAGAAGCCGTCCGATTGCGAGAGTTT
CGCCGTCGCTTGCTCGTAGT

Product: putative Cell volume regulation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MMHEESIALTIAAVGVVGLGCQWLAWRLRLPAILFLLLAGILAGPVFGVLNPEALMGDLLFPLVSLAVAVILFEGSLTLN
FKEIRGVSNTVWSIVTVGALVSWGITSTAAHWLLGFEWPLALMFGSLTVVTGPTVIVPLLRTVRPTARLANILRWEGILI
DPLGALFVVMVYEFIVSSSHAHSLEVFSLILLVGFSIGIASGVAVAAVLRRGLLPEYLQPFAVLSVVLGVFAASNALESE
SGLLTVTVMGMWLANAKGVNIQHILHFKEHLTILLITGLFILLAARIEVADFQALGWSALGLFVVMQLLARPASIFISTL
RSTLNVREKAFLAWVAPRGIVAASISSLFAIKLMEFGIADAKLLVPLTFMVIIGTVVLQSATARPMALALKVSEPAPKGF
LIIGANDVARQVGLAIAKYDCRVVVTDSNWDYIRQARMTGLEHYYGNPISSHAEDYLNLIGIGHVLALSPDKHFNIMACM
QFLSDFGDKRVFCLNDNPTNNVSEKHLVAQEYHGLPFLGGEVSYKKLASLVGQGAEVKHTKLSENFTYQDYQQIHKESFV
LPLFSVDSRGRVQMCQDVASFAPKEGEIVVSLIKSHESP

Sequences:

>Translated_599_residues
MMHEESIALTIAAVGVVGLGCQWLAWRLRLPAILFLLLAGILAGPVFGVLNPEALMGDLLFPLVSLAVAVILFEGSLTLN
FKEIRGVSNTVWSIVTVGALVSWGITSTAAHWLLGFEWPLALMFGSLTVVTGPTVIVPLLRTVRPTARLANILRWEGILI
DPLGALFVVMVYEFIVSSSHAHSLEVFSLILLVGFSIGIASGVAVAAVLRRGLLPEYLQPFAVLSVVLGVFAASNALESE
SGLLTVTVMGMWLANAKGVNIQHILHFKEHLTILLITGLFILLAARIEVADFQALGWSALGLFVVMQLLARPASIFISTL
RSTLNVREKAFLAWVAPRGIVAASISSLFAIKLMEFGIADAKLLVPLTFMVIIGTVVLQSATARPMALALKVSEPAPKGF
LIIGANDVARQVGLAIAKYDCRVVVTDSNWDYIRQARMTGLEHYYGNPISSHAEDYLNLIGIGHVLALSPDKHFNIMACM
QFLSDFGDKRVFCLNDNPTNNVSEKHLVAQEYHGLPFLGGEVSYKKLASLVGQGAEVKHTKLSENFTYQDYQQIHKESFV
LPLFSVDSRGRVQMCQDVASFAPKEGEIVVSLIKSHESP
>Mature_599_residues
MMHEESIALTIAAVGVVGLGCQWLAWRLRLPAILFLLLAGILAGPVFGVLNPEALMGDLLFPLVSLAVAVILFEGSLTLN
FKEIRGVSNTVWSIVTVGALVSWGITSTAAHWLLGFEWPLALMFGSLTVVTGPTVIVPLLRTVRPTARLANILRWEGILI
DPLGALFVVMVYEFIVSSSHAHSLEVFSLILLVGFSIGIASGVAVAAVLRRGLLPEYLQPFAVLSVVLGVFAASNALESE
SGLLTVTVMGMWLANAKGVNIQHILHFKEHLTILLITGLFILLAARIEVADFQALGWSALGLFVVMQLLARPASIFISTL
RSTLNVREKAFLAWVAPRGIVAASISSLFAIKLMEFGIADAKLLVPLTFMVIIGTVVLQSATARPMALALKVSEPAPKGF
LIIGANDVARQVGLAIAKYDCRVVVTDSNWDYIRQARMTGLEHYYGNPISSHAEDYLNLIGIGHVLALSPDKHFNIMACM
QFLSDFGDKRVFCLNDNPTNNVSEKHLVAQEYHGLPFLGGEVSYKKLASLVGQGAEVKHTKLSENFTYQDYQQIHKESFV
LPLFSVDSRGRVQMCQDVASFAPKEGEIVVSLIKSHESP

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=323, Percent_Identity=26.9349845201238, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 65004; Mature: 65004

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMHEESIALTIAAVGVVGLGCQWLAWRLRLPAILFLLLAGILAGPVFGVLNPEALMGDLL
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
FPLVSLAVAVILFEGSLTLNFKEIRGVSNTVWSIVTVGALVSWGITSTAAHWLLGFEWPL
HHHHHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
ALMFGSLTVVTGPTVIVPLLRTVRPTARLANILRWEGILIDPLGALFVVMVYEFIVSSSH
HHHHCCHHEECCCHHHHHHHHHCCHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCC
AHSLEVFSLILLVGFSIGIASGVAVAAVLRRGLLPEYLQPFAVLSVVLGVFAASNALESE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
SGLLTVTVMGMWLANAKGVNIQHILHFKEHLTILLITGLFILLAARIEVADFQALGWSAL
CCEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLFVVMQLLARPASIFISTLRSTLNVREKAFLAWVAPRGIVAASISSLFAIKLMEFGIAD
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCC
AKLLVPLTFMVIIGTVVLQSATARPMALALKVSEPAPKGFLIIGANDVARQVGLAIAKYD
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHEEEC
CRVVVTDSNWDYIRQARMTGLEHYYGNPISSHAEDYLNLIGIGHVLALSPDKHFNIMACM
CEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHH
QFLSDFGDKRVFCLNDNPTNNVSEKHLVAQEYHGLPFLGGEVSYKKLASLVGQGAEVKHT
HHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEE
KLSENFTYQDYQQIHKESFVLPLFSVDSRGRVQMCQDVASFAPKEGEIVVSLIKSHESP
ECCCCCCHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MMHEESIALTIAAVGVVGLGCQWLAWRLRLPAILFLLLAGILAGPVFGVLNPEALMGDLL
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
FPLVSLAVAVILFEGSLTLNFKEIRGVSNTVWSIVTVGALVSWGITSTAAHWLLGFEWPL
HHHHHHHHHHHHCCCCEEEEHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
ALMFGSLTVVTGPTVIVPLLRTVRPTARLANILRWEGILIDPLGALFVVMVYEFIVSSSH
HHHHCCHHEECCCHHHHHHHHHCCHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHCCCC
AHSLEVFSLILLVGFSIGIASGVAVAAVLRRGLLPEYLQPFAVLSVVLGVFAASNALESE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
SGLLTVTVMGMWLANAKGVNIQHILHFKEHLTILLITGLFILLAARIEVADFQALGWSAL
CCEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLFVVMQLLARPASIFISTLRSTLNVREKAFLAWVAPRGIVAASISSLFAIKLMEFGIAD
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCC
AKLLVPLTFMVIIGTVVLQSATARPMALALKVSEPAPKGFLIIGANDVARQVGLAIAKYD
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHEEEC
CRVVVTDSNWDYIRQARMTGLEHYYGNPISSHAEDYLNLIGIGHVLALSPDKHFNIMACM
CEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHH
QFLSDFGDKRVFCLNDNPTNNVSEKHLVAQEYHGLPFLGGEVSYKKLASLVGQGAEVKHT
HHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEE
KLSENFTYQDYQQIHKESFVLPLFSVDSRGRVQMCQDVASFAPKEGEIVVSLIKSHESP
ECCCCCCHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]