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The map label for this gene is uvrB

Identifier: 226225037

GI number: 226225037

Start: 2538205

End: 2540181

Strand: Reverse

Name: uvrB

Synonym: Lm4b_02458

Alternate gene names: 226225037

Gene position: 2540181-2538205 (Counterclockwise)

Preceding gene: 226225038

Following gene: 226225036

Centisome position: 87.21

GC content: 40.01

Gene sequence:

>1977_bases
TTGAAGGATAAATTTGAGTTAGTTTCTAAGTATAGCCCACAAGGAGACCAACCTAGAGCGATAGAACAATTAGTTGCGGG
ATTAAAAAAAGGCTTGAAACACCAAACTTTACTTGGTGCAACCGGTACAGGGAAAACTTTTACCGTATCCAACGTGATTC
AGGAAGTAAATAAGCCAACACTTGTCATGGCCCACAATAAGACGTTAGCGGGACAGCTGTATAGCGAGTTTAAAGAATTT
TTCCCAAATAATGCTGTAGAATATTTTGTCAGTTACTATGATTACTATCAACCAGAAGCCTATGTTCCGCAAAGCGACAC
GTATATCGAAAAAGATGCAAGTATCAATGATGAAATTGATAAGCTTCGTCACTCTGCTACCGCTGCGCTTTTTGAACGTC
GTGATGTAATTATCATTGCGAGTGTATCGTGTATTTATGGCTTAGGTTCGCCGATTGAATATGGTGAGATGCTCGTTTCG
CTTCGTGTTGGTATGGAAATTAGCCGTGATCAGCTACTGCGTAAATTAGTAGACATTCAATATGATCGAAATGATATAGA
TTTTCAACGTGGGCGCTTCCGTGTTCGCGGCGATGTTGTCGAAATTTTCCCGGCATCAAGAGACGAGCACTGCATGAGGA
TTGAATTTTTCGGTGATGAAATTGAACGTATTAGAGAGGTAGATGCACTTACTGGCGAAATTATTGGAGAAAGAGAACAT
GTTTCCATTTTCCCGGCATCTCACTTTGTTACCAGACCTGATATTATGAAAAAAGCAATTGTTAATATAAAAGCGGAACT
CGAAGACCGCCTTCAAGTTTTACGTGCAGATAATAAATTACTCGAAGCACAACGTCTTGAACAACGGACGAATTATGATT
TAGAAATGATGGAAGAAATGGGTTATTGCTCTGGTATTGAGAACTATTCTAGACATTTATCCCTTCGTCCAGCGGGAGTT
ACACCATACACGTTACTCGATTACTTCCCAGACGATTTCCAAATGGTAATTGATGAGTCACACGTTACGATGCCACAAAT
CCGTGGTATGTTTAACGGTGACCAAGCCAGAAAACAAATGCTAGTTGATCATGGTTTTAGACTACCAAGTGCTTTAGATA
ACCGTCCGCTAAGATTAGAAGAATTTGAAAAACATATCAATCAAATTATGTTCATTTCCGCCACACCAGGCCCTTATGAA
CTAGAAAAAAATCCGGATGTCATTGAACAAATCATCCGACCAACCGGTTTGCTAGATCCAATCGTAGAAATTCGCCCGAT
TCAAGGACAAATCGATGACTTAATGGATGAGATTAATGATCGTGTCGAGAAAAACGAACGTGTTTTAATCACCACTTTAA
CGAAAAAAATGTCAGAGGATTTGACCAATTATCTCAAAGAAGCTGGTGTTAAAGTACAATATCTCCACTCGGAAGTGAAG
ACGTTAGAGCGAATCGAAATCATTCGCGACCTCCGACTTGGTGTGTATGATGTTATCGTTGGAATTAATTTACTTCGCGA
AGGAATCGATTTACCTGAAGTATCTCTTGTCGCTATTTTAGATGCGGACAAAGAAGGATTCCTTCGTTCCGAGCGTTCCT
TAATTCAAACAATGGGTCGAGCCGCTCGTAATGAAAACGGTCGAGTAATCATGTATGCTGATAAAATGACCGATTCGATG
CGCAATTCTATTGGCGAAACAGAACGCCGTCGTAAAATCCAAATTGAATATAATGAAAAACATGGCATTACGCCAAAAAC
AATCAAAAAAGAAATTCGTGGTATCATCGCAGCGACTTCTGCCGCAGATGAAAGAGAAGCAGTGAAGCAACATGATTTAA
GCAAAATGTCTAAGAAAGAACGCGATGTGTTCATTGAAGGTATGGAACATGAAATGAAAGAAGCAGCCAAAGCACTTGAT
TTCGAACGTGCTGCTGAACTTCGCGATGCTTTACTGGAAATAAAAGCGGAAGGATGA

Upstream 100 bases:

>100_bases
AACGGATCTGAAAAATCCGCTTTTTGCTTTGCTAGACTTTTCACAAATAAAGCTTTTCAGATACCAGAATCGGACCGATA
AAGAATAGGGGGAATCCGAG

Downstream 100 bases:

>100_bases
AGCGAAATTGGATAAAGAGAAAATAGTAATTCAGGGTGCAAGAGCCCATAACTTAAAAAACATTGATGTAGAGATTCCTA
GAGACAAATTAGTAGTTATG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MKDKFELVSKYSPQGDQPRAIEQLVAGLKKGLKHQTLLGATGTGKTFTVSNVIQEVNKPTLVMAHNKTLAGQLYSEFKEF
FPNNAVEYFVSYYDYYQPEAYVPQSDTYIEKDASINDEIDKLRHSATAALFERRDVIIIASVSCIYGLGSPIEYGEMLVS
LRVGMEISRDQLLRKLVDIQYDRNDIDFQRGRFRVRGDVVEIFPASRDEHCMRIEFFGDEIERIREVDALTGEIIGEREH
VSIFPASHFVTRPDIMKKAIVNIKAELEDRLQVLRADNKLLEAQRLEQRTNYDLEMMEEMGYCSGIENYSRHLSLRPAGV
TPYTLLDYFPDDFQMVIDESHVTMPQIRGMFNGDQARKQMLVDHGFRLPSALDNRPLRLEEFEKHINQIMFISATPGPYE
LEKNPDVIEQIIRPTGLLDPIVEIRPIQGQIDDLMDEINDRVEKNERVLITTLTKKMSEDLTNYLKEAGVKVQYLHSEVK
TLERIEIIRDLRLGVYDVIVGINLLREGIDLPEVSLVAILDADKEGFLRSERSLIQTMGRAARNENGRVIMYADKMTDSM
RNSIGETERRRKIQIEYNEKHGITPKTIKKEIRGIIAATSAADEREAVKQHDLSKMSKKERDVFIEGMEHEMKEAAKALD
FERAAELRDALLEIKAEG

Sequences:

>Translated_658_residues
MKDKFELVSKYSPQGDQPRAIEQLVAGLKKGLKHQTLLGATGTGKTFTVSNVIQEVNKPTLVMAHNKTLAGQLYSEFKEF
FPNNAVEYFVSYYDYYQPEAYVPQSDTYIEKDASINDEIDKLRHSATAALFERRDVIIIASVSCIYGLGSPIEYGEMLVS
LRVGMEISRDQLLRKLVDIQYDRNDIDFQRGRFRVRGDVVEIFPASRDEHCMRIEFFGDEIERIREVDALTGEIIGEREH
VSIFPASHFVTRPDIMKKAIVNIKAELEDRLQVLRADNKLLEAQRLEQRTNYDLEMMEEMGYCSGIENYSRHLSLRPAGV
TPYTLLDYFPDDFQMVIDESHVTMPQIRGMFNGDQARKQMLVDHGFRLPSALDNRPLRLEEFEKHINQIMFISATPGPYE
LEKNPDVIEQIIRPTGLLDPIVEIRPIQGQIDDLMDEINDRVEKNERVLITTLTKKMSEDLTNYLKEAGVKVQYLHSEVK
TLERIEIIRDLRLGVYDVIVGINLLREGIDLPEVSLVAILDADKEGFLRSERSLIQTMGRAARNENGRVIMYADKMTDSM
RNSIGETERRRKIQIEYNEKHGITPKTIKKEIRGIIAATSAADEREAVKQHDLSKMSKKERDVFIEGMEHEMKEAAKALD
FERAAELRDALLEIKAEG
>Mature_658_residues
MKDKFELVSKYSPQGDQPRAIEQLVAGLKKGLKHQTLLGATGTGKTFTVSNVIQEVNKPTLVMAHNKTLAGQLYSEFKEF
FPNNAVEYFVSYYDYYQPEAYVPQSDTYIEKDASINDEIDKLRHSATAALFERRDVIIIASVSCIYGLGSPIEYGEMLVS
LRVGMEISRDQLLRKLVDIQYDRNDIDFQRGRFRVRGDVVEIFPASRDEHCMRIEFFGDEIERIREVDALTGEIIGEREH
VSIFPASHFVTRPDIMKKAIVNIKAELEDRLQVLRADNKLLEAQRLEQRTNYDLEMMEEMGYCSGIENYSRHLSLRPAGV
TPYTLLDYFPDDFQMVIDESHVTMPQIRGMFNGDQARKQMLVDHGFRLPSALDNRPLRLEEFEKHINQIMFISATPGPYE
LEKNPDVIEQIIRPTGLLDPIVEIRPIQGQIDDLMDEINDRVEKNERVLITTLTKKMSEDLTNYLKEAGVKVQYLHSEVK
TLERIEIIRDLRLGVYDVIVGINLLREGIDLPEVSLVAILDADKEGFLRSERSLIQTMGRAARNENGRVIMYADKMTDSM
RNSIGETERRRKIQIEYNEKHGITPKTIKKEIRGIIAATSAADEREAVKQHDLSKMSKKERDVFIEGMEHEMKEAAKALD
FERAAELRDALLEIKAEG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=666, Percent_Identity=58.5585585585586, Blast_Score=773, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75564; Mature: 75564

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKFELVSKYSPQGDQPRAIEQLVAGLKKGLKHQTLLGATGTGKTFTVSNVIQEVNKPT
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHEEEECCCCCCEEEHHHHHHHCCCCE
LVMAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYVPQSDTYIEKDASINDEID
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHH
KLRHSATAALFERRDVIIIASVSCIYGLGSPIEYGEMLVSLRVGMEISRDQLLRKLVDIQ
HHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
YDRNDIDFQRGRFRVRGDVVEIFPASRDEHCMRIEFFGDEIERIREVDALTGEIIGEREH
CCCCCCCHHCCCEEEECCEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCE
VSIFPASHFVTRPDIMKKAIVNIKAELEDRLQVLRADNKLLEAQRLEQRTNYDLEMMEEM
EEEECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
GYCSGIENYSRHLSLRPAGVTPYTLLDYFPDDFQMVIDESHVTMPQIRGMFNGDQARKQM
HHHCCHHHHHHCEECCCCCCCHHHHHHCCCCCHHHHCCCCCCCHHHHHCCCCCHHHHHHH
LVDHGFRLPSALDNRPLRLEEFEKHINQIMFISATPGPYELEKNPDVIEQIIRPTGLLDP
HHHCCCCCCHHCCCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCC
IVEIRPIQGQIDDLMDEINDRVEKNERVLITTLTKKMSEDLTNYLKEAGVKVQYLHSEVK
HHHEECCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
TLERIEIIRDLRLGVYDVIVGINLLREGIDLPEVSLVAILDADKEGFLRSERSLIQTMGR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
AARNENGRVIMYADKMTDSMRNSIGETERRRKIQIEYNEKHGITPKTIKKEIRGIIAATS
HHCCCCCCEEEEEHHHHHHHHHHHCCHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHCC
AADEREAVKQHDLSKMSKKERDVFIEGMEHEMKEAAKALDFERAAELRDALLEIKAEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKDKFELVSKYSPQGDQPRAIEQLVAGLKKGLKHQTLLGATGTGKTFTVSNVIQEVNKPT
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHEEEECCCCCCEEEHHHHHHHCCCCE
LVMAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYVPQSDTYIEKDASINDEID
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHH
KLRHSATAALFERRDVIIIASVSCIYGLGSPIEYGEMLVSLRVGMEISRDQLLRKLVDIQ
HHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
YDRNDIDFQRGRFRVRGDVVEIFPASRDEHCMRIEFFGDEIERIREVDALTGEIIGEREH
CCCCCCCHHCCCEEEECCEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCE
VSIFPASHFVTRPDIMKKAIVNIKAELEDRLQVLRADNKLLEAQRLEQRTNYDLEMMEEM
EEEECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
GYCSGIENYSRHLSLRPAGVTPYTLLDYFPDDFQMVIDESHVTMPQIRGMFNGDQARKQM
HHHCCHHHHHHCEECCCCCCCHHHHHHCCCCCHHHHCCCCCCCHHHHHCCCCCHHHHHHH
LVDHGFRLPSALDNRPLRLEEFEKHINQIMFISATPGPYELEKNPDVIEQIIRPTGLLDP
HHHCCCCCCHHCCCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCC
IVEIRPIQGQIDDLMDEINDRVEKNERVLITTLTKKMSEDLTNYLKEAGVKVQYLHSEVK
HHHEECCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
TLERIEIIRDLRLGVYDVIVGINLLREGIDLPEVSLVAILDADKEGFLRSERSLIQTMGR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
AARNENGRVIMYADKMTDSMRNSIGETERRRKIQIEYNEKHGITPKTIKKEIRGIIAATS
HHCCCCCCEEEEEHHHHHHHHHHHCCHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHCC
AADEREAVKQHDLSKMSKKERDVFIEGMEHEMKEAAKALDFERAAELRDALLEIKAEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]