Click here to switch to the map view.

The map label for this gene is nadC

Identifier: 226224621

GI number: 226224621

Start: 2092798

End: 2093643

Strand: Direct

Name: nadC

Synonym: Lm4b_02036

Alternate gene names: 226224621

Gene position: 2092798-2093643 (Clockwise)

Preceding gene: 226224620

Following gene: 226224622

Centisome position: 71.85

GC content: 42.2

Gene sequence:

>846_bases
ATGAATTCCATACTTATGAATCAAGCAATTCAAGCATTTTTACTAGAAGATATCGGTCAACATGACTTAAGTGCAGAAAC
TGTTTTCCCCCGTGACACAATGGGGGAAGGTGTTTTCCTAGCAAAAGAAACAGGTATTCTTTGTGGCATTTCCATCCCAC
CGAAAGTTTACGAACTGCTCGGTGGAAATATACAATTTGAAGCTTATAAAAAAGATGGTGACTGGATTCAAAAAGGCGAT
ATTATCGCGGCTGTTACGGCTCCAGTTCGCACGTTACTTTCCGGTGAGCGGGTCATTTTAAATTTAATGCAACGGATGAG
TGGTATCGCTAGCCAAACTAATTTTGCTGTCAAACAACTGGATGATTCCGCTATTCGAATTTGCGACACGAGGAAAACAG
CGCCCGGTCTGCGTGCCTTCGATAAATACGCGGTACAGACTGGTGGCGGTTTTAATCATCGCAATGGTCTATACGATGGT
GTTATGCTAAAAGACAACCACATCGCCTTCTCTGGAGGTATTACAAGTGCTGTATCTACTGTACGGGAAAAACTTGGCCA
TATGGTAAAAATCGAAGTGGAAACGGAAACTGCTGAACAAGTAAAAGAAGCCGTTCAAGCCGGCGCAGATATCATAATGT
TTGATAATCGCACACCGGAAGAAATCAAGCAACTGGTTAAGCTAGTTCCCCCGCACATTACTACAGAAATTTCCGGTAAT
GTCACTTTAGAAAATATTCATCGTTATAAGGGTTCTGGGGCAAATTACCTTTCTTTAGGCTCCTTAACGCATTCCGTTCG
TGCATTTGACATCAGTTTCAATAGCAAAGGAGGAATAAAGGCATGA

Upstream 100 bases:

>100_bases
AAATTAGCCACATGCTTATCACCGCAAAACTAATCGCCGAAAGCGCGCTCAAACGAACAGAAAGTCTCGGCGCACATCGA
ATATTAAAAGGAGTAATAAA

Downstream 100 bases:

>100_bases
ATTTACTAGAAACGGTCGAACAAGATACAATGCCAACTCATTATAAGCAAATGACGCAGGCCGAAATGATTGCTCGTGTG
ACGGAAATTAAAGCCCAGCT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MNSILMNQAIQAFLLEDIGQHDLSAETVFPRDTMGEGVFLAKETGILCGISIPPKVYELLGGNIQFEAYKKDGDWIQKGD
IIAAVTAPVRTLLSGERVILNLMQRMSGIASQTNFAVKQLDDSAIRICDTRKTAPGLRAFDKYAVQTGGGFNHRNGLYDG
VMLKDNHIAFSGGITSAVSTVREKLGHMVKIEVETETAEQVKEAVQAGADIIMFDNRTPEEIKQLVKLVPPHITTEISGN
VTLENIHRYKGSGANYLSLGSLTHSVRAFDISFNSKGGIKA

Sequences:

>Translated_281_residues
MNSILMNQAIQAFLLEDIGQHDLSAETVFPRDTMGEGVFLAKETGILCGISIPPKVYELLGGNIQFEAYKKDGDWIQKGD
IIAAVTAPVRTLLSGERVILNLMQRMSGIASQTNFAVKQLDDSAIRICDTRKTAPGLRAFDKYAVQTGGGFNHRNGLYDG
VMLKDNHIAFSGGITSAVSTVREKLGHMVKIEVETETAEQVKEAVQAGADIIMFDNRTPEEIKQLVKLVPPHITTEISGN
VTLENIHRYKGSGANYLSLGSLTHSVRAFDISFNSKGGIKA
>Mature_281_residues
MNSILMNQAIQAFLLEDIGQHDLSAETVFPRDTMGEGVFLAKETGILCGISIPPKVYELLGGNIQFEAYKKDGDWIQKGD
IIAAVTAPVRTLLSGERVILNLMQRMSGIASQTNFAVKQLDDSAIRICDTRKTAPGLRAFDKYAVQTGGGFNHRNGLYDG
VMLKDNHIAFSGGITSAVSTVREKLGHMVKIEVETETAEQVKEAVQAGADIIMFDNRTPEEIKQLVKLVPPHITTEISGN
VTLENIHRYKGSGANYLSLGSLTHSVRAFDISFNSKGGIKA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=244, Percent_Identity=34.0163934426229, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1786299, Length=271, Percent_Identity=36.90036900369, Blast_Score=162, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321162, Length=280, Percent_Identity=32.5, Blast_Score=143, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30581; Mature: 30581

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSILMNQAIQAFLLEDIGQHDLSAETVFPRDTMGEGVFLAKETGILCGISIPPKVYELL
CCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCEEEEECCCEEEECCCCHHHHHHH
GGNIQFEAYKKDGDWIQKGDIIAAVTAPVRTLLSGERVILNLMQRMSGIASQTNFAVKQL
CCCEEEEEEECCCCEEECCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
DDSAIRICDTRKTAPGLRAFDKYAVQTGGGFNHRNGLYDGVMLKDNHIAFSGGITSAVST
CCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEEECCHHHHHHH
VREKLGHMVKIEVETETAEQVKEAVQAGADIIMFDNRTPEEIKQLVKLVPPHITTEISGN
HHHHCCCEEEEEEECCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCC
VTLENIHRYKGSGANYLSLGSLTHSVRAFDISFNSKGGIKA
EEHHHHHHHCCCCCCEEEECCHHCEEEEEEEEECCCCCCCC
>Mature Secondary Structure
MNSILMNQAIQAFLLEDIGQHDLSAETVFPRDTMGEGVFLAKETGILCGISIPPKVYELL
CCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCEEEEECCCEEEECCCCHHHHHHH
GGNIQFEAYKKDGDWIQKGDIIAAVTAPVRTLLSGERVILNLMQRMSGIASQTNFAVKQL
CCCEEEEEEECCCCEEECCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
DDSAIRICDTRKTAPGLRAFDKYAVQTGGGFNHRNGLYDGVMLKDNHIAFSGGITSAVST
CCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEEECCHHHHHHH
VREKLGHMVKIEVETETAEQVKEAVQAGADIIMFDNRTPEEIKQLVKLVPPHITTEISGN
HHHHCCCEEEEEEECCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCC
VTLENIHRYKGSGANYLSLGSLTHSVRAFDISFNSKGGIKA
EEHHHHHHHCCCCCCEEEECCHHCEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]