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The map label for this gene is hbd [H]

Identifier: 226950629

GI number: 226950629

Start: 3651996

End: 3652826

Strand: Reverse

Name: hbd [H]

Synonym: CLM_3613

Alternate gene names: 226950629

Gene position: 3652826-3651996 (Counterclockwise)

Preceding gene: 226950630

Following gene: 226950628

Centisome position: 87.91

GC content: 30.93

Gene sequence:

>831_bases
ATGAAAGTATTTATTTTAGGTGGCGGAACAATGGGAGCAGGTATCGTTGAAGTTTTTGCTAAAGCCGGCCATGAAGTTGT
TTTAAAAAGATTCGTTGGTAAGGGAATGGATAAAATAATAAAAAGCTTTGATAAGCAAGTTAAAAAAGGAAAAATGACAG
AAGAAGAAAAAAATGATTGCATAAATAGAATAACAGTTACAACAGATATGGATTTAGCCAAAGATGCTGATCTAGTTGTT
GAAGCGTCTAAAGAAGACATGGAAATGAAGAAGGATATATTTGGTCAATTGGATAAGATTTGTAAACCAGAAACTATATT
TGCAACAAATACATCTTCTTTATCAATAACGACAATTGCTAGTAGCACAAATAGACCAGATAAAGTAATAGGAATGCATT
TCTTTAATCCAGCTCCTGTAATGAAATTAATAGAAGTAATAAAAGGTATAGCGACTTCAGAAGAAACTAAAAACACTGTA
ATTGAAATATCAAAGAAATTAGGAAAAGAACCAGTAGAAGTAGAGGAAGCGCCAGGATTTGTAGTTAATAGAATGCTTAT
ACCTATGATAAATGAAGCTATTGGTATATATGCAGAAGGAATTGCTACTGTTGAAGATATAGATTTAGCTATGAAATTAG
GAGCTAATCATCCTATTGGACCATTAGCTTTAGCAGATTTAATTGGTAATGATGTATGTTTGGCTATAATGGATGTATTA
CACTCTGAATTTGGGGATTCAAAATATAGACCTCATCCACTATTAATAAAAATGGTTAGAGGAAATTTATTAGGAAGAAA
AACAGGAAAAGGATTTTATGAATATAAATAA

Upstream 100 bases:

>100_bases
TGTTTTGCAACAGAAGACCAAAAAGAAGGAATGGGAGCTTTTTTAGAAAAAAGAAAACCAAATTTTATTAATAAATATTA
AATTTTAAGGGGGTATAAAA

Downstream 100 bases:

>100_bases
TAATTAAATTTGGGGGTATGGAAAATGAAAAATGTTGTTATTGCTAGTGCTGTAAGAACACCTATAGGAAAATTTGGAGG
AACATTAAAAAGTGTTTCAG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MKVFILGGGTMGAGIVEVFAKAGHEVVLKRFVGKGMDKIIKSFDKQVKKGKMTEEEKNDCINRITVTTDMDLAKDADLVV
EASKEDMEMKKDIFGQLDKICKPETIFATNTSSLSITTIASSTNRPDKVIGMHFFNPAPVMKLIEVIKGIATSEETKNTV
IEISKKLGKEPVEVEEAPGFVVNRMLIPMINEAIGIYAEGIATVEDIDLAMKLGANHPIGPLALADLIGNDVCLAIMDVL
HSEFGDSKYRPHPLLIKMVRGNLLGRKTGKGFYEYK

Sequences:

>Translated_276_residues
MKVFILGGGTMGAGIVEVFAKAGHEVVLKRFVGKGMDKIIKSFDKQVKKGKMTEEEKNDCINRITVTTDMDLAKDADLVV
EASKEDMEMKKDIFGQLDKICKPETIFATNTSSLSITTIASSTNRPDKVIGMHFFNPAPVMKLIEVIKGIATSEETKNTV
IEISKKLGKEPVEVEEAPGFVVNRMLIPMINEAIGIYAEGIATVEDIDLAMKLGANHPIGPLALADLIGNDVCLAIMDVL
HSEFGDSKYRPHPLLIKMVRGNLLGRKTGKGFYEYK
>Mature_276_residues
MKVFILGGGTMGAGIVEVFAKAGHEVVLKRFVGKGMDKIIKSFDKQVKKGKMTEEEKNDCINRITVTTDMDLAKDADLVV
EASKEDMEMKKDIFGQLDKICKPETIFATNTSSLSITTIASSTNRPDKVIGMHFFNPAPVMKLIEVIKGIATSEETKNTV
IEISKKLGKEPVEVEEAPGFVVNRMLIPMINEAIGIYAEGIATVEDIDLAMKLGANHPIGPLALADLIGNDVCLAIMDVL
HSEFGDSKYRPHPLLIKMVRGNLLGRKTGKGFYEYK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=285, Percent_Identity=45.2631578947368, Blast_Score=234, Evalue=5e-62,
Organism=Homo sapiens, GI296179427, Length=302, Percent_Identity=42.7152317880795, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI20127408, Length=277, Percent_Identity=36.101083032491, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI261878539, Length=291, Percent_Identity=36.7697594501718, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI68989263, Length=291, Percent_Identity=36.7697594501718, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI115430219, Length=233, Percent_Identity=29.6137339055794, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1787661, Length=279, Percent_Identity=41.5770609318996, Blast_Score=235, Evalue=2e-63,
Organism=Escherichia coli, GI1788682, Length=260, Percent_Identity=37.6923076923077, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1790281, Length=243, Percent_Identity=32.9218106995885, Blast_Score=137, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17553560, Length=284, Percent_Identity=42.2535211267606, Blast_Score=221, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17549919, Length=286, Percent_Identity=39.5104895104895, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17563036, Length=291, Percent_Identity=36.426116838488, Blast_Score=190, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI25144276, Length=279, Percent_Identity=37.9928315412186, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17508951, Length=279, Percent_Identity=37.9928315412186, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17508953, Length=279, Percent_Identity=37.9928315412186, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=36.5248226950355, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71985923, Length=279, Percent_Identity=36.2007168458781, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71985930, Length=276, Percent_Identity=35.1449275362319, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI193203623, Length=191, Percent_Identity=26.1780104712042, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115533614, Length=191, Percent_Identity=26.1780104712042, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19921000, Length=279, Percent_Identity=34.0501792114695, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24583077, Length=279, Percent_Identity=34.0501792114695, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24583079, Length=279, Percent_Identity=34.0501792114695, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI45549573, Length=239, Percent_Identity=28.4518828451883, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI20129993, Length=239, Percent_Identity=25.9414225941423, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30232; Mature: 30232

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFILGGGTMGAGIVEVFAKAGHEVVLKRFVGKGMDKIIKSFDKQVKKGKMTEEEKNDC
CEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHH
INRITVTTDMDLAKDADLVVEASKEDMEMKKDIFGQLDKICKPETIFATNTSSLSITTIA
HHEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEE
SSTNRPDKVIGMHFFNPAPVMKLIEVIKGIATSEETKNTVIEISKKLGKEPVEVEEAPGF
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
VVNRMLIPMINEAIGIYAEGIATVEDIDLAMKLGANHPIGPLALADLIGNDVCLAIMDVL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHH
HSEFGDSKYRPHPLLIKMVRGNLLGRKTGKGFYEYK
HHHCCCCCCCCCHHHHHHHHCCHHCCCCCCCCCCCC
>Mature Secondary Structure
MKVFILGGGTMGAGIVEVFAKAGHEVVLKRFVGKGMDKIIKSFDKQVKKGKMTEEEKNDC
CEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHH
INRITVTTDMDLAKDADLVVEASKEDMEMKKDIFGQLDKICKPETIFATNTSSLSITTIA
HHEEEEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEE
SSTNRPDKVIGMHFFNPAPVMKLIEVIKGIATSEETKNTVIEISKKLGKEPVEVEEAPGF
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
VVNRMLIPMINEAIGIYAEGIATVEDIDLAMKLGANHPIGPLALADLIGNDVCLAIMDVL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHH
HSEFGDSKYRPHPLLIKMVRGNLLGRKTGKGFYEYK
HHHCCCCCCCCCHHHHHHHHCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA