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The map label for this gene is mutH [H]

Identifier: 227080849

GI number: 227080849

Start: 673295

End: 673960

Strand: Reverse

Name: mutH [H]

Synonym: VCM66_0626

Alternate gene names: 227080849

Gene position: 673960-673295 (Counterclockwise)

Preceding gene: 227080850

Following gene: 227080848

Centisome position: 23.3

GC content: 53.45

Gene sequence:

>666_bases
ATGAAACCAGCACCGACGACTCAACAAGAATTACTCACGCGAGCCCAACAAATTGCAGGGCTAAGTTTTGCTGAACTCGC
CGATGAAGCAGGCATGACCGTACCGCCAGATCTGCGTAAAGACAAAGGCTGGGTAGGCCAGTTACTGGAATGGCACTTAG
GGGCGACAGCAGGCAGTCGTCCACAACAAGATTTTGAACATCTCGGGATTGAGTTAAAGAGCATTCCCATCAGTTACACC
GGAAAACCGTTGGAGACCACTTTCGTTTGCGTCGCCCCACTCACCGGAGTTCATGGCTTAACATGGGAGCAAAGTCATGT
GCGCAATAAGCTCTCTAAGGTGCTCTGGATCCCGGTACAAGGTGAGCGCGAGATCCCGCTCGCTGAGCGCTGTGTGGGCT
CTCCTTTGCTGTGGAGCCCTTCTCCCGAAGAAGAAGCGCAGCTCAAAGCGGACTGGGAAGAGCTAATGGAATGGATTGTG
CTGGGTAAAGTGGCACAAATTACCGCTAAACACGGTGAAGTGCTGCAACTGCGCCCTAAAGCCGCCAACGGTCGAGCGCT
CACTGAAGCCTATGGGGCCAACGGACGCCCAATCAAAGCCCTGCCACGTGGTTTTTATCTGCGTACCCAATTTACTGCGC
AAATTCTGCAGCGCTATTACGCCTAG

Upstream 100 bases:

>100_bases
CCTCTTAATCTCATTTCAAGCATCAAAAATCGTTCATCCATGGCAAGCGCAAGCAAAATCAGTACAATCCCCACTGTGAT
TATCCAAACCGAAAGCCTTT

Downstream 100 bases:

>100_bases
TTATCTTCACAACGATCTTTTTTGTTTTCGCAGTGTCGTGACTCGCTTATAGTGAAAAAACTGTCTCCCTCGTGACTGGG
TTCTCTTTGTGGCGACAGCG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MKPAPTTQQELLTRAQQIAGLSFAELADEAGMTVPPDLRKDKGWVGQLLEWHLGATAGSRPQQDFEHLGIELKSIPISYT
GKPLETTFVCVAPLTGVHGLTWEQSHVRNKLSKVLWIPVQGEREIPLAERCVGSPLLWSPSPEEEAQLKADWEELMEWIV
LGKVAQITAKHGEVLQLRPKAANGRALTEAYGANGRPIKALPRGFYLRTQFTAQILQRYYA

Sequences:

>Translated_221_residues
MKPAPTTQQELLTRAQQIAGLSFAELADEAGMTVPPDLRKDKGWVGQLLEWHLGATAGSRPQQDFEHLGIELKSIPISYT
GKPLETTFVCVAPLTGVHGLTWEQSHVRNKLSKVLWIPVQGEREIPLAERCVGSPLLWSPSPEEEAQLKADWEELMEWIV
LGKVAQITAKHGEVLQLRPKAANGRALTEAYGANGRPIKALPRGFYLRTQFTAQILQRYYA
>Mature_221_residues
MKPAPTTQQELLTRAQQIAGLSFAELADEAGMTVPPDLRKDKGWVGQLLEWHLGATAGSRPQQDFEHLGIELKSIPISYT
GKPLETTFVCVAPLTGVHGLTWEQSHVRNKLSKVLWIPVQGEREIPLAERCVGSPLLWSPSPEEEAQLKADWEELMEWIV
LGKVAQITAKHGEVLQLRPKAANGRALTEAYGANGRPIKALPRGFYLRTQFTAQILQRYYA

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=216, Percent_Identity=62.962962962963, Blast_Score=289, Evalue=9e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 24585; Mature: 24585

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPAPTTQQELLTRAQQIAGLSFAELADEAGMTVPPDLRKDKGWVGQLLEWHLGATAGSR
CCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
PQQDFEHLGIELKSIPISYTGKPLETTFVCVAPLTGVHGLTWEQSHVRNKLSKVLWIPVQ
CHHHHHHHCEEEEECCEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHEEEEECC
GEREIPLAERCVGSPLLWSPSPEEEAQLKADWEELMEWIVLGKVAQITAKHGEVLQLRPK
CCCCCCHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEECCC
AANGRALTEAYGANGRPIKALPRGFYLRTQFTAQILQRYYA
CCCCCCHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPAPTTQQELLTRAQQIAGLSFAELADEAGMTVPPDLRKDKGWVGQLLEWHLGATAGSR
CCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
PQQDFEHLGIELKSIPISYTGKPLETTFVCVAPLTGVHGLTWEQSHVRNKLSKVLWIPVQ
CHHHHHHHCEEEEECCEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHEEEEECC
GEREIPLAERCVGSPLLWSPSPEEEAQLKADWEELMEWIVLGKVAQITAKHGEVLQLRPK
CCCCCCHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEECCC
AANGRALTEAYGANGRPIKALPRGFYLRTQFTAQILQRYYA
CCCCCCHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA