Click here to switch to the map view.

The map label for this gene is tkt

Identifier: 226223907

GI number: 226223907

Start: 1316355

End: 1318349

Strand: Direct

Name: tkt

Synonym: Lm4b_01314

Alternate gene names: 226223907

Gene position: 1316355-1318349 (Clockwise)

Preceding gene: 226223906

Following gene: 226223908

Centisome position: 45.19

GC content: 39.85

Gene sequence:

>1995_bases
TTGTTCGATAACACAGATAGTTTAGCAGTGAATACAATTCGTACATTATCAATGGACGCAATTCAAAAAGCAAATTCTGG
TCATCCAGGATTACCAATGGGAGCAGCACCAATGGCTTACGCACTTTGGTCGCGTGTATTAAATACTAACCCTAAGAATT
CACATTGGTTTAACCGAGATCGTTTTGTACTTTCTGCTGGACACGGCTCAATGCTTTTATATAGTTTATTACACTTAAGT
GGATTCAAATTAGAATTAGAAGATCTTAAAAATTTCCGTCAATGGGAAAGTAAAACTCCTGGTCACCCAGAATATCGTTA
TACAGATGGTGTAGACGCAACTACTGGTCCACTTGGTCAAGGTATTGCGATGGCTGTTGGTATGGCTATGGCAGAAAGAC
ATTTAGAAGCGAAATATAATAAAGATGGTTTCCCGGTAGTGGATCATTATACTTATGCACTATGCGGAGATGGTGACTTA
ATGGAAGGTGTTGCTTCAGAAGCGGCTTCTTATGCAGGTCATCAACAATTAGGAAGATTAGTTGTTCTCTATGATTCCAA
TGATATCTCTCTTGATGGTGATTTAGACAAATCTTTCTCTGAAAATGTAAAACAACGCTTTGAAGCTTATGGCTGGGAAC
ATTTATTAGTAAAAGACGGTAATGATACAGCTGAAATTTTAGCAGCAATCGAAAAAGCGAAACAAAACACTTCTCAACCT
ACTATGATTGAAGTGAAAACTGTTATCGGTTTTGGTGCTCCAAATGCCGGTACAAGTAAAGTTCACGGTGCTCCACTAGG
CGATGAAGGTATTTTAGAAGCGAAAAAAGCTTATGGTTGGAACTACGAAGAGAAATTCTTTGTTCCTGAAGAAGTTACTG
CTCGCTTTAAAGAAACAATTGGCGAACGTGGTGAAAAAGCAGAAACAGCTTGGAATGAGTTATTTGCTTCCTATAAAGCA
GAATATCCAGAGCTTGCGAAACAATTAGAAGATAGCTTGAACAACAAGTTACCAGCTGATTGGGATGAGGATCTTCCAGT
ATATGATGATTCAAAAGCACTTGCTAGCCGTGCTTCCAGTGGAGAAGTTATCAATGCGTTAGCTGGAAAAATCCCAACTA
TTTTTGGCGGATCTGCTGACCTTGCAGGTTCGAATAATACAACAATTAAAACAGACGGTGAATTTACAAAAGCGACTCCA
GCTGAAAGAAACATTTGGTTTGGTGTTCGTGAATTTGCGATGGGCGCTGCATTAAATGGTATGGCACTTCACGGCGGATT
ACAAGTATACGGTGGTACATTCTTCGTATTCTCTGACTATGTACGTGCTGCTATTCGTTTATCAGCTATTCAACATTTAC
CAGTAACCTATGTAATGACGCATGATAGTATTGCAGTTGGGGAAGATGGCCCAACACATGAGCCAATCGAACAACTTGCA
AGCTTACGCGCAATGCCAGGGCTTTCTGTTATTCGTCCTGCTGATGGAAATGAAGTTGTGGAGGCTTGGAAACTTGCTAT
CACTTCTACATCTACACCGCATGTACTTGTTCTTACTCGTCAAGGCCTACCAACACTACCAAATTCTGCTAAATTAACTG
CAGAAGGCGTTAAAAAAGGTGCTTATGTTATTTCCCCAGCTAAAGGTGACGTGCCAGAAGCAATCATCCTAGCGAGTGGT
TCTGAAGTTAACTTAGCTATTGAAGCGCAAAAAGAACTTCAAGTTCAAGGAACAGATGTATCAGTTGTCAGTGTGCCATC
ATTTGATCTATTCGAGCAACAATCTGCTGAGTACAAAGAAAGTGTATTACCGAATGCTGTTAGAAAACGTGTAGCAGTAG
AGATGGGCGCTAGCTTTGGATGGGAACGTTATGTTGGTTTAGATGGTAAAGTTATCGGAATTGACAAATTTGGTGCTTCT
GCTCCAGGTGAAACAGTTATTAAGAATTACGGCTTTACTGTTGAAAACGTAGTTAATACAGTAAAATCACTTTAA

Upstream 100 bases:

>100_bases
AATCAATTAAGCAATTTAAAGCAATTATTAGTTGTGTTAATTGCTTTTTAGGCTTATTATTAAAAGTAGTTAAAATTATA
TTGAAGAGAGGATGTTTCAT

Downstream 100 bases:

>100_bases
TTAAACAATCAGACCGTTGCTAATTTTTCTAGAGCGGTCTGTTTTTTTATGCTTTTTTTAGATTGCGCCGTAGTACCATT
AATGGTATAATTACGAGGTT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 664; Mature: 664

Protein sequence:

>664_residues
MFDNTDSLAVNTIRTLSMDAIQKANSGHPGLPMGAAPMAYALWSRVLNTNPKNSHWFNRDRFVLSAGHGSMLLYSLLHLS
GFKLELEDLKNFRQWESKTPGHPEYRYTDGVDATTGPLGQGIAMAVGMAMAERHLEAKYNKDGFPVVDHYTYALCGDGDL
MEGVASEAASYAGHQQLGRLVVLYDSNDISLDGDLDKSFSENVKQRFEAYGWEHLLVKDGNDTAEILAAIEKAKQNTSQP
TMIEVKTVIGFGAPNAGTSKVHGAPLGDEGILEAKKAYGWNYEEKFFVPEEVTARFKETIGERGEKAETAWNELFASYKA
EYPELAKQLEDSLNNKLPADWDEDLPVYDDSKALASRASSGEVINALAGKIPTIFGGSADLAGSNNTTIKTDGEFTKATP
AERNIWFGVREFAMGAALNGMALHGGLQVYGGTFFVFSDYVRAAIRLSAIQHLPVTYVMTHDSIAVGEDGPTHEPIEQLA
SLRAMPGLSVIRPADGNEVVEAWKLAITSTSTPHVLVLTRQGLPTLPNSAKLTAEGVKKGAYVISPAKGDVPEAIILASG
SEVNLAIEAQKELQVQGTDVSVVSVPSFDLFEQQSAEYKESVLPNAVRKRVAVEMGASFGWERYVGLDGKVIGIDKFGAS
APGETVIKNYGFTVENVVNTVKSL

Sequences:

