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The map label for this gene is ligA [H]

Identifier: 226950614

GI number: 226950614

Start: 3634977

End: 3635705

Strand: Reverse

Name: ligA [H]

Synonym: CLM_3598

Alternate gene names: 226950614

Gene position: 3635705-3634977 (Counterclockwise)

Preceding gene: 226950615

Following gene: 226950613

Centisome position: 87.5

GC content: 22.36

Gene sequence:

>729_bases
ATGGATAATATAAACTTCATAAATAGAATTAAAATCATGGTAGGAGAGAAAGGAATAAATATTAAAGAGTTAAATGATGA
AACCATAAATATTTTATTTAAAAATGGGCTTTTAAATAATGCTTATGATATCTTTTTATTAAAAAAAGAAGAACTATATA
AAATAGATGGTTTTACAAAAGAATATGTAGATGAACTTATAAAATCTATTAATAAAACTAAAAATTGTAGCTTTGAAAAA
TTTATATATGCATGTTCTATACCTAAAGTTACAGAAAAAGAAGCCATAGTTATTGCTCACACTTTTTTAAATTTTACAGA
TTTAGTAATAGATATAAACAATAACGATTGTGATAGATTAAAAAGAATAGATGGAATGAGTGAAGAAATAGTAGAAAGTA
TAAAAAGAAATAAGGTTCTTTTAGTTAATTTATTTATGTATGTTAATCCAATTTCTATAGATGAAAAGAATACAAATATT
AAGAGATATAAATTCGCTATAACAGGAGTACTAAATAAGGATACAAGTTATTATGAGGAAATGATAAAGGAAGCTAATTG
TATAGTGGTAGATAATGTAACAAAGGATGTAGATTATTTGGTATTTGGTGATTTAGCTAATGCTATTAAAATGATGGACG
CTAAAAAATATAATACTAGGTTAATATCAGAACGTCAATTAGTAGATATATTAAAGGAAATTAAAGAGAATAATAAAATG
AAAAATTAA

Upstream 100 bases:

>100_bases
TTTGAGTAATTTAGCAAAAGAAGATTTAATAAAAAAAATTTTGAATTTAGAAAAAGAAATTTAAGGTGTAAATATATATA
ACAAAGATGGGGAGATATAG

Downstream 100 bases:

>100_bases
AAATTGTAAAACAAATAAATAGCAAAAACTATTGATATATCAAGTTATCAATAGTTTTTTTGTTCCAATAAGCTTAGTTA
TAAGTAAAAAATTTAAAATC

Product: BRCT domain-containing protein

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [NAD+] [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MDNINFINRIKIMVGEKGINIKELNDETINILFKNGLLNNAYDIFLLKKEELYKIDGFTKEYVDELIKSINKTKNCSFEK
FIYACSIPKVTEKEAIVIAHTFLNFTDLVIDINNNDCDRLKRIDGMSEEIVESIKRNKVLLVNLFMYVNPISIDEKNTNI
KRYKFAITGVLNKDTSYYEEMIKEANCIVVDNVTKDVDYLVFGDLANAIKMMDAKKYNTRLISERQLVDILKEIKENNKM
KN

Sequences:

>Translated_242_residues
MDNINFINRIKIMVGEKGINIKELNDETINILFKNGLLNNAYDIFLLKKEELYKIDGFTKEYVDELIKSINKTKNCSFEK
FIYACSIPKVTEKEAIVIAHTFLNFTDLVIDINNNDCDRLKRIDGMSEEIVESIKRNKVLLVNLFMYVNPISIDEKNTNI
KRYKFAITGVLNKDTSYYEEMIKEANCIVVDNVTKDVDYLVFGDLANAIKMMDAKKYNTRLISERQLVDILKEIKENNKM
KN
>Mature_242_residues
MDNINFINRIKIMVGEKGINIKELNDETINILFKNGLLNNAYDIFLLKKEELYKIDGFTKEYVDELIKSINKTKNCSFEK
FIYACSIPKVTEKEAIVIAHTFLNFTDLVIDINNNDCDRLKRIDGMSEEIVESIKRNKVLLVNLFMYVNPISIDEKNTNI
KRYKFAITGVLNKDTSYYEEMIKEANCIVVDNVTKDVDYLVFGDLANAIKMMDAKKYNTRLISERQLVDILKEIKENNKM
KN

Specific function: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of dam

COG id: COG0272

COG function: function code L; NAD-dependent DNA ligase (contains BRCT domain type II)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 BRCT domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001357
- InterPro:   IPR018239
- InterPro:   IPR004150
- InterPro:   IPR001679
- InterPro:   IPR013839
- InterPro:   IPR013840
- InterPro:   IPR003583
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR010994
- InterPro:   IPR004149 [H]

Pfam domain/function: PF00533 BRCT; PF01653 DNA_ligase_aden; PF03120 DNA_ligase_OB; PF03119 DNA_ligase_ZBD [H]

EC number: =6.5.1.2 [H]

Molecular weight: Translated: 28183; Mature: 28183

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNINFINRIKIMVGEKGINIKELNDETINILFKNGLLNNAYDIFLLKKEELYKIDGFTK
CCCCCCEEEEEEEECCCCCCEEECCCCEEEEEEECCCCCCCEEEEEECHHHHEEECCCCH
EYVDELIKSINKTKNCSFEKFIYACSIPKVTEKEAIVIAHTFLNFTDLVIDINNNDCDRL
HHHHHHHHHHCCCCCCCHHHEEEEECCCCCCCCCEEEEEEEHHCEEEEEEECCCCCHHHH
KRIDGMSEEIVESIKRNKVLLVNLFMYVNPISIDEKNTNIKRYKFAITGVLNKDTSYYEE
HHHCCCHHHHHHHHHCCCEEEEEEEHHCCCCCCCCCCCCCEEEEEEEEEEECCCHHHHHH
MIKEANCIVVDNVTKDVDYLVFGDLANAIKMMDAKKYNTRLISERQLVDILKEIKENNKM
HHHCCCEEEEECCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KN
CC
>Mature Secondary Structure
MDNINFINRIKIMVGEKGINIKELNDETINILFKNGLLNNAYDIFLLKKEELYKIDGFTK
CCCCCCEEEEEEEECCCCCCEEECCCCEEEEEEECCCCCCCEEEEEECHHHHEEECCCCH
EYVDELIKSINKTKNCSFEKFIYACSIPKVTEKEAIVIAHTFLNFTDLVIDINNNDCDRL
HHHHHHHHHHCCCCCCCHHHEEEEECCCCCCCCCEEEEEEEHHCEEEEEEECCCCCHHHH
KRIDGMSEEIVESIKRNKVLLVNLFMYVNPISIDEKNTNIKRYKFAITGVLNKDTSYYEE
HHHCCCHHHHHHHHHCCCEEEEEEEHHCCCCCCCCCCCCCEEEEEEEEEEECCCHHHHHH
MIKEANCIVVDNVTKDVDYLVFGDLANAIKMMDAKKYNTRLISERQLVDILKEIKENNKM
HHHCCCEEEEECCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA