BacMap

Definition	Listeria monocytogenes Clip81459, complete genome.
Accession	NC_012488
Length	2,912,690

Click here to switch to the map view.

The map label for this gene is ppiB [C]

Identifier: 226224928

GI number: 226224928

Start: 2424534

End: 2425118

Strand: Reverse

Name: ppiB [C]

Synonym: Lm4b_02348

Alternate gene names: 226224928

Gene position: 2425118-2424534 (Counterclockwise)

Preceding gene: 226224937

Following gene: 226224926

Centisome position: 83.26

GC content: 43.08

Gene sequence:

>585_bases
ATGACTTACCCACAATTATCAAAAGAAGTGGCACCTAACGAAATTGAAGCAGAAATGATTACAAACCGAGGAACTATCCG
CATCAAATTGTTCCCTGAAATTGCACCAAAAACAGTAGAAAACTTTGTTACACATTCCAAAAACGGCTACTATGATGGCC
TTATTTTCCACCGTGTTATTCCTGAATTCATGATCCAAGGTGGCGACCCAGACGGCCGCGGTACTGGTGGCGAAAGTATT
TGGGGCGAATCTTTTGAAGATGAATTCTCTACAGAAGCTTTCAATTTACGCGGAGCTTTATCCATGGCAAACGCTGGTCC
AAACACAAACGGCAGTCAATTCTTCATCGTTCAAAAACCAGATATGCCTGCTGACATGCTTGGTCAAATGGAACAAGCTG
GCTTCCCAGTAGAAATTATCGAAGCTTACAAACAAGGCGGAACACCATGGTTAGACGGCCGCCACACAGTTTTCGGTCAC
GTAATCGAAGGCATGGACGTAGTAGACGAAATCGCCAACCTACCAACTGGCATGCAAGACAAACCAGTGAATGATGTTGT
GATTGAGAAGATTAATATTAAATAA

Upstream 100 bases:

>100_bases
TATACTAGTACTGTATCTGATTGCTGTCGTTGTTAATTTGCTTATTATTTGGCTACGTTAGTAAACAATAAATTTAAACA
AAAGAAGGAGTTTTTACAAT

Downstream 100 bases:

>100_bases
TGAAATTAGAGCACTTTCTTGGTTTTAAGAAAGTGCTCTTTTTGTATAGGAAATGTAATATTTATTTAAAGTAGGGGATA
AATAGTTGAAGTTATACATT

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MTYPQLSKEVAPNEIEAEMITNRGTIRIKLFPEIAPKTVENFVTHSKNGYYDGLIFHRVIPEFMIQGGDPDGRGTGGESI
WGESFEDEFSTEAFNLRGALSMANAGPNTNGSQFFIVQKPDMPADMLGQMEQAGFPVEIIEAYKQGGTPWLDGRHTVFGH
VIEGMDVVDEIANLPTGMQDKPVNDVVIEKINIK

Sequences:

>Translated_194_residues
MTYPQLSKEVAPNEIEAEMITNRGTIRIKLFPEIAPKTVENFVTHSKNGYYDGLIFHRVIPEFMIQGGDPDGRGTGGESI
WGESFEDEFSTEAFNLRGALSMANAGPNTNGSQFFIVQKPDMPADMLGQMEQAGFPVEIIEAYKQGGTPWLDGRHTVFGH
VIEGMDVVDEIANLPTGMQDKPVNDVVIEKINIK
>Mature_193_residues
TYPQLSKEVAPNEIEAEMITNRGTIRIKLFPEIAPKTVENFVTHSKNGYYDGLIFHRVIPEFMIQGGDPDGRGTGGESIW
GESFEDEFSTEAFNLRGALSMANAGPNTNGSQFFIVQKPDMPADMLGQMEQAGFPVEIIEAYKQGGTPWLDGRHTVFGHV
IEGMDVVDEIANLPTGMQDKPVNDVVIEKINIK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=176, Percent_Identity=51.1363636363636, Blast_Score=161, Evalue=4e-40,
Organism=Homo sapiens, GI19557636, Length=181, Percent_Identity=43.646408839779, Blast_Score=144, Evalue=4e-35,
Organism=Homo sapiens, GI7706339, Length=171, Percent_Identity=43.859649122807, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI4505991, Length=180, Percent_Identity=45.5555555555556, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI4758950, Length=173, Percent_Identity=43.9306358381503, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI5031987, Length=152, Percent_Identity=46.0526315789474, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI64276486, Length=144, Percent_Identity=41.6666666666667, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI4826932, Length=177, Percent_Identity=41.8079096045198, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI42560244, Length=177, Percent_Identity=40.6779661016949, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI10863927, Length=152, Percent_Identity=44.078947368421, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI5174637, Length=170, Percent_Identity=41.1764705882353, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI5454154, Length=178, Percent_Identity=41.0112359550562, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI6631100, Length=177, Percent_Identity=40.1129943502825, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI22547212, Length=178, Percent_Identity=39.3258426966292, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI7657473, Length=178, Percent_Identity=39.3258426966292, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI303305009, Length=156, Percent_Identity=41.6666666666667, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI22547215, Length=178, Percent_Identity=39.3258426966292, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI45439316, Length=152, Percent_Identity=42.1052631578947, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI256017253, Length=152, Percent_Identity=44.078947368421, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI221139811, Length=152, Percent_Identity=44.078947368421, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI256017251, Length=152, Percent_Identity=44.078947368421, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI310129267, Length=155, Percent_Identity=41.2903225806452, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI310120620, Length=155, Percent_Identity=41.2903225806452, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI209417936, Length=155, Percent_Identity=41.9354838709677, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI30102944, Length=155, Percent_Identity=41.9354838709677, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI219842199, Length=155, Percent_Identity=41.9354838709677, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI178057341, Length=155, Percent_Identity=41.9354838709677, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI310110104, Length=155, Percent_Identity=40.6451612903226, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI310127646, Length=152, Percent_Identity=41.4473684210526, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI310114371, Length=152, Percent_Identity=41.4473684210526, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI310119221, Length=152, Percent_Identity=41.4473684210526, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI169164185, Length=152, Percent_Identity=40.1315789473684, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI169163623, Length=152, Percent_Identity=40.1315789473684, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI169163387, Length=152, Percent_Identity=40.1315789473684, Blast_Score=97, Evalue=7e-21,
Organism=Homo sapiens, GI14277126, Length=199, Percent_Identity=34.1708542713568, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI310132444, Length=152, Percent_Identity=39.4736842105263, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI310113152, Length=152, Percent_Identity=39.4736842105263, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI150418007, Length=155, Percent_Identity=40, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI27735045, Length=176, Percent_Identity=32.9545454545455, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI20911035, Length=176, Percent_Identity=32.3863636363636, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI239751853, Length=152, Percent_Identity=38.1578947368421, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI113428306, Length=152, Percent_Identity=38.1578947368421, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI169214050, Length=152, Percent_Identity=38.1578947368421, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310127745, Length=154, Percent_Identity=37.6623376623377, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI310119290, Length=154, Percent_Identity=37.6623376623377, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI310114540, Length=154, Percent_Identity=37.6623376623377, Blast_Score=84, Evalue=7e-17,
Organism=Escherichia coli, GI1786736, Length=180, Percent_Identity=35, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1789763, Length=175, Percent_Identity=32.5714285714286, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=182, Percent_Identity=47.8021978021978, Blast_Score=145, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17532641, Length=178, Percent_Identity=41.5730337078652, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17552780, Length=170, Percent_Identity=47.6470588235294, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17539496, Length=172, Percent_Identity=43.0232558139535, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI71980594, Length=174, Percent_Identity=38.5057471264368, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17539498, Length=152, Percent_Identity=44.078947368421, Blast_Score=120, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71980590, Length=164, Percent_Identity=39.6341463414634, Blast_Score=120, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17559074, Length=177, Percent_Identity=42.9378531073446, Blast_Score=119, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17566266, Length=159, Percent_Identity=44.6540880503145, Blast_Score=118, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17506307, Length=170, Percent_Identity=45.2941176470588, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17551284, Length=175, Percent_Identity=42.8571428571429, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17551282, Length=175, Percent_Identity=42.8571428571429, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17552782, Length=159, Percent_Identity=44.6540880503145, Blast_Score=116, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17565860, Length=180, Percent_Identity=41.1111111111111, Blast_Score=113, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17532643, Length=178, Percent_Identity=39.8876404494382, Blast_Score=109, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71997782, Length=142, Percent_Identity=40.1408450704225, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17552784, Length=181, Percent_Identity=37.5690607734807, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32563659, Length=176, Percent_Identity=30.1136363636364, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323562, Length=174, Percent_Identity=43.6781609195402, Blast_Score=126, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321848, Length=174, Percent_Identity=43.6781609195402, Blast_Score=125, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320359, Length=160, Percent_Identity=45, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320510, Length=171, Percent_Identity=43.859649122807, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323246, Length=185, Percent_Identity=39.4594594594595, Blast_Score=109, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19922376, Length=174, Percent_Identity=40.2298850574713, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI19922912, Length=175, Percent_Identity=48.5714285714286, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17986117, Length=175, Percent_Identity=41.7142857142857, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI20130249, Length=170, Percent_Identity=47.0588235294118, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24652460, Length=182, Percent_Identity=36.2637362637363, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI17647301, Length=152, Percent_Identity=44.078947368421, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24664125, Length=171, Percent_Identity=43.2748538011696, Blast_Score=113, Evalue=9e-26,
Organism=Drosophila melanogaster, GI21357783, Length=171, Percent_Identity=43.2748538011696, Blast_Score=113, Evalue=9e-26,
Organism=Drosophila melanogaster, GI45549139, Length=152, Percent_Identity=44.7368421052632, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24650807, Length=177, Percent_Identity=38.9830508474576, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17136360, Length=175, Percent_Identity=40, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24586038, Length=180, Percent_Identity=37.2222222222222, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21357249, Length=103, Percent_Identity=46.6019417475728, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI21355677, Length=176, Percent_Identity=30.1136363636364, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24661775, Length=178, Percent_Identity=32.0224719101124, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21355237, Length=178, Percent_Identity=32.0224719101124, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24661771, Length=178, Percent_Identity=32.0224719101124, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21434; Mature: 21303

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYPQLSKEVAPNEIEAEMITNRGTIRIKLFPEIAPKTVENFVTHSKNGYYDGLIFHRVI
CCCCCCCHHCCCCHHHHHEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHH
PEFMIQGGDPDGRGTGGESIWGESFEDEFSTEAFNLRGALSMANAGPNTNGSQFFIVQKP
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHEEECCCCCCCCCCEEEEEECC
DMPADMLGQMEQAGFPVEIIEAYKQGGTPWLDGRHTVFGHVIEGMDVVDEIANLPTGMQD
CCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
KPVNDVVIEKINIK
CCCCHHEEEEECCC
>Mature Secondary Structure 
TYPQLSKEVAPNEIEAEMITNRGTIRIKLFPEIAPKTVENFVTHSKNGYYDGLIFHRVI
CCCCCCHHCCCCHHHHHEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHH
PEFMIQGGDPDGRGTGGESIWGESFEDEFSTEAFNLRGALSMANAGPNTNGSQFFIVQKP
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHEEECCCCCCCCCCEEEEEECC
DMPADMLGQMEQAGFPVEIIEAYKQGGTPWLDGRHTVFGHVIEGMDVVDEIANLPTGMQD
CCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
KPVNDVVIEKINIK
CCCCHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA