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The map label for this gene is gatD [H]

Identifier: 226950870

GI number: 226950870

Start: 3925931

End: 3926980

Strand: Reverse

Name: gatD [H]

Synonym: CLM_3884

Alternate gene names: 226950870

Gene position: 3926980-3925931 (Counterclockwise)

Preceding gene: 226950871

Following gene: 226950869

Centisome position: 94.51

GC content: 32.57

Gene sequence:

>1050_bases
ATGGAAGGAAAAATGAAAGCAGTAGCTTTACATGCAATTAAGGATTTGAGATATGAGGAAGTAGATATACCTACTATAGG
CGAAAATGATGTATTAGTAAGAGTTAAATATGTTGGTATATGTGGTTCAGATATGCCAAGAGCTATGGTAAGTGGAGCAT
ATCATTATCCAACAATAACAGGACATGAATTTTCAGGAGAAGTAGTTGAAATTGGTAATAATGTAGATGATATAAAGGTA
GGAGAGAGAATAGCAGTAGCACCATTAATACCATGTGGAGAATGTGAATTCTGTAAAAAAGGCAACTTTGCTTTATGTGA
AACTTATGAATTTTTAGGTTCTAGAAATGATGGTGGTTTTGCAGAATATGTTAGAGTTCCAAAAGAAAACGTATTAATAC
TTCCAGAAGATTTAGATTATGAAACAGCAGCAGGAATAGAACCAGCATCTATATCATACCAAGCAATGAGCAAAACAGGA
ATAAAAGTTGGTGATACTGTAGCAATTGTTGGTTGTGGTCCTATAGGACAATTTGCTATTCAATGGGCAAAGATATTTGG
TGCATCAAAGGTAATAGCTGTGGATGTTTTAGAGGATAAACTTAACTTAGCTAAAGAATTAGGCGCAGATATCATAATAA
ACAGTAAAGAATGTAATGCAGTTGAAAAAGTATTAGAAATTACCAATGGTGGAGTAGAGGCTGTTGTAGAAACTGCAGGA
ATGAAAATTACAGAAGAACAATCTGTTCTTATGTGTAGAAAACTTGGAAAGGTTGTATTCTTAGGAATATCACATGATGA
ATTAAGATTTAGCGAAAAAACTTTTGATAGAATAATGCGTGGAGAAATTACATTACAAGGTTCATGGAATTCATATGCAG
CTCCATTCCCAGGAATAGCTTGGAGAACTACATTAGATTTCATGGAAAAAGGACAAATAGTATTTAAACCAATGGTATCT
CATAAAATCAAACTTGAAGAATTACCAGGGTATTTCCACAAAATGTTTAACAAAGAAATTAATTATAATAAGGTATTAGT
TGAAATTTAG

Upstream 100 bases:

>100_bases
ACTAATAATGAAACAGCAGAAACGGTACTAAACTTACATGAGCAATTTACTAAAAATAAAAAATAAATATAATTTAAAAC
TTTGAAGGGAGTCTTATAAA

Downstream 100 bases:

>100_bases
TAGAGGTGAATTTATGTTTATAAAAATAGTAATTGTTATTGGACTTGCATGGCTTCTACAAACTGTATTAGGTTTTTTAC
AATTTAAAAATTTTAATAAA

Product: putative L-iditol 2-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MEGKMKAVALHAIKDLRYEEVDIPTIGENDVLVRVKYVGICGSDMPRAMVSGAYHYPTITGHEFSGEVVEIGNNVDDIKV
GERIAVAPLIPCGECEFCKKGNFALCETYEFLGSRNDGGFAEYVRVPKENVLILPEDLDYETAAGIEPASISYQAMSKTG
IKVGDTVAIVGCGPIGQFAIQWAKIFGASKVIAVDVLEDKLNLAKELGADIIINSKECNAVEKVLEITNGGVEAVVETAG
MKITEEQSVLMCRKLGKVVFLGISHDELRFSEKTFDRIMRGEITLQGSWNSYAAPFPGIAWRTTLDFMEKGQIVFKPMVS
HKIKLEELPGYFHKMFNKEINYNKVLVEI

Sequences:

>Translated_349_residues
MEGKMKAVALHAIKDLRYEEVDIPTIGENDVLVRVKYVGICGSDMPRAMVSGAYHYPTITGHEFSGEVVEIGNNVDDIKV
GERIAVAPLIPCGECEFCKKGNFALCETYEFLGSRNDGGFAEYVRVPKENVLILPEDLDYETAAGIEPASISYQAMSKTG
IKVGDTVAIVGCGPIGQFAIQWAKIFGASKVIAVDVLEDKLNLAKELGADIIINSKECNAVEKVLEITNGGVEAVVETAG
MKITEEQSVLMCRKLGKVVFLGISHDELRFSEKTFDRIMRGEITLQGSWNSYAAPFPGIAWRTTLDFMEKGQIVFKPMVS
HKIKLEELPGYFHKMFNKEINYNKVLVEI
>Mature_349_residues
MEGKMKAVALHAIKDLRYEEVDIPTIGENDVLVRVKYVGICGSDMPRAMVSGAYHYPTITGHEFSGEVVEIGNNVDDIKV
GERIAVAPLIPCGECEFCKKGNFALCETYEFLGSRNDGGFAEYVRVPKENVLILPEDLDYETAAGIEPASISYQAMSKTG
IKVGDTVAIVGCGPIGQFAIQWAKIFGASKVIAVDVLEDKLNLAKELGADIIINSKECNAVEKVLEITNGGVEAVVETAG
MKITEEQSVLMCRKLGKVVFLGISHDELRFSEKTFDRIMRGEITLQGSWNSYAAPFPGIAWRTTLDFMEKGQIVFKPMVS
HKIKLEELPGYFHKMFNKEINYNKVLVEI

Specific function: Converts galactitol 1-phosphate to tagatose 6-phosphate [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=345, Percent_Identity=29.2753623188406, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI4501929, Length=358, Percent_Identity=28.4916201117318, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501939, Length=343, Percent_Identity=26.2390670553936, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI156523966, Length=353, Percent_Identity=25.4957507082153, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI71565152, Length=372, Percent_Identity=24.4623655913978, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI71565154, Length=279, Percent_Identity=29.3906810035842, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI34577061, Length=357, Percent_Identity=27.7310924369748, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI71743840, Length=289, Percent_Identity=28.0276816608997, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI262073058, Length=289, Percent_Identity=28.0276816608997, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1788407, Length=327, Percent_Identity=37.6146788990826, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1788073, Length=337, Percent_Identity=30.5637982195846, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788075, Length=356, Percent_Identity=31.7415730337079, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI226510992, Length=346, Percent_Identity=31.5028901734104, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1787863, Length=328, Percent_Identity=30.7926829268293, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI87082125, Length=288, Percent_Identity=31.5972222222222, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1786825, Length=286, Percent_Identity=32.1678321678322, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1790045, Length=338, Percent_Identity=26.3313609467456, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790718, Length=309, Percent_Identity=27.1844660194175, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87081918, Length=317, Percent_Identity=31.5457413249211, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1786552, Length=370, Percent_Identity=27.2972972972973, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI87082401, Length=135, Percent_Identity=37.037037037037, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994910, Length=234, Percent_Identity=27.3504273504274, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786518, Length=294, Percent_Identity=26.8707482993197, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=343, Percent_Identity=32.3615160349854, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17562878, Length=352, Percent_Identity=30.6818181818182, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71988145, Length=342, Percent_Identity=27.7777777777778, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17562584, Length=341, Percent_Identity=30.2052785923754, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562582, Length=343, Percent_Identity=30.0291545189504, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI25146526, Length=378, Percent_Identity=23.8095238095238, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=380, Percent_Identity=23.9473684210526, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=314, Percent_Identity=23.8853503184713, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323099, Length=354, Percent_Identity=29.6610169491525, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319955, Length=335, Percent_Identity=29.8507462686567, Blast_Score=152, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322619, Length=335, Percent_Identity=29.8507462686567, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6319621, Length=344, Percent_Identity=31.3953488372093, Blast_Score=136, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6323961, Length=337, Percent_Identity=29.3768545994065, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323729, Length=332, Percent_Identity=29.5180722891566, Blast_Score=126, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6324486, Length=337, Percent_Identity=29.080118694362, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=26.1333333333333, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319258, Length=284, Percent_Identity=29.5774647887324, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319257, Length=382, Percent_Identity=22.5130890052356, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319949, Length=225, Percent_Identity=32, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=228, Percent_Identity=28.9473684210526, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17737897, Length=336, Percent_Identity=29.4642857142857, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI17137530, Length=336, Percent_Identity=29.4642857142857, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17737895, Length=371, Percent_Identity=23.989218328841, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI221457811, Length=187, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45550770, Length=187, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45551930, Length=187, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.251 [H]

Molecular weight: Translated: 38487; Mature: 38487

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGKMKAVALHAIKDLRYEEVDIPTIGENDVLVRVKYVGICGSDMPRAMVSGAYHYPTIT
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHCCCEECCEEC
GHEFSGEVVEIGNNVDDIKVGERIAVAPLIPCGECEFCKKGNFALCETYEFLGSRNDGGF
CCCCCCCEEEECCCCCCEECCCEEEEEECCCCCCCCHHCCCCEEEEEEHHHHCCCCCCCH
AEYVRVPKENVLILPEDLDYETAAGIEPASISYQAMSKTGIKVGDTVAIVGCGPIGQFAI
HHHEECCCCCEEEECCCCCCHHHCCCCCCCCCHHHHHCCCCEECCEEEEEECCCHHHHHH
QWAKIFGASKVIAVDVLEDKLNLAKELGADIIINSKECNAVEKVLEITNGGVEAVVETAG
HHHHHHCCCCEEEEEEHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHCC
MKITEEQSVLMCRKLGKVVFLGISHDELRFSEKTFDRIMRGEITLQGSWNSYAAPFPGIA
CEEECHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
WRTTLDFMEKGQIVFKPMVSHKIKLEELPGYFHKMFNKEINYNKVLVEI
HHHHHHHHHCCCEEEEEHHHCEEEHHHCCHHHHHHHCCCCCCCEEEEEC
>Mature Secondary Structure
MEGKMKAVALHAIKDLRYEEVDIPTIGENDVLVRVKYVGICGSDMPRAMVSGAYHYPTIT
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHCCCEECCEEC
GHEFSGEVVEIGNNVDDIKVGERIAVAPLIPCGECEFCKKGNFALCETYEFLGSRNDGGF
CCCCCCCEEEECCCCCCEECCCEEEEEECCCCCCCCHHCCCCEEEEEEHHHHCCCCCCCH
AEYVRVPKENVLILPEDLDYETAAGIEPASISYQAMSKTGIKVGDTVAIVGCGPIGQFAI
HHHEECCCCCEEEECCCCCCHHHCCCCCCCCCHHHHHCCCCEECCEEEEEECCCHHHHHH
QWAKIFGASKVIAVDVLEDKLNLAKELGADIIINSKECNAVEKVLEITNGGVEAVVETAG
HHHHHHCCCCEEEEEEHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHCC
MKITEEQSVLMCRKLGKVVFLGISHDELRFSEKTFDRIMRGEITLQGSWNSYAAPFPGIA
CEEECHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
WRTTLDFMEKGQIVFKPMVSHKIKLEELPGYFHKMFNKEINYNKVLVEI
HHHHHHHHHCCCEEEEEHHHCEEEHHHCCHHHHHHHCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]