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The map label for this gene is ezrA [H]

Identifier: 226224195

GI number: 226224195

Start: 1620107

End: 1621822

Strand: Reverse

Name: ezrA [H]

Synonym: Lm4b_01605

Alternate gene names: 226224195

Gene position: 1621822-1620107 (Counterclockwise)

Preceding gene: 226224198

Following gene: 226224194

Centisome position: 55.68

GC content: 37.41

Gene sequence:

>1716_bases
ATGTACTACATGTTAATCGGCTTTATTATCGTAGTTATTGCAGTCATTGGTGCAGGCTACATATTAAAAAGAAAACATTA
CCAAAGAATAAACGAGTTAGAAGAGAAAAAGATTAAACTCAGAGAGCGGCCGGTTATTGATGAACTTTCAAAAGTGAAAA
AATTAAAACTAACAGGTCAGACAGAAGCGCTTTTTGAATCATGGCGTTCGTCCTGGGATGAAATTGAAACTAGATTATTT
CCAGATTTAGAAGAAGTGTTATTAGAAGCAGAGATGAACACGGACCGTTACAAGTTCCGTTCTGCTACACACGCTGAAAA
TGATATTGAGCAAATGCTCGTTGTAATTGAAAAGCAAATGGATCAAATTCTTGGTGGACTAAAAGAGCTACTTATTAGTG
AAGAAAAAAATGCCAAAGAAAGTCGTGCCACGAAAGAAAAATTTGCGGAGTTGCGCCGAGAAGTTTTGACAAGAGGATTT
AAACTTGGAGAAACGTTACCATATATTGAGACAAAACTAAGTGAACTGTCAGAAAGCTTAAATAGCTATGATTCATTAAC
TGACCAAGGTGATCATTTAGAGGCACGAGAAATCGTTATAGTGGTTCAAAAAGAAATGCAAGTAATCGAAGCGCAAATGG
AGCGAATCCCGTCATTACTGCATGAAACAGATACCATTTTGCCAGAAGAAATGACTAAACTTCGCGCTGGCTATGAAGAA
ATGGTGCGAAAAGGTTATTATTTAGCTCAAATGGAGTTAGATAAAGAGATTTCTCGCATGAAAAATCAAATTGATAAAAT
GAAAAAAAATGTAATTAATCTTGATTTAGATGAAGCGGAACAAGGAGTAGAAGAATTACATAATGAAATCGATTTGTTTT
ATGATACGCTTGAACACGAAGCAGAAGCTCGCCATTTCGTGAAAGAAAATCATAGCCCAACTTCTGACAAGTTACAACGC
CAAAATGCCGTTTCAGATGCACTTGCTGAACAAATTACAGAAGTAAAACAAACCTATCATGTTGCTGAAGATGATCTAGC
GGTTTATTTAAAAACGAGCGCTAAATTGAGTGAAGCAAAAGAAAACTTTGAACAATTAACTGCTCTAATTGCTAGTGGTG
AGATTGCCTACTCGGCAGCGCAAGATACATTGAAAGAAATTGATGCAGCGCTTATTACGATTAGCGCTGAGCAGGACAAA
TTCGCTGAAGAATTGCGTTCTTTGCGTAAAGATGAACTAGAAGCGCGTGATGATGCTGAACGGATGCGTCGTGCAATTAT
TACACTAGATCGCAAAATGGAACGAGAACGTTTGCCAGGTCTTCCAGAAGAGTATTTATCGCTACGAGAGCATATGGGGG
AATCCATTAATGCGCTTGAGAAACGTTTGGAAGAGAAACCGCTAAATATGAAAGCAGTAAGCCAAGATTGGCGTATTGCA
GAAGAAGATTTAACTCATTTAACTGAAAAAGCCGAGGAAATGATGGAGAATGTTCGCTTAGTTGAGCATGTTATCCAATA
TGCTAACCGCTATCGATTGCGTAACAAAGAACTTGCAGATGAACTCGTTCAAGCAGAAAACCATTTCTACAATGATTATC
AGTATAAAAAAGCATTAGAAATTGCTGTAACCGCGCTGGAAAAAGTGGAAACAGGAGCATTTAAAAAAGTCGAAAAAGCG
TATGAATCAAAAGTAAGCGTCGACGATATTGAATAA

Upstream 100 bases:

>100_bases
ATACTACATATGGAAAGATGTACATAATTGAAAAGATGTATGAGCAGCACGAGTGTGGCTGTTTTTCTTTCACAAGTTAA
CGTTGATGGGAGGATTTTGG

Downstream 100 bases:

>100_bases
AAACGTAAAAACAGGTATTTCTATTTTTATAATAGGAATCCTGTTTTTTTATGAAAATAGTAGTTGGAAAGTGTTGGAAT
TATGATAAAATGGAGAGTGG

Product: septation ring formation regulator EzrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MYYMLIGFIIVVIAVIGAGYILKRKHYQRINELEEKKIKLRERPVIDELSKVKKLKLTGQTEALFESWRSSWDEIETRLF
PDLEEVLLEAEMNTDRYKFRSATHAENDIEQMLVVIEKQMDQILGGLKELLISEEKNAKESRATKEKFAELRREVLTRGF
KLGETLPYIETKLSELSESLNSYDSLTDQGDHLEAREIVIVVQKEMQVIEAQMERIPSLLHETDTILPEEMTKLRAGYEE
MVRKGYYLAQMELDKEISRMKNQIDKMKKNVINLDLDEAEQGVEELHNEIDLFYDTLEHEAEARHFVKENHSPTSDKLQR
QNAVSDALAEQITEVKQTYHVAEDDLAVYLKTSAKLSEAKENFEQLTALIASGEIAYSAAQDTLKEIDAALITISAEQDK
FAEELRSLRKDELEARDDAERMRRAIITLDRKMERERLPGLPEEYLSLREHMGESINALEKRLEEKPLNMKAVSQDWRIA
EEDLTHLTEKAEEMMENVRLVEHVIQYANRYRLRNKELADELVQAENHFYNDYQYKKALEIAVTALEKVETGAFKKVEKA
YESKVSVDDIE

Sequences:

>Translated_571_residues
MYYMLIGFIIVVIAVIGAGYILKRKHYQRINELEEKKIKLRERPVIDELSKVKKLKLTGQTEALFESWRSSWDEIETRLF
PDLEEVLLEAEMNTDRYKFRSATHAENDIEQMLVVIEKQMDQILGGLKELLISEEKNAKESRATKEKFAELRREVLTRGF
KLGETLPYIETKLSELSESLNSYDSLTDQGDHLEAREIVIVVQKEMQVIEAQMERIPSLLHETDTILPEEMTKLRAGYEE
MVRKGYYLAQMELDKEISRMKNQIDKMKKNVINLDLDEAEQGVEELHNEIDLFYDTLEHEAEARHFVKENHSPTSDKLQR
QNAVSDALAEQITEVKQTYHVAEDDLAVYLKTSAKLSEAKENFEQLTALIASGEIAYSAAQDTLKEIDAALITISAEQDK
FAEELRSLRKDELEARDDAERMRRAIITLDRKMERERLPGLPEEYLSLREHMGESINALEKRLEEKPLNMKAVSQDWRIA
EEDLTHLTEKAEEMMENVRLVEHVIQYANRYRLRNKELADELVQAENHFYNDYQYKKALEIAVTALEKVETGAFKKVEKA
YESKVSVDDIE
>Mature_571_residues
MYYMLIGFIIVVIAVIGAGYILKRKHYQRINELEEKKIKLRERPVIDELSKVKKLKLTGQTEALFESWRSSWDEIETRLF
PDLEEVLLEAEMNTDRYKFRSATHAENDIEQMLVVIEKQMDQILGGLKELLISEEKNAKESRATKEKFAELRREVLTRGF
KLGETLPYIETKLSELSESLNSYDSLTDQGDHLEAREIVIVVQKEMQVIEAQMERIPSLLHETDTILPEEMTKLRAGYEE
MVRKGYYLAQMELDKEISRMKNQIDKMKKNVINLDLDEAEQGVEELHNEIDLFYDTLEHEAEARHFVKENHSPTSDKLQR
QNAVSDALAEQITEVKQTYHVAEDDLAVYLKTSAKLSEAKENFEQLTALIASGEIAYSAAQDTLKEIDAALITISAEQDK
FAEELRSLRKDELEARDDAERMRRAIITLDRKMERERLPGLPEEYLSLREHMGESINALEKRLEEKPLNMKAVSQDWRIA
EEDLTHLTEKAEEMMENVRLVEHVIQYANRYRLRNKELADELVQAENHFYNDYQYKKALEIAVTALEKVETGAFKKVEKA
YESKVSVDDIE

Specific function: Negative regulator of ftsZ ring formation; modulates the frequency and position of ftsZ ring formation. Inhibits ftsZ ring formation at polar sites. Interacts either with ftsZ or with one of its binding partners to promote depolymerization [H]

COG id: COG4477

COG function: function code D; Negative regulator of septation ring formation

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein. Note=Colocalized with ftsZ to the nascent septal site [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ezrA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010379 [H]

Pfam domain/function: PF06160 EzrA [H]

EC number: NA

Molecular weight: Translated: 66489; Mature: 66489

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYYMLIGFIIVVIAVIGAGYILKRKHYQRINELEEKKIKLRERPVIDELSKVKKLKLTGQ
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCH
TEALFESWRSSWDEIETRLFPDLEEVLLEAEMNTDRYKFRSATHAENDIEQMLVVIEKQM
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHCHHCCHHHHHHHHHHHHHHH
DQILGGLKELLISEEKNAKESRATKEKFAELRREVLTRGFKLGETLPYIETKLSELSESL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHH
NSYDSLTDQGDHLEAREIVIVVQKEMQVIEAQMERIPSLLHETDTILPEEMTKLRAGYEE
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHH
MVRKGYYLAQMELDKEISRMKNQIDKMKKNVINLDLDEAEQGVEELHNEIDLFYDTLEHE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AEARHFVKENHSPTSDKLQRQNAVSDALAEQITEVKQTYHVAEDDLAVYLKTSAKLSEAK
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHH
ENFEQLTALIASGEIAYSAAQDTLKEIDAALITISAEQDKFAEELRSLRKDELEARDDAE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHCCHHHH
RMRRAIITLDRKMERERLPGLPEEYLSLREHMGESINALEKRLEEKPLNMKAVSQDWRIA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHCCCCCHH
EEDLTHLTEKAEEMMENVRLVEHVIQYANRYRLRNKELADELVQAENHFYNDYQYKKALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHH
IAVTALEKVETGAFKKVEKAYESKVSVDDIE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MYYMLIGFIIVVIAVIGAGYILKRKHYQRINELEEKKIKLRERPVIDELSKVKKLKLTGQ
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCH
TEALFESWRSSWDEIETRLFPDLEEVLLEAEMNTDRYKFRSATHAENDIEQMLVVIEKQM
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHCHHCCHHHHHHHHHHHHHHH
DQILGGLKELLISEEKNAKESRATKEKFAELRREVLTRGFKLGETLPYIETKLSELSESL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHH
NSYDSLTDQGDHLEAREIVIVVQKEMQVIEAQMERIPSLLHETDTILPEEMTKLRAGYEE
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHH
MVRKGYYLAQMELDKEISRMKNQIDKMKKNVINLDLDEAEQGVEELHNEIDLFYDTLEHE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AEARHFVKENHSPTSDKLQRQNAVSDALAEQITEVKQTYHVAEDDLAVYLKTSAKLSEAK
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHH
ENFEQLTALIASGEIAYSAAQDTLKEIDAALITISAEQDKFAEELRSLRKDELEARDDAE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHCCHHHH
RMRRAIITLDRKMERERLPGLPEEYLSLREHMGESINALEKRLEEKPLNMKAVSQDWRIA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHCCCCCHH
EEDLTHLTEKAEEMMENVRLVEHVIQYANRYRLRNKELADELVQAENHFYNDYQYKKALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHH
IAVTALEKVETGAFKKVEKAYESKVSVDDIE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]