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The map label for this gene is dut [H]

Identifier: 226948502

GI number: 226948502

Start: 1451320

End: 1451946

Strand: Direct

Name: dut [H]

Synonym: CLM_1391

Alternate gene names: 226948502

Gene position: 1451320-1451946 (Clockwise)

Preceding gene: 226948500

Following gene: 226948505

Centisome position: 34.93

GC content: 27.91

Gene sequence:

>627_bases
ATGAACAATAAAGTTAATGTTTATATAAAGGTTTCAGAGGATGGTAAAATGCCAAGATATGGATCCTTAAATGCTGCAGG
CTGTGATTTATATGCTACAAAGTATATGGAGATAAAGCCAGGGGAAATAAAAGTTATGCCATTAAATTTTGTTATGGCTA
TGGATGAAAACTTAGAAGCACAAATAAGACCAAGAAGTGGATTATCCTTAAAAACTAACTTAAGAGTTCCTAATAGTCCA
GGAACTATAGATAGTGATTATAGGGATACAGTAGGAGTTATACTGGAAAATACATATGATATAGCTAATTTGCCTTATGA
TATAGCAAAAGATCCTAATGTATTGAAAGTTTTAAAAGAAAAATATAAAGAAATATCTTTAATTGATTATTTAAATAGTA
AAGAAGATATAAATCTAGATACTAATAATTTTTTAAGTATATTGAAGCAAAAGATATATTTAGATGAAAAGGGAAATCCT
TATGGAACTATATATATAAATAAAGGAGAGAGAATAGCTCAAATGGTATTCAAAGAATATAAAAGAGCTAATTTTATAGA
ATGCGAAAATCCTAAAGAAATAGGAGAAAATAGAGGCGGAGGATTTGGACATACAGGAGTAAAATAA

Upstream 100 bases:

>100_bases
TATAAAAAATTACTCATTAATATTATAATCATATATTTTTATAGTATAATATGTATAGTTAACAAAAGTATAAGATTATG
TCAAAAGAGGTGAAAGTAGT

Downstream 100 bases:

>100_bases
TATTAATAAAAGGTGCTGAAAGTTAATTTTCAGCACCTTTTATTGAATTATATATTGTTTTTAGTTATTTAATTTGTTAC
ATTCACTAAGAGTTTTTACA

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MNNKVNVYIKVSEDGKMPRYGSLNAAGCDLYATKYMEIKPGEIKVMPLNFVMAMDENLEAQIRPRSGLSLKTNLRVPNSP
GTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKEKYKEISLIDYLNSKEDINLDTNNFLSILKQKIYLDEKGNP
YGTIYINKGERIAQMVFKEYKRANFIECENPKEIGENRGGGFGHTGVK

Sequences:

>Translated_208_residues
MNNKVNVYIKVSEDGKMPRYGSLNAAGCDLYATKYMEIKPGEIKVMPLNFVMAMDENLEAQIRPRSGLSLKTNLRVPNSP
GTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKEKYKEISLIDYLNSKEDINLDTNNFLSILKQKIYLDEKGNP
YGTIYINKGERIAQMVFKEYKRANFIECENPKEIGENRGGGFGHTGVK
>Mature_208_residues
MNNKVNVYIKVSEDGKMPRYGSLNAAGCDLYATKYMEIKPGEIKVMPLNFVMAMDENLEAQIRPRSGLSLKTNLRVPNSP
GTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKEKYKEISLIDYLNSKEDINLDTNNFLSILKQKIYLDEKGNP
YGTIYINKGERIAQMVFKEYKRANFIECENPKEIGENRGGGFGHTGVK

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 23573; Mature: 23573

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKVNVYIKVSEDGKMPRYGSLNAAGCDLYATKYMEIKPGEIKVMPLNFVMAMDENLEA
CCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEEEEEEEECCCCEE
QIRPRSGLSLKTNLRVPNSPGTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKE
EECCCCCCEEEEEEECCCCCCCCCCCCHHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
KYKEISLIDYLNSKEDINLDTNNFLSILKQKIYLDEKGNPYGTIYINKGERIAQMVFKEY
HHHHEEHHHHCCCCCCCCCCHHHHHHHHHHHHEECCCCCEEEEEEEECCHHHHHHHHHHH
KRANFIECENPKEIGENRGGGFGHTGVK
HCCCCEECCCHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNNKVNVYIKVSEDGKMPRYGSLNAAGCDLYATKYMEIKPGEIKVMPLNFVMAMDENLEA
CCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEEEEEEEECCCCEE
QIRPRSGLSLKTNLRVPNSPGTIDSDYRDTVGVILENTYDIANLPYDIAKDPNVLKVLKE
EECCCCCCEEEEEEECCCCCCCCCCCCHHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
KYKEISLIDYLNSKEDINLDTNNFLSILKQKIYLDEKGNPYGTIYINKGERIAQMVFKEY
HHHHEEHHHHCCCCCCCCCCHHHHHHHHHHHHEECCCCCEEEEEEEECCHHHHHHHHHHH
KRANFIECENPKEIGENRGGGFGHTGVK
HCCCCEECCCHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA