Click here to switch to the map view.

The map label for this gene is lysN [H]

Identifier: 226949043

GI number: 226949043

Start: 2020801

End: 2021991

Strand: Direct

Name: lysN [H]

Synonym: CLM_1959

Alternate gene names: 226949043

Gene position: 2020801-2021991 (Clockwise)

Preceding gene: 226949036

Following gene: 226949044

Centisome position: 48.63

GC content: 30.65

Gene sequence:

>1191_bases
ATGAATATACGTTTTTCAGAAAGAGCAGCAGGATTAAAAGCATCAGAGATAAGAGAATTATTAAAATTAACTGAAATGCC
AGAAATAATTTCTTTTGCGGGAGGATTACCAGCACCAGAATTATTCCCTGTAGAAGAAATGAAAGGTATAATGCAAGAAG
TATTAGATACTCAAGGAAGAGCAGCATTACAATATAGCTCTACTGAAGGGTATAAACCATTAAGAGAAATCATAGCTAAT
GAAAGAATGAAACCAGCAGGTGTAAACGTTTCTTTTGAAAATATTGCTATAACTAATGGTTCCCAACAAGGTATAGAATT
TTCAGCTAAAATTTTCTTAAATGAAGGAGATATAGTTGTTTGTGAAAGTCCTAGTTATTTAGGTGCTATAAATGCATTTA
AATCTTATAGACCTAAATTTGTTGAAATACCTATGGACGATAATGGAATGATTATAGAAGAATTAGAAAAAGCTTTAGCA
GAGAATAAAGGCAAAGTTAAAATGATATATACAATCCCTGATTTCCAAAATCCAACTGGTAGAACTATGCCAGACGATAG
AAGAAAGAGAATAGCAGAGCTAGCTGCAGAATATGAAATACCTGTAATAGAAGATAATCCATATGGAGATCTTATATATG
AAGGTGAAAGACATCCATCTATAAAGAGTTTTGATAAAGAAGGATGGGTTATTTATCTTGGAACTTTCTCTAAAAACTTC
TGTCCAGGATTAAGACTTGCATGGGTTTGTGCTGAAAAAGAAATATTAGATAAATATATAATTGTAAAACAAGGTGTTGA
TTTACAGGCTGGTACATTAGATCAAAGAGCAACAGCTTTATTTATGCAGAAATATGATTTAAATGAACATATTGAAAAAA
TTAAAAAAGTTTATGAAAAACGCAGAGATTTAATGCTAGATAGTATGAAAAAATACTTCCCAGCAGATGTAAAATATACT
CATCCTGTTGGAGGATTATTTACATGGGTTGAATTAAGAGAAGATTTAGATGCTAAAGAATTAATGAAAGATGCTTTAGC
TGAAAATGTTGCTTATGTACCTGGTGGTTCTTTCTTCCCTAACGGAGGACATGAAAATTACTTTAGATTAAACTACTCTT
GTATGAGTGATGAAAAAATAGTTGAAGGTGTAAAAAGACTAGGTAAAGTTTTAGATAAATATTATAAATAA

Upstream 100 bases:

>100_bases
TTTTTTATATATTAAAAAGAAGGATATAATGAGTGCTTGTAGAATAGATATAATTACAAGGGTATTGATTAACCTATTAT
ATTTTTGGAGGGATTTGCTA

Downstream 100 bases:

>100_bases
TATTAAATTATTTTAATAAAACGTACTGGATAAAATAAATTATCTCCTTTTAGGTTAAAATAAAACTAGAAGGAGATGAT
TTATGTGTATGATGTAAAGG

Product: class I/II aminotransferase

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MNIRFSERAAGLKASEIRELLKLTEMPEIISFAGGLPAPELFPVEEMKGIMQEVLDTQGRAALQYSSTEGYKPLREIIAN
ERMKPAGVNVSFENIAITNGSQQGIEFSAKIFLNEGDIVVCESPSYLGAINAFKSYRPKFVEIPMDDNGMIIEELEKALA
ENKGKVKMIYTIPDFQNPTGRTMPDDRRKRIAELAAEYEIPVIEDNPYGDLIYEGERHPSIKSFDKEGWVIYLGTFSKNF
CPGLRLAWVCAEKEILDKYIIVKQGVDLQAGTLDQRATALFMQKYDLNEHIEKIKKVYEKRRDLMLDSMKKYFPADVKYT
HPVGGLFTWVELREDLDAKELMKDALAENVAYVPGGSFFPNGGHENYFRLNYSCMSDEKIVEGVKRLGKVLDKYYK

Sequences:

>Translated_396_residues
MNIRFSERAAGLKASEIRELLKLTEMPEIISFAGGLPAPELFPVEEMKGIMQEVLDTQGRAALQYSSTEGYKPLREIIAN
ERMKPAGVNVSFENIAITNGSQQGIEFSAKIFLNEGDIVVCESPSYLGAINAFKSYRPKFVEIPMDDNGMIIEELEKALA
ENKGKVKMIYTIPDFQNPTGRTMPDDRRKRIAELAAEYEIPVIEDNPYGDLIYEGERHPSIKSFDKEGWVIYLGTFSKNF
CPGLRLAWVCAEKEILDKYIIVKQGVDLQAGTLDQRATALFMQKYDLNEHIEKIKKVYEKRRDLMLDSMKKYFPADVKYT
HPVGGLFTWVELREDLDAKELMKDALAENVAYVPGGSFFPNGGHENYFRLNYSCMSDEKIVEGVKRLGKVLDKYYK
>Mature_396_residues
MNIRFSERAAGLKASEIRELLKLTEMPEIISFAGGLPAPELFPVEEMKGIMQEVLDTQGRAALQYSSTEGYKPLREIIAN
ERMKPAGVNVSFENIAITNGSQQGIEFSAKIFLNEGDIVVCESPSYLGAINAFKSYRPKFVEIPMDDNGMIIEELEKALA
ENKGKVKMIYTIPDFQNPTGRTMPDDRRKRIAELAAEYEIPVIEDNPYGDLIYEGERHPSIKSFDKEGWVIYLGTFSKNF
CPGLRLAWVCAEKEILDKYIIVKQGVDLQAGTLDQRATALFMQKYDLNEHIEKIKKVYEKRRDLMLDSMKKYFPADVKYT
HPVGGLFTWVELREDLDAKELMKDALAENVAYVPGGSFFPNGGHENYFRLNYSCMSDEKIVEGVKRLGKVLDKYYK

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=419, Percent_Identity=26.9689737470167, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI33469970, Length=419, Percent_Identity=26.9689737470167, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1790797, Length=381, Percent_Identity=29.9212598425197, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1787710, Length=383, Percent_Identity=28.4595300261097, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI48994949, Length=399, Percent_Identity=24.3107769423559, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788722, Length=374, Percent_Identity=25.9358288770053, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321236, Length=484, Percent_Identity=23.5537190082645, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321929, Length=468, Percent_Identity=23.2905982905983, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321000, Length=251, Percent_Identity=26.2948207171315, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21356535, Length=415, Percent_Identity=25.3012048192771, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 45045; Mature: 45045

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIRFSERAAGLKASEIRELLKLTEMPEIISFAGGLPAPELFPVEEMKGIMQEVLDTQGR
CCCCCCHHHCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCC
AALQYSSTEGYKPLREIIANERMKPAGVNVSFENIAITNGSQQGIEFSAKIFLNEGDIVV
EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEECEEEEECCCCCCCEEEEEEEEECCCEEE
CESPSYLGAINAFKSYRPKFVEIPMDDNGMIIEELEKALAENKGKVKMIYTIPDFQNPTG
ECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
RTMPDDRRKRIAELAAEYEIPVIEDNPYGDLIYEGERHPSIKSFDKEGWVIYLGTFSKNF
CCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCC
CPGLRLAWVCAEKEILDKYIIVKQGVDLQAGTLDQRATALFMQKYDLNEHIEKIKKVYEK
CCCCEEEEEEHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
RRDLMLDSMKKYFPADVKYTHPVGGLFTWVELREDLDAKELMKDALAENVAYVPGGSFFP
HHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHCEEECCCCCCCC
NGGHENYFRLNYSCMSDEKIVEGVKRLGKVLDKYYK
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIRFSERAAGLKASEIRELLKLTEMPEIISFAGGLPAPELFPVEEMKGIMQEVLDTQGR
CCCCCCHHHCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCC
AALQYSSTEGYKPLREIIANERMKPAGVNVSFENIAITNGSQQGIEFSAKIFLNEGDIVV
EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEECEEEEECCCCCCCEEEEEEEEECCCEEE
CESPSYLGAINAFKSYRPKFVEIPMDDNGMIIEELEKALAENKGKVKMIYTIPDFQNPTG
ECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCC
RTMPDDRRKRIAELAAEYEIPVIEDNPYGDLIYEGERHPSIKSFDKEGWVIYLGTFSKNF
CCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCC
CPGLRLAWVCAEKEILDKYIIVKQGVDLQAGTLDQRATALFMQKYDLNEHIEKIKKVYEK
CCCCEEEEEEHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
RRDLMLDSMKKYFPADVKYTHPVGGLFTWVELREDLDAKELMKDALAENVAYVPGGSFFP
HHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHCEEECCCCCCCC
NGGHENYFRLNYSCMSDEKIVEGVKRLGKVLDKYYK
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA