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The map label for this gene is isdG

Identifier: 226223107

GI number: 226223107

Start: 516635

End: 517000

Strand: Direct

Name: isdG

Synonym: Lm4b_00504

Alternate gene names: 226223107

Gene position: 516635-517000 (Clockwise)

Preceding gene: 226223106

Following gene: 226223108

Centisome position: 17.74

GC content: 42.9

Gene sequence:

>366_bases
ATGATTATTGTAACTAATACGATTAAGGTAGAAAAAGGCGCAGCAGAGCACGTTATCCGTCAGTTCACAGGCGCAAATGG
CGACGGACATCCAACAAAAGATATCGCAGAAGTAGAAGGTTTCCTAGGCTTCGAACTATGGCACAGCAAACCAGAAGACA
AAGACTATGAAGAAGTAGTCGTAACAAGCAAATGGGAAAGTGAAGAAGCCCAACGCAATTGGGTGAAAAGCGATTCCTTC
AAAAAAGCACACGGCAGAACAAAAGACACTAGAGAACAAAGAGAAGACCGCAAAGGCATCGTAGGAAATGCAATCGCTCG
TTTTGAAGTGGTTCACGTGCAAAACCCTGTGATTGTTGAAAAATAA

Upstream 100 bases:

>100_bases
AAGCCCATTCCCTAAAATTGACATTGAGAATCATTATCAATATAATGGAAGGAACTAGCCTATTATACATACAATACAAT
TATCCAAGGGGGATTTAAGA

Downstream 100 bases:

>100_bases
GAAGTGAATGAACAAGCCGTTTCGAGGTAGATGGCTTGTTTTTTTGCGCGCTCGAATTTTCAGATAATTATTGAATTTTT
ATATCTTATGCGGTATATTA

Product: heme-degrading monooxygenase IsdG

Products: NA

Alternate protein names: Heme oxygenase; Iron-regulated surface determinant isdG; Iron-responsive surface determinant isdG

Number of amino acids: Translated: 121; Mature: 121

Protein sequence:

>121_residues
MIIVTNTIKVEKGAAEHVIRQFTGANGDGHPTKDIAEVEGFLGFELWHSKPEDKDYEEVVVTSKWESEEAQRNWVKSDSF
KKAHGRTKDTREQREDRKGIVGNAIARFEVVHVQNPVIVEK

Sequences:

>Translated_121_residues
MIIVTNTIKVEKGAAEHVIRQFTGANGDGHPTKDIAEVEGFLGFELWHSKPEDKDYEEVVVTSKWESEEAQRNWVKSDSF
KKAHGRTKDTREQREDRKGIVGNAIARFEVVHVQNPVIVEK
>Mature_121_residues
MIIVTNTIKVEKGAAEHVIRQFTGANGDGHPTKDIAEVEGFLGFELWHSKPEDKDYEEVVVTSKWESEEAQRNWVKSDSF
KKAHGRTKDTREQREDRKGIVGNAIARFEVVHVQNPVIVEK

Specific function: Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subseque

COG id: COG2329

COG function: function code R; Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase isdG subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISDG_LISIN (Q7AP29)

Other databases:

- EMBL:   AL596165
- RefSeq:   NP_469830.1
- ProteinModelPortal:   Q7AP29
- GeneID:   1128937
- GenomeReviews:   AL592022_GR
- KEGG:   lin:lin0487
- GenoList:   LIN0487
- HOGENOM:   HBG112566
- OMA:   WTKSSAF
- ProtClustDB:   PRK13316
- BioCyc:   LINN272626:LIN0487-MONOMER
- BRENDA:   1.14.99.3
- GO:   GO:0005737
- HAMAP:   MF_01272
- InterPro:   IPR007138
- InterPro:   IPR011008

Pfam domain/function: PF03992 ABM; SSF54909 Dimer_A_B_barrel

EC number: =1.14.99.3

Molecular weight: Translated: 13786; Mature: 13786

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVTNTIKVEKGAAEHVIRQFTGANGDGHPTKDIAEVEGFLGFELWHSKPEDKDYEEVV
CEEECCEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHEE
VTSKWESEEAQRNWVKSDSFKKAHGRTKDTREQREDRKGIVGNAIARFEVVHVQNPVIVE
EECCCCCHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHCCCCCCHHHHEEEEECCCCEEEC
K
C
>Mature Secondary Structure
MIIVTNTIKVEKGAAEHVIRQFTGANGDGHPTKDIAEVEGFLGFELWHSKPEDKDYEEVV
CEEECCEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHEE
VTSKWESEEAQRNWVKSDSFKKAHGRTKDTREQREDRKGIVGNAIARFEVVHVQNPVIVE
EECCCCCHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHCCCCCCHHHHEEEEECCCCEEEC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669