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The map label for this gene is proG [H]

Identifier: 226223988

GI number: 226223988

Start: 1396159

End: 1396998

Strand: Reverse

Name: proG [H]

Synonym: Lm4b_01396

Alternate gene names: 226223988

Gene position: 1396998-1396159 (Counterclockwise)

Preceding gene: 226224009

Following gene: 226223985

Centisome position: 47.96

GC content: 37.02

Gene sequence:

>840_bases
ATGGCAAAAATAGGTTTTATTGGTTTTGGAAGTATGGCATCGTTAATTGCGACTAAAATAATTGAAACTGAGGTTGCAAC
TCCCGAAGAACTCATCCTTTATTCCAATTCAAAAAACGAACATTTCAACCAATTTTATAATAAATATCCAACTGCTAAGC
TAGCTGATAACGAAGCCGAAATTTTCACAAAAGCAGATCATAGCTTCGTTTGTAAGTTACCTCTCGCAGTTTTACCACTT
ATGAAAGATTGTGCTGCGGTATTGACACCTGATCGTCATGTGATTTCTATTGCAGCTGGTGTGAGTACTTCAGATATTAT
TGAAATCACTCCGGGTTTACAGGTAAGTAAATTAATCCCTTCTCTCACAACTGCTGTTAATGTTGGAACTACTTTGATTG
CGCACGCTGACACAGTGAATCAAGCTAACACTTCTTGGTTAGAAACGACATTTGAGCATTTTGGACATGTAATGACTATC
CGAGAGGAAAATATGGATATCGCTAGCGATTTAACTAGCTCTTCTCCTGGAATAATTGCTGCTATTTTCGAGCAATTTGT
AGAAGCTGCTCTTAGAAGATCTTCATTATCAGATGCGGAAGTATTTCAAATGATTAATTTTGCTTTAGCTGGGACTTCTA
AATTATTAGTAGAAGAAGATTACACGTTTAGTGGCTTAATTGAACGCGTTGCTACAAAGGGCGGGATCACTGCTGAAGGC
ATTGAACTCAGTGAGGAGCAGTTACCCCAATTTTTTGACGAACTCCTTGACCGAACTCAAACAAAATATGCTTCTAGTAA
AAAAGAAATTCAAGCACAAAAGCAAGATTTACTTTTATAA

Upstream 100 bases:

>100_bases
GGCACAAGCGCATTAACGTGAAAAAGTAAACAATCAAGTTTAGTTGCAATCCTCTTTTATTCCCTTCATAATAAAATGAA
TAATGAAAGGCGGGATGGAA

Downstream 100 bases:

>100_bases
AAAAGGGTTGCGACTACAAATCGCAACCTTTTTTTATTCATGCTCTGGATTAATTTCCACATTTACTCTTCTTGGTTTAC
TTCCTTCGTGAGGTCCAACT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase 3; P5CR 3 [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MAKIGFIGFGSMASLIATKIIETEVATPEELILYSNSKNEHFNQFYNKYPTAKLADNEAEIFTKADHSFVCKLPLAVLPL
MKDCAAVLTPDRHVISIAAGVSTSDIIEITPGLQVSKLIPSLTTAVNVGTTLIAHADTVNQANTSWLETTFEHFGHVMTI
REENMDIASDLTSSSPGIIAAIFEQFVEAALRRSSLSDAEVFQMINFALAGTSKLLVEEDYTFSGLIERVATKGGITAEG
IELSEEQLPQFFDELLDRTQTKYASSKKEIQAQKQDLLL

Sequences:

>Translated_279_residues
MAKIGFIGFGSMASLIATKIIETEVATPEELILYSNSKNEHFNQFYNKYPTAKLADNEAEIFTKADHSFVCKLPLAVLPL
MKDCAAVLTPDRHVISIAAGVSTSDIIEITPGLQVSKLIPSLTTAVNVGTTLIAHADTVNQANTSWLETTFEHFGHVMTI
REENMDIASDLTSSSPGIIAAIFEQFVEAALRRSSLSDAEVFQMINFALAGTSKLLVEEDYTFSGLIERVATKGGITAEG
IELSEEQLPQFFDELLDRTQTKYASSKKEIQAQKQDLLL
>Mature_278_residues
AKIGFIGFGSMASLIATKIIETEVATPEELILYSNSKNEHFNQFYNKYPTAKLADNEAEIFTKADHSFVCKLPLAVLPLM
KDCAAVLTPDRHVISIAAGVSTSDIIEITPGLQVSKLIPSLTTAVNVGTTLIAHADTVNQANTSWLETTFEHFGHVMTIR
EENMDIASDLTSSSPGIIAAIFEQFVEAALRRSSLSDAEVFQMINFALAGTSKLLVEEDYTFSGLIERVATKGGITAEGI
ELSEEQLPQFFDELLDRTQTKYASSKKEIQAQKQDLLL

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=252, Percent_Identity=26.1904761904762, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786585, Length=246, Percent_Identity=23.9837398373984, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17569021, Length=240, Percent_Identity=23.75, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 30527; Mature: 30396

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIGFIGFGSMASLIATKIIETEVATPEELILYSNSKNEHFNQFYNKYPTAKLADNEAE
CCEEEEECCHHHHHHHHHHHHHHHCCCCHHEEEEECCCCHHHHHHHHHCCCCEECCCCHH
IFTKADHSFVCKLPLAVLPLMKDCAAVLTPDRHVISIAAGVSTSDIIEITPGLQVSKLIP
EEEECCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEECCCCCHHHHHH
SLTTAVNVGTTLIAHADTVNQANTSWLETTFEHFGHVMTIREENMDIASDLTSSSPGIIA
HHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCCCHHH
AIFEQFVEAALRRSSLSDAEVFQMINFALAGTSKLLVEEDYTFSGLIERVATKGGITAEG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEECC
IELSEEQLPQFFDELLDRTQTKYASSKKEIQAQKQDLLL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKIGFIGFGSMASLIATKIIETEVATPEELILYSNSKNEHFNQFYNKYPTAKLADNEAE
CEEEEECCHHHHHHHHHHHHHHHCCCCHHEEEEECCCCHHHHHHHHHCCCCEECCCCHH
IFTKADHSFVCKLPLAVLPLMKDCAAVLTPDRHVISIAAGVSTSDIIEITPGLQVSKLIP
EEEECCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEECCCCCHHHHHH
SLTTAVNVGTTLIAHADTVNQANTSWLETTFEHFGHVMTIREENMDIASDLTSSSPGIIA
HHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCCCHHH
AIFEQFVEAALRRSSLSDAEVFQMINFALAGTSKLLVEEDYTFSGLIERVATKGGITAEG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEECC
IELSEEQLPQFFDELLDRTQTKYASSKKEIQAQKQDLLL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 1766370; 11418582 [H]