Click here to switch to the map view.

The map label for this gene is tktB [C]

Identifier: 226950845

GI number: 226950845

Start: 3902632

End: 3903456

Strand: Reverse

Name: tktB [C]

Synonym: CLM_3857

Alternate gene names: 226950845

Gene position: 3903456-3902632 (Counterclockwise)

Preceding gene: 226950846

Following gene: 226950844

Centisome position: 93.94

GC content: 33.94

Gene sequence:

>825_bases
ATGAAGAAGAACATAGAAGAGCTACAAGATATAGCTAAAGTTATTAGAAAAGATATAGTTTCAATGTTAACTGAATCTGC
TTCTGGACATCCAGGAGGTTCTTTATCAGCAGTAGAGATATTGACTGCTTTATATTTTAATGAGATGAATATAGACCCTA
CTAATACTAGGGATTTAAATAGGGACAGATTTGTTCTTTCTAAAGGGCATGCTGCTCCAGTATTATATAGTACTTTAGCA
AGAAGAGGATTTTTTAATCCAGAAGAGCTAAAGACTTTAAGAAAAATTGGATCAATATTACAAGGTCATCCAAATATGAA
TGACGTTCCAGGTATAGATATGTCAACAGGCTCTTTAGGTCAAGGAATATCAACAGCAGTAGGTATGGCTGTAGCCGGAA
AACTTGATGAAAAAGATTACAGAGTATATACACTACTTGGAGATGGAGAATTAGAGGAAGGACAAGTTTGGGAAGCAGCT
ATGGCAGCAGCTCATTACAAATTAGATAATTTGACTGCCTTTGTAGATTACAATGGATTACAAATAGATGGACCTTGTAG
TGAAGTTATGTCAGCGGAACCTATAGCGGATAAATTTAGAGCTTTTAATTGGAATGTTATAGAAATAGATGGACATGATT
TCAATTCTATATTAAATGCTATAGAAAGTTCAAAAAATACTAAAGAAAGACCAACTATGATAGTATGTAAAACTATAAAA
GGTAAGGGTGTTTCTTTTATGGAAAATGAAGCTGGATGGCATGGTAAAGCACCAAGTGCAGAAGAATGTGAAAAAGCTAT
ATGTGAAATCGGAGGTGACAAATAA

Upstream 100 bases:

>100_bases
GTTTTAATATATAGCTTTTGCACCTATATATTAAAATTAATTTTTATGTTACAATAATATAGTAAATAAGGGTAATTAAA
AAATACTTGGAGGTAAAAAT

Downstream 100 bases:

>100_bases
TGGGAGTTAAAATAGCTACAAGAGAAGCATACGGAAAAACATTAGCTAAATTAGCAGAAGAAAATTCAAAGATAGTGGTT
TTAGATGCAGACCTTTCAAA

Product: transketolase, thiamine diphosphate binding subunit

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MKKNIEELQDIAKVIRKDIVSMLTESASGHPGGSLSAVEILTALYFNEMNIDPTNTRDLNRDRFVLSKGHAAPVLYSTLA
RRGFFNPEELKTLRKIGSILQGHPNMNDVPGIDMSTGSLGQGISTAVGMAVAGKLDEKDYRVYTLLGDGELEEGQVWEAA
MAAAHYKLDNLTAFVDYNGLQIDGPCSEVMSAEPIADKFRAFNWNVIEIDGHDFNSILNAIESSKNTKERPTMIVCKTIK
GKGVSFMENEAGWHGKAPSAEECEKAICEIGGDK

Sequences:

>Translated_274_residues
MKKNIEELQDIAKVIRKDIVSMLTESASGHPGGSLSAVEILTALYFNEMNIDPTNTRDLNRDRFVLSKGHAAPVLYSTLA
RRGFFNPEELKTLRKIGSILQGHPNMNDVPGIDMSTGSLGQGISTAVGMAVAGKLDEKDYRVYTLLGDGELEEGQVWEAA
MAAAHYKLDNLTAFVDYNGLQIDGPCSEVMSAEPIADKFRAFNWNVIEIDGHDFNSILNAIESSKNTKERPTMIVCKTIK
GKGVSFMENEAGWHGKAPSAEECEKAICEIGGDK
>Mature_274_residues
MKKNIEELQDIAKVIRKDIVSMLTESASGHPGGSLSAVEILTALYFNEMNIDPTNTRDLNRDRFVLSKGHAAPVLYSTLA
RRGFFNPEELKTLRKIGSILQGHPNMNDVPGIDMSTGSLGQGISTAVGMAVAGKLDEKDYRVYTLLGDGELEEGQVWEAA
MAAAHYKLDNLTAFVDYNGLQIDGPCSEVMSAEPIADKFRAFNWNVIEIDGHDFNSILNAIESSKNTKERPTMIVCKTIK
GKGVSFMENEAGWHGKAPSAEECEKAICEIGGDK

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=273, Percent_Identity=42.8571428571429, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI4507521, Length=273, Percent_Identity=42.8571428571429, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI133778974, Length=269, Percent_Identity=40.8921933085502, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI225637459, Length=270, Percent_Identity=31.4814814814815, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI225637461, Length=233, Percent_Identity=32.1888412017167, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI225637463, Length=160, Percent_Identity=38.75, Blast_Score=118, Evalue=5e-27,
Organism=Escherichia coli, GI1788808, Length=275, Percent_Identity=35.2727272727273, Blast_Score=167, Evalue=5e-43,
Organism=Escherichia coli, GI48994911, Length=258, Percent_Identity=37.984496124031, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17539652, Length=262, Percent_Identity=46.1832061068702, Blast_Score=226, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6325331, Length=284, Percent_Identity=36.6197183098592, Blast_Score=158, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6319593, Length=286, Percent_Identity=34.6153846153846, Blast_Score=154, Evalue=1e-38,
Organism=Drosophila melanogaster, GI45551847, Length=255, Percent_Identity=41.1764705882353, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI45550715, Length=255, Percent_Identity=41.1764705882353, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24666278, Length=267, Percent_Identity=41.1985018726592, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24645119, Length=217, Percent_Identity=42.3963133640553, Blast_Score=183, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 29929; Mature: 29929

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNIEELQDIAKVIRKDIVSMLTESASGHPGGSLSAVEILTALYFNEMNIDPTNTRDLN
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
RDRFVLSKGHAAPVLYSTLARRGFFNPEELKTLRKIGSILQGHPNMNDVPGIDMSTGSLG
CCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
QGISTAVGMAVAGKLDEKDYRVYTLLGDGELEEGQVWEAAMAAAHYKLDNLTAFVDYNGL
CCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCE
QIDGPCSEVMSAEPIADKFRAFNWNVIEIDGHDFNSILNAIESSKNTKERPTMIVCKTIK
EECCCHHHHHCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEEECC
GKGVSFMENEAGWHGKAPSAEECEKAICEIGGDK
CCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKNIEELQDIAKVIRKDIVSMLTESASGHPGGSLSAVEILTALYFNEMNIDPTNTRDLN
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
RDRFVLSKGHAAPVLYSTLARRGFFNPEELKTLRKIGSILQGHPNMNDVPGIDMSTGSLG
CCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
QGISTAVGMAVAGKLDEKDYRVYTLLGDGELEEGQVWEAAMAAAHYKLDNLTAFVDYNGL
CCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCE
QIDGPCSEVMSAEPIADKFRAFNWNVIEIDGHDFNSILNAIESSKNTKERPTMIVCKTIK
EECCCHHHHHCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEEECC
GKGVSFMENEAGWHGKAPSAEECEKAICEIGGDK
CCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]