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The map label for this gene is mnaA [H]

Identifier: 226225085

GI number: 226225085

Start: 2586174

End: 2587313

Strand: Reverse

Name: mnaA [H]

Synonym: Lm4b_02506

Alternate gene names: 226225085

Gene position: 2587313-2586174 (Counterclockwise)

Preceding gene: 226225086

Following gene: 226225084

Centisome position: 88.83

GC content: 40.53

Gene sequence:

>1140_bases
TTGGCTAAAATCAAAGTAATGAGTATCTTTGGGACAAGACCAGAAGCAATAAAAATGGCACCACTCGTTTTGGCACTAGA
AAAAGAACCAGAAACATTTGAGTCAACGGTAGTGATTACAGCTCAACACCGTGAAATGCTAGATCAAGTCTTAGAGATTT
TTGATATTAAACCAGATATTGACTTAGATATTATGAAAAAAGGCCAAACTTTAGCTGAAATAACTTCGCGTGTAATGAAT
GGAATTAATGAAGTTATTGCAGCCGAAAATCCGGATATCGTTCTAGTTCACGGCGATACAACAACAAGTTTTGCAGCAGG
ACTAGCTACCTTTTATCAACAAAAAATGCTCGGACATGTCGAAGCTGGACTTAGAACATGGAATAAATATTCGCCGTTTC
CAGAAGAAATGAATCGCCAGTTAACTGGTGTAATGGCGGATATGCACTTTTCTCCAACTAAACAAGCGAAAGAAAATCTG
CTTGCGGAAGGAAAAGATCCGGGTACTATTTTTGTGACTGGAAATACGGCGATTGATGCCCTTAGAACAACTGTGCAAAA
AGATTACCACCATCCAATCTTGGAAAATCTTGGCGACAATCGTTTAATACTTATGACGGCTCACCGCAGGGAAAATTTAG
GCGAACCGATGCAAGGGATGTTTGAGGCGGTTCGAGAAATCGTGGAAAGTCGTGAGGATGTTGAACTCGTTTATCCGATG
CATTTGAATCCAGCCGTTAGAGAAAAAGCGACGAAAATCTTAGGTGGACATGAACGCATTCATTTAATCGAGCCACTCGA
CGCAATTGATTTTCATAATTTCTTGCGCAAGTCTTATCTTGTTTTTACCGATTCAGGCGGCGTACAAGAAGAAGCTCCAG
GCATGGGCGTGCCAGTTTTAGTTTTACGTGATACGACGGAGCGTCCAGAAGGAATCGAAGCCGGGACGTTGAAACTAATT
GGAACAAATAAAGAGAATCTAATTAAAGAAGCACTGAATTTGCTGGATAATAAAGAAAATCATGATAAAATGGCACACGC
GGTAAATCCATATGGCGACGGATTCGCAGCTAATCGAATTTTAGCAGCAATCAAGAGTCACTTTGAAGAAACTGGTCGAC
CAGAAGATTTTATCGTGTAA

Upstream 100 bases:

>100_bases
TTAGTGAGATAAGGAATTATAAACAGTGTTGCTTTTTGGCAGACTGGGAAATTTTTTGTCGAACTATTTCTGAGGAGTTT
TTTTATAAGGAGGTTCGCAA

Downstream 100 bases:

>100_bases
AACACAGTGGAAAACTAGGCGTTGAAGTCTAGTTTTCCTCTTTTTTCAGAATGAAAGCGCCTTATTGTTACAGATATGTT
ACACGCTCGATTTTCACTAG

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MAKIKVMSIFGTRPEAIKMAPLVLALEKEPETFESTVVITAQHREMLDQVLEIFDIKPDIDLDIMKKGQTLAEITSRVMN
GINEVIAAENPDIVLVHGDTTTSFAAGLATFYQQKMLGHVEAGLRTWNKYSPFPEEMNRQLTGVMADMHFSPTKQAKENL
LAEGKDPGTIFVTGNTAIDALRTTVQKDYHHPILENLGDNRLILMTAHRRENLGEPMQGMFEAVREIVESREDVELVYPM
HLNPAVREKATKILGGHERIHLIEPLDAIDFHNFLRKSYLVFTDSGGVQEEAPGMGVPVLVLRDTTERPEGIEAGTLKLI
GTNKENLIKEALNLLDNKENHDKMAHAVNPYGDGFAANRILAAIKSHFEETGRPEDFIV

Sequences:

>Translated_379_residues
MAKIKVMSIFGTRPEAIKMAPLVLALEKEPETFESTVVITAQHREMLDQVLEIFDIKPDIDLDIMKKGQTLAEITSRVMN
GINEVIAAENPDIVLVHGDTTTSFAAGLATFYQQKMLGHVEAGLRTWNKYSPFPEEMNRQLTGVMADMHFSPTKQAKENL
LAEGKDPGTIFVTGNTAIDALRTTVQKDYHHPILENLGDNRLILMTAHRRENLGEPMQGMFEAVREIVESREDVELVYPM
HLNPAVREKATKILGGHERIHLIEPLDAIDFHNFLRKSYLVFTDSGGVQEEAPGMGVPVLVLRDTTERPEGIEAGTLKLI
GTNKENLIKEALNLLDNKENHDKMAHAVNPYGDGFAANRILAAIKSHFEETGRPEDFIV
>Mature_378_residues
AKIKVMSIFGTRPEAIKMAPLVLALEKEPETFESTVVITAQHREMLDQVLEIFDIKPDIDLDIMKKGQTLAEITSRVMNG
INEVIAAENPDIVLVHGDTTTSFAAGLATFYQQKMLGHVEAGLRTWNKYSPFPEEMNRQLTGVMADMHFSPTKQAKENLL
AEGKDPGTIFVTGNTAIDALRTTVQKDYHHPILENLGDNRLILMTAHRRENLGEPMQGMFEAVREIVESREDVELVYPMH
LNPAVREKATKILGGHERIHLIEPLDAIDFHNFLRKSYLVFTDSGGVQEEAPGMGVPVLVLRDTTERPEGIEAGTLKLIG
TNKENLIKEALNLLDNKENHDKMAHAVNPYGDGFAANRILAAIKSHFEETGRPEDFIV

Specific function: Catalyzes the conversion of UDP-N-acetylglucosamine into UDP-N-acetylmannosamine, a precursor of the teichoic acid linkage unit [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Homo sapiens, GI190014632, Length=383, Percent_Identity=23.4986945169713, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI4885285, Length=383, Percent_Identity=23.4986945169713, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI298566312, Length=383, Percent_Identity=23.4986945169713, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI48994967, Length=377, Percent_Identity=50.132625994695, Blast_Score=368, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 42324; Mature: 42193

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVMSIFGTRPEAIKMAPLVLALEKEPETFESTVVITAQHREMLDQVLEIFDIKPDI
CCEEEEEEEECCCCCHHHHCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCC
DLDIMKKGQTLAEITSRVMNGINEVIAAENPDIVLVHGDTTTSFAAGLATFYQQKMLGHV
CHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
EAGLRTWNKYSPFPEEMNRQLTGVMADMHFSPTKQAKENLLAEGKDPGTIFVTGNTAIDA
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHH
LRTTVQKDYHHPILENLGDNRLILMTAHRRENLGEPMQGMFEAVREIVESREDVELVYPM
HHHHHHHHCCCHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEC
HLNPAVREKATKILGGHERIHLIEPLDAIDFHNFLRKSYLVFTDSGGVQEEAPGMGVPVL
CCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCEE
VLRDTTERPEGIEAGTLKLIGTNKENLIKEALNLLDNKENHDKMAHAVNPYGDGFAANRI
EEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHH
LAAIKSHFEETGRPEDFIV
HHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AKIKVMSIFGTRPEAIKMAPLVLALEKEPETFESTVVITAQHREMLDQVLEIFDIKPDI
CEEEEEEEECCCCCHHHHCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCC
DLDIMKKGQTLAEITSRVMNGINEVIAAENPDIVLVHGDTTTSFAAGLATFYQQKMLGHV
CHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
EAGLRTWNKYSPFPEEMNRQLTGVMADMHFSPTKQAKENLLAEGKDPGTIFVTGNTAIDA
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHH
LRTTVQKDYHHPILENLGDNRLILMTAHRRENLGEPMQGMFEAVREIVESREDVELVYPM
HHHHHHHHCCCHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEC
HLNPAVREKATKILGGHERIHLIEPLDAIDFHNFLRKSYLVFTDSGGVQEEAPGMGVPVL
CCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCEE
VLRDTTERPEGIEAGTLKLIGTNKENLIKEALNLLDNKENHDKMAHAVNPYGDGFAANRI
EEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHH
LAAIKSHFEETGRPEDFIV
HHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8126437; 12107153; 9384377 [H]