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The map label for this gene is clpC

Identifier: 226222861

GI number: 226222861

Start: 247197

End: 249659

Strand: Direct

Name: clpC

Synonym: Lm4b_00252

Alternate gene names: 226222861

Gene position: 247197-249659 (Clockwise)

Preceding gene: 226222860

Following gene: 226222862

Centisome position: 8.49

GC content: 40.4

Gene sequence:

>2463_bases
ATGATGTTTGGACGATTTACGCAAAGAGCTCAGAAAGTACTCGCGTTGTCACAAGAAGAGGCGATGCGTTTGAATCATAG
TAATTTAGGAACAGAACATATTTTATTAGGGCTTGTAAGAGAAGGCGAAGGAATTGCGGCAAAAGCTCTCTATGAACTGG
GAATTAGTTCTGAAAAAGTGCAGCAAGAGGTAGAAGGATTAATTGGTCATGGGGAAAAAGCTGTGACGACGATCCAATAT
ACACCTCGTGCGAAAAAAGTAATTGAACTGTCCATGGATGAGGCTCGTAAATTAGGGCATACTTATGTTGGAACAGAACA
TATCTTACTGGGGCTTATTCGTGAAGGCGAAGGAGTTGCGGCTCGAGTTTTAAGTAATCTTGGTATTAGTTTGAATAAAG
CTCGTCAGCAAGTTTTACAGCTCTTAGGCGGCGGGGATGCTACTGGGGCAGGAAGACAAACAAATACACAGGCTACACCG
ACTTTAGATAGTTTGGCACGTGATTTAACAGTTATTGCTCGGGAAGATAATTTGGATCCGGTTATTGGCCGTTCTAAAGA
AATCCAACGTGTGATTGAAGTGCTTAGTCGTCGTACGAAGAATAACCCAGTACTTATTGGAGAACCTGGTGTTGGTAAAA
CAGCGATTGCAGAAGGACTAGCGCAACAAATTGTTCGTAATGAAGTGCCTGAGACTTTACGTGGAAAACGTGTAATGACA
CTGGATATGGGGACTGTTGTGGCAGGGACAAAATATCGTGGTGAATTTGAAGACCGTTTGAAAAAAGTAATGGATGAGAT
TCGTCAAGCCGGCAATGTTATTCTATTTATTGATGAATTGCATACCTTAATTGGTGCTGGTGGAGCGGAAGGTGCGATTG
ATGCCTCGAATATCTTGAAGCCGCCTCTAGCTCGTGGTGAGTTGCAATGTATTGGTGCAACAACACTGGATGAGTACCGT
AAATATATTGAAAAAGATGCTGCACTTGAGAGACGTTTCCAACCGATTAAAGTAGATGAGCCAACTGTAGAAGAATCCAT
TCAAATTTTACATGGGTTGCGTGATCGTTATGAGGCGCATCACCGTGTTGCGATTACTGATGAAGCGCTTGAGGCTGCTG
TTCGTCTATCTGATCGGTACATTTCAGACCGTTTCTTACCGGATAAAGCGATTGATGTTATTGATGAATCTGGTTCTAAA
GTACGTTTGAAATCTTTTACAACGCCAAAAAATGTAAAAGAAATGGAAAACAATTTATCCGATTTGAAAAAAGAAAAAGA
TGCGGCTGTTCAAGGGCAAGAATTTGAAAAAGCAGCGTCATTACGCGATAAAGAACAAAAACTTAAAAAATCATTAGAAG
AAACAAAAGCGAATTGGCAAGAAAAGCAAGGGCTTGACCATAGTGAAGTAACAGAAGAGATTGTTGCTGAAGTTGTTGCA
AGTTGGACTGGGATTCCAGTTGCAAAACTTGCGGAAACAGAGACAAATAAACTTTTAAATATGGAGAAACTTTTACATGA
ACGCGTGATTGGGCAAGATGCTGCGGTGAAAGCTGTTTCGCTAGCTGTACGTAGAGCTCGTGCTGGACTTAAAGATCCTA
AGCGTCCAATTGGTTCCTTTATTTTCCTTGGACCTACTGGTGTTGGGAAAACAGAACTTGCTCGCGCGCTTGCTGAGTCT
ATGTTTGGCGATGAGGATTCGATGATTCGAATTGACATGTCTGAGTACATGGAGAAATTCTCGACTGCTCGTTTAGTTGG
GGCTCCTCCAGGTTATGTAGGCTATGAAGAAGGTGGGCAACTGACAGAAAAAGTTCGTCAAAAACCTTATTCAGTAGTTC
TTTTAGATGAAATTGAAAAAGCGCATCCGGATGTATTTAATATGTTGCTACAAGTGCTTGACGATGGTCGTTTGACTGAT
TCTAAAGGACGGGTGGTTGATTTTAGAAATACGGTCATCATTATGACTTCCAATATTGGGGCTCAAGAAATGAAACAAGA
TAAATCAATGGGCTTTAATGTTATTGATCCGCTTAAAGACCATAAAGCTATGGAGCACCGTGTTTTACAAGATTTAAAAC
AGGCGTTCCGGCCAGAGTTTATCAACCGAATTGATGAAACAATTGTATTCCATTCGCTACAAGAAAAAGAATTGAAACAA
ATTGTTACTTTGCTGACTGCTCAATTAACAAAACGATTAGCCGAACGCGATATTCATGTGAAATTAACTGAAGGTGCGAA
ATCCAAAATTGCTAAAGACGGATACGATCCAGAATACGGAGCCCGTCCTTTGAAACGAGCTATTCAAAAAGAAGTGGAAG
ATATGCTTTCTGAAGAATTACTTCGTGGTAACATTAAAGTAGGCGATTACGTGGAAATTGGTGTAAAAGATGGCAAGTTA
GAGGTTAGAAAAAAAGACGCACCAAAAAAGAAAACAACCGCAAAAAAAGTAAAAACTAAATAA

Upstream 100 bases:

>100_bases
CGAGATATGGATGAATTAGAAGAGAAAGTAATACGGGCCAAAGTGATTCGCGAGATTTTGGGCGATAAATGATGAGGCTT
ACGATAAGGAGGAAACAACA

Downstream 100 bases:

>100_bases
CAAACACGCCTCCCTTAATCAATTTTGAAGGGAGGTTTTTTATGGAAAAATCAGGATTCGTGTCAAAAAAACGAATTTGA
TGAAAAGGATTAACGCGAAC

Product: endopeptidase Clp ATP-binding chain C

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 820; Mature: 820

Protein sequence:

>820_residues
MMFGRFTQRAQKVLALSQEEAMRLNHSNLGTEHILLGLVREGEGIAAKALYELGISSEKVQQEVEGLIGHGEKAVTTIQY
TPRAKKVIELSMDEARKLGHTYVGTEHILLGLIREGEGVAARVLSNLGISLNKARQQVLQLLGGGDATGAGRQTNTQATP
TLDSLARDLTVIAREDNLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVRNEVPETLRGKRVMT
LDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNVILFIDELHTLIGAGGAEGAIDASNILKPPLARGELQCIGATTLDEYR
KYIEKDAALERRFQPIKVDEPTVEESIQILHGLRDRYEAHHRVAITDEALEAAVRLSDRYISDRFLPDKAIDVIDESGSK
VRLKSFTTPKNVKEMENNLSDLKKEKDAAVQGQEFEKAASLRDKEQKLKKSLEETKANWQEKQGLDHSEVTEEIVAEVVA
SWTGIPVAKLAETETNKLLNMEKLLHERVIGQDAAVKAVSLAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAES
MFGDEDSMIRIDMSEYMEKFSTARLVGAPPGYVGYEEGGQLTEKVRQKPYSVVLLDEIEKAHPDVFNMLLQVLDDGRLTD
SKGRVVDFRNTVIIMTSNIGAQEMKQDKSMGFNVIDPLKDHKAMEHRVLQDLKQAFRPEFINRIDETIVFHSLQEKELKQ
IVTLLTAQLTKRLAERDIHVKLTEGAKSKIAKDGYDPEYGARPLKRAIQKEVEDMLSEELLRGNIKVGDYVEIGVKDGKL
EVRKKDAPKKKTTAKKVKTK

Sequences:

>Translated_820_residues
MMFGRFTQRAQKVLALSQEEAMRLNHSNLGTEHILLGLVREGEGIAAKALYELGISSEKVQQEVEGLIGHGEKAVTTIQY
TPRAKKVIELSMDEARKLGHTYVGTEHILLGLIREGEGVAARVLSNLGISLNKARQQVLQLLGGGDATGAGRQTNTQATP
TLDSLARDLTVIAREDNLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVRNEVPETLRGKRVMT
LDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNVILFIDELHTLIGAGGAEGAIDASNILKPPLARGELQCIGATTLDEYR
KYIEKDAALERRFQPIKVDEPTVEESIQILHGLRDRYEAHHRVAITDEALEAAVRLSDRYISDRFLPDKAIDVIDESGSK
VRLKSFTTPKNVKEMENNLSDLKKEKDAAVQGQEFEKAASLRDKEQKLKKSLEETKANWQEKQGLDHSEVTEEIVAEVVA
SWTGIPVAKLAETETNKLLNMEKLLHERVIGQDAAVKAVSLAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAES
MFGDEDSMIRIDMSEYMEKFSTARLVGAPPGYVGYEEGGQLTEKVRQKPYSVVLLDEIEKAHPDVFNMLLQVLDDGRLTD
SKGRVVDFRNTVIIMTSNIGAQEMKQDKSMGFNVIDPLKDHKAMEHRVLQDLKQAFRPEFINRIDETIVFHSLQEKELKQ
IVTLLTAQLTKRLAERDIHVKLTEGAKSKIAKDGYDPEYGARPLKRAIQKEVEDMLSEELLRGNIKVGDYVEIGVKDGKL
EVRKKDAPKKKTTAKKVKTK
>Mature_820_residues
MMFGRFTQRAQKVLALSQEEAMRLNHSNLGTEHILLGLVREGEGIAAKALYELGISSEKVQQEVEGLIGHGEKAVTTIQY
TPRAKKVIELSMDEARKLGHTYVGTEHILLGLIREGEGVAARVLSNLGISLNKARQQVLQLLGGGDATGAGRQTNTQATP
TLDSLARDLTVIAREDNLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVRNEVPETLRGKRVMT
LDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNVILFIDELHTLIGAGGAEGAIDASNILKPPLARGELQCIGATTLDEYR
KYIEKDAALERRFQPIKVDEPTVEESIQILHGLRDRYEAHHRVAITDEALEAAVRLSDRYISDRFLPDKAIDVIDESGSK
VRLKSFTTPKNVKEMENNLSDLKKEKDAAVQGQEFEKAASLRDKEQKLKKSLEETKANWQEKQGLDHSEVTEEIVAEVVA
SWTGIPVAKLAETETNKLLNMEKLLHERVIGQDAAVKAVSLAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAES
MFGDEDSMIRIDMSEYMEKFSTARLVGAPPGYVGYEEGGQLTEKVRQKPYSVVLLDEIEKAHPDVFNMLLQVLDDGRLTD
SKGRVVDFRNTVIIMTSNIGAQEMKQDKSMGFNVIDPLKDHKAMEHRVLQDLKQAFRPEFINRIDETIVFHSLQEKELKQ
IVTLLTAQLTKRLAERDIHVKLTEGAKSKIAKDGYDPEYGARPLKRAIQKEVEDMLSEELLRGNIKVGDYVEIGVKDGKL
EVRKKDAPKKKTTAKKVKTK

Specific function: Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=318, Percent_Identity=36.4779874213836, Blast_Score=210, Evalue=4e-54,
Organism=Escherichia coli, