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The map label for this gene is gnd [H]

Identifier: 226223977

GI number: 226223977

Start: 1384647

End: 1386065

Strand: Direct

Name: gnd [H]

Synonym: Lm4b_01385

Alternate gene names: 226223977

Gene position: 1384647-1386065 (Clockwise)

Preceding gene: 226223976

Following gene: 226223978

Centisome position: 47.54

GC content: 39.39

Gene sequence:

>1419_bases
ATGGCAAAACAAGAAATTGGCGTTATAGGAATGGGCGTTATGGGTCGTAACTTGGCTCTAAACATTGAAAGCCGCGGTCA
TACAGTATCTATCTTTAACCGCTCGACTGAAAAAACGAAAGCAGTTATGGAAGAAAATGCGGACAAAAAATTAGTACCAA
CTTATAGTTTAGAGGAATTTGTCGAATCTCTTGAAGTGCCTCGCCGTATCCTTATTATGGTAAAAGCTGGCGATGCTACA
GATATGATGATTGAAGCAGTTAAACCTTTCTTAAACGAAGGCGATATTTTAATTGATGGCGGTAATGCTTTCTTCAAAGA
TACGATTCGTCGTAATAAAGAACTAAGTGAAGAAGGATTTAACTTCATCGGAACTGGTGTATCAGGCGGAGAAGAAGGTG
CACTAAAAGGTCCTTCTATCATGCCAGGTGGTCAACGCAAGGCATATGACCTTGTAGCACCTATTTTACGTGAAATTGCT
GCAGTAGCAGACGGAGAACCTTGTGTGACTTATATTGGTCCAGACGGTGCCGGACATTACGTTAAAATGGTGCATAATGG
TATCGAATACGGCGATATGCAATTAATCGCAGAAGCTTACACTATTTTGAAAGAAATCGGTGGATTAAGCCATGATGAAC
TTGCTGACGTATTTGAAGAATGGAACAACGGGGAACTTGATAGCTATTTAATCGAGATCACTAAAAACATCCTAAAAGTA
AAAGACGAAGAAACTGGCAAACCTATTGTCGATGTTATCCTTGATAAAGCAGGTCAAAAAGGAACTGGTAAATGGACTAG
CCAAAGCGCACTCGACTTAGGTGTTCCACTTTCCTTAATTACAGAATCTGTATTTGCTCGTTACATCTCTGCACTTAAAG
ATGAACGCGTTTATGCAAGTACTGTTTTATCTGGCCCATCTAATTATCGTTTTGAAGGCGACAAAAAAGCATTTGTTGAA
TCTGTTCGTCGTGCGCTTTATTTCAGCAAAATCGCATCTTATGCACAAGGTTTTGCACAAATGAGAGCAGCTAGTGAAGA
AAACGATTGGGACTTACAATACGGCGAAATTGCGAAAATTTTCCGCGCTGGTTGTATTATCCGTGCTCGTTTCTTACAAA
AAATTACTGATGCTTATAATAAAGATAAAAATCTTAAAAACTTATTATTAGATCCATATTTCAAAGATATTGCACATAAC
TACCAAGGCGACCTTCGTACAGTTGTTGCAGAAGCAGTAAAAGCTGGAATTCCAGTTCCAACATTCACTGCAGCAATTAG
CTACTACGATAGCTATCGTTCAGAAGTATTATCTGCAAATCTAATCCAAGCACAACGCGACTACTTTGGCGCTCATACGT
ATGAAAGAGTCGACAAACCTGGCGTATTCCATACAGAATGGCCACAAGTAGAAGATTGA

Upstream 100 bases:

>100_bases
CAATTCTTTGATATAGTAAATGATGTTGATACTTTTATGTGTCATGTTGAAGTAAGACAGATTTTTCTGCCTTAATAAAC
CGGAAAGGAAGAAGTGCAAA

Downstream 100 bases:

>100_bases
TGGAAGATAAGGCATCCACTTTAACGAGTGGGTGCCTTTTTTATGAGATTTGAATTAGTAAATCATGGTAAAGTGCTAAA
AAATAGTGAAAATATCTATT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MAKQEIGVIGMGVMGRNLALNIESRGHTVSIFNRSTEKTKAVMEENADKKLVPTYSLEEFVESLEVPRRILIMVKAGDAT
DMMIEAVKPFLNEGDILIDGGNAFFKDTIRRNKELSEEGFNFIGTGVSGGEEGALKGPSIMPGGQRKAYDLVAPILREIA
AVADGEPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYTILKEIGGLSHDELADVFEEWNNGELDSYLIEITKNILKV
KDEETGKPIVDVILDKAGQKGTGKWTSQSALDLGVPLSLITESVFARYISALKDERVYASTVLSGPSNYRFEGDKKAFVE
SVRRALYFSKIASYAQGFAQMRAASEENDWDLQYGEIAKIFRAGCIIRARFLQKITDAYNKDKNLKNLLLDPYFKDIAHN
YQGDLRTVVAEAVKAGIPVPTFTAAISYYDSYRSEVLSANLIQAQRDYFGAHTYERVDKPGVFHTEWPQVED

Sequences:

>Translated_472_residues
MAKQEIGVIGMGVMGRNLALNIESRGHTVSIFNRSTEKTKAVMEENADKKLVPTYSLEEFVESLEVPRRILIMVKAGDAT
DMMIEAVKPFLNEGDILIDGGNAFFKDTIRRNKELSEEGFNFIGTGVSGGEEGALKGPSIMPGGQRKAYDLVAPILREIA
AVADGEPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYTILKEIGGLSHDELADVFEEWNNGELDSYLIEITKNILKV
KDEETGKPIVDVILDKAGQKGTGKWTSQSALDLGVPLSLITESVFARYISALKDERVYASTVLSGPSNYRFEGDKKAFVE
SVRRALYFSKIASYAQGFAQMRAASEENDWDLQYGEIAKIFRAGCIIRARFLQKITDAYNKDKNLKNLLLDPYFKDIAHN
YQGDLRTVVAEAVKAGIPVPTFTAAISYYDSYRSEVLSANLIQAQRDYFGAHTYERVDKPGVFHTEWPQVED
>Mature_471_residues
AKQEIGVIGMGVMGRNLALNIESRGHTVSIFNRSTEKTKAVMEENADKKLVPTYSLEEFVESLEVPRRILIMVKAGDATD
MMIEAVKPFLNEGDILIDGGNAFFKDTIRRNKELSEEGFNFIGTGVSGGEEGALKGPSIMPGGQRKAYDLVAPILREIAA
VADGEPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYTILKEIGGLSHDELADVFEEWNNGELDSYLIEITKNILKVK
DEETGKPIVDVILDKAGQKGTGKWTSQSALDLGVPLSLITESVFARYISALKDERVYASTVLSGPSNYRFEGDKKAFVES
VRRALYFSKIASYAQGFAQMRAASEENDWDLQYGEIAKIFRAGCIIRARFLQKITDAYNKDKNLKNLLLDPYFKDIAHNY
QGDLRTVVAEAVKAGIPVPTFTAAISYYDSYRSEVLSANLIQAQRDYFGAHTYERVDKPGVFHTEWPQVED

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=55.1063829787234, Blast_Score=509, Evalue=1e-144,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=75.2136752136752, Blast_Score=718, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=53.0785562632696, Blast_Score=512, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6321695, Length=453, Percent_Identity=50.7726269315673, Blast_Score=471, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6321977, Length=453, Percent_Identity=51.8763796909492, Blast_Score=459, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24639279, Length=468, Percent_Identity=53.2051282051282, Blast_Score=478, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52340; Mature: 52209

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQEIGVIGMGVMGRNLALNIESRGHTVSIFNRSTEKTKAVMEENADKKLVPTYSLEEF
CCCCCCCEEEECCCCCCEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHH
VESLEVPRRILIMVKAGDATDMMIEAVKPFLNEGDILIDGGNAFFKDTIRRNKELSEEGF
HHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCC
NFIGTGVSGGEEGALKGPSIMPGGQRKAYDLVAPILREIAAVADGEPCVTYIGPDGAGHY
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
VKMVHNGIEYGDMQLIAEAYTILKEIGGLSHDELADVFEEWNNGELDSYLIEITKNILKV
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
KDEETGKPIVDVILDKAGQKGTGKWTSQSALDLGVPLSLITESVFARYISALKDERVYAS
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHH
TVLSGPSNYRFEGDKKAFVESVRRALYFSKIASYAQGFAQMRAASEENDWDLQYGEIAKI
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
FRAGCIIRARFLQKITDAYNKDKNLKNLLLDPYFKDIAHNYQGDLRTVVAEAVKAGIPVP
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
TFTAAISYYDSYRSEVLSANLIQAQRDYFGAHTYERVDKPGVFHTEWPQVED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKQEIGVIGMGVMGRNLALNIESRGHTVSIFNRSTEKTKAVMEENADKKLVPTYSLEEF
CCCCCCEEEECCCCCCEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHH
VESLEVPRRILIMVKAGDATDMMIEAVKPFLNEGDILIDGGNAFFKDTIRRNKELSEEGF
HHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCC
NFIGTGVSGGEEGALKGPSIMPGGQRKAYDLVAPILREIAAVADGEPCVTYIGPDGAGHY
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
VKMVHNGIEYGDMQLIAEAYTILKEIGGLSHDELADVFEEWNNGELDSYLIEITKNILKV
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
KDEETGKPIVDVILDKAGQKGTGKWTSQSALDLGVPLSLITESVFARYISALKDERVYAS
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHH
TVLSGPSNYRFEGDKKAFVESVRRALYFSKIASYAQGFAQMRAASEENDWDLQYGEIAKI
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
FRAGCIIRARFLQKITDAYNKDKNLKNLLLDPYFKDIAHNYQGDLRTVVAEAVKAGIPVP
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
TFTAAISYYDSYRSEVLSANLIQAQRDYFGAHTYERVDKPGVFHTEWPQVED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042 [H]