>Translated_664_residues
MFDNTDSLAVNTIRTLSMDAIQKANSGHPGLPMGAAPMAYALWSRVLNTNPKNSHWFNRDRFVLSAGHGSMLLYSLLHLS
GFKLELEDLKNFRQWESKTPGHPEYRYTDGVDATTGPLGQGIAMAVGMAMAERHLEAKYNKDGFPVVDHYTYALCGDGDL
MEGVASEAASYAGHQQLGRLVVLYDSNDISLDGDLDKSFSENVKQRFEAYGWEHLLVKDGNDTAEILAAIEKAKQNTSQP
TMIEVKTVIGFGAPNAGTSKVHGAPLGDEGILEAKKAYGWNYEEKFFVPEEVTARFKETIGERGEKAETAWNELFASYKA
EYPELAKQLEDSLNNKLPADWDEDLPVYDDSKALASRASSGEVINALAGKIPTIFGGSADLAGSNNTTIKTDGEFTKATP
AERNIWFGVREFAMGAALNGMALHGGLQVYGGTFFVFSDYVRAAIRLSAIQHLPVTYVMTHDSIAVGEDGPTHEPIEQLA
SLRAMPGLSVIRPADGNEVVEAWKLAITSTSTPHVLVLTRQGLPTLPNSAKLTAEGVKKGAYVISPAKGDVPEAIILASG
SEVNLAIEAQKELQVQGTDVSVVSVPSFDLFEQQSAEYKESVLPNAVRKRVAVEMGASFGWERYVGLDGKVIGIDKFGAS
APGETVIKNYGFTVENVVNTVKSL
>Mature_664_residues
MFDNTDSLAVNTIRTLSMDAIQKANSGHPGLPMGAAPMAYALWSRVLNTNPKNSHWFNRDRFVLSAGHGSMLLYSLLHLS
GFKLELEDLKNFRQWESKTPGHPEYRYTDGVDATTGPLGQGIAMAVGMAMAERHLEAKYNKDGFPVVDHYTYALCGDGDL
MEGVASEAASYAGHQQLGRLVVLYDSNDISLDGDLDKSFSENVKQRFEAYGWEHLLVKDGNDTAEILAAIEKAKQNTSQP
TMIEVKTVIGFGAPNAGTSKVHGAPLGDEGILEAKKAYGWNYEEKFFVPEEVTARFKETIGERGEKAETAWNELFASYKA
EYPELAKQLEDSLNNKLPADWDEDLPVYDDSKALASRASSGEVINALAGKIPTIFGGSADLAGSNNTTIKTDGEFTKATP
AERNIWFGVREFAMGAALNGMALHGGLQVYGGTFFVFSDYVRAAIRLSAIQHLPVTYVMTHDSIAVGEDGPTHEPIEQLA
SLRAMPGLSVIRPADGNEVVEAWKLAITSTSTPHVLVLTRQGLPTLPNSAKLTAEGVKKGAYVISPAKGDVPEAIILASG
SEVNLAIEAQKELQVQGTDVSVVSVPSFDLFEQQSAEYKESVLPNAVRKRVAVEMGASFGWERYVGLDGKVIGIDKFGAS
APGETVIKNYGFTVENVVNTVKSL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=501, Percent_Identity=28.7425149700599, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI4507521, Length=501, Percent_Identity=28.7425149700599, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI133778974, Length=582, Percent_Identity=26.1168384879725, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI225637459, Length=450, Percent_Identity=23.7777777777778, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI225637463, Length=451, Percent_Identity=23.7250554323725, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI225637461, Length=451, Percent_Identity=23.7250554323725, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI48994911, Length=660, Percent_Identity=47.7272727272727, Blast_Score=612, Evalue=1e-176,
Organism=Escherichia coli, GI1788808, Length=654, Percent_Identity=46.4831804281346, Blast_Score=590, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI17539652, Length=672, Percent_Identity=25.1488095238095, Blast_Score=155, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=664, Percent_Identity=47.4397590361446, Blast_Score=598, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6319593, Length=667, Percent_Identity=46.0269865067466, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI45551847, Length=520, Percent_Identity=28.4615384615385, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI45550715, Length=520, Percent_Identity=28.4615384615385, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24666278, Length=507, Percent_Identity=27.2189349112426, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24645119, Length=491, Percent_Identity=28.3095723014257, Blast_Score=143, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71872; Mature: 71872

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2 ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNTDSLAVNTIRTLSMDAIQKANSGHPGLPMGAAPMAYALWSRVLNTNPKNSHWFNRD
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
RFVLSAGHGSMLLYSLLHLSGFKLELEDLKNFRQWESKTPGHPEYRYTDGVDATTGPLGQ
EEEEECCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCC
GIAMAVGMAMAERHLEAKYNKDGFPVVDHYTYALCGDGDLMEGVASEAASYAGHQQLGRL
HHHHHHHHHHHHHHHHHCCCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHCCHHHHCCE
VVLYDSNDISLDGDLDKSFSENVKQRFEAYGWEHLLVKDGNDTAEILAAIEKAKQNTSQP
EEEECCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCC
TMIEVKTVIGFGAPNAGTSKVHGAPLGDEGILEAKKAYGWNYEEKFFVPEEVTARFKETI
EEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEECCHHHHHHHHHHH
GERGEKAETAWNELFASYKAEYPELAKQLEDSLNNKLPADWDEDLPVYDDSKALASRASS
HCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCC
GEVINALAGKIPTIFGGSADLAGSNNTTIKTDGEFTKATPAERNIWFGVREFAMGAALNG
CHHHHHHHCCCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCEEHHHHHHHHHHHCCC
MALHGGLQVYGGTFFVFSDYVRAAIRLSAIQHLPVTYVMTHDSIAVGEDGPTHEPIEQLA
EEEECCEEEECCEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHH
SLRAMPGLSVIRPADGNEVVEAWKLAITSTSTPHVLVLTRQGLPTLPNSAKLTAEGVKKG
HHHCCCCCCEECCCCCHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCEEEHHHHCCC
AYVISPAKGDVPEAIILASGSEVNLAIEAQKELQVQGTDVSVVSVPSFDLFEQQSAEYKE
CEEEECCCCCCCCEEEEECCCEEEEEEEECCCEEEECCCEEEEECCCHHHHHHHHHHHHH
SVLPNAVRKRVAVEMGASFGWERYVGLDGKVIGIDKFGASAPGETVIKNYGFTVENVVNT
HHCHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHHH
VKSL
HHCC
>Mature Secondary Structure
MFDNTDSLAVNTIRTLSMDAIQKANSGHPGLPMGAAPMAYALWSRVLNTNPKNSHWFNRD
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
RFVLSAGHGSMLLYSLLHLSGFKLELEDLKNFRQWESKTPGHPEYRYTDGVDATTGPLGQ
EEEEECCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCC
GIAMAVGMAMAERHLEAKYNKDGFPVVDHYTYALCGDGDLMEGVASEAASYAGHQQLGRL
HHHHHHHHHHHHHHHHHCCCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHCCHHHHCCE
VVLYDSNDISLDGDLDKSFSENVKQRFEAYGWEHLLVKDGNDTAEILAAIEKAKQNTSQP
EEEECCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCC
TMIEVKTVIGFGAPNAGTSKVHGAPLGDEGILEAKKAYGWNYEEKFFVPEEVTARFKETI
EEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEECCHHHHHHHHHHH
GERGEKAETAWNELFASYKAEYPELAKQLEDSLNNKLPADWDEDLPVYDDSKALASRASS
HCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCC
GEVINALAGKIPTIFGGSADLAGSNNTTIKTDGEFTKATPAERNIWFGVREFAMGAALNG
CHHHHHHHCCCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCEEHHHHHHHHHHHCCC
MALHGGLQVYGGTFFVFSDYVRAAIRLSAIQHLPVTYVMTHDSIAVGEDGPTHEPIEQLA
EEEECCEEEECCEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHH
SLRAMPGLSVIRPADGNEVVEAWKLAITSTSTPHVLVLTRQGLPTLPNSAKLTAEGVKKG
HHHCCCCCCEECCCCCHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCEEEHHHHCCC
AYVISPAKGDVPEAIILASGSEVNLAIEAQKELQVQGTDVSVVSVPSFDLFEQQSAEYKE
CEEEECCCCCCCCEEEEECCCEEEEEEEECCCEEEECCCEEEEECCCHHHHHHHHHHHHH
SVLPNAVRKRVAVEMGASFGWERYVGLDGKVIGIDKFGASAPGETVIKNYGFTVENVVNT
HHCHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHHH
VKSL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 9068642 [H]