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The map label for this gene is metH

Identifier: 227080601

GI number: 227080601

Start: 393764

End: 397444

Strand: Direct

Name: metH

Synonym: VCM66_0375

Alternate gene names: 227080601

Gene position: 393764-397444 (Clockwise)

Preceding gene: 227080599

Following gene: 227080603

Centisome position: 13.61

GC content: 49.77

Gene sequence:

>3681_bases
GTGGGAAAAGAAGTAAGACAACAACTCGAACAGCAATTGAAACAACGTATCCTACTGATTGATGGTGGTATGGGTACCAT
GATTCAGAGTTATAAGTTACAAGAGGAAGACTATCGCGGTGCACGATTTGTCGATTGGCACTGTGATTTGAAAGGAAATA
ACGACCTCTTAGTGCTTACTCAGCCGCAAATTATTAAAGAGATTCACTCCGCTTACCTTGAAGCGGGGGCGGATATTCTT
GAGACCAACACCTTTAACTCAACCACGATTGCCATGGCAGACTATGACATGCAATCGCTCAGTGCTGAAATTAACTTTGC
CGCGGCTAAGCTTGCACGTGAAGTCGCGGATGAGTGGACGGCTAAAGATCCAAGTCGGCCACGCTATGTGGCTGGTGTGC
TTGGGCCAACCAACCGTACTTGCTCTATTTCGCCAGATGTGAACGATCCAGGATTTCGTAACGTCACTTTTGATGGGCTT
GTTGAAGCCTATTCCGAATCGACGCGCGCTTTGATCAAAGGTGGCAGCGATCTGATCCTCATTGAAACCATCTTCGATAC
ACTTAACGCCAAAGCCTGTGCGTTTGCGGTCGATAGCGTATTTGAAGAGCTGGGCATCAGCTTACCTGTGATGATTTCCG
GCACGATTACCGATGCCTCTGGGCGAACTCTGTCAGGACAGACAACGGAAGCTTTCTACAACGCCTTGCGTCATGTACGG
CCGATTTCGTTTGGCTTGAACTGTGCGTTAGGTCCTGATGAGCTGCGCCAGTACGTGGAAGAGCTTTCACGCATTTCAGA
ATGCTATGTTTCCGCGCACCCAAATGCCGGACTGCCCAATGCGTTTGGTGAATACGATCTCTCTGCCGAGGAAATGGCAG
AACATATTGCGGAATGGGCACAAGCTGGCTTTTTGAATTTGGTCGGTGGTTGCTGTGGAACTACACCTGAGCATATCGCC
GCCATTGCCAAAGCCGTCGAGGGTGTAAAACCAAGGGCTCTGCCAGATCTGAAAGTAGAATGTCGTCTCTCGGGTTTAGA
GCCGCTCAATATTGGCCCTGAAACCTTGTTTGTTAACGTGGGCGAACGTACTAACGTCACCGGTTCTGCGCGTTTTAAGC
GTTTAATTAAAGAAGAGCAATACGACGAAGCGCTCGATGTGGCGCGTGAGCAAGTCGAAAACGGCGCGCAGATCATTGAT
ATCAACATGGATGAAGGCATGTTGGACGCCGAGGCGTGTATGGTGCGCTTTTTGAATCTATGCGCCTCTGAACCAGAAAT
ATCCAAAGTTCCGGTGATGGTCGACTCCTCTAAATGGGAAGTCATTGAAGCGGGTCTGAAATGCATTCAGGGTAAAGGCA
TCGTCAACTCTATCTCTCTAAAAGAAGGGAAAGAGAAGTTTATTGCCCAAGCCAAATTGGTGCGCCGCTACGGTGCCGCG
GTGATTGTGATGGCATTTGACGAAGTGGGCCAAGCCGATACCCGTGAGCGCAAATTAGAGATCTGTCGTCGGGCTTACCA
TATTTTGGTCGATGAGGTGGGCTTCCCACCGGAAGATATTATTTTTGACCCGAACATCTTTGCTGTTGCGACCGGAATTG
ATGAGCACAATAACTACGCACTGGATTTCATTAATGCAGTGGCGGACATTAAGCGTGAGCTGCCGCATGCGATGATTTCT
GGCGGTGTTTCTAACGTTTCCTTCTCTTTCCGCGGCAACAACTATGTGCGTGAAGCGATCCATGCTGTTTTCCTTTATCA
CTGCTTCAAACACGGCATGGACATGGGGATTGTCAACGCAGGGCAGCTTGAAATCTACGATAACGTTCCGCTGAAACTGC
GTGAGGCAGTGGAAGATGTGATCCTCAATCGACGTAGCGATGGCACGGAAAGACTGCTTGAGATCGCCGAAGCGTATCGC
GAAAACAGTGTTGGTAAAGAAGAGGATGCTTCTGCATTAGAGTGGCGCGCATGGCCTGTGGCTAAGCGCCTAGAGCACGC
TTTAGTCAAAGGCATCACCGAATTTATCGTCCAAGACACTGAAGAAGCACGTCAGCAAGCCAGTAAACCACTGGAAGTGA
TTGAAGGGCCGCTGATGGATGGTATGAACGTGGTCGGTGACTTGTTCGGGGAAGGGAAAATGTTCCTACCGCAAGTCGTA
AAATCAGCGCGTGTCATGAAACAAGCCGTTGCGTATCTTGAGCCTTTCATTAATGCGCAAAAAAGTGGTAGCACTTCAAA
TGGTAAGATTTTGCTGGCGACCGTAAAAGGCGATGTGCATGACATTGGTAAGAACATTGTTGGCGTCGTGCTGCAGTGTA
ATAACTTCGAGATCATCGATCTTGGTGTGATGGTGCCTTGCGAGCAGATCCTCAAAGTCGCACGCGAGCAAAATGTCGAT
ATCATCGGTCTCTCTGGGCTTATCACGCCGTCTTTGGATGAGATGGTACACGTGGCGAAAGAGATGGAGCGACAAGGGTT
TGAACTGCCACTTTTGATTGGTGGGGCAACAACGTCTAAAGCGCATACTGCGGTGAAGATTGAACAGAATTATCATGCGC
CTGTAGTGTACGTGAATAACGCGTCGCGCGCGGTAGGGGTGTGCACATCATTATTGTCTGATGAACAGCGCCCCGGATTT
ATCGAACGTTTGGATCTCGATTATGAGCGCACGCGTGATCAGCATGCTCGTAAAACGCCCAAATCGCGCCCAGTCACGTT
AGAGCAGGCACGTGCTAATAAAGCGGCGCTGGATTGGGCAAATTACACGCCGCCCGCTCCTGCGAAACCGGGTGTGCATG
TGTTTGAAAACATTGCGTTAGCCACACTACGTCCTTATATCGATTGGACGCCTTTTTTTATGACTTGGTCGCTTATGGGC
AAATACCCTGCCATTTTGGAGCATGAAGAGGTCGGTGAAGAGGCCAAACGTCTGTTTCATGATGCCAATGCCTTACTTGA
TAAAGTAGAGCGAGAAGGACTACTGAAAGCCAGTGGTATGTGTGCACTGTTTCCAGCAGCCAGCGTGGGCGATGACATTG
AGGTGTACAGTGATGAATCGCGTACGCAAGTCGCGCATGTGCTGTACAACTTGCGTCAGCAGACTGAGAAACCGAAAGGG
GCCAACTACTGTTTGTCGGACTATGTTGCTCCGAAAGAGAGCGGTAAACGTGATTGGATTGGCGCGTTTGCAGTAACTGG
TGGCATTGGTGAGCGAGCCTTGGCCGATGCTTATAAAGCTCAGGGTGATGATTACAATGCGATCATGATCCAAGCGGTAG
CCGATCGTTTGGCGGAAGCCTTTGCGGAATATCTGCATGAAAAAGTGCGTAAAGAGATTTGGGGTTATGCGAGCGATGAA
AATCTCTCCAATGATGACCTGATCCGTGAGCGTTATCAGGGCATTCGACCCGCGCCGGGGTATCCCGCGTGTCCTGAGCA
TACCGAGAAAGCGACTTTGTGGCAGATGCTAAATGTCGAAGAGACCATAGGTATGTCACTGACCACAAGCTATGCGATGT
GGCCGGGCGCTTCGGTATCCGGTTGGTATTTCTCGCATCCCGATTCTCGCTATTTTGCGGTAGCGCAGATCCAACCAGAT
CAACTGCACAGCTACGCTGAGCGTAAAGGTTGGCGTTTGGAAGAAGCTGAAAAGTGGCTAGCGCCTAACCTTGATGCTTA
A

Upstream 100 bases:

>100_bases
TCGTCAAGGTGAGTCACGAAAGAATGGCTGTTTTAGACGTCTAGATTTCTGAATTTTGTGTGATAGGATGTGGCAAACGC
ATAAGGAATGAGGCGGTATT

Downstream 100 bases:

>100_bases
TCAGTAAGACCTCCATCCACAATAAAAGAGGCCACATCATGTGGCCTCTGGTTTTATCTCGTGAGTTTGATTTTACTCTT
GCTCAAACAGCTCTTTATGC

Product: B12-dependent methionine synthase

Products: NA

Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12 dependent; MS

Number of amino acids: Translated: 1226; Mature: 1225

Protein sequence:

>1226_residues
MGKEVRQQLEQQLKQRILLIDGGMGTMIQSYKLQEEDYRGARFVDWHCDLKGNNDLLVLTQPQIIKEIHSAYLEAGADIL
ETNTFNSTTIAMADYDMQSLSAEINFAAAKLAREVADEWTAKDPSRPRYVAGVLGPTNRTCSISPDVNDPGFRNVTFDGL
VEAYSESTRALIKGGSDLILIETIFDTLNAKACAFAVDSVFEELGISLPVMISGTITDASGRTLSGQTTEAFYNALRHVR
PISFGLNCALGPDELRQYVEELSRISECYVSAHPNAGLPNAFGEYDLSAEEMAEHIAEWAQAGFLNLVGGCCGTTPEHIA
AIAKAVEGVKPRALPDLKVECRLSGLEPLNIGPETLFVNVGERTNVTGSARFKRLIKEEQYDEALDVAREQVENGAQIID
INMDEGMLDAEACMVRFLNLCASEPEISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFIAQAKLVRRYGAA
VIVMAFDEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYALDFINAVADIKRELPHAMIS
GGVSNVSFSFRGNNYVREAIHAVFLYHCFKHGMDMGIVNAGQLEIYDNVPLKLREAVEDVILNRRSDGTERLLEIAEAYR
ENSVGKEEDASALEWRAWPVAKRLEHALVKGITEFIVQDTEEARQQASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVV
KSARVMKQAVAYLEPFINAQKSGSTSNGKILLATVKGDVHDIGKNIVGVVLQCNNFEIIDLGVMVPCEQILKVAREQNVD
IIGLSGLITPSLDEMVHVAKEMERQGFELPLLIGGATTSKAHTAVKIEQNYHAPVVYVNNASRAVGVCTSLLSDEQRPGF
IERLDLDYERTRDQHARKTPKSRPVTLEQARANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFMTWSLMG
KYPAILEHEEVGEEAKRLFHDANALLDKVEREGLLKASGMCALFPAASVGDDIEVYSDESRTQVAHVLYNLRQQTEKPKG
ANYCLSDYVAPKESGKRDWIGAFAVTGGIGERALADAYKAQGDDYNAIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDE
NLSNDDLIRERYQGIRPAPGYPACPEHTEKATLWQMLNVEETIGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVAQIQPD
QLHSYAERKGWRLEEAEKWLAPNLDA

Sequences:

>Translated_1226_residues
MGKEVRQQLEQQLKQRILLIDGGMGTMIQSYKLQEEDYRGARFVDWHCDLKGNNDLLVLTQPQIIKEIHSAYLEAGADIL
ETNTFNSTTIAMADYDMQSLSAEINFAAAKLAREVADEWTAKDPSRPRYVAGVLGPTNRTCSISPDVNDPGFRNVTFDGL
VEAYSESTRALIKGGSDLILIETIFDTLNAKACAFAVDSVFEELGISLPVMISGTITDASGRTLSGQTTEAFYNALRHVR
PISFGLNCALGPDELRQYVEELSRISECYVSAHPNAGLPNAFGEYDLSAEEMAEHIAEWAQAGFLNLVGGCCGTTPEHIA
AIAKAVEGVKPRALPDLKVECRLSGLEPLNIGPETLFVNVGERTNVTGSARFKRLIKEEQYDEALDVAREQVENGAQIID
INMDEGMLDAEACMVRFLNLCASEPEISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFIAQAKLVRRYGAA
VIVMAFDEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYALDFINAVADIKRELPHAMIS
GGVSNVSFSFRGNNYVREAIHAVFLYHCFKHGMDMGIVNAGQLEIYDNVPLKLREAVEDVILNRRSDGTERLLEIAEAYR
ENSVGKEEDASALEWRAWPVAKRLEHALVKGITEFIVQDTEEARQQASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVV
KSARVMKQAVAYLEPFINAQKSGSTSNGKILLATVKGDVHDIGKNIVGVVLQCNNFEIIDLGVMVPCEQILKVAREQNVD
IIGLSGLITPSLDEMVHVAKEMERQGFELPLLIGGATTSKAHTAVKIEQNYHAPVVYVNNASRAVGVCTSLLSDEQRPGF
IERLDLDYERTRDQHARKTPKSRPVTLEQARANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFMTWSLMG
KYPAILEHEEVGEEAKRLFHDANALLDKVEREGLLKASGMCALFPAASVGDDIEVYSDESRTQVAHVLYNLRQQTEKPKG
ANYCLSDYVAPKESGKRDWIGAFAVTGGIGERALADAYKAQGDDYNAIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDE
NLSNDDLIRERYQGIRPAPGYPACPEHTEKATLWQMLNVEETIGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVAQIQPD
QLHSYAERKGWRLEEAEKWLAPNLDA
>Mature_1225_residues
GKEVRQQLEQQLKQRILLIDGGMGTMIQSYKLQEEDYRGARFVDWHCDLKGNNDLLVLTQPQIIKEIHSAYLEAGADILE
TNTFNSTTIAMADYDMQSLSAEINFAAAKLAREVADEWTAKDPSRPRYVAGVLGPTNRTCSISPDVNDPGFRNVTFDGLV
EAYSESTRALIKGGSDLILIETIFDTLNAKACAFAVDSVFEELGISLPVMISGTITDASGRTLSGQTTEAFYNALRHVRP
ISFGLNCALGPDELRQYVEELSRISECYVSAHPNAGLPNAFGEYDLSAEEMAEHIAEWAQAGFLNLVGGCCGTTPEHIAA
IAKAVEGVKPRALPDLKVECRLSGLEPLNIGPETLFVNVGERTNVTGSARFKRLIKEEQYDEALDVAREQVENGAQIIDI
NMDEGMLDAEACMVRFLNLCASEPEISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFIAQAKLVRRYGAAV
IVMAFDEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYALDFINAVADIKRELPHAMISG
GVSNVSFSFRGNNYVREAIHAVFLYHCFKHGMDMGIVNAGQLEIYDNVPLKLREAVEDVILNRRSDGTERLLEIAEAYRE
NSVGKEEDASALEWRAWPVAKRLEHALVKGITEFIVQDTEEARQQASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFINAQKSGSTSNGKILLATVKGDVHDIGKNIVGVVLQCNNFEIIDLGVMVPCEQILKVAREQNVDI
IGLSGLITPSLDEMVHVAKEMERQGFELPLLIGGATTSKAHTAVKIEQNYHAPVVYVNNASRAVGVCTSLLSDEQRPGFI
ERLDLDYERTRDQHARKTPKSRPVTLEQARANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFMTWSLMGK
YPAILEHEEVGEEAKRLFHDANALLDKVEREGLLKASGMCALFPAASVGDDIEVYSDESRTQVAHVLYNLRQQTEKPKGA
NYCLSDYVAPKESGKRDWIGAFAVTGGIGERALADAYKAQGDDYNAIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDEN
LSNDDLIRERYQGIRPAPGYPACPEHTEKATLWQMLNVEETIGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVAQIQPDQ
LHSYAERKGWRLEEAEKWLAPNLDA

Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate

COG id: COG1410

COG function: function code E; Methionine synthase I, cobalamin-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain

Homologues:

Organism=Homo sapiens, GI169790923, Length=1254, Percent_Identity=52.7113237639553, Blast_Score=1319, Evalue=0.0,
Organism=Escherichia coli, GI1790450, Length=1218, Percent_Identity=75.3694581280788, Blast_Score=1923, Evalue=0.0,
Organism=Escherichia coli, GI1786456, Length=321, Percent_Identity=24.2990654205607, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17535405, Length=1242, Percent_Identity=52.5764895330113, Blast_Score=1291, Evalue=0.0,

Paralogues:

None

Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): METH_VIBCH (Q9KUW9)

Other databases:

- EMBL:   AE003852
- PIR:   E82328
- RefSeq:   NP_230044.1
- ProteinModelPortal:   Q9KUW9
- SMR:   Q9KUW9
- GeneID:   2614987
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC0390
- TIGR:   VC_0390
- HOGENOM:   HBG289648
- OMA:   RNQPVEK
- ProtClustDB:   PRK09490
- BRENDA:   2.1.1.13
- GO:   GO:0005622
- InterPro:   IPR006158
- InterPro:   IPR011005
- InterPro:   IPR003759
- InterPro:   IPR011822
- InterPro:   IPR000489
- InterPro:   IPR003726
- InterPro:   IPR004223
- Gene3D:   G3DSA:3.40.50.280
- Gene3D:   G3DSA:3.20.20.20
- Gene3D:   G3DSA:3.10.196.10
- Gene3D:   G3DSA:1.10.1240.10
- Gene3D:   G3DSA:3.20.20.330
- PIRSF:   PIRSF000381
- TIGRFAMs:   TIGR02082

Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans; SSF52242 Cbl-bd; SSF51717 DHP_synth_like; SSF56507 Met_synth_B12; SSF47644 Met_synth_Cbl-bd; SSF82282 S_methyl_trans

EC number: =2.1.1.13

Molecular weight: Translated: 135795; Mature: 135663

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50974 ADOMET_ACTIVATION; PS51332 B12_BINDING; PS51337 B12_BINDING_NTER; PS50970 HCY; PS50972 PTERIN_BINDING

Important sites: BINDING 805-805 BINDING 948-948 BINDING 1136-1136 BINDING 1140-1140

