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The map label for this gene is sstT [H]

Identifier: 226947456

GI number: 226947456

Start: 273330

End: 274493

Strand: Reverse

Name: sstT [H]

Synonym: CLM_0285

Alternate gene names: 226947456

Gene position: 274493-273330 (Counterclockwise)

Preceding gene: 226947457

Following gene: 226947434

Centisome position: 6.61

GC content: 32.47

Gene sequence:

>1164_bases
ATGAAAAAACTTTTTAACAATCTAATTTTTAAATTAGTTCTAGGAGTTATTATAGGTATATTAATTGGATCCTATGCTTC
TAAACCCACAATAGGTGTAGTAATTACTATAAAATATATTTTAGGACAGATTATTTTCTTTGCTGTACCTTTAATAATAT
TAGGTTTTATAACACCATCTATAGCAAAATTAAAACAAAATGCTAGTAAATTTGTAGGTATAACAGTCCTCATAGCATAC
ATTTCTTCTGTGGCAGCAGCATTTTTGTCTATGGTGGCTGGTTATGTCTTGATTCCTAAGCTTTCCATAGCTTCTAATCC
AGAAGGATTAAAAAAATTACCTGAGTTAGTGTTTAAATTAGACATACCACCTATAATGAGCGTTATGAGTGCTTTAGCTT
TGGCTTTATTACTAGGATTGGCTACTGGATGGACTAATTCTGACCTAATTGAAAAGATACTGGATCAATTCCAGAATATA
ATTCTAAGCATAGTAAATAAGGTTATTATTCCTATATTGCCATTTTTTATAGCAACAAATTTTGCTGCTTTAGCATATGA
AGGTAGTCTAAGTACACAATTACCAGTATTCTTAAAAGTTATAATTATAGTTTTAATAGGTCATTTTATTTGGCTTACTG
TGCTTTATTTAGTTGGAGGCGCTATTTCAAAGGAAAATCCATGGGAAGTGCTAAAGCACTATGGGCCTGCTTACCTTACA
GCGGTAGGAACTATGTCTAGTGCAGCTACTTTACCCGTAGCTTTAAAATCCGCTAAAAAATCTAAAGTTCTTAGAGAAGA
TATTGTGGATTTCGCTATACCACTATGCTCTAACATCCACTTATGTGGTTCTGTTTTAACAGAAGTATTCTTTGTAATGA
CAGTTTCTCAAATTCTATATGGGAAATTACCTGCTTTCTCAACTATGCTATTATTTATATTATTATTAGGTATATTCGCA
ATTGGAGCTCCTGGAGTTCCTGGAGGAACAGTTATGGCATCTCTAGGATTAATAATTAGTGTTTTAGCCTTTAATGAAGC
TGGAACCGCTTTAATTTTAACTATATTTGCCCTTCAAGATAGCTTTGGAACTGCATGTAATGTAACTGGTGATGGCGCCA
TAGCACTAATGCTTACAGGTATTGCTAAGAAAAAGAATTTATAA

Upstream 100 bases:

>100_bases
ACTAAAAATTTAACACTTAAATAAAATTTAATACTGATTAAATTTTTTAGTTTTTTCTTGTTAAGAGTGATTATCAAATT
AGTGTAAGGAGGATTATGTA

Downstream 100 bases:

>100_bases
ACAGATTTCATATAGATATTTAATTTTAATATAGCAAAGATAAAAAAATACATTTCATAAACAAATTAGTTTATGAAATG
TATTTTTTATCGTAGCAGTA

Product: sodium:dicarboxylate symporter family protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: Na(+)/serine-threonine symporter [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKKLFNNLIFKLVLGVIIGILIGSYASKPTIGVVITIKYILGQIIFFAVPLIILGFITPSIAKLKQNASKFVGITVLIAY
ISSVAAAFLSMVAGYVLIPKLSIASNPEGLKKLPELVFKLDIPPIMSVMSALALALLLGLATGWTNSDLIEKILDQFQNI
ILSIVNKVIIPILPFFIATNFAALAYEGSLSTQLPVFLKVIIIVLIGHFIWLTVLYLVGGAISKENPWEVLKHYGPAYLT
AVGTMSSAATLPVALKSAKKSKVLREDIVDFAIPLCSNIHLCGSVLTEVFFVMTVSQILYGKLPAFSTMLLFILLLGIFA
IGAPGVPGGTVMASLGLIISVLAFNEAGTALILTIFALQDSFGTACNVTGDGAIALMLTGIAKKKNL

Sequences:

>Translated_387_residues
MKKLFNNLIFKLVLGVIIGILIGSYASKPTIGVVITIKYILGQIIFFAVPLIILGFITPSIAKLKQNASKFVGITVLIAY
ISSVAAAFLSMVAGYVLIPKLSIASNPEGLKKLPELVFKLDIPPIMSVMSALALALLLGLATGWTNSDLIEKILDQFQNI
ILSIVNKVIIPILPFFIATNFAALAYEGSLSTQLPVFLKVIIIVLIGHFIWLTVLYLVGGAISKENPWEVLKHYGPAYLT
AVGTMSSAATLPVALKSAKKSKVLREDIVDFAIPLCSNIHLCGSVLTEVFFVMTVSQILYGKLPAFSTMLLFILLLGIFA
IGAPGVPGGTVMASLGLIISVLAFNEAGTALILTIFALQDSFGTACNVTGDGAIALMLTGIAKKKNL
>Mature_387_residues
MKKLFNNLIFKLVLGVIIGILIGSYASKPTIGVVITIKYILGQIIFFAVPLIILGFITPSIAKLKQNASKFVGITVLIAY
ISSVAAAFLSMVAGYVLIPKLSIASNPEGLKKLPELVFKLDIPPIMSVMSALALALLLGLATGWTNSDLIEKILDQFQNI
ILSIVNKVIIPILPFFIATNFAALAYEGSLSTQLPVFLKVIIIVLIGHFIWLTVLYLVGGAISKENPWEVLKHYGPAYLT
AVGTMSSAATLPVALKSAKKSKVLREDIVDFAIPLCSNIHLCGSVLTEVFFVMTVSQILYGKLPAFSTMLLFILLLGIFA
IGAPGVPGGTVMASLGLIISVLAFNEAGTALILTIFALQDSFGTACNVTGDGAIALMLTGIAKKKNL

Specific function: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Caenorhabditis elegans, GI71996953, Length=282, Percent_Identity=24.468085106383, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193206505, Length=164, Percent_Identity=31.0975609756098, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR023025 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 41183; Mature: 41183

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLFNNLIFKLVLGVIIGILIGSYASKPTIGVVITIKYILGQIIFFAVPLIILGFITPS
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHH
IAKLKQNASKFVGITVLIAYISSVAAAFLSMVAGYVLIPKLSIASNPEGLKKLPELVFKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
DIPPIMSVMSALALALLLGLATGWTNSDLIEKILDQFQNIILSIVNKVIIPILPFFIATN
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAALAYEGSLSTQLPVFLKVIIIVLIGHFIWLTVLYLVGGAISKENPWEVLKHYGPAYLT
HHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHH
AVGTMSSAATLPVALKSAKKSKVLREDIVDFAIPLCSNIHLCGSVLTEVFFVMTVSQILY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GKLPAFSTMLLFILLLGIFAIGAPGVPGGTVMASLGLIISVLAFNEAGTALILTIFALQD
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SFGTACNVTGDGAIALMLTGIAKKKNL
CCCCEECCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKLFNNLIFKLVLGVIIGILIGSYASKPTIGVVITIKYILGQIIFFAVPLIILGFITPS
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHH
IAKLKQNASKFVGITVLIAYISSVAAAFLSMVAGYVLIPKLSIASNPEGLKKLPELVFKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
DIPPIMSVMSALALALLLGLATGWTNSDLIEKILDQFQNIILSIVNKVIIPILPFFIATN
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAALAYEGSLSTQLPVFLKVIIIVLIGHFIWLTVLYLVGGAISKENPWEVLKHYGPAYLT
HHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHH
AVGTMSSAATLPVALKSAKKSKVLREDIVDFAIPLCSNIHLCGSVLTEVFFVMTVSQILY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GKLPAFSTMLLFILLLGIFAIGAPGVPGGTVMASLGLIISVLAFNEAGTALILTIFALQD
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SFGTACNVTGDGAIALMLTGIAKKKNL
CCCCEECCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA