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The map label for this gene is uppS [H]

Identifier: 226949784

GI number: 226949784

Start: 2738350

End: 2739108

Strand: Reverse

Name: uppS [H]

Synonym: CLM_2724

Alternate gene names: 226949784

Gene position: 2739108-2738350 (Counterclockwise)

Preceding gene: 226949785

Following gene: 226949783

Centisome position: 65.92

GC content: 29.78

Gene sequence:

>759_bases
ATGAAAAATTTTTTTTCAAGTAACAAAAAAGCTAGTATAGATACGAATTTAGATATGAACAATATACCAAAACATATTGC
TATCATAATGGATGGAAACGGAAGATGGGCAAAGGAAAGAAGTTTGCCTAGGACTATGGGACACAAAGCTGGTGTAGAGA
CTATAAGAGAAATAGTTAAAGAATGCAATAATTTAGGGGTCAAATACTTAACATTATATGCTTTTTCTACGGAAAACTGG
AAAAGACCTAAAGATGAAGTTAGCGCTCTTATGACTTTATTAGTTCAATATTTAAGAAAGGAAGTAAAAGAGCTTAATGA
AAACAATGTAATAGTTAATGCAATAGGTAACATAGAGAAGTTACCAGAGGTGTGTATAAAGGAACTAGAAAAAGCCTACG
AAGAAACTAAAGATAACACAGGATTAGTATTAAATTTAGCCTTAAATTATGGTGGGAGAGATGAAATAATAAGGGCAGTA
AAATATATGTATGAAGATATAAAAGTAGGAAAGATAAAAGAAGAGGATATAAATGAAGAAAATCTTCCTGATTATCTTTA
TACAAAGGGTATGCTAGATCCGGATTTAATAATAAGACCTAGCGGAGAAAAAAGAATAAGCAATTTTTTATTATGGCAAT
GTGCTTATTCAGAATTTTGGTATTCAGACATAAAGTGGCCTGATTTTAAAAAAGAGCATCTTCATAAAGCTATATATGAT
TATCAAAATAGAGATAGAAGATTTGGAACTGTAAAATAA

Upstream 100 bases:

>100_bases
TAAGTGCAAAAGAAAAGGAAATACTATCTATATAAACATTATAACCTGCTTATTAGCAGGTTTTTTAATAATTTAGAGTA
AATATGTTGGGGGTAACTTT

Downstream 100 bases:

>100_bases
CCTTTTAGAATAGGAGAGAGTAATATGGATAGCAGATATATAGGGGCATTAGTATTAGCGCCCTTTGTAATATTCCTATT
TATAGGAGGAGTATTTTTAA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MKNFFSSNKKASIDTNLDMNNIPKHIAIIMDGNGRWAKERSLPRTMGHKAGVETIREIVKECNNLGVKYLTLYAFSTENW
KRPKDEVSALMTLLVQYLRKEVKELNENNVIVNAIGNIEKLPEVCIKELEKAYEETKDNTGLVLNLALNYGGRDEIIRAV
KYMYEDIKVGKIKEEDINEENLPDYLYTKGMLDPDLIIRPSGEKRISNFLLWQCAYSEFWYSDIKWPDFKKEHLHKAIYD
YQNRDRRFGTVK

Sequences:

>Translated_252_residues
MKNFFSSNKKASIDTNLDMNNIPKHIAIIMDGNGRWAKERSLPRTMGHKAGVETIREIVKECNNLGVKYLTLYAFSTENW
KRPKDEVSALMTLLVQYLRKEVKELNENNVIVNAIGNIEKLPEVCIKELEKAYEETKDNTGLVLNLALNYGGRDEIIRAV
KYMYEDIKVGKIKEEDINEENLPDYLYTKGMLDPDLIIRPSGEKRISNFLLWQCAYSEFWYSDIKWPDFKKEHLHKAIYD
YQNRDRRFGTVK
>Mature_252_residues
MKNFFSSNKKASIDTNLDMNNIPKHIAIIMDGNGRWAKERSLPRTMGHKAGVETIREIVKECNNLGVKYLTLYAFSTENW
KRPKDEVSALMTLLVQYLRKEVKELNENNVIVNAIGNIEKLPEVCIKELEKAYEETKDNTGLVLNLALNYGGRDEIIRAV
KYMYEDIKVGKIKEEDINEENLPDYLYTKGMLDPDLIIRPSGEKRISNFLLWQCAYSEFWYSDIKWPDFKKEHLHKAIYD
YQNRDRRFGTVK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=38.3928571428571, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=38.3928571428571, Blast_Score=157, Evalue=9e-39,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=46.0176991150442, Blast_Score=221, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=37.1681415929204, Blast_Score=153, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6319474, Length=233, Percent_Identity=36.480686695279, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=222, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18857969, Length=230, Percent_Identity=37.8260869565217, Blast_Score=159, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29495; Mature: 29495

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFFSSNKKASIDTNLDMNNIPKHIAIIMDGNGRWAKERSLPRTMGHKAGVETIREIVK
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHH
ECNNLGVKYLTLYAFSTENWKRPKDEVSALMTLLVQYLRKEVKELNENNVIVNAIGNIEK
HHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHH
LPEVCIKELEKAYEETKDNTGLVLNLALNYGGRDEIIRAVKYMYEDIKVGKIKEEDINEE
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHCCCCC
NLPDYLYTKGMLDPDLIIRPSGEKRISNFLLWQCAYSEFWYSDIKWPDFKKEHLHKAIYD
CCCHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
YQNRDRRFGTVK
HHCCCCCCCCCC
>Mature Secondary Structure
MKNFFSSNKKASIDTNLDMNNIPKHIAIIMDGNGRWAKERSLPRTMGHKAGVETIREIVK
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHH
ECNNLGVKYLTLYAFSTENWKRPKDEVSALMTLLVQYLRKEVKELNENNVIVNAIGNIEK
HHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHH
LPEVCIKELEKAYEETKDNTGLVLNLALNYGGRDEIIRAVKYMYEDIKVGKIKEEDINEE
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHCCCCC
NLPDYLYTKGMLDPDLIIRPSGEKRISNFLLWQCAYSEFWYSDIKWPDFKKEHLHKAIYD
CCCHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
YQNRDRRFGTVK
HHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]