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The map label for this gene is cdd [H]

Identifier: 226224064

GI number: 226224064

Start: 1480493

End: 1480888

Strand: Reverse

Name: cdd [H]

Synonym: Lm4b_01473

Alternate gene names: 226224064

Gene position: 1480888-1480493 (Counterclockwise)

Preceding gene: 226224065

Following gene: 226224063

Centisome position: 50.84

GC content: 41.16

Gene sequence:

>396_bases
ATGAAAGAAAATAATTTTATCTCACTCGCTAAACAAGCAAGAGAATTTGCGTATGTTCCTTACTCGAAATTTCCAGTAGG
AGCAGCTCTTGTTACGAAAGATGACGAGGTTGTACTTGGCTGTAATATCGAGAATGCATCATTCGGTTTAACAAACTGCG
CAGAACGGACAGCTATTTTTAAAGCTGTATCAGAAGGAAAACGAGATTTTAAACAGTTAGTTGTCGTAGCGGATACAGAC
GGTCCAGTTTCGCCGTGTGGGGCATGCAGACAAGTCATCAGTGAATTTTGTGCGCCAGATATGCCAGTAATATTAACAAA
CTTAACAGGGAAAACAGCGACGGTAACGGTGAAAGAACTTTTACCAGGCGCATTCACATCGGAGGATATGTTATGA

Upstream 100 bases:

>100_bases
ACTGTTAGCAGCAATTGTAGCAAGTTTTATTGGACTGATTATATTCATACCATACTTTTGCCAGATGTTTTTATAAAAAG
AAGGGATTGTGACTTGGTAA

Downstream 100 bases:

>100_bases
GTGAACCATTTAAATCAGGATTTGTAGCTATAGTTGGGCGGCCTAACGTTGGGAAATCAACTTTATTAAATCACATCATT
GGCCAAAAAATTGCCATTAT

Product: cytidine deaminase

Products: NA

Alternate protein names: CDA; Cytidine aminohydrolase [H]

Number of amino acids: Translated: 131; Mature: 131

Protein sequence:

>131_residues
MKENNFISLAKQAREFAYVPYSKFPVGAALVTKDDEVVLGCNIENASFGLTNCAERTAIFKAVSEGKRDFKQLVVVADTD
GPVSPCGACRQVISEFCAPDMPVILTNLTGKTATVTVKELLPGAFTSEDML

Sequences:

>Translated_131_residues
MKENNFISLAKQAREFAYVPYSKFPVGAALVTKDDEVVLGCNIENASFGLTNCAERTAIFKAVSEGKRDFKQLVVVADTD
GPVSPCGACRQVISEFCAPDMPVILTNLTGKTATVTVKELLPGAFTSEDML
>Mature_131_residues
MKENNFISLAKQAREFAYVPYSKFPVGAALVTKDDEVVLGCNIENASFGLTNCAERTAIFKAVSEGKRDFKQLVVVADTD
GPVSPCGACRQVISEFCAPDMPVILTNLTGKTATVTVKELLPGAFTSEDML

Specific function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis [H]

COG id: COG0295

COG function: function code F; Cytidine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI11386157, Length=128, Percent_Identity=49.21875, Blast_Score=128, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17540514, Length=126, Percent_Identity=48.4126984126984, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17551074, Length=129, Percent_Identity=47.2868217054264, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323274, Length=119, Percent_Identity=43.6974789915966, Blast_Score=103, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24582741, Length=125, Percent_Identity=49.6, Blast_Score=109, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24582744, Length=101, Percent_Identity=47.5247524752475, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920920, Length=104, Percent_Identity=48.0769230769231, Blast_Score=93, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002125
- InterPro:   IPR006262
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.5 [H]

Molecular weight: Translated: 14083; Mature: 14083

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKENNFISLAKQAREFAYVPYSKFPVGAALVTKDDEVVLGCNIENASFGLTNCAERTAIF
CCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHH
KAVSEGKRDFKQLVVVADTDGPVSPCGACRQVISEFCAPDMPVILTNLTGKTATVTVKEL
HHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEHHHH
LPGAFTSEDML
CCCCCCCCCCC
>Mature Secondary Structure
MKENNFISLAKQAREFAYVPYSKFPVGAALVTKDDEVVLGCNIENASFGLTNCAERTAIF
CCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHH
KAVSEGKRDFKQLVVVADTDGPVSPCGACRQVISEFCAPDMPVILTNLTGKTATVTVKEL
HHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEHHHH
LPGAFTSEDML
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11739901 [H]