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The map label for this gene is metC [H]

Identifier: 226948007

GI number: 226948007

Start: 928954

End: 930096

Strand: Reverse

Name: metC [H]

Synonym: CLM_0868

Alternate gene names: 226948007

Gene position: 930096-928954 (Counterclockwise)

Preceding gene: 226948008

Following gene: 226948006

Centisome position: 22.38

GC content: 30.53

Gene sequence:

>1143_bases
ATGAAAATTGAATCATTATTAATTCATGGTGGAATAGATGGAGATAAGCATACAGGTGCAGTAAATGTACCTATTTATCA
AACTTCAACTTACAAGCAATTTAAGTTTGGAGAAAATACAGGTTATGAATATTCAAGAACAGGAAATCCAACAAGGGAAG
CTTTAGAAAAACTTGTAGCAGATTTAGAAAAAGGTTATAAAGGTTTTGCCTTTGCTTCAGGATTGGCTGCTATAACTGCA
GTATTATCACTATTTAAATCAGGAGATGAAATAGTAATTTCAAATAATGTATATGGTGGAACTTTTAGAGTTTTAGATAA
AGTCTTTAACCACTTTGATATTAAATATTCTATAGTTGATACTTCTAACTTAGATGAAGTAAAAAATAGCATAAATGAAA
ATGTAAAAGCTATATATATAGAAACACCAACTAATCCTCTTATGGATATTACAAATATAGAAGAAATATCAAAAATAGCT
AAGGAAAATGATATATATACTATAGTTGATAATACCTTCATGACCCCTTACCTACAGAAGCCAATAAGTCTTGGAGCAGA
TATAGTTATTCATAGTGCTACAAAATATCTAGGAGGGCATAGTGATGTAGTTGCTGGAATTGCTGTTGTAAATAGTGAAG
ATTTAGCTGAAAGACTTCATTTTATACAGAATTCTACTGGTGGGGTTCTAGCTCCTTTTGATTCTTTCCTTTTAATTAGA
GGAATCAAAACATTAGCAATAAGAATGGATAGACATAATTCAAATGCAAAACTTATTGCTGAATTCCTAAGAGAAAGAGA
TGAGGTAGTAAAAGTATATTATCCTGGTTTTCATACTCATCCAGGACATAAAATCCAATCAAAACAAGCTAATGGATATG
GTGGAATGATATCTTTTGTTCTTAAGGATGGTTATGATTATAAAAAGTTTTTTGAAGGTCTTAAGATGGTAACCTTTGGA
GAAAGCTTAGGAGGAGTTGAATCTTTAGCTTGCCATCCAGCTTCTATGACTCACGGTGCTATACCTTATGAATTAAGACA
AAAAGTTGGTATTGTAGATAATTTAATAAGATTATCCGTTGGTATAGAAAATGCTGACGATTTAATAGAAGATTTAAAAA
ATGCATTTAAGGAGAGTAGATAA

Upstream 100 bases:

>100_bases
TAAAATTTTAGATTGAAATAACTGAACAATAAAGTTATTTCAATCTAAAAAAACAAGCAAGAAATGTAATCACAGTTAAA
TTCTAAGGAGGAATAAAAAA

Downstream 100 bases:

>100_bases
AATGGTTAAAGTAGAAAGTTTTTCATTAGATCATACAAAGGTTAAGGCCCCTTTTGTAAGGAAATGTGGAACTCAAAAAG
GTGAAATGGGTGATACAATT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKIESLLIHGGIDGDKHTGAVNVPIYQTSTYKQFKFGENTGYEYSRTGNPTREALEKLVADLEKGYKGFAFASGLAAITA
VLSLFKSGDEIVISNNVYGGTFRVLDKVFNHFDIKYSIVDTSNLDEVKNSINENVKAIYIETPTNPLMDITNIEEISKIA
KENDIYTIVDNTFMTPYLQKPISLGADIVIHSATKYLGGHSDVVAGIAVVNSEDLAERLHFIQNSTGGVLAPFDSFLLIR
GIKTLAIRMDRHNSNAKLIAEFLRERDEVVKVYYPGFHTHPGHKIQSKQANGYGGMISFVLKDGYDYKKFFEGLKMVTFG
ESLGGVESLACHPASMTHGAIPYELRQKVGIVDNLIRLSVGIENADDLIEDLKNAFKESR

Sequences:

>Translated_380_residues
MKIESLLIHGGIDGDKHTGAVNVPIYQTSTYKQFKFGENTGYEYSRTGNPTREALEKLVADLEKGYKGFAFASGLAAITA
VLSLFKSGDEIVISNNVYGGTFRVLDKVFNHFDIKYSIVDTSNLDEVKNSINENVKAIYIETPTNPLMDITNIEEISKIA
KENDIYTIVDNTFMTPYLQKPISLGADIVIHSATKYLGGHSDVVAGIAVVNSEDLAERLHFIQNSTGGVLAPFDSFLLIR
GIKTLAIRMDRHNSNAKLIAEFLRERDEVVKVYYPGFHTHPGHKIQSKQANGYGGMISFVLKDGYDYKKFFEGLKMVTFG
ESLGGVESLACHPASMTHGAIPYELRQKVGIVDNLIRLSVGIENADDLIEDLKNAFKESR
>Mature_380_residues
MKIESLLIHGGIDGDKHTGAVNVPIYQTSTYKQFKFGENTGYEYSRTGNPTREALEKLVADLEKGYKGFAFASGLAAITA
VLSLFKSGDEIVISNNVYGGTFRVLDKVFNHFDIKYSIVDTSNLDEVKNSINENVKAIYIETPTNPLMDITNIEEISKIA
KENDIYTIVDNTFMTPYLQKPISLGADIVIHSATKYLGGHSDVVAGIAVVNSEDLAERLHFIQNSTGGVLAPFDSFLLIR
GIKTLAIRMDRHNSNAKLIAEFLRERDEVVKVYYPGFHTHPGHKIQSKQANGYGGMISFVLKDGYDYKKFFEGLKMVTFG
ESLGGVESLACHPASMTHGAIPYELRQKVGIVDNLIRLSVGIENADDLIEDLKNAFKESR

Specific function: The enzymatic degradation of amino acids in cheese is believed to generate aroma compounds and therefore to be essential for flavor development. Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine but is also able to catalyze an alpha

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=357, Percent_Identity=47.0588235294118, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI299473759, Length=357, Percent_Identity=42.5770308123249, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI25453487, Length=356, Percent_Identity=41.2921348314607, Blast_Score=265, Evalue=4e-71,
Organism=Escherichia coli, GI1790375, Length=380, Percent_Identity=38.9473684210526, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI1789383, Length=393, Percent_Identity=26.4631043256997, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17560056, Length=344, Percent_Identity=46.2209302325581, Blast_Score=326, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17538055, Length=345, Percent_Identity=46.6666666666667, Blast_Score=320, Evalue=6e-88,
Organism=Caenorhabditis elegans, GI71980708, Length=370, Percent_Identity=39.1891891891892, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319307, Length=388, Percent_Identity=44.5876288659794, Blast_Score=318, Evalue=8e-88,
Organism=Saccharomyces cerevisiae, GI6321254, Length=402, Percent_Identity=32.3383084577114, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6323333, Length=432, Percent_Identity=34.2592592592593, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321170, Length=322, Percent_Identity=33.2298136645963, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321904, Length=393, Percent_Identity=31.2977099236641, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322590, Length=302, Percent_Identity=28.476821192053, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323557, Length=336, Percent_Identity=25, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322970, Length=272, Percent_Identity=26.4705882352941, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19922554, Length=374, Percent_Identity=46.524064171123, Blast_Score=343, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42061; Mature: 42061

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIESLLIHGGIDGDKHTGAVNVPIYQTSTYKQFKFGENTGYEYSRTGNPTREALEKLVA
CCCCEEEEECCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHH
DLEKGYKGFAFASGLAAITAVLSLFKSGDEIVISNNVYGGTFRVLDKVFNHFDIKYSIVD
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEEC
TSNLDEVKNSINENVKAIYIETPTNPLMDITNIEEISKIAKENDIYTIVDNTFMTPYLQK
CCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHC
PISLGADIVIHSATKYLGGHSDVVAGIAVVNSEDLAERLHFIQNSTGGVLAPFDSFLLIR
HHHCCCCEEEEHHHHHHCCCHHHHHHEEEECCHHHHHHHHHHHCCCCCEECCHHHHHHHH
GIKTLAIRMDRHNSNAKLIAEFLRERDEVVKVYYPGFHTHPGHKIQSKQANGYGGMISFV
HHHHEEEEECCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHEEH
LKDGYDYKKFFEGLKMVTFGESLGGVESLACHPASMTHGAIPYELRQKVGIVDNLIRLSV
HHCCCCHHHHHHHHEEEEECCHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
GIENADDLIEDLKNAFKESR
CCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIESLLIHGGIDGDKHTGAVNVPIYQTSTYKQFKFGENTGYEYSRTGNPTREALEKLVA
CCCCEEEEECCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHH
DLEKGYKGFAFASGLAAITAVLSLFKSGDEIVISNNVYGGTFRVLDKVFNHFDIKYSIVD
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEEC
TSNLDEVKNSINENVKAIYIETPTNPLMDITNIEEISKIAKENDIYTIVDNTFMTPYLQK
CCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHC
PISLGADIVIHSATKYLGGHSDVVAGIAVVNSEDLAERLHFIQNSTGGVLAPFDSFLLIR
HHHCCCCEEEEHHHHHHCCCHHHHHHEEEECCHHHHHHHHHHHCCCCCEECCHHHHHHHH
GIKTLAIRMDRHNSNAKLIAEFLRERDEVVKVYYPGFHTHPGHKIQSKQANGYGGMISFV
HHHHEEEEECCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHEEH
LKDGYDYKKFFEGLKMVTFGESLGGVESLACHPASMTHGAIPYELRQKVGIVDNLIRLSV
HHCCCCHHHHHHHHEEEEECCHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
GIENADDLIEDLKNAFKESR
CCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]