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKEVRQQLEQQLKQRILLIDGGMGTMIQSYKLQEEDYRGARFVDWHCDLKGNNDLLVLT
CCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEE
QPQIIKEIHSAYLEAGADILETNTFNSTTIAMADYDMQSLSAEINFAAAKLAREVADEWT
CHHHHHHHHHHHHHCCCHHEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHC
AKDPSRPRYVAGVLGPTNRTCSISPDVNDPGFRNVTFDGLVEAYSESTRALIKGGSDLIL
CCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
IETIFDTLNAKACAFAVDSVFEELGISLPVMISGTITDASGRTLSGQTTEAFYNALRHVR
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEECCCHHHHHHHHHHHCC
PISFGLNCALGPDELRQYVEELSRISECYVSAHPNAGLPNAFGEYDLSAEEMAEHIAEWA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
QAGFLNLVGGCCGTTPEHIAAIAKAVEGVKPRALPDLKVECRLSGLEPLNIGPETLFVNV
HCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEC
GERTNVTGSARFKRLIKEEQYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLNL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH
CASEPEISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFIAQAKLVRRYGAA
HCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHCCE
VIVMAFDEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYA
EEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCEEEEEECCCCCCCHH
LDFINAVADIKRELPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKHGMDMGIVNA
HHHHHHHHHHHHHCCHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEECC
GQLEIYDNVPLKLREAVEDVILNRRSDGTERLLEIAEAYRENSVGKEEDASALEWRAWPV
CCEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AKRLEHALVKGITEFIVQDTEEARQQASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVV
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHCCHHCHHHHHHHHHCCCCCHHHHHH
KSARVMKQAVAYLEPFINAQKSGSTSNGKILLATVKGDVHDIGKNIVGVVLQCNNFEIID
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHEEEEEECCCEEEEE
LGVMVPCEQILKVAREQNVDIIGLSGLITPSLDEMVHVAKEMERQGFELPLLIGGATTSK
ECCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
AHTAVKIEQNYHAPVVYVNNASRAVGVCTSLLSDEQRPGFIERLDLDYERTRDQHARKTP
CEEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHCCC
KSRPVTLEQARANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFMTWSLMG
CCCCEEHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
KYPAILEHEEVGEEAKRLFHDANALLDKVEREGLLKASGMCALFPAASVGDDIEVYSDES
CCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEECCCCCCCCCCEEECCCH
RTQVAHVLYNLRQQTEKPKGANYCLSDYVAPKESGKRDWIGAFAVTGGIGERALADAYKA
HHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCEEHHEEECCCCHHHHHHHHHC
QGDDYNAIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDENLSNDDLIRERYQGIRPAPG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCC
YPACPEHTEKATLWQMLNVEETIGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVAQIQPD
CCCCCCCCHHHHHHHHHCHHHHHCCEEECCEEECCCCCCCCCEECCCCCCEEEEEECCHH
QLHSYAERKGWRLEEAEKWLAPNLDA
HHHHHHHHCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
GKEVRQQLEQQLKQRILLIDGGMGTMIQSYKLQEEDYRGARFVDWHCDLKGNNDLLVLT
CHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEEE
QPQIIKEIHSAYLEAGADILETNTFNSTTIAMADYDMQSLSAEINFAAAKLAREVADEWT
CHHHHHHHHHHHHHCCCHHEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHC
AKDPSRPRYVAGVLGPTNRTCSISPDVNDPGFRNVTFDGLVEAYSESTRALIKGGSDLIL
CCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
IETIFDTLNAKACAFAVDSVFEELGISLPVMISGTITDASGRTLSGQTTEAFYNALRHVR
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEECCCHHHHHHHHHHHCC
PISFGLNCALGPDELRQYVEELSRISECYVSAHPNAGLPNAFGEYDLSAEEMAEHIAEWA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
QAGFLNLVGGCCGTTPEHIAAIAKAVEGVKPRALPDLKVECRLSGLEPLNIGPETLFVNV
HCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEC
GERTNVTGSARFKRLIKEEQYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLNL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH
CASEPEISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFIAQAKLVRRYGAA
HCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHCCE
VIVMAFDEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYA
EEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCEEEEEECCCCCCCHH
LDFINAVADIKRELPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKHGMDMGIVNA
HHHHHHHHHHHHHCCHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEECC
GQLEIYDNVPLKLREAVEDVILNRRSDGTERLLEIAEAYRENSVGKEEDASALEWRAWPV
CCEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AKRLEHALVKGITEFIVQDTEEARQQASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVV
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHCCHHCHHHHHHHHHCCCCCHHHHHH
KSARVMKQAVAYLEPFINAQKSGSTSNGKILLATVKGDVHDIGKNIVGVVLQCNNFEIID
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHEEEEEECCCEEEEE
LGVMVPCEQILKVAREQNVDIIGLSGLITPSLDEMVHVAKEMERQGFELPLLIGGATTSK
ECCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
AHTAVKIEQNYHAPVVYVNNASRAVGVCTSLLSDEQRPGFIERLDLDYERTRDQHARKTP
CEEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHCCC
KSRPVTLEQARANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFMTWSLMG
CCCCEEHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
KYPAILEHEEVGEEAKRLFHDANALLDKVEREGLLKASGMCALFPAASVGDDIEVYSDES
CCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEECCCCCCCCCCEEECCCH
RTQVAHVLYNLRQQTEKPKGANYCLSDYVAPKESGKRDWIGAFAVTGGIGERALADAYKA
HHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCEEHHEEECCCCHHHHHHHHHC
QGDDYNAIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDENLSNDDLIRERYQGIRPAPG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCC
YPACPEHTEKATLWQMLNVEETIGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVAQIQPD
CCCCCCCCHHHHHHHHHCHHHHHCCEEECCEEECCCCCCCCCEECCCCCCEEEEEECCHH
QLHSYAERKGWRLEEAEKWLAPNLDA
HHHHHHHHCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301