Click here to switch to the map view.

The map label for this gene is glmS

Identifier: 227080697

GI number: 227080697

Start: 502174

End: 504006

Strand: Direct

Name: glmS

Synonym: VCM66_0472

Alternate gene names: 227080697

Gene position: 502174-504006 (Clockwise)

Preceding gene: 227080696

Following gene: 227080704

Centisome position: 17.36

GC content: 49.48

Gene sequence:

>1833_bases
ATGTGTGGAATTGTTGGTGCGGTTGCACAACGCGATGTTGCTGAAATTTTAGTACAAGGCCTACGCCGTCTTGAATACCG
CGGCTATGACTCTGCGGGCGTAGCTGTTGTGGATAGCGATAAGCAGCTCACGCGTTTACGCCGTTTGGGTAAAGTACAAG
AGTTGGCGGATGCGGTTGAAGCGGCGCAAGTCGCGGGCGGTACAGGTATCGCGCATACCCGTTGGGCAACGCATGGTGAG
CCTTCTGAGATCAATGCTCACCCCCATATTTCTGGTGACATTACGGTGGTACACAACGGCATTATCGAAAACCATGAAAT
GCTGCGTACTATGCTGCAAGATCGTGGTTATGTGTTTACTTCACAAACGGATACTGAAGTCATTGCTCATTTAGTGGAGT
GGGAATTGCGCAGTGCTTCCTCTTTATTAGAAGCGGTACAAACCACCGTTAAACAGCTTACAGGAGCTTACGGCACTGTG
GTGATGGATCGTAACGACCCTTCGCGCTTAGTGGTCGCTCGCTCAGGTAGCCCAATTGTGATTGGTTTTGGTATCGGTGA
AAACTTCCTTGCGTCAGACCAACTCGCGCTACTTAACGTCACACGCCGCTTTATGTATCTGGAAGAGGGGGATGTAGCGG
AAATGACTCGTCGTGATGTGCGCGTATTTGATGCTCTGGGGCAACCCGTACAACGTGAAATCAGCGAATCCAATCTAGAA
CATGATGCTGCGGACAAAGGTCACTACCGCCACTACATGCAAAAAGAGATTTTCGAGCAGCCAAAGGCGCTGATCAATAC
CATGGAAGGGCGTATTACCCATGACTGCGTGGTGGTGGAAAGCATTGGTGTGCACGCGGCAGAGATTCTGGCAAAAGTGG
AACATGTACAGATCGTCGCCTGCGGTACTTCTTATAATGCAGGGATGACGGCACGTTACTGGTTTGAATCGTTAGCGGGT
GTGAGCTGTGATGTCGAAATCGCGTCTGAATTCCGCTATCGCAAATTTGTCACGCGCCCCAATAGCCTACTGATCACTCT
ATCTCAGTCTGGTGAAACGGCAGATACCTTAGCCGCGCTACGTTTAGCGAAAGAGAAAGGCTATATGGCGGCGATGACGA
TTTGTAACGTTGCGGGTTCTTCTCTCGTGCGTGAATCGGATTTCGCCTTTATGACTCGCGCAGGTACTGAGATTGGTGTG
GCTTCAACCAAAGCCTTTACCACTCAGCTAGTCACATTGTTGATGCTGGTGACTGCACTTGGTAAGCAGCAACAGCGCAT
TGGTCGCGAGTTAGAAGCTGAGATCGTACATGCATTGCATCAACTGCCGAAGCAGATTGAAACCGCATTGTCGTTTGAAA
AACAGATCGAAACGCTCGCGGAAGATTTTGCTGATAAGCATCATACCCTCTTCTTGGGGCGCGGTGAGTACTACCCGATT
GCGGTAGAAGCGTCTCTTAAACTGAAAGAGATCTCTTACATCCACGCAGAAGCCTATGCAGCGGGCGAGCTAAAGCATGG
CCCATTGGCGTTAATTGATGCGGATATGCCAGTGGTTGTGGTTGCACCAAGCAATGAACTGTTAGAAAAGCTTAAATCCA
ATATTGAAGAAGTGCGTGCGCGCGGTGGTTTATTGTACGTATTTGCCGATGAAGTGGCGGGCTTTGAAGCGGATGAGACG
ATGAAAATCATTGCGATGCCGCATGTTAGCGAGATTGTGGCTCCGATTTATTACACCATCCCAATGCAACTGCTCTCTTA
CCATGTGGCTTTAATCAAAGGTACCGATGTTGACCAGCCTCGTAACCTTGCTAAAGCGGTAACTGTCGAGTAA

Upstream 100 bases:

>100_bases
CTCACCAAGTGCGCGTGATCCGTGCAACCGTGAAATAAAAATCCCTTAGCGCGACTTATTAAGTCAGGGCGCGACAGTAT
AAAAAATATGGAGTTTAACT

Downstream 100 bases:

>100_bases
ATGTTCAATAAATCAAAGGGCTACCAGATGGTAGCCCTTTGTTTATCCAGCGCATTGCCATTAAGGATTGGTATTTAAGT
ACGCTTGTGTCGAGATCCGA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MCGIVGAVAQRDVAEILVQGLRRLEYRGYDSAGVAVVDSDKQLTRLRRLGKVQELADAVEAAQVAGGTGIAHTRWATHGE
PSEINAHPHISGDITVVHNGIIENHEMLRTMLQDRGYVFTSQTDTEVIAHLVEWELRSASSLLEAVQTTVKQLTGAYGTV
VMDRNDPSRLVVARSGSPIVIGFGIGENFLASDQLALLNVTRRFMYLEEGDVAEMTRRDVRVFDALGQPVQREISESNLE
HDAADKGHYRHYMQKEIFEQPKALINTMEGRITHDCVVVESIGVHAAEILAKVEHVQIVACGTSYNAGMTARYWFESLAG
VSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAALRLAKEKGYMAAMTICNVAGSSLVRESDFAFMTRAGTEIGV
ASTKAFTTQLVTLLMLVTALGKQQQRIGRELEAEIVHALHQLPKQIETALSFEKQIETLAEDFADKHHTLFLGRGEYYPI
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVVAPSNELLEKLKSNIEEVRARGGLLYVFADEVAGFEADET
MKIIAMPHVSEIVAPIYYTIPMQLLSYHVALIKGTDVDQPRNLAKAVTVE

Sequences:

>Translated_610_residues
MCGIVGAVAQRDVAEILVQGLRRLEYRGYDSAGVAVVDSDKQLTRLRRLGKVQELADAVEAAQVAGGTGIAHTRWATHGE
PSEINAHPHISGDITVVHNGIIENHEMLRTMLQDRGYVFTSQTDTEVIAHLVEWELRSASSLLEAVQTTVKQLTGAYGTV
VMDRNDPSRLVVARSGSPIVIGFGIGENFLASDQLALLNVTRRFMYLEEGDVAEMTRRDVRVFDALGQPVQREISESNLE
HDAADKGHYRHYMQKEIFEQPKALINTMEGRITHDCVVVESIGVHAAEILAKVEHVQIVACGTSYNAGMTARYWFESLAG
VSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAALRLAKEKGYMAAMTICNVAGSSLVRESDFAFMTRAGTEIGV
ASTKAFTTQLVTLLMLVTALGKQQQRIGRELEAEIVHALHQLPKQIETALSFEKQIETLAEDFADKHHTLFLGRGEYYPI
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVVAPSNELLEKLKSNIEEVRARGGLLYVFADEVAGFEADET
MKIIAMPHVSEIVAPIYYTIPMQLLSYHVALIKGTDVDQPRNLAKAVTVE
>Mature_610_residues
MCGIVGAVAQRDVAEILVQGLRRLEYRGYDSAGVAVVDSDKQLTRLRRLGKVQELADAVEAAQVAGGTGIAHTRWATHGE
PSEINAHPHISGDITVVHNGIIENHEMLRTMLQDRGYVFTSQTDTEVIAHLVEWELRSASSLLEAVQTTVKQLTGAYGTV
VMDRNDPSRLVVARSGSPIVIGFGIGENFLASDQLALLNVTRRFMYLEEGDVAEMTRRDVRVFDALGQPVQREISESNLE
HDAADKGHYRHYMQKEIFEQPKALINTMEGRITHDCVVVESIGVHAAEILAKVEHVQIVACGTSYNAGMTARYWFESLAG
VSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAALRLAKEKGYMAAMTICNVAGSSLVRESDFAFMTRAGTEIGV
ASTKAFTTQLVTLLMLVTALGKQQQRIGRELEAEIVHALHQLPKQIETALSFEKQIETLAEDFADKHHTLFLGRGEYYPI
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVVAPSNELLEKLKSNIEEVRARGGLLYVFADEVAGFEADET
MKIIAMPHVSEIVAPIYYTIPMQLLSYHVALIKGTDVDQPRNLAKAVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=685, Percent_Identity=37.5182481751825, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI4826742, Length=689, Percent_Identity=36.2844702467344, Blast_Score=401, Evalue=1e-111,
Organism=Homo sapiens, GI29570798, Length=274, Percent_Identity=25.9124087591241, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=71.6393442622951, Blast_Score=912, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=174, Percent_Identity=29.3103448275862, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082251, Length=348, Percent_Identity=21.551724137931, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=432, Percent_Identity=38.8888888888889, Blast_Score=275, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17532899, Length=437, Percent_Identity=37.5286041189931, Blast_Score=271, Evalue=7e-73,
Organism=Caenorhabditis elegans, GI17532897, Length=437, Percent_Identity=37.5286041189931, Blast_Score=271, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6322745, Length=457, Percent_Identity=36.980306345733, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6323731, Length=429, Percent_Identity=30.7692307692308, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=35.7843137254902, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357745, Length=693, Percent_Identity=36.5079365079365, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI28573187, Length=260, Percent_Identity=25.3846153846154, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24659598, Length=280, Percent_Identity=22.8571428571429, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_VIBCH (Q9KUM8)

Other databases:

- EMBL:   AE003852
- PIR:   E82316
- RefSeq:   NP_230141.1
- ProteinModelPortal:   Q9KUM8
- SMR:   Q9KUM8
- GeneID:   2615281
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC0487
- TIGR:   VC_0487
- HOGENOM:   HBG645312
- OMA:   LGIGENF
- ProtClustDB:   PRK00331
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67100; Mature: 67100

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 605-605

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAQRDVAEILVQGLRRLEYRGYDSAGVAVVDSDKQLTRLRRLGKVQELADAVE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
AAQVAGGTGIAHTRWATHGEPSEINAHPHISGDITVVHNGIIENHEMLRTMLQDRGYVFT
HHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEE
SQTDTEVIAHLVEWELRSASSLLEAVQTTVKQLTGAYGTVVMDRNDPSRLVVARSGSPIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEE
IGFGIGENFLASDQLALLNVTRRFMYLEEGDVAEMTRRDVRVFDALGQPVQREISESNLE
EEECCCCCCCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
HDAADKGHYRHYMQKEIFEQPKALINTMEGRITHDCVVVESIGVHAAEILAKVEHVQIVA
CCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHEEEEEE
CGTSYNAGMTARYWFESLAGVSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAAL
ECCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKEKGYMAAMTICNVAGSSLVRESDFAFMTRAGTEIGVASTKAFTTQLVTLLMLVTAL
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
GKQQQRIGRELEAEIVHALHQLPKQIETALSFEKQIETLAEDFADKHHTLFLGRGEYYPI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEE
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVVAPSNELLEKLKSNIEEVRA
EEECCEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHH
RGGLLYVFADEVAGFEADETMKIIAMPHVSEIVAPIYYTIPMQLLSYHVALIKGTDVDQP
CCCEEEEEEHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
RNLAKAVTVE
HHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVAQRDVAEILVQGLRRLEYRGYDSAGVAVVDSDKQLTRLRRLGKVQELADAVE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
AAQVAGGTGIAHTRWATHGEPSEINAHPHISGDITVVHNGIIENHEMLRTMLQDRGYVFT
HHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEE
SQTDTEVIAHLVEWELRSASSLLEAVQTTVKQLTGAYGTVVMDRNDPSRLVVARSGSPIV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEE
IGFGIGENFLASDQLALLNVTRRFMYLEEGDVAEMTRRDVRVFDALGQPVQREISESNLE
EEECCCCCCCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
HDAADKGHYRHYMQKEIFEQPKALINTMEGRITHDCVVVESIGVHAAEILAKVEHVQIVA
CCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHEEEEEE
CGTSYNAGMTARYWFESLAGVSCDVEIASEFRYRKFVTRPNSLLITLSQSGETADTLAAL
ECCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
RLAKEKGYMAAMTICNVAGSSLVRESDFAFMTRAGTEIGVASTKAFTTQLVTLLMLVTAL
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
GKQQQRIGRELEAEIVHALHQLPKQIETALSFEKQIETLAEDFADKHHTLFLGRGEYYPI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEE
AVEASLKLKEISYIHAEAYAAGELKHGPLALIDADMPVVVVAPSNELLEKLKSNIEEVRA
EEECCEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHH
RGGLLYVFADEVAGFEADETMKIIAMPHVSEIVAPIYYTIPMQLLSYHVALIKGTDVDQP
CCCEEEEEEHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
RNLAKAVTVE
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301