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The map label for this gene is dxr [H]

Identifier: 226223918

GI number: 226223918

Start: 1326362

End: 1327504

Strand: Direct

Name: dxr [H]

Synonym: Lm4b_01325

Alternate gene names: 226223918

Gene position: 1326362-1327504 (Clockwise)

Preceding gene: 226223917

Following gene: 226223919

Centisome position: 45.54

GC content: 39.9

Gene sequence:

>1143_bases
ATGAAAAAAATTATTTTGCTAGGTGCAACTGGTTCTATTGGAACACAAACGCTTGCAATCATTCGCGAAAACCCTGAAAA
ATTTCAAATTGTTGCGCTTAGTTTTGGGCGTAATATGGAACGTGGTAGGGCGATTATAAAAGAATTTAAACCCAAAATGG
TCGCTGTTTGGCATACGAGAGATCGTGTGATATTAGAAGCAGAATTCCCAAACGTGAAATTTTTTAATGGTTTAGAAGGG
CTTAGAGAAGTAGCGACCTATTTAGATGGAGATGTGCTTTTAAATGCAGTTATGGGGAGCGTTGGCTTACTTCCGACATT
AGATGCAATCGAAGCTGGGAAGGCCATTGCAATTGCTAATAAAGAAACGCTTGTTACGGCTGGACATTTAGTCATGCGTG
CGGCGAAAGAAAAAAACATTTCACTATTACCTGTTGATAGCGAACATTCTGCTATTTTACAAGCATTAAACGGAGAAAAT
ACGGAAAGAATCGAAAAACTAGTTTTGACAGCGAGCGGTGGAAGTTTCCGAGATAAGACGAGGGAACAACTCAGCGAGGT
TACGGTGAAAGAAGCGTTAAAACATCCGAACTGGAATATGGGGAATAAATTAACAATTGATTCAGCGACGATGTTTAACA
AAGGTTTGGAAGTGATGGAGGCGCACTGGCTGTTTGGTGTGGACTACGATGATATAGAAGTCGTTATCCAGCGCGAAAGT
ATTATCCATTCTATGGTGCAGTTTGTGGATGGAAGTTTCATCGCACAACTTGGAACGCCAGATATGCGGATGCCAATTCA
ATATGCTTTAACCTATCCCGACAGACTTTATATACCGTATGAAAAAGAATTCCGGATTACTGATTTTTCCGCACTTCATT
TTGAAAAAGTGGATTATGAAAGATTTCCGGCATTGAAACTCGCGTATAATGCTGGTAAAATAGGTGGAACAATGCCGACA
GTTTTGAATGCGGCAAATGAAATTGCTGTGGCTGGCTTTTTAAATGGACAGGTGGCTTTTTATAATATTGAAGCACTTGT
TGAGAATGCAATGAATCGTCATACTAGCATTTCTGACCCTGACTTGGATACCATTTTACAAGTCGATCAAGAAACACGCG
CGTATGTAAAGACACTTTTATAG

Upstream 100 bases:

>100_bases
TCTTACCAGGGCATGGTGGTATTTTAGACCGCTTTGATAGCTTGTTGTTCGTTTTACCTCTGCTACATATACTTCAAATT
ATTTAATTGGAGATGGGATA

Downstream 100 bases:

>100_bases
AGGTGAAGCTATTTTGACAACTATTATTGCTTTTATTTTCGTATTCGGACTGATTGTATTTTTCCATGAACTAGGACATT
TTCTTTTTGCAAAACGTGCT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKKIILLGATGSIGTQTLAIIRENPEKFQIVALSFGRNMERGRAIIKEFKPKMVAVWHTRDRVILEAEFPNVKFFNGLEG
LREVATYLDGDVLLNAVMGSVGLLPTLDAIEAGKAIAIANKETLVTAGHLVMRAAKEKNISLLPVDSEHSAILQALNGEN
TERIEKLVLTASGGSFRDKTREQLSEVTVKEALKHPNWNMGNKLTIDSATMFNKGLEVMEAHWLFGVDYDDIEVVIQRES
IIHSMVQFVDGSFIAQLGTPDMRMPIQYALTYPDRLYIPYEKEFRITDFSALHFEKVDYERFPALKLAYNAGKIGGTMPT
VLNAANEIAVAGFLNGQVAFYNIEALVENAMNRHTSISDPDLDTILQVDQETRAYVKTLL

Sequences:

>Translated_380_residues
MKKIILLGATGSIGTQTLAIIRENPEKFQIVALSFGRNMERGRAIIKEFKPKMVAVWHTRDRVILEAEFPNVKFFNGLEG
LREVATYLDGDVLLNAVMGSVGLLPTLDAIEAGKAIAIANKETLVTAGHLVMRAAKEKNISLLPVDSEHSAILQALNGEN
TERIEKLVLTASGGSFRDKTREQLSEVTVKEALKHPNWNMGNKLTIDSATMFNKGLEVMEAHWLFGVDYDDIEVVIQRES
IIHSMVQFVDGSFIAQLGTPDMRMPIQYALTYPDRLYIPYEKEFRITDFSALHFEKVDYERFPALKLAYNAGKIGGTMPT
VLNAANEIAVAGFLNGQVAFYNIEALVENAMNRHTSISDPDLDTILQVDQETRAYVKTLL
>Mature_380_residues
MKKIILLGATGSIGTQTLAIIRENPEKFQIVALSFGRNMERGRAIIKEFKPKMVAVWHTRDRVILEAEFPNVKFFNGLEG
LREVATYLDGDVLLNAVMGSVGLLPTLDAIEAGKAIAIANKETLVTAGHLVMRAAKEKNISLLPVDSEHSAILQALNGEN
TERIEKLVLTASGGSFRDKTREQLSEVTVKEALKHPNWNMGNKLTIDSATMFNKGLEVMEAHWLFGVDYDDIEVVIQRES
IIHSMVQFVDGSFIAQLGTPDMRMPIQYALTYPDRLYIPYEKEFRITDFSALHFEKVDYERFPALKLAYNAGKIGGTMPT
VLNAANEIAVAGFLNGQVAFYNIEALVENAMNRHTSISDPDLDTILQVDQETRAYVKTLL

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=392, Percent_Identity=41.5816326530612, Blast_Score=289, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42333; Mature: 42333

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIILLGATGSIGTQTLAIIRENPEKFQIVALSFGRNMERGRAIIKEFKPKMVAVWHTR
CCEEEEEECCCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECC
DRVILEAEFPNVKFFNGLEGLREVATYLDGDVLLNAVMGSVGLLPTLDAIEAGKAIAIAN
CEEEEEECCCCCEEHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEC
KETLVTAGHLVMRAAKEKNISLLPVDSEHSAILQALNGENTERIEKLVLTASGGSFRDKT
CCEEEEHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCHHHHEEEEEEECCCCCHHHH
REQLSEVTVKEALKHPNWNMGNKLTIDSATMFNKGLEVMEAHWLFGVDYDDIEVVIQRES
HHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHCHHHEEEHEEECCCCCCEEEEEEHHH
IIHSMVQFVDGSFIAQLGTPDMRMPIQYALTYPDRLYIPYEKEFRITDFSALHFEKVDYE
HHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCEEEECCCCCEEEECCCHHEEECCCHH
RFPALKLAYNAGKIGGTMPTVLNAANEIAVAGFLNGQVAFYNIEALVENAMNRHTSISDP
HCCCEEEEECCCCCCCCHHHHHHCCCCEEEEEEECCEEEEEEHHHHHHHHHHCCCCCCCC
DLDTILQVDQETRAYVKTLL
CHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MKKIILLGATGSIGTQTLAIIRENPEKFQIVALSFGRNMERGRAIIKEFKPKMVAVWHTR
CCEEEEEECCCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECC
DRVILEAEFPNVKFFNGLEGLREVATYLDGDVLLNAVMGSVGLLPTLDAIEAGKAIAIAN
CEEEEEECCCCCEEHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEC
KETLVTAGHLVMRAAKEKNISLLPVDSEHSAILQALNGENTERIEKLVLTASGGSFRDKT
CCEEEEHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCHHHHEEEEEEECCCCCHHHH
REQLSEVTVKEALKHPNWNMGNKLTIDSATMFNKGLEVMEAHWLFGVDYDDIEVVIQRES
HHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHCHHHEEEHEEECCCCCCEEEEEEHHH
IIHSMVQFVDGSFIAQLGTPDMRMPIQYALTYPDRLYIPYEKEFRITDFSALHFEKVDYE
HHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCEEEECCCCCEEEECCCHHEEECCCHH
RFPALKLAYNAGKIGGTMPTVLNAANEIAVAGFLNGQVAFYNIEALVENAMNRHTSISDP
HCCCEEEEECCCCCCCCHHHHHHCCCCEEEEEEECCEEEEEEHHHHHHHHHHCCCCCCCC
DLDTILQVDQETRAYVKTLL
CHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]