Click here to switch to the map view.

The map label for this gene is uvrA [H]

Identifier: 226950836

GI number: 226950836

Start: 3890921

End: 3893743

Strand: Reverse

Name: uvrA [H]

Synonym: CLM_3848

Alternate gene names: 226950836

Gene position: 3893743-3890921 (Counterclockwise)

Preceding gene: 226950837

Following gene: 226950835

Centisome position: 93.71

GC content: 30.75

Gene sequence:

>2823_bases
ATGAAGGATAAAATTATTATTAAAGGCGCTAAGGTTAATAATTTAAAAAATATAAATCTTCAGTTGCCGAGAGATAAGTA
TATAGTATTTACAGGCCTATCTGGTTCTGGTAAATCCTCATTAGCTTTTGATACTTTATATGCAGAGGGACAGAGAAGAT
ATGTAGAATCTTTATCTGCCTATGCTAGACAGTTTTTAGGACAAATGGATAAACCAGAAGTAGATTATATAGAAGGGTTA
TCACCGGCCATATCTATTGATCAAAAAACCACTAATAGAAATCCACGTTCAACTGTTGGAACTGTGACAGAAATATATGA
TTATTTAAGACTGCTATATGCAAAAATAGGGAAACCTCATTGCCCTAAATGTGGAAAAGAAATAACTCAACAAACAGTAG
ATCAAATGGTAGATAAAATAATGACTATGGAGGAAAGGACTAAAATACAAGTGTTATCTCCCATTATAAATGGAAGAAAA
GGTGAGCACATTAAGACTATAGAAAACATAATAAAATCAGGGTATGTAAGAGCCAGAATAGATGGAAATATAGTAGATTT
AGAAGAGGAAGAAATAAAGTTAGAAAAAAATAAAAAACATACCATAGAGGCTGTAGTAGATAGATTAGTAGTTAAAGAAG
GCATAGAAAGTAGACTTGCAGATTCTATGGAAACTGCATTAAAGCTATCAGAAGGAATAGTAATAATAAATGTTGTGGGA
CAAGAGGATATGCTTTTTAGTGAAAAATTTGCTTGTGTAGATTGTAATATAAGTATAGGAGAAATAGCTCCTAGAATGTT
TTCTTTTAACTCCCCTTATGGAAAGTGTGATAAATGTGATGGATTAGGTACCTTAATGGAAATAGATGAGGACTTAGTTA
TACCGAATAAAAGTAAGAGTATAGTAGAGGGAGCAATAATTCCATTAGGCAGTGGTAGTTTAAAGGAAGATTCATGGACT
TTTAGTATATTAAAAGCTTTGTCAAAGGAATATAAATTTGATTTAAATACTCCTATAGAAAAATTAGATCCTAAAATAGT
AAAGATTATTTTATATGGACTAGATGGAAAAAGAATAAAAGTAAATTATAAAAAAGAAAATAGAATCATGGAATTAAATC
ATGCTTATGAAGGTGTTATAAATAATCTTAGAAGAAGATATATAGAAACTAATTCTGATTATATAAAAAGAGATATTGAA
AGATATATGAGTGATAATCCTTGTCCAAAATGCAAAGGTGCAAGACTTCATGATGAGGCTTTATCTGTTACAGTAGCAGA
TAAAAATATATTTGAGTTTTGTAATATGTCCATAAAAAAAGAACTTGATTTTATAGAATCTTTAGAGTTATCTAAAAAAG
AGGAAATAATAAGCAATCAAATACTAAAAGAGATTCGCAGTAGACTAAAATTTTTAATAGATGTAGGTTTAGATTATCTT
ACATTATCTAGAAATGCATCAACTTTATCTGGAGGAGAGTCTCAAAGAATAAGATTGGCTACACAAATAGGCTCTAGTTT
AGTAGGGGTTTTATATATATTAGATGAACCTAGTATAGGACTTCATCAAAGAGATAATGATAGACTTATAAAAACATTAA
AAAATTTAAGGGACTTAGGGAATACTTTAGTAGTTGTAGAACATGACGAAGATACCATAAGAGAAGCAGACTATATTGTT
GATATAGGTCCAGGTGCTGGTGAACATGGTGGAGAAGTAGTAGCAGCAGGAACCTTAGAAGATATAATGAATACCGAAAA
GTCTATAACAGGACAATATATAAAGGGAGTTAGAACTATATCAGTACCTAAAGAAAGACGAAAATGTGAAGGTAATTATA
TATCCATAAAGGGAGCTAGAGAAAATAATTTGAAAAACGTAAGCGCTAAATTCCCTATAGGATTATTTACTTGTGTAACA
GGAGTTTCAGGTTCAGGCAAAAGTACCCTAGTTAATGAAATATTATATAAAGGTATTCATAAAAAGCTAAATAATTCAAA
GGATAATCCAGGTAAACATAAGGAGATTACTGGCATAGAAAATGTAGATAAGGTTATAAATATAGATCAGAGCCCTATAG
GTAGAACCCCAAGATCCAATCCTGCCACCTATACGGGAGTATTTGATATTATAAGAGAAGTTTTTTCAAATACTCAAGAG
GCTAAGATGCGAGGATATAAACCAGGGAGATTTAGTTTCAATGTCAAAGGTGGAAGATGTGAGGCTTGCACTGGAGACGG
AATTATAAAAATTGAAATGCAATTTTTATCTGATGTATATGTTCCTTGTGAAGTATGTAAAGGAAAAAGATATAATAGAG
AAACTTTAGAAGTAAAATATAAAGGGAAGAATATATCAGATGTATTAAATATGACTGTAGAAGAAGCTCTAGACTTTTTT
GAAAATATTCCACGTATAAAAAGTAAGCTTCAAACTCTTATGGATGTGGGCTTAAGCTATATAAGATTGGGTCAATCCTC
TACACAACTTTCAGGAGGGGAAGCTCAAAGAATAAAATTAGCTTATGAGTTATCTAAAAGAAGTACAGGAAAAACTCTCT
ATATATTAGATGAGCCTACTACTGGACTTCATATGGAGGATGTAAATAAGTTAATAAGTATACTACAAAGATTAACAAAT
TCAGGTAATACTGTAGTGGTTATAGAGCATAATTTAGATGTTATAAAAAATGCCGATTATTTAATAGATTTAGGACCAGA
AGGCGGAGAAAAGGGAGGAACTATAATAGCAGAGGGAACCCCAGAAAAAATTTCAAGAGCTAGTAACTCATATACAGGAC
AATATTTAAAAAAGATGTTATAA

Upstream 100 bases:

>100_bases
ACAAAATTTACAGTTTGAAAAAGCGGCTCATTTGAGAGATGTAATATACAAATTAAAAAAAGATAAAGAAACAGAACTTT
AAGGAGTGTAATAACAAATA

Downstream 100 bases:

>100_bases
TTTATTTGGGACTAGCATATAAACATATAGGTGCTAGTCCTTTAAATACAAATATTTTAGCATAATATACCAACAGGGAA
GGTAAAGAAGGTGATAGTAT

Product: excinuclease ABC subunit A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 940; Mature: 940

Protein sequence:

>940_residues
MKDKIIIKGAKVNNLKNINLQLPRDKYIVFTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLGQMDKPEVDYIEGL
SPAISIDQKTTNRNPRSTVGTVTEIYDYLRLLYAKIGKPHCPKCGKEITQQTVDQMVDKIMTMEERTKIQVLSPIINGRK
GEHIKTIENIIKSGYVRARIDGNIVDLEEEEIKLEKNKKHTIEAVVDRLVVKEGIESRLADSMETALKLSEGIVIINVVG
QEDMLFSEKFACVDCNISIGEIAPRMFSFNSPYGKCDKCDGLGTLMEIDEDLVIPNKSKSIVEGAIIPLGSGSLKEDSWT
FSILKALSKEYKFDLNTPIEKLDPKIVKIILYGLDGKRIKVNYKKENRIMELNHAYEGVINNLRRRYIETNSDYIKRDIE
RYMSDNPCPKCKGARLHDEALSVTVADKNIFEFCNMSIKKELDFIESLELSKKEEIISNQILKEIRSRLKFLIDVGLDYL
TLSRNASTLSGGESQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNDRLIKTLKNLRDLGNTLVVVEHDEDTIREADYIV
DIGPGAGEHGGEVVAAGTLEDIMNTEKSITGQYIKGVRTISVPKERRKCEGNYISIKGARENNLKNVSAKFPIGLFTCVT
GVSGSGKSTLVNEILYKGIHKKLNNSKDNPGKHKEITGIENVDKVINIDQSPIGRTPRSNPATYTGVFDIIREVFSNTQE
AKMRGYKPGRFSFNVKGGRCEACTGDGIIKIEMQFLSDVYVPCEVCKGKRYNRETLEVKYKGKNISDVLNMTVEEALDFF
ENIPRIKSKLQTLMDVGLSYIRLGQSSTQLSGGEAQRIKLAYELSKRSTGKTLYILDEPTTGLHMEDVNKLISILQRLTN
SGNTVVVIEHNLDVIKNADYLIDLGPEGGEKGGTIIAEGTPEKISRASNSYTGQYLKKML

Sequences:

>Translated_940_residues
MKDKIIIKGAKVNNLKNINLQLPRDKYIVFTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLGQMDKPEVDYIEGL
SPAISIDQKTTNRNPRSTVGTVTEIYDYLRLLYAKIGKPHCPKCGKEITQQTVDQMVDKIMTMEERTKIQVLSPIINGRK
GEHIKTIENIIKSGYVRARIDGNIVDLEEEEIKLEKNKKHTIEAVVDRLVVKEGIESRLADSMETALKLSEGIVIINVVG
QEDMLFSEKFACVDCNISIGEIAPRMFSFNSPYGKCDKCDGLGTLMEIDEDLVIPNKSKSIVEGAIIPLGSGSLKEDSWT
FSILKALSKEYKFDLNTPIEKLDPKIVKIILYGLDGKRIKVNYKKENRIMELNHAYEGVINNLRRRYIETNSDYIKRDIE
RYMSDNPCPKCKGARLHDEALSVTVADKNIFEFCNMSIKKELDFIESLELSKKEEIISNQILKEIRSRLKFLIDVGLDYL
TLSRNASTLSGGESQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNDRLIKTLKNLRDLGNTLVVVEHDEDTIREADYIV
DIGPGAGEHGGEVVAAGTLEDIMNTEKSITGQYIKGVRTISVPKERRKCEGNYISIKGARENNLKNVSAKFPIGLFTCVT
GVSGSGKSTLVNEILYKGIHKKLNNSKDNPGKHKEITGIENVDKVINIDQSPIGRTPRSNPATYTGVFDIIREVFSNTQE
AKMRGYKPGRFSFNVKGGRCEACTGDGIIKIEMQFLSDVYVPCEVCKGKRYNRETLEVKYKGKNISDVLNMTVEEALDFF
ENIPRIKSKLQTLMDVGLSYIRLGQSSTQLSGGEAQRIKLAYELSKRSTGKTLYILDEPTTGLHMEDVNKLISILQRLTN
SGNTVVVIEHNLDVIKNADYLIDLGPEGGEKGGTIIAEGTPEKISRASNSYTGQYLKKML
>Mature_940_residues
MKDKIIIKGAKVNNLKNINLQLPRDKYIVFTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLGQMDKPEVDYIEGL
SPAISIDQKTTNRNPRSTVGTVTEIYDYLRLLYAKIGKPHCPKCGKEITQQTVDQMVDKIMTMEERTKIQVLSPIINGRK
GEHIKTIENIIKSGYVRARIDGNIVDLEEEEIKLEKNKKHTIEAVVDRLVVKEGIESRLADSMETALKLSEGIVIINVVG
QEDMLFSEKFACVDCNISIGEIAPRMFSFNSPYGKCDKCDGLGTLMEIDEDLVIPNKSKSIVEGAIIPLGSGSLKEDSWT
FSILKALSKEYKFDLNTPIEKLDPKIVKIILYGLDGKRIKVNYKKENRIMELNHAYEGVINNLRRRYIETNSDYIKRDIE
RYMSDNPCPKCKGARLHDEALSVTVADKNIFEFCNMSIKKELDFIESLELSKKEEIISNQILKEIRSRLKFLIDVGLDYL
TLSRNASTLSGGESQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNDRLIKTLKNLRDLGNTLVVVEHDEDTIREADYIV
DIGPGAGEHGGEVVAAGTLEDIMNTEKSITGQYIKGVRTISVPKERRKCEGNYISIKGARENNLKNVSAKFPIGLFTCVT
GVSGSGKSTLVNEILYKGIHKKLNNSKDNPGKHKEITGIENVDKVINIDQSPIGRTPRSNPATYTGVFDIIREVFSNTQE
AKMRGYKPGRFSFNVKGGRCEACTGDGIIKIEMQFLSDVYVPCEVCKGKRYNRETLEVKYKGKNISDVLNMTVEEALDFF
ENIPRIKSKLQTLMDVGLSYIRLGQSSTQLSGGEAQRIKLAYELSKRSTGKTLYILDEPTTGLHMEDVNKLISILQRLTN
SGNTVVVIEHNLDVIKNADYLIDLGPEGGEKGGTIIAEGTPEKISRASNSYTGQYLKKML

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=944, Percent_Identity=57.8389830508475, Blast_Score=1117, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 105138; Mature: 105138

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS00063 ALDOKETO_REDUCTASE_3 ; PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKIIIKGAKVNNLKNINLQLPRDKYIVFTGLSGSGKSSLAFDTLYAEGQRRYVESLSA
CCCCEEEECCCCCCEEECEEECCCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHH
YARQFLGQMDKPEVDYIEGLSPAISIDQKTTNRNPRSTVGTVTEIYDYLRLLYAKIGKPH
HHHHHHCCCCCCCHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
CPKCGKEITQQTVDQMVDKIMTMEERTKIQVLSPIINGRKGEHIKTIENIIKSGYVRARI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEE
DGNIVDLEEEEIKLEKNKKHTIEAVVDRLVVKEGIESRLADSMETALKLSEGIVIINVVG
CCCEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEC
QEDMLFSEKFACVDCNISIGEIAPRMFSFNSPYGKCDKCDGLGTLMEIDEDLVIPNKSKS
CCCHHHCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCEECCCCCCH
IVEGAIIPLGSGSLKEDSWTFSILKALSKEYKFDLNTPIEKLDPKIVKIILYGLDGKRIK
HHCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCHHEEEEEEECCCCCEEE
VNYKKENRIMELNHAYEGVINNLRRRYIETNSDYIKRDIERYMSDNPCPKCKGARLHDEA
EEEECCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
LSVTVADKNIFEFCNMSIKKELDFIESLELSKKEEIISNQILKEIRSRLKFLIDVGLDYL
EEEEEECHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
TLSRNASTLSGGESQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNDRLIKTLKNLRDLG
EECCCCCCCCCCCCCCEEHHHHHHHHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
NTLVVVEHDEDTIREADYIVDIGPGAGEHGGEVVAAGTLEDIMNTEKSITGQYIKGVRTI
CEEEEEECCCHHHHCCCEEEECCCCCCCCCCCEEECCCHHHHHCCHHHHHHHHHCCCEEE
SVPKERRKCEGNYISIKGARENNLKNVSAKFPIGLFTCVTGVSGSGKSTLVNEILYKGIH
CCCHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
KKLNNSKDNPGKHKEITGIENVDKVINIDQSPIGRTPRSNPATYTGVFDIIREVFSNTQE
HHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHH
AKMRGYKPGRFSFNVKGGRCEACTGDGIIKIEMQFLSDVYVPCEVCKGKRYNRETLEVKY
HHHCCCCCCCEEEEECCCEEEEECCCCEEEEEEHHHHCCCCCHHHHCCCCCCCCEEEEEE
KGKNISDVLNMTVEEALDFFENIPRIKSKLQTLMDVGLSYIRLGQSSTQLSGGEAQRIKL
CCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCEEEE
AYELSKRSTGKTLYILDEPTTGLHMEDVNKLISILQRLTNSGNTVVVIEHNLDVIKNADY
EEEHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCCE
LIDLGPEGGEKGGTIIAEGTPEKISRASNSYTGQYLKKML
EEEECCCCCCCCCEEEECCCHHHHHHCCCCHHHHHHHHHC
>Mature Secondary Structure
MKDKIIIKGAKVNNLKNINLQLPRDKYIVFTGLSGSGKSSLAFDTLYAEGQRRYVESLSA
CCCCEEEECCCCCCEEECEEECCCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHH
YARQFLGQMDKPEVDYIEGLSPAISIDQKTTNRNPRSTVGTVTEIYDYLRLLYAKIGKPH
HHHHHHCCCCCCCHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
CPKCGKEITQQTVDQMVDKIMTMEERTKIQVLSPIINGRKGEHIKTIENIIKSGYVRARI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEE
DGNIVDLEEEEIKLEKNKKHTIEAVVDRLVVKEGIESRLADSMETALKLSEGIVIINVVG
CCCEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEC
QEDMLFSEKFACVDCNISIGEIAPRMFSFNSPYGKCDKCDGLGTLMEIDEDLVIPNKSKS
CCCHHHCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCEECCCCCCH
IVEGAIIPLGSGSLKEDSWTFSILKALSKEYKFDLNTPIEKLDPKIVKIILYGLDGKRIK
HHCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCHHEEEEEEECCCCCEEE
VNYKKENRIMELNHAYEGVINNLRRRYIETNSDYIKRDIERYMSDNPCPKCKGARLHDEA
EEEECCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
LSVTVADKNIFEFCNMSIKKELDFIESLELSKKEEIISNQILKEIRSRLKFLIDVGLDYL
EEEEEECHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
TLSRNASTLSGGESQRIRLATQIGSSLVGVLYILDEPSIGLHQRDNDRLIKTLKNLRDLG
EECCCCCCCCCCCCCCEEHHHHHHHHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
NTLVVVEHDEDTIREADYIVDIGPGAGEHGGEVVAAGTLEDIMNTEKSITGQYIKGVRTI
CEEEEEECCCHHHHCCCEEEECCCCCCCCCCCEEECCCHHHHHCCHHHHHHHHHCCCEEE
SVPKERRKCEGNYISIKGARENNLKNVSAKFPIGLFTCVTGVSGSGKSTLVNEILYKGIH
CCCHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
KKLNNSKDNPGKHKEITGIENVDKVINIDQSPIGRTPRSNPATYTGVFDIIREVFSNTQE
HHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHH
AKMRGYKPGRFSFNVKGGRCEACTGDGIIKIEMQFLSDVYVPCEVCKGKRYNRETLEVKY
HHHCCCCCCCEEEEECCCEEEEECCCCEEEEEEHHHHCCCCCHHHHCCCCCCCCEEEEEE
KGKNISDVLNMTVEEALDFFENIPRIKSKLQTLMDVGLSYIRLGQSSTQLSGGEAQRIKL
CCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCEEEE
AYELSKRSTGKTLYILDEPTTGLHMEDVNKLISILQRLTNSGNTVVVIEHNLDVIKNADY
EEEHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCCE
LIDLGPEGGEKGGTIIAEGTPEKISRASNSYTGQYLKKML
EEEECCCCCCCCCEEEECCCHHHHHHCCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]