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The map label for this gene is nhaR

Identifier: 227080858

GI number: 227080858

Start: 681503

End: 682393

Strand: Direct

Name: nhaR

Synonym: VCM66_0635

Alternate gene names: 227080858

Gene position: 681503-682393 (Clockwise)

Preceding gene: 227080856

Following gene: 227080859

Centisome position: 23.56

GC content: 43.77

Gene sequence:

>891_bases
ATGTCTCATCTTAACTATAACCACCTCTATTATTTCTGGATGGTGTGTAAACAAGGCTCGGTAACCAAAGCGGCCGATGC
TCTGTTTTTAACGCCCCAAACCGTGACGGGGCAGATCAAAGCTTTGGAAGATCGACTTGATGGTAAGTTGACGAAACGTA
ATGGGCGCAGTATTGAGCCGACTGAATTGGGACAGTTGGTCTTTAAATACGCTGATCGTATGTTTGGCTTGAGTTATGAA
ATGTTGGATATCGTTAACTATAGCCAGCGTTCAAACTTGTTGTTTGATGTGGGTGTGGCAGACGCCTTATCCAAAAGATT
GGTGAGCAAAATATTGCTGACCTCAGTACCCGGTGATAACCGGATTCATCTACGCTGCTTTGAATCAACCCATGAGATGC
TATTAGAGCAGTTAGCCCAGCATAAGTTGGATATGATCTTATCTGATTGCCCAGTGGATTCGAGCCAAAGTCCCGGCTTA
TTTAGTAAAAAACTCGGTGAGAGTCGCATGAGTTTTTTCAGCTTTGGTGACGTGGATTTTGCGCCATTCCCCGCGGTGTT
GCAGAGTAAAAAATTGTTAGTTCCAGGCAGTCGAACCGCAATGGGGCGTAAAGTGCGGCAGTGGTTTGATCGTCAAGGGT
TACAACCACATATTCTCGGTGAATTTGATGACTCTGCTTTAATGAAAGCGTTTGCTATCTATCACAGTGATGCCGTGTTT
ATGGCTCCCTCTTTTTATGTCTCAGAAGTGGATGCGGAATCATCATTGAAACTCATCGGACATGTGGATGAGATTAAAGA
GGAGTATTATGTCATCTTCGCTGAACGCATGATCCAGCACCCAGCAGTAAAAAATGTCTGTGATGCTGATTTTACTAACT
TATTTTTGTGA

Upstream 100 bases:

>100_bases
CTAACTAAACGGTTTATTGTTTCGGTTTATCCGAACTTATTGTTGTAAAAGATCGCATCTGTTATAAGGAAAACGGGATT
TCTAGCGGGTAGTCGATTTC

Downstream 100 bases:

>100_bases
ATAATTATCACTGTTAAGTCTTTGATCACTACCCAATGATAAGTGAAAACAATAAACTAGCGTTCTTGATTAGTTTTTTA
TCATTATCAGCGAGTTTTCT

Product: transcriptional activator NhaR

Products: NA

Alternate protein names: Na(+)/H(+) antiporter regulatory protein

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSHLNYNHLYYFWMVCKQGSVTKAADALFLTPQTVTGQIKALEDRLDGKLTKRNGRSIEPTELGQLVFKYADRMFGLSYE
MLDIVNYSQRSNLLFDVGVADALSKRLVSKILLTSVPGDNRIHLRCFESTHEMLLEQLAQHKLDMILSDCPVDSSQSPGL
FSKKLGESRMSFFSFGDVDFAPFPAVLQSKKLLVPGSRTAMGRKVRQWFDRQGLQPHILGEFDDSALMKAFAIYHSDAVF
MAPSFYVSEVDAESSLKLIGHVDEIKEEYYVIFAERMIQHPAVKNVCDADFTNLFL

Sequences:

>Translated_296_residues
MSHLNYNHLYYFWMVCKQGSVTKAADALFLTPQTVTGQIKALEDRLDGKLTKRNGRSIEPTELGQLVFKYADRMFGLSYE
MLDIVNYSQRSNLLFDVGVADALSKRLVSKILLTSVPGDNRIHLRCFESTHEMLLEQLAQHKLDMILSDCPVDSSQSPGL
FSKKLGESRMSFFSFGDVDFAPFPAVLQSKKLLVPGSRTAMGRKVRQWFDRQGLQPHILGEFDDSALMKAFAIYHSDAVF
MAPSFYVSEVDAESSLKLIGHVDEIKEEYYVIFAERMIQHPAVKNVCDADFTNLFL
>Mature_295_residues
SHLNYNHLYYFWMVCKQGSVTKAADALFLTPQTVTGQIKALEDRLDGKLTKRNGRSIEPTELGQLVFKYADRMFGLSYEM
LDIVNYSQRSNLLFDVGVADALSKRLVSKILLTSVPGDNRIHLRCFESTHEMLLEQLAQHKLDMILSDCPVDSSQSPGLF
SKKLGESRMSFFSFGDVDFAPFPAVLQSKKLLVPGSRTAMGRKVRQWFDRQGLQPHILGEFDDSALMKAFAIYHSDAVFM
APSFYVSEVDAESSLKLIGHVDEIKEEYYVIFAERMIQHPAVKNVCDADFTNLFL

Specific function: Plays a role in the positive regulation of nhaA (Probable)

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1786202, Length=295, Percent_Identity=62.3728813559322, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1788297, Length=248, Percent_Identity=25.4032258064516, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAR_VIBCH (P52692)

Other databases:

- EMBL:   X66866
- EMBL:   AJ002395
- EMBL:   AE003852
- PIR:   S37312
- RefSeq:   NP_230326.1
- ProteinModelPortal:   P52692
- GeneID:   2615466
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC0677
- TIGR:   VC_0677
- HOGENOM:   HBG685425
- OMA:   LCLTPQT
- ProtClustDB:   PRK11062
- GO:   GO:0005737
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate

EC number: NA

Molecular weight: Translated: 33560; Mature: 33429

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHLNYNHLYYFWMVCKQGSVTKAADALFLTPQTVTGQIKALEDRLDGKLTKRNGRSIEP
CCCCCCCCEEEEEEEECCCCCCHHCCEEEECCCHHHHHHHHHHHHHCCEEECCCCCCCCH
TELGQLVFKYADRMFGLSYEMLDIVNYSQRSNLLFDVGVADALSKRLVSKILLTSVPGDN
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCC
RIHLRCFESTHEMLLEQLAQHKLDMILSDCPVDSSQSPGLFSKKLGESRMSFFSFGDVDF
EEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
APFPAVLQSKKLLVPGSRTAMGRKVRQWFDRQGLQPHILGEFDDSALMKAFAIYHSDAVF
CCCHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCEEE
MAPSFYVSEVDAESSLKLIGHVDEIKEEYYVIFAERMIQHPAVKNVCDADFTNLFL
ECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHCC
>Mature Secondary Structure 
SHLNYNHLYYFWMVCKQGSVTKAADALFLTPQTVTGQIKALEDRLDGKLTKRNGRSIEP
CCCCCCCEEEEEEEECCCCCCHHCCEEEECCCHHHHHHHHHHHHHCCEEECCCCCCCCH
TELGQLVFKYADRMFGLSYEMLDIVNYSQRSNLLFDVGVADALSKRLVSKILLTSVPGDN
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCC
RIHLRCFESTHEMLLEQLAQHKLDMILSDCPVDSSQSPGLFSKKLGESRMSFFSFGDVDF
EEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
APFPAVLQSKKLLVPGSRTAMGRKVRQWFDRQGLQPHILGEFDDSALMKAFAIYHSDAVF
CCCHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCEEE
MAPSFYVSEVDAESSLKLIGHVDEIKEEYYVIFAERMIQHPAVKNVCDADFTNLFL
ECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8231807; 9457888; 10952301