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The map label for this gene is hemH [H]

Identifier: 226224819

GI number: 226224819

Start: 2306277

End: 2307206

Strand: Reverse

Name: hemH [H]

Synonym: Lm4b_02238b

Alternate gene names: 226224819

Gene position: 2307206-2306277 (Counterclockwise)

Preceding gene: 226224820

Following gene: 226224818

Centisome position: 79.21

GC content: 38.28

Gene sequence:

>930_bases
ATGACTAAAAAAGTAGGTCTACTTGTAATGGCATACGGGACACCGTACAAAGATGAAGATATTGAACGTTACTATACAGA
TATTCGTCATGGTCATAAGCCAAGTGAAGAAATGATTGCGGATTTGCGCGGAAGATACCATGCAATTGGTGGATTATCTC
CACTCGCAAAAATTACTGAAGCACAAGCCTATGGATTAGAAAAAGCGTTAAATGAATCGCAGGACGAAGTAGAATTCAAG
GCATATATCGGTTTAAAACATATTGAACCTTTTATTGAAGACGCTGTAGAAGCTATGCATAAAGATGGAATAGAAGAAGC
AATCTCGATTGTTTTAGCGCCACACTACTCTAGCTTTAGCGTCGAAGCTTACAACAAAAGAGCAAAAGATGCAGCTGATA
AACTAGGTGGCCTTCGTATCAAAGCAATCAATGATTGGTACAAACAACCCAAATTTATTCAAATGTGGGCTGATAGAATT
AACGAAACAGCAAAACAAATTCCAGCTGATGAATTATTGGATACTGTTTTAATTGTTTCCGCACACAGTTTACCGGAGAA
AATTAAACAACATAATGACCCGTACCCAGATCAACTGCAAGAAACAGCAGATTTCATTTTCGAAAAAGTAGTAGTACCTC
ATTACGCGTTAGGTTGGCAAAGTGAAGGGAAAACTGGGGAGCCGTGGCTCGGACCTGATGTACAAGATTTAACAAGAGAA
CTTTACGGTCGAGAAAAATATAAACACTTTATCTATACACCAGTTGGATTTGTGGCTGAACATTTAGAGGTTTTATATGA
TAATGATTATGAATGTAAAGTAGTTACCGATGAAGTGGGCGCGACTTATCACCGACCACCAATGCCAAACTCGGACCCAG
AATTCTTAGAAGTATTAAGGACGGTTGTTTGGGAAAAATATAGCAATTAA

Upstream 100 bases:

>100_bases
GACATGGCGTTTTCCCGGAAGTACCACCAGAAATGTTGAAGAAACTAACTAATTACATCCATGAACGTAGCGAAATTCTA
TTAAAAAAGGATGATATAAA

Downstream 100 bases:

>100_bases
ATAAAGTACTTGCCGGGATATTCGTTATTCCGGCATATTTTTTTAAAACAAAGAAAACGTTTTCAATATTTTTAGCTAAA
TACTATGAAGTTTTAATCAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTKKVGLLVMAYGTPYKDEDIERYYTDIRHGHKPSEEMIADLRGRYHAIGGLSPLAKITEAQAYGLEKALNESQDEVEFK
AYIGLKHIEPFIEDAVEAMHKDGIEEAISIVLAPHYSSFSVEAYNKRAKDAADKLGGLRIKAINDWYKQPKFIQMWADRI
NETAKQIPADELLDTVLIVSAHSLPEKIKQHNDPYPDQLQETADFIFEKVVVPHYALGWQSEGKTGEPWLGPDVQDLTRE
LYGREKYKHFIYTPVGFVAEHLEVLYDNDYECKVVTDEVGATYHRPPMPNSDPEFLEVLRTVVWEKYSN

Sequences:

>Translated_309_residues
MTKKVGLLVMAYGTPYKDEDIERYYTDIRHGHKPSEEMIADLRGRYHAIGGLSPLAKITEAQAYGLEKALNESQDEVEFK
AYIGLKHIEPFIEDAVEAMHKDGIEEAISIVLAPHYSSFSVEAYNKRAKDAADKLGGLRIKAINDWYKQPKFIQMWADRI
NETAKQIPADELLDTVLIVSAHSLPEKIKQHNDPYPDQLQETADFIFEKVVVPHYALGWQSEGKTGEPWLGPDVQDLTRE
LYGREKYKHFIYTPVGFVAEHLEVLYDNDYECKVVTDEVGATYHRPPMPNSDPEFLEVLRTVVWEKYSN
>Mature_308_residues
TKKVGLLVMAYGTPYKDEDIERYYTDIRHGHKPSEEMIADLRGRYHAIGGLSPLAKITEAQAYGLEKALNESQDEVEFKA
YIGLKHIEPFIEDAVEAMHKDGIEEAISIVLAPHYSSFSVEAYNKRAKDAADKLGGLRIKAINDWYKQPKFIQMWADRIN
ETAKQIPADELLDTVLIVSAHSLPEKIKQHNDPYPDQLQETADFIFEKVVVPHYALGWQSEGKTGEPWLGPDVQDLTREL
YGREKYKHFIYTPVGFVAEHLEVLYDNDYECKVVTDEVGATYHRPPMPNSDPEFLEVLRTVVWEKYSN

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=267, Percent_Identity=32.2097378277154, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI60499021, Length=267, Percent_Identity=32.2097378277154, Blast_Score=128, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6324750, Length=319, Percent_Identity=25.705329153605, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17864156, Length=324, Percent_Identity=27.4691358024691, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45552018, Length=165, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24651774, Length=255, Percent_Identity=25.0980392156863, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35405; Mature: 35274

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00435 PEROXIDASE_1 ; PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKVGLLVMAYGTPYKDEDIERYYTDIRHGHKPSEEMIADLRGRYHAIGGLSPLAKITE
CCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
AQAYGLEKALNESQDEVEFKAYIGLKHIEPFIEDAVEAMHKDGIEEAISIVLAPHYSSFS
HHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
VEAYNKRAKDAADKLGGLRIKAINDWYKQPKFIQMWADRINETAKQIPADELLDTVLIVS
HHHHHHHHHHHHHHHCCEEEEEEHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AHSLPEKIKQHNDPYPDQLQETADFIFEKVVVPHYALGWQSEGKTGEPWLGPDVQDLTRE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
LYGREKYKHFIYTPVGFVAEHLEVLYDNDYECKVVTDEVGATYHRPPMPNSDPEFLEVLR
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCCCCHHHHHHHH
TVVWEKYSN
HHHHHHCCC
>Mature Secondary Structure 
TKKVGLLVMAYGTPYKDEDIERYYTDIRHGHKPSEEMIADLRGRYHAIGGLSPLAKITE
CCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
AQAYGLEKALNESQDEVEFKAYIGLKHIEPFIEDAVEAMHKDGIEEAISIVLAPHYSSFS
HHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
VEAYNKRAKDAADKLGGLRIKAINDWYKQPKFIQMWADRINETAKQIPADELLDTVLIVS
HHHHHHHHHHHHHHHCCEEEEEEHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AHSLPEKIKQHNDPYPDQLQETADFIFEKVVVPHYALGWQSEGKTGEPWLGPDVQDLTRE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
LYGREKYKHFIYTPVGFVAEHLEVLYDNDYECKVVTDEVGATYHRPPMPNSDPEFLEVLR
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCCCCHHHHHHHH
TVVWEKYSN
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]