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The map label for this gene is glmS [H]

Identifier: 226950862

GI number: 226950862

Start: 3918734

End: 3920560

Strand: Reverse

Name: glmS [H]

Synonym: CLM_3875

Alternate gene names: 226950862

Gene position: 3920560-3918734 (Counterclockwise)

Preceding gene: 226950863

Following gene: 226950861

Centisome position: 94.35

GC content: 31.14

Gene sequence:

>1827_bases
ATGTGCGGAATAGTAGGTTACGTAGGATTTAGGAAGGCAAGCGATGTAATCGTGGATGGATTATCGAAATTAGAGTATAG
AGGATATGACTCTGCAGGAATCGCTGTTAATGATGGAAAGGAAATAGAGTTTCAAAAGTACAAAGGTAGACTAAATGTTT
TAAGTGAAAATTTAGAAAATAAGCCTATGGAGGGAACTATAGGAATAGGTCATACAAGATGGGCTACTCACGGAGTGCCA
TCTGATGTGAATTCACATCCACATTTAAATATGGATGAAACAATTGCAGTAGTTCATAATGGTATAATTGAAAATTATAT
GGAAATAAAAGAATGGTTGGTTTCTGAAGGCGTAAAATTTAAATCAGAAACAGATACTGAAGTAATAGCGCATTTAGTTG
ATCATTATTATGAAGGTGATTTATTACAGGCAGTATTTAAGGCTATAAAAAAATTAAGAGGAGCTTATGCTCTAGGAGTA
GTTTGTAAAGATAACCCAGAACAATTAGTAGCTGTAAGAAAAGATAGTCCATTAATAGTAGGAATTGGAGAGAATGAAAA
CTTCATTGCATCTGATGTACCAGCTATTTTAAAATATACTAGAGATGTATATTTCTTAGATAATGGAGAAGTAGTTACTT
TAGAAAAAGACAAAATAAAAATTTACAACGAAAAGGAAGAAGAAATCACAAAAGAACCTTTCCATGTAATGTGGGATGTG
GAAGCAGCATCTAAGGGTGGATATGACCACTTCATGATAAAAGAAATAAATGAACAACCAAATGGTATAAAAGAAACTTT
AGTTAGAAGATTAGATGAAAATGGTAAAATAAAATTAGATGATATAAAACTAACAAAAGAAGACTTAGATGAAATAAATA
AAGTTTATATAGTTGCTTGTGGAACTGCATACAATGCAGGAATAACAGGAAGATATGCTATTGAAAGATTTGCAAAAATA
GCTGTAGAAACAGATGTAGCTTCAGAGTTTAGATATAGAAATCCATTTATAGACGACAAAACATTAATTATTGTTGTAAG
TCAATCTGGAGAAACAGCAGATACTTTAGCAGTTGTAAGAGAAGGAAAAGAAAAAGGAGCGAGAGTTCTAGCTATTACTA
ATGTTGTAGGATCTTCTATAGCTAGAGAAGCAGATGATGTATTTTATACTTGGGCGGGGCCTGAAGTAGCAGTTGCATCA
ACTAAAGCATATACAACTCAACTTGTAGCATTGTATATGATCGCATTAGATATGGGTATAAAAAGAGGAACAATAACTGA
AGAATTTTATAATGATATAATAAGTGAATTAAAACTTATACCTGAAAAAGTACAAAAAATACTTGATCAACATGATGATA
TAAAAGAAATAGCAAAAGAAATAAAAGACAATGAACATGCATTTTATATAGGAAGAGGATTAGATTATAATCTTTCATTA
GAAGGTTCATTAAAGATAAAAGAAATATCTTATATGCATGCAGAAGCTTTTGCTGCTGGTGAATTAAAGCATGGTACTAT
AGCTCTTATTGAAGAAAATACACCAGTAGTAGCTACAATGACTCAAACAGATTTATTTGAAAAGAGTATTTCTAATATAA
AAGAAGTTAAATCAAGAGGAGCACATGTTATTGCTATAACTCAGGAAGGAAATAAAGAAGCAGAGCAAGTAGCGGATAAA
GTAATTTATATACCAAGAACAAATGATATATTACAAAGTATTATTGCAGTAGTGCCTCATCAATTATTAGCATACTATGT
AGCAATACTAAAAGACCGCGATGTAGATAAGCCAAGAAATTTAGCTAAATCTGTTACAGTTGAATAA

Upstream 100 bases:

>100_bases
TAAAAGCTATAATAAAAGTTAGAAGTGATTCTGATTACAAAAAAGCTTTAGTGAGGACTTTCTTCTTAAATTATTAATAT
AATCTAAGGAGGATTTTTTT

Downstream 100 bases:

>100_bases
AAAATAGCTTTCTATAAAATTATATCTAGTTTTGTAAAAAAATTTTATAATTTGAAATCAGAGATTTTGCATCAAAATTC
CAGTAAAAATTTTATTTTTA

Product: glutamine-fructose-6-phosphate transaminase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIVGYVGFRKASDVIVDGLSKLEYRGYDSAGIAVNDGKEIEFQKYKGRLNVLSENLENKPMEGTIGIGHTRWATHGVP
SDVNSHPHLNMDETIAVVHNGIIENYMEIKEWLVSEGVKFKSETDTEVIAHLVDHYYEGDLLQAVFKAIKKLRGAYALGV
VCKDNPEQLVAVRKDSPLIVGIGENENFIASDVPAILKYTRDVYFLDNGEVVTLEKDKIKIYNEKEEEITKEPFHVMWDV
EAASKGGYDHFMIKEINEQPNGIKETLVRRLDENGKIKLDDIKLTKEDLDEINKVYIVACGTAYNAGITGRYAIERFAKI
AVETDVASEFRYRNPFIDDKTLIIVVSQSGETADTLAVVREGKEKGARVLAITNVVGSSIAREADDVFYTWAGPEVAVAS
TKAYTTQLVALYMIALDMGIKRGTITEEFYNDIISELKLIPEKVQKILDQHDDIKEIAKEIKDNEHAFYIGRGLDYNLSL
EGSLKIKEISYMHAEAFAAGELKHGTIALIEENTPVVATMTQTDLFEKSISNIKEVKSRGAHVIAITQEGNKEAEQVADK
VIYIPRTNDILQSIIAVVPHQLLAYYVAILKDRDVDKPRNLAKSVTVE

Sequences:

>Translated_608_residues
MCGIVGYVGFRKASDVIVDGLSKLEYRGYDSAGIAVNDGKEIEFQKYKGRLNVLSENLENKPMEGTIGIGHTRWATHGVP
SDVNSHPHLNMDETIAVVHNGIIENYMEIKEWLVSEGVKFKSETDTEVIAHLVDHYYEGDLLQAVFKAIKKLRGAYALGV
VCKDNPEQLVAVRKDSPLIVGIGENENFIASDVPAILKYTRDVYFLDNGEVVTLEKDKIKIYNEKEEEITKEPFHVMWDV
EAASKGGYDHFMIKEINEQPNGIKETLVRRLDENGKIKLDDIKLTKEDLDEINKVYIVACGTAYNAGITGRYAIERFAKI
AVETDVASEFRYRNPFIDDKTLIIVVSQSGETADTLAVVREGKEKGARVLAITNVVGSSIAREADDVFYTWAGPEVAVAS
TKAYTTQLVALYMIALDMGIKRGTITEEFYNDIISELKLIPEKVQKILDQHDDIKEIAKEIKDNEHAFYIGRGLDYNLSL
EGSLKIKEISYMHAEAFAAGELKHGTIALIEENTPVVATMTQTDLFEKSISNIKEVKSRGAHVIAITQEGNKEAEQVADK
VIYIPRTNDILQSIIAVVPHQLLAYYVAILKDRDVDKPRNLAKSVTVE
>Mature_608_residues
MCGIVGYVGFRKASDVIVDGLSKLEYRGYDSAGIAVNDGKEIEFQKYKGRLNVLSENLENKPMEGTIGIGHTRWATHGVP
SDVNSHPHLNMDETIAVVHNGIIENYMEIKEWLVSEGVKFKSETDTEVIAHLVDHYYEGDLLQAVFKAIKKLRGAYALGV
VCKDNPEQLVAVRKDSPLIVGIGENENFIASDVPAILKYTRDVYFLDNGEVVTLEKDKIKIYNEKEEEITKEPFHVMWDV
EAASKGGYDHFMIKEINEQPNGIKETLVRRLDENGKIKLDDIKLTKEDLDEINKVYIVACGTAYNAGITGRYAIERFAKI
AVETDVASEFRYRNPFIDDKTLIIVVSQSGETADTLAVVREGKEKGARVLAITNVVGSSIAREADDVFYTWAGPEVAVAS
TKAYTTQLVALYMIALDMGIKRGTITEEFYNDIISELKLIPEKVQKILDQHDDIKEIAKEIKDNEHAFYIGRGLDYNLSL
EGSLKIKEISYMHAEAFAAGELKHGTIALIEENTPVVATMTQTDLFEKSISNIKEVKSRGAHVIAITQEGNKEAEQVADK
VIYIPRTNDILQSIIAVVPHQLLAYYVAILKDRDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=683, Percent_Identity=35.1390922401171, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI205277386, Length=682, Percent_Identity=35.0439882697947, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI29570798, Length=201, Percent_Identity=28.8557213930348, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=44.3719412724307, Blast_Score=523, Evalue=1e-149,
Organism=Escherichia coli, GI87082251, Length=315, Percent_Identity=23.4920634920635, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788651, Length=249, Percent_Identity=29.3172690763052, Blast_Score=83, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17539970, Length=430, Percent_Identity=37.4418604651163, Blast_Score=286, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17532899, Length=430, Percent_Identity=36.7441860465116, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=36.7441860465116, Blast_Score=285, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI17554892, Length=251, Percent_Identity=27.8884462151394, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322745, Length=432, Percent_Identity=38.8888888888889, Blast_Score=298, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6323731, Length=431, Percent_Identity=31.0904872389791, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=37.6811594202899, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=35.6622998544396, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI28573187, Length=141, Percent_Identity=31.2056737588652, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67924; Mature: 67924

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYVGFRKASDVIVDGLSKLEYRGYDSAGIAVNDGKEIEFQKYKGRLNVLSENLEN
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEHHHHCCHHHHHHHHHCC
KPMEGTIGIGHTRWATHGVPSDVNSHPHLNMDETIAVVHNGIIENYMEIKEWLVSEGVKF
CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KSETDTEVIAHLVDHYYEGDLLQAVFKAIKKLRGAYALGVVCKDNPEQLVAVRKDSPLIV
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHEEEEECCCCEEE
GIGENENFIASDVPAILKYTRDVYFLDNGEVVTLEKDKIKIYNEKEEEITKEPFHVMWDV
EECCCCCEEHHHHHHHHHHCCCEEEECCCCEEEEECCCEEEECCCHHHHCCCCCEEEEEE
EAASKGGYDHFMIKEINEQPNGIKETLVRRLDENGKIKLDDIKLTKEDLDEINKVYIVAC
ECCCCCCCCEEEHEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHHHCCCEEEEEEE
GTAYNAGITGRYAIERFAKIAVETDVASEFRYRNPFIDDKTLIIVVSQSGETADTLAVVR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHH
EGKEKGARVLAITNVVGSSIAREADDVFYTWAGPEVAVASTKAYTTQLVALYMIALDMGI
CCHHCCCEEEEEHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCC
KRGTITEEFYNDIISELKLIPEKVQKILDQHDDIKEIAKEIKDNEHAFYIGRGLDYNLSL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCEEEEEE
EGSLKIKEISYMHAEAFAAGELKHGTIALIEENTPVVATMTQTDLFEKSISNIKEVKSRG
CCCEEEEHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCC
AHVIAITQEGNKEAEQVADKVIYIPRTNDILQSIIAVVPHQLLAYYVAILKDRDVDKPRN
CEEEEEECCCCCHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LAKSVTVE
HHHHCCCC
>Mature Secondary Structure
MCGIVGYVGFRKASDVIVDGLSKLEYRGYDSAGIAVNDGKEIEFQKYKGRLNVLSENLEN
CCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEHHHHCCHHHHHHHHHCC
KPMEGTIGIGHTRWATHGVPSDVNSHPHLNMDETIAVVHNGIIENYMEIKEWLVSEGVKF
CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KSETDTEVIAHLVDHYYEGDLLQAVFKAIKKLRGAYALGVVCKDNPEQLVAVRKDSPLIV
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHEEEEECCCCEEE
GIGENENFIASDVPAILKYTRDVYFLDNGEVVTLEKDKIKIYNEKEEEITKEPFHVMWDV
EECCCCCEEHHHHHHHHHHCCCEEEECCCCEEEEECCCEEEECCCHHHHCCCCCEEEEEE
EAASKGGYDHFMIKEINEQPNGIKETLVRRLDENGKIKLDDIKLTKEDLDEINKVYIVAC
ECCCCCCCCEEEHEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHHHCCCEEEEEEE
GTAYNAGITGRYAIERFAKIAVETDVASEFRYRNPFIDDKTLIIVVSQSGETADTLAVVR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHH
EGKEKGARVLAITNVVGSSIAREADDVFYTWAGPEVAVASTKAYTTQLVALYMIALDMGI
CCHHCCCEEEEEHHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCC
KRGTITEEFYNDIISELKLIPEKVQKILDQHDDIKEIAKEIKDNEHAFYIGRGLDYNLSL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCEEEEEE
EGSLKIKEISYMHAEAFAAGELKHGTIALIEENTPVVATMTQTDLFEKSISNIKEVKSRG
CCCEEEEHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCC
AHVIAITQEGNKEAEQVADKVIYIPRTNDILQSIIAVVPHQLLAYYVAILKDRDVDKPRN
CEEEEEECCCCCHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LAKSVTVE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]