Click here to switch to the map view.

The map label for this gene is folB [H]

Identifier: 227080707

GI number: 227080707

Start: 515423

End: 515812

Strand: Direct

Name: folB [H]

Synonym: VCM66_0482

Alternate gene names: 227080707

Gene position: 515423-515812 (Clockwise)

Preceding gene: 227080705

Following gene: 227080708

Centisome position: 17.82

GC content: 53.33

Gene sequence:

>390_bases
TTGGGTATCCGACCTGTGAACAGGAAGCGATTGAGCATGGATAAAGTGTTTATTGAACAGTTGGAAGTGATCACGACGAT
TGGGGTCTACGACTGGGAACAGCAGATCAAGCAGAAATTGGTGCTCGATCTGGAAATGGCGCACGACAACCGTGCAGCGG
GAAAAAGTGATGATGTAGCGGATGCTCTGGACTATGCCCAAGTCAGCCAAGCTGTGCTGGAGCATATCGAACAAGGGCGT
TTTTTACTGGTAGAGCGTGTGGCTGAAGAAGTGGCTGAACTGATCATGACTCGCTTTGCTGTGCCTTGGCTCCGCATCCG
CTTGACCAAGCCGGGCGCAGTGCCGCAAGCCAAAGGAGTCGGCGTGATCATCGAGCGAGCGCGTGGATGA

Upstream 100 bases:

>100_bases
TCCCTGTTGAATAAGAAAAAATCTTTTAGGATTTAGCATCTTGAACAGGTTTGGGTATATCATATCGCGATTGAGCGGAT
AGTACGATTTTTTCATCGGT

Downstream 100 bases:

>100_bases
TCACCGCTTATATTGGTGTGGGCTCAAATCAGGATCGCCATCAGTCGATTGAAGCTGGCCTTCGTGCATTAGCCGAGCTG
GCGAGCCAGTGGCGTCTGTC

Product: putative dihydroneopterin aldolase FolB

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 129; Mature: 128

Protein sequence:

>129_residues
MGIRPVNRKRLSMDKVFIEQLEVITTIGVYDWEQQIKQKLVLDLEMAHDNRAAGKSDDVADALDYAQVSQAVLEHIEQGR
FLLVERVAEEVAELIMTRFAVPWLRIRLTKPGAVPQAKGVGVIIERARG

Sequences:

>Translated_129_residues
MGIRPVNRKRLSMDKVFIEQLEVITTIGVYDWEQQIKQKLVLDLEMAHDNRAAGKSDDVADALDYAQVSQAVLEHIEQGR
FLLVERVAEEVAELIMTRFAVPWLRIRLTKPGAVPQAKGVGVIIERARG
>Mature_128_residues
GIRPVNRKRLSMDKVFIEQLEVITTIGVYDWEQQIKQKLVLDLEMAHDNRAAGKSDDVADALDYAQVSQAVLEHIEQGRF
LLVERVAEEVAELIMTRFAVPWLRIRLTKPGAVPQAKGVGVIIERARG

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=117, Percent_Identity=68.3760683760684, Blast_Score=169, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 14578; Mature: 14447

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIRPVNRKRLSMDKVFIEQLEVITTIGVYDWEQQIKQKLVLDLEMAHDNRAAGKSDDVA
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
DALDYAQVSQAVLEHIEQGRFLLVERVAEEVAELIMTRFAVPWLRIRLTKPGAVPQAKGV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCCC
GVIIERARG
EEEEECCCC
>Mature Secondary Structure 
GIRPVNRKRLSMDKVFIEQLEVITTIGVYDWEQQIKQKLVLDLEMAHDNRAAGKSDDVA
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
DALDYAQVSQAVLEHIEQGRFLLVERVAEEVAELIMTRFAVPWLRIRLTKPGAVPQAKGV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCCC
GVIIERARG
EEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]