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The map label for this gene is ttcA [H]

Identifier: 226947389

GI number: 226947389

Start: 193534

End: 194256

Strand: Reverse

Name: ttcA [H]

Synonym: CLM_0209

Alternate gene names: 226947389

Gene position: 194256-193534 (Counterclockwise)

Preceding gene: 226947397

Following gene: 226947388

Centisome position: 4.67

GC content: 27.94

Gene sequence:

>723_bases
ATGCAAAAGTTATTAGGAAAGCTTAGAAGAGCAGTAGGAGATTTTAATCTAATACAAAATGGAGATAAAATAGCTGTTGG
TTTATCTGGTGGAAAAGATAGTATAGTTTTACTTCATCTACTAAAAAAATATCAAAGTTTTTCTCCTGAAAAATTTGATT
TAATAGCTATAACATTAGATACAATGACAGGAGCAGATTTTTCTCCTCTTGAAAATGTATGCTCTAATATAAATGTTCCA
CTATACATATATAAGACCCCTATAAAAGAAATAGTCTTTGATTTAAGAAAAGAAAAAAACCCTTGTTCTTTATGTGCTAA
TTTAAGGAGGGGGGCTTTAAATAATTATTCTAAAGAATTAGGATGTAACAAAATAGCCTTAGGTCATCATAAAAATGATG
CTATAGAAACTTTATTAATGTCTATGTTATATGAAGGAAGGGTAAGTTGCTTTTCCCCAAAAACTTATCTAAATAAAGCC
AACATAACAATAATTAGGCCTATGATATATATAGATGAAATAGCAATTAAAAGTATGATTAAAAGATATGATTTACCTAT
AATTAAAAATCCTTGTCCGGCTAATGGTAACACTAAAAGGCAATATATGAAAGAACTTACCTATACTTTAGAAAAAGATA
TTCCTAAAGTTAAAGACAGACTACTTGGCTGCTTAACCAATATTAATCAAATAAACCTATGGGACAAAGATAAAATCCAA
TAA

Upstream 100 bases:

>100_bases
TTCTCACTATTTTATTTTCATAAATTTATTTGTAATATATATGTATTAATTTATAATATATTTATAATATAAATTTATAC
ATATACTAGGGAGGAATATA

Downstream 100 bases:

>100_bases
TATTTAACTCCTTATATTCATATATATTAATATAAGGAGGGGTGTGTTTTGAATATAGAGAAAACTCATTATATGGAATC
ATTATCTTATTATAAAATAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MQKLLGKLRRAVGDFNLIQNGDKIAVGLSGGKDSIVLLHLLKKYQSFSPEKFDLIAITLDTMTGADFSPLENVCSNINVP
LYIYKTPIKEIVFDLRKEKNPCSLCANLRRGALNNYSKELGCNKIALGHHKNDAIETLLMSMLYEGRVSCFSPKTYLNKA
NITIIRPMIYIDEIAIKSMIKRYDLPIIKNPCPANGNTKRQYMKELTYTLEKDIPKVKDRLLGCLTNINQINLWDKDKIQ

Sequences:

>Translated_240_residues
MQKLLGKLRRAVGDFNLIQNGDKIAVGLSGGKDSIVLLHLLKKYQSFSPEKFDLIAITLDTMTGADFSPLENVCSNINVP
LYIYKTPIKEIVFDLRKEKNPCSLCANLRRGALNNYSKELGCNKIALGHHKNDAIETLLMSMLYEGRVSCFSPKTYLNKA
NITIIRPMIYIDEIAIKSMIKRYDLPIIKNPCPANGNTKRQYMKELTYTLEKDIPKVKDRLLGCLTNINQINLWDKDKIQ
>Mature_240_residues
MQKLLGKLRRAVGDFNLIQNGDKIAVGLSGGKDSIVLLHLLKKYQSFSPEKFDLIAITLDTMTGADFSPLENVCSNINVP
LYIYKTPIKEIVFDLRKEKNPCSLCANLRRGALNNYSKELGCNKIALGHHKNDAIETLLMSMLYEGRVSCFSPKTYLNKA
NITIIRPMIYIDEIAIKSMIKRYDLPIIKNPCPANGNTKRQYMKELTYTLEKDIPKVKDRLLGCLTNINQINLWDKDKIQ

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=246, Percent_Identity=34.9593495934959, Blast_Score=137, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI193211090, Length=234, Percent_Identity=29.0598290598291, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17540090, Length=223, Percent_Identity=27.8026905829596, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651972, Length=225, Percent_Identity=30.2222222222222, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 27270; Mature: 27270

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLLGKLRRAVGDFNLIQNGDKIAVGLSGGKDSIVLLHLLKKYQSFSPEKFDLIAITLD
CHHHHHHHHHHHCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEE
TMTGADFSPLENVCSNINVPLYIYKTPIKEIVFDLRKEKNPCSLCANLRRGALNNYSKEL
CCCCCCCCHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GCNKIALGHHKNDAIETLLMSMLYEGRVSCFSPKTYLNKANITIIRPMIYIDEIAIKSMI
CCCCEEECCCCHHHHHHHHHHHHHHCCCCEECCHHHHCCCCEEEEHHHHHHHHHHHHHHH
KRYDLPIIKNPCPANGNTKRQYMKELTYTLEKDIPKVKDRLLGCLTNINQINLWDKDKIQ
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEECCCCCCCCC
>Mature Secondary Structure
MQKLLGKLRRAVGDFNLIQNGDKIAVGLSGGKDSIVLLHLLKKYQSFSPEKFDLIAITLD
CHHHHHHHHHHHCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEE
TMTGADFSPLENVCSNINVPLYIYKTPIKEIVFDLRKEKNPCSLCANLRRGALNNYSKEL
CCCCCCCCHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GCNKIALGHHKNDAIETLLMSMLYEGRVSCFSPKTYLNKANITIIRPMIYIDEIAIKSMI
CCCCEEECCCCHHHHHHHHHHHHHHCCCCEECCHHHHCCCCEEEEHHHHHHHHHHHHHHH
KRYDLPIIKNPCPANGNTKRQYMKELTYTLEKDIPKVKDRLLGCLTNINQINLWDKDKIQ
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA