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The map label for this gene is argF [H]

Identifier: 226949948

GI number: 226949948

Start: 2911518

End: 2912519

Strand: Reverse

Name: argF [H]

Synonym: CLM_2900

Alternate gene names: 226949948

Gene position: 2912519-2911518 (Counterclockwise)

Preceding gene: 226949949

Following gene: 226949947

Centisome position: 70.09

GC content: 33.53

Gene sequence:

>1002_bases
ATGTTTAACTTAAAAAACAGAAACTTTTTAACACTAATGGATTTCACACCAAAGGAAATAAACTATTTCTTAGATTTAGC
TAGAGATTTAAAAAGAGCTAAATATACAGGAACTGAAGTACAAAGATTGAAAGGCAAAAACATTGCTTTAATATTTGAAA
AAGCTTCAACTAGAACAAGATGCGCATTTGAAGTTGGAGCAAAAGACCAAGGAGCTCATGTAACTTACTTAGGACCAACA
GGAAGCCATATTGGTAAAAAAGAATCAGCTGCAGATACTGCAAGAGTTTTAGGAAGAATGTATGATGGTATAGAATATAG
AGGATTTGGTCAAGAAATCGTTGAAACTTTAGCTGAATACGCTGGAGTACCAGTTTGGAACGGATTAACAGATGAAGATC
ACCCAACTCAAATATTAGCTGACTTCTTAACAATAAGAGAACATTTCAATAAACCACTAAATGAAATCAAATTTGCTTAT
GTTGGAGATGGTGCTAATAATATGGCAAATGCTCTTATGATAGGTGCTGTTAAAATGGGAATGGACTTTAGAATAGTTTC
TCCAAAAGAAATACCAACTGATGCTGCATTAGTTGCTAAATGCAAGGAAATAGCAGCTGGAACTGGCGCTAAAGTTACAA
TAACTGATAATATCGAAGAAGGTGTTAAAGGTTGTGACGTTCTATATACAGATGTTTGGGTATCAATGGGAGAACCAGAT
TCAGTATGGGAAAGCAAAATAAAATTATTAACTCCATACAGAGTTGACATGAACATGATAAAAATGACTGGAAATCCTGA
TGCTAAATTCATGCACTGCTTACCAGCATTCCATGATGAAGAAACAGCAGTAGGTAAAGAAATAAAAGAAAAATATGGTT
TATCAGAAATGGAAGTTTCTCATGAATTATTCGAAAGCAAATACTCAATTGTATTTGATGAAGCTGAAAACAGAATGCAC
ACTATAAAAGCTGTTATGGTTGCAACATTAGGAGATCAATAA

Upstream 100 bases:

>100_bases
AGATAATTAATTAAAAAGCTAACAGGGTTGCATAATACATATGTAATCTAAAATATAAAAGTTTATAATACAAATATTAT
ACTATTAGGAGGAATAACAT

Downstream 100 bases:

>100_bases
TCATTAAATATATAAGATAAAAGGAAGAATGGAAACATTCTTCCTTTTATTTTTGATATACAAAAAAATGATAAAACAAT
TTTAGAACACTTGAAATTTA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MFNLKNRNFLTLMDFTPKEINYFLDLARDLKRAKYTGTEVQRLKGKNIALIFEKASTRTRCAFEVGAKDQGAHVTYLGPT
GSHIGKKESAADTARVLGRMYDGIEYRGFGQEIVETLAEYAGVPVWNGLTDEDHPTQILADFLTIREHFNKPLNEIKFAY
VGDGANNMANALMIGAVKMGMDFRIVSPKEIPTDAALVAKCKEIAAGTGAKVTITDNIEEGVKGCDVLYTDVWVSMGEPD
SVWESKIKLLTPYRVDMNMIKMTGNPDAKFMHCLPAFHDEETAVGKEIKEKYGLSEMEVSHELFESKYSIVFDEAENRMH
TIKAVMVATLGDQ

Sequences:

>Translated_333_residues
MFNLKNRNFLTLMDFTPKEINYFLDLARDLKRAKYTGTEVQRLKGKNIALIFEKASTRTRCAFEVGAKDQGAHVTYLGPT
GSHIGKKESAADTARVLGRMYDGIEYRGFGQEIVETLAEYAGVPVWNGLTDEDHPTQILADFLTIREHFNKPLNEIKFAY
VGDGANNMANALMIGAVKMGMDFRIVSPKEIPTDAALVAKCKEIAAGTGAKVTITDNIEEGVKGCDVLYTDVWVSMGEPD
SVWESKIKLLTPYRVDMNMIKMTGNPDAKFMHCLPAFHDEETAVGKEIKEKYGLSEMEVSHELFESKYSIVFDEAENRMH
TIKAVMVATLGDQ
>Mature_333_residues
MFNLKNRNFLTLMDFTPKEINYFLDLARDLKRAKYTGTEVQRLKGKNIALIFEKASTRTRCAFEVGAKDQGAHVTYLGPT
GSHIGKKESAADTARVLGRMYDGIEYRGFGQEIVETLAEYAGVPVWNGLTDEDHPTQILADFLTIREHFNKPLNEIKFAY
VGDGANNMANALMIGAVKMGMDFRIVSPKEIPTDAALVAKCKEIAAGTGAKVTITDNIEEGVKGCDVLYTDVWVSMGEPD
SVWESKIKLLTPYRVDMNMIKMTGNPDAKFMHCLPAFHDEETAVGKEIKEKYGLSEMEVSHELFESKYSIVFDEAENRMH
TIKAVMVATLGDQ

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=331, Percent_Identity=39.2749244712991, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI18105007, Length=341, Percent_Identity=25.8064516129032, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1790703, Length=332, Percent_Identity=59.6385542168675, Blast_Score=420, Evalue=1e-119,
Organism=Escherichia coli, GI1786469, Length=334, Percent_Identity=58.3832335329341, Blast_Score=413, Evalue=1e-117,
Organism=Escherichia coli, GI48994908, Length=374, Percent_Identity=24.5989304812834, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI2367364, Length=232, Percent_Identity=29.7413793103448, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322373, Length=328, Percent_Identity=32.6219512195122, Blast_Score=162, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6322331, Length=306, Percent_Identity=26.797385620915, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24642586, Length=230, Percent_Identity=26.5217391304348, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 37159; Mature: 37159

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNLKNRNFLTLMDFTPKEINYFLDLARDLKRAKYTGTEVQRLKGKNIALIFEKASTRTR
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCE
CAFEVGAKDQGAHVTYLGPTGSHIGKKESAADTARVLGRMYDGIEYRGFGQEIVETLAEY
EEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
AGVPVWNGLTDEDHPTQILADFLTIREHFNKPLNEIKFAYVGDGANNMANALMIGAVKMG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCEEEEECCCCHHHHHHHHHHHHHHC
MDFRIVSPKEIPTDAALVAKCKEIAAGTGAKVTITDNIEEGVKGCDVLYTDVWVSMGEPD
CCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHCCCHHHEEEEEHEEECCCCH
SVWESKIKLLTPYRVDMNMIKMTGNPDAKFMHCLPAFHDEETAVGKEIKEKYGLSEMEVS
HHHHHHHEEECCEEECCEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHH
HELFESKYSIVFDEAENRMHTIKAVMVATLGDQ
HHHHHCHHEEEEECHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFNLKNRNFLTLMDFTPKEINYFLDLARDLKRAKYTGTEVQRLKGKNIALIFEKASTRTR
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCE
CAFEVGAKDQGAHVTYLGPTGSHIGKKESAADTARVLGRMYDGIEYRGFGQEIVETLAEY
EEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
AGVPVWNGLTDEDHPTQILADFLTIREHFNKPLNEIKFAYVGDGANNMANALMIGAVKMG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCEEEEECCCCHHHHHHHHHHHHHHC
MDFRIVSPKEIPTDAALVAKCKEIAAGTGAKVTITDNIEEGVKGCDVLYTDVWVSMGEPD
CCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHCCCHHHEEEEEHEEECCCCH
SVWESKIKLLTPYRVDMNMIKMTGNPDAKFMHCLPAFHDEETAVGKEIKEKYGLSEMEVS
HHHHHHHEEECCEEECCEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHH
HELFESKYSIVFDEAENRMHTIKAVMVATLGDQ
HHHHHCHHEEEEECHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA