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The map label for this gene is epiP [H]

Identifier: 226950761

GI number: 226950761

Start: 3795028

End: 3796470

Strand: Reverse

Name: epiP [H]

Synonym: CLM_3771

Alternate gene names: 226950761

Gene position: 3796470-3795028 (Counterclockwise)

Preceding gene: 226950762

Following gene: 226950759

Centisome position: 91.37

GC content: 28.14

Gene sequence:

>1443_bases
ATGATAAAAAAACTAAATTTCAAAAAAATTTATTTATTATTATTTTTAATTTTTATGTTTAGTATTATATTTCAAAGTAG
TAAAGTACAAGCTATAGAAACAAATGAAAATAAAGATATTAACATAGTTGTTTTATTTAATAATAATCGTATTGATACTA
ATGTTAAAAATTTAATTGAAAATTCTGGTGGAAAGATAAAAAATATATTATCAGAGGTTGGATGCATGGAGGTTAAATGT
AACAGTAATCTTATATCACAAATCAAATCTTATAATACTGTAAAATCGTTAGGACCAAATCATAATATTCAAATTCCAAA
AGAAAAAACAATAAAATTTAAAGAACGTATAAATAGAGGATATAAGTCAACAGAAACTAATAAGGATGGAGATTTATATG
ATTTATATCAATGGGATATTAAGAGAATGACAAATAACGGTAAAAGTTTTCAGTTGAATACTGGTAACCATAATGTAGTA
ATAGCTGTTTTAGATTCAGGAATAGATAAAGACCATCCAGATTTAAAAAATAATCTATTAGGAGGAGAAAATTTTATCCC
AAAGGATTTTAATAATGATAAAACAGAAATTGGTGATCCAAGAGATATAGAAGATAGATTAGGACATGGAACATGTATTT
CAGGAAGTATTGCTGGTAATGGAAGAATTAAAGGCATAGCTCCTAATATTGGATTTAAAAGCTATCGCGTATTTGATTCA
AGAGGACATACAAACGCTACTATAATGTCATCTGCTATAATAAAAGCAACTGATGATGGAGCAAATGTTATCAATTTAAG
CATGGCAGGGTATGATTTAAAGGGTAAATGCTACTGGACTGATCCTGATACTGGTGTTAAACATGACTTAGGAGATGATA
TGGCTGAATATGAGTTATATAAACGTGCAATTCAATATGCATTAAATCATAATGTTACAGTAGTTACTGCAGCAGGAAAT
GATGGACTTGATTGTTGTAATACTAAAAGTTTAACAGAATTTCTTAATAATAGAGATAAAGAAGATGGCTTTAGCTATGA
AGGGGTTACTTATGAAATACCAGGAAGTATTGATGGAGTTATAAATGTTTCAGCTACAGGAAAAAATGATAAAATTGCAA
CGTATTCAAACTATGGTAAGAATTTTATTGATGTAGCAGCACCAGGTGGCGATCATTCTAAAACAGAATCTTTAGATATT
AATGATATGTGTTTAAGCACAGCAATTGAAGGTCAATATAGGTTTGAAGTAGGTACATCAATAGCAGCTCCAAAGGTTTC
AGCGATAGCAGGACTTCTTTTATGTAAAAATAAAAATCTTACACCAAAGGAAGTTGCAGAAAAAATTTATGAAACATGTG
ATATATTAGATAATGATGAATCAAAACAATATTATGGATCAGGACTTGCTAATGCATATAATGCTCTAGAAAAAAATAAA
TAA

Upstream 100 bases:

>100_bases
TAATTTTCATTTTTTTATAAGAGCAATAAAAATATACAAAAATTTAAAAAAATGTTGTATTGTGGATGATATACAAATTA
TTTTATAAGGAGATGTTATT

Downstream 100 bases:

>100_bases
ATTAATTTATACATAAGACACACTAGATTTTAACATCTATAATTAAAATACATTGCTAAAACTAATATGGAATTTTTTTG
AAATTCACTCATGAATTTTA

Product: nisin leader peptide-processing serine protease NisP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MIKKLNFKKIYLLLFLIFMFSIIFQSSKVQAIETNENKDINIVVLFNNNRIDTNVKNLIENSGGKIKNILSEVGCMEVKC
NSNLISQIKSYNTVKSLGPNHNIQIPKEKTIKFKERINRGYKSTETNKDGDLYDLYQWDIKRMTNNGKSFQLNTGNHNVV
IAVLDSGIDKDHPDLKNNLLGGENFIPKDFNNDKTEIGDPRDIEDRLGHGTCISGSIAGNGRIKGIAPNIGFKSYRVFDS
RGHTNATIMSSAIIKATDDGANVINLSMAGYDLKGKCYWTDPDTGVKHDLGDDMAEYELYKRAIQYALNHNVTVVTAAGN
DGLDCCNTKSLTEFLNNRDKEDGFSYEGVTYEIPGSIDGVINVSATGKNDKIATYSNYGKNFIDVAAPGGDHSKTESLDI
NDMCLSTAIEGQYRFEVGTSIAAPKVSAIAGLLLCKNKNLTPKEVAEKIYETCDILDNDESKQYYGSGLANAYNALEKNK

Sequences:

>Translated_480_residues
MIKKLNFKKIYLLLFLIFMFSIIFQSSKVQAIETNENKDINIVVLFNNNRIDTNVKNLIENSGGKIKNILSEVGCMEVKC
NSNLISQIKSYNTVKSLGPNHNIQIPKEKTIKFKERINRGYKSTETNKDGDLYDLYQWDIKRMTNNGKSFQLNTGNHNVV
IAVLDSGIDKDHPDLKNNLLGGENFIPKDFNNDKTEIGDPRDIEDRLGHGTCISGSIAGNGRIKGIAPNIGFKSYRVFDS
RGHTNATIMSSAIIKATDDGANVINLSMAGYDLKGKCYWTDPDTGVKHDLGDDMAEYELYKRAIQYALNHNVTVVTAAGN
DGLDCCNTKSLTEFLNNRDKEDGFSYEGVTYEIPGSIDGVINVSATGKNDKIATYSNYGKNFIDVAAPGGDHSKTESLDI
NDMCLSTAIEGQYRFEVGTSIAAPKVSAIAGLLLCKNKNLTPKEVAEKIYETCDILDNDESKQYYGSGLANAYNALEKNK
>Mature_480_residues
MIKKLNFKKIYLLLFLIFMFSIIFQSSKVQAIETNENKDINIVVLFNNNRIDTNVKNLIENSGGKIKNILSEVGCMEVKC
NSNLISQIKSYNTVKSLGPNHNIQIPKEKTIKFKERINRGYKSTETNKDGDLYDLYQWDIKRMTNNGKSFQLNTGNHNVV
IAVLDSGIDKDHPDLKNNLLGGENFIPKDFNNDKTEIGDPRDIEDRLGHGTCISGSIAGNGRIKGIAPNIGFKSYRVFDS
RGHTNATIMSSAIIKATDDGANVINLSMAGYDLKGKCYWTDPDTGVKHDLGDDMAEYELYKRAIQYALNHNVTVVTAAGN
DGLDCCNTKSLTEFLNNRDKEDGFSYEGVTYEIPGSIDGVINVSATGKNDKIATYSNYGKNFIDVAAPGGDHSKTESLDI
NDMCLSTAIEGQYRFEVGTSIAAPKVSAIAGLLLCKNKNLTPKEVAEKIYETCDILDNDESKQYYGSGLANAYNALEKNK

Specific function: Protease which cleaves the matured lantibiotic from the modified prepeptide (Probable) [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=286, Percent_Identity=25.8741258741259, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550681, Length=296, Percent_Identity=23.6486486486486, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR008357
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 53102; Mature: 53102

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKLNFKKIYLLLFLIFMFSIIFQSSKVQAIETNENKDINIVVLFNNNRIDTNVKNLIE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCHHHHHHHH
NSGGKIKNILSEVGCMEVKCNSNLISQIKSYNTVKSLGPNHNIQIPKEKTIKFKERINRG
CCCCHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHCCC
YKSTETNKDGDLYDLYQWDIKRMTNNGKSFQLNTGNHNVVIAVLDSGIDKDHPDLKNNLL
CCCCCCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCCCCHHHCCC
GGENFIPKDFNNDKTEIGDPRDIEDRLGHGTCISGSIAGNGRIKGIAPNIGFKSYRVFDS
CCCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEEECEECCCCEEEEECCCCCCCEEEEECC
RGHTNATIMSSAIIKATDDGANVINLSMAGYDLKGKCYWTDPDTGVKHDLGDDMAEYELY
CCCCCCEEEECEEEEECCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHH
KRAIQYALNHNVTVVTAAGNDGLDCCNTKSLTEFLNNRDKEDGFSYEGVTYEIPGSIDGV
HHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCE
INVSATGKNDKIATYSNYGKNFIDVAAPGGDHSKTESLDINDMCLSTAIEGQYRFEVGTS
EEEEECCCCCCEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCC
IAAPKVSAIAGLLLCKNKNLTPKEVAEKIYETCDILDNDESKQYYGSGLANAYNALEKNK
CCCCHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MIKKLNFKKIYLLLFLIFMFSIIFQSSKVQAIETNENKDINIVVLFNNNRIDTNVKNLIE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCHHHHHHHH
NSGGKIKNILSEVGCMEVKCNSNLISQIKSYNTVKSLGPNHNIQIPKEKTIKFKERINRG
CCCCHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHCCC
YKSTETNKDGDLYDLYQWDIKRMTNNGKSFQLNTGNHNVVIAVLDSGIDKDHPDLKNNLL
CCCCCCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCCCCHHHCCC
GGENFIPKDFNNDKTEIGDPRDIEDRLGHGTCISGSIAGNGRIKGIAPNIGFKSYRVFDS
CCCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEEECEECCCCEEEEECCCCCCCEEEEECC
RGHTNATIMSSAIIKATDDGANVINLSMAGYDLKGKCYWTDPDTGVKHDLGDDMAEYELY
CCCCCCEEEECEEEEECCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHH
KRAIQYALNHNVTVVTAAGNDGLDCCNTKSLTEFLNNRDKEDGFSYEGVTYEIPGSIDGV
HHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCE
INVSATGKNDKIATYSNYGKNFIDVAAPGGDHSKTESLDINDMCLSTAIEGQYRFEVGTS
EEEEECCCCCCEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCC
IAAPKVSAIAGLLLCKNKNLTPKEVAEKIYETCDILDNDESKQYYGSGLANAYNALEKNK
CCCCHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1740156 [H]