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The map label for this gene is yisK [H]

Identifier: 226224874

GI number: 226224874

Start: 2357715

End: 2358563

Strand: Reverse

Name: yisK [H]

Synonym: Lm4b_02293

Alternate gene names: 226224874

Gene position: 2358563-2357715 (Counterclockwise)

Preceding gene: 226224875

Following gene: 226224873

Centisome position: 80.98

GC content: 35.34

Gene sequence:

>849_bases
ATGAAATGGTTGAGTTATCAGCATGAGGGCGATTTTAATTATGGCATTTTAACACCTGAAAATAAAATTATCCCTGCACA
AACAATTTTTTCGAATCCACCTGCTACTCTTTTAGACTTTATCAAAGAAAAGCCGCTTGTCCCTGAACTAAAAGGAATCA
AAGGGGATATTGATTTAGCTGAAGTAGAAATCCAAGTTCCTATCACCCCACCAAATAATATTATTGCAATTGGGAAAAAT
TATTATAATCATGTGCTAGAGATGGGGAGCAAAGAAGACGTTCCAGAACATATCCTTGTATTTACAAAAAGTGCTAATAG
TTTATTGCCGCATAATGGCAAAATTGAGCTACATCAAAACCTAACTAGTCAATTAGATTATGAAGGCGAACTCGCAATAA
TTATAGGAGAAAAGGTAAGAGATTTATCCGAGCAAGATGCATTATCCGCCATATTTGGATTTACTATTTTAAATGATGTA
ACAGCTCGGGATCTTCAGAAAAAACATAAACAATTTTACCTTGGGAAAAGTCTTGATGCCAGTTGTCCAATGGGACCATA
TGTGCTGGAAAACAATGGAAGTAAAGAAGTTGTTTTTCATATTGAAACTAAGGTTAACGGTGAAATAAGACAGTCTGACT
CTACAGATAAATGTATATTTAATTTAGCTAGGATTATTTCTGATTTATCAAAAGGGCATACATTGTTGCCTGGGGATGTG
ATAGCTACAGGAACTCCAAGTGGTGTGGGGAAAGGCATGACACCTCCAACTTTTCTGCAAGCTGGAGATGTTGTCGAAAT
TACTATTGATAAAATTGGGACACTGACTAACAAAGTAAGAAAATCTTAA

Upstream 100 bases:

>100_bases
AGCGATTCAAGCGATAAGTGGTAAAAAAGTTGATGCAGCTTATTTATATTTCTTCGATGGACAACATATATGTCAAATAA
ACACAAAGGAAGGTTTTTAA

Downstream 100 bases:

>100_bases
TAAGAAAGAGGGATGTATTATGTGGGGTTATATTCATTTGATTTCATGGGTGGCTATTGTTGTACTAACGGTTACAGCTT
TACTCATTTATTCGAAATCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MKWLSYQHEGDFNYGILTPENKIIPAQTIFSNPPATLLDFIKEKPLVPELKGIKGDIDLAEVEIQVPITPPNNIIAIGKN
YYNHVLEMGSKEDVPEHILVFTKSANSLLPHNGKIELHQNLTSQLDYEGELAIIIGEKVRDLSEQDALSAIFGFTILNDV
TARDLQKKHKQFYLGKSLDASCPMGPYVLENNGSKEVVFHIETKVNGEIRQSDSTDKCIFNLARIISDLSKGHTLLPGDV
IATGTPSGVGKGMTPPTFLQAGDVVEITIDKIGTLTNKVRKS

Sequences:

>Translated_282_residues
MKWLSYQHEGDFNYGILTPENKIIPAQTIFSNPPATLLDFIKEKPLVPELKGIKGDIDLAEVEIQVPITPPNNIIAIGKN
YYNHVLEMGSKEDVPEHILVFTKSANSLLPHNGKIELHQNLTSQLDYEGELAIIIGEKVRDLSEQDALSAIFGFTILNDV
TARDLQKKHKQFYLGKSLDASCPMGPYVLENNGSKEVVFHIETKVNGEIRQSDSTDKCIFNLARIISDLSKGHTLLPGDV
IATGTPSGVGKGMTPPTFLQAGDVVEITIDKIGTLTNKVRKS
>Mature_282_residues
MKWLSYQHEGDFNYGILTPENKIIPAQTIFSNPPATLLDFIKEKPLVPELKGIKGDIDLAEVEIQVPITPPNNIIAIGKN
YYNHVLEMGSKEDVPEHILVFTKSANSLLPHNGKIELHQNLTSQLDYEGELAIIIGEKVRDLSEQDALSAIFGFTILNDV
TARDLQKKHKQFYLGKSLDASCPMGPYVLENNGSKEVVFHIETKVNGEIRQSDSTDKCIFNLARIISDLSKGHTLLPGDV
IATGTPSGVGKGMTPPTFLQAGDVVEITIDKIGTLTNKVRKS

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=223, Percent_Identity=37.219730941704, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI40786394, Length=226, Percent_Identity=36.283185840708, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI13654274, Length=214, Percent_Identity=35.0467289719626, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI215422413, Length=183, Percent_Identity=37.1584699453552, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI66348062, Length=183, Percent_Identity=36.6120218579235, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1787428, Length=216, Percent_Identity=33.7962962962963, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17557057, Length=216, Percent_Identity=32.4074074074074, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324161, Length=231, Percent_Identity=25.974025974026, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28572127, Length=288, Percent_Identity=35.7638888888889, Blast_Score=160, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24663695, Length=252, Percent_Identity=31.3492063492063, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI28571789, Length=211, Percent_Identity=30.3317535545024, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 31045; Mature: 31045

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWLSYQHEGDFNYGILTPENKIIPAQTIFSNPPATLLDFIKEKPLVPELKGIKGDIDLA
CCCCCCCCCCCCCEEEECCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCHHCCCCCCCEEE
EVEIQVPITPPNNIIAIGKNYYNHVLEMGSKEDVPEHILVFTKSANSLLPHNGKIELHQN
EEEEEEECCCCCCEEEECCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECC
LTSQLDYEGELAIIIGEKVRDLSEQDALSAIFGFTILNDVTARDLQKKHKQFYLGKSLDA
HHHHCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
SCPMGPYVLENNGSKEVVFHIETKVNGEIRQSDSTDKCIFNLARIISDLSKGHTLLPGDV
CCCCCCEEEECCCCEEEEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCEECCCCE
IATGTPSGVGKGMTPPTFLQAGDVVEITIDKIGTLTNKVRKS
EECCCCCCCCCCCCCCHHCCCCCEEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MKWLSYQHEGDFNYGILTPENKIIPAQTIFSNPPATLLDFIKEKPLVPELKGIKGDIDLA
CCCCCCCCCCCCCEEEECCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCHHCCCCCCCEEE
EVEIQVPITPPNNIIAIGKNYYNHVLEMGSKEDVPEHILVFTKSANSLLPHNGKIELHQN
EEEEEEECCCCCCEEEECCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECC
LTSQLDYEGELAIIIGEKVRDLSEQDALSAIFGFTILNDVTARDLQKKHKQFYLGKSLDA
HHHHCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
SCPMGPYVLENNGSKEVVFHIETKVNGEIRQSDSTDKCIFNLARIISDLSKGHTLLPGDV
CCCCCCEEEECCCCEEEEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCEECCCCE
IATGTPSGVGKGMTPPTFLQAGDVVEITIDKIGTLTNKVRKS
EECCCCCCCCCCCCCCHHCCCCCEEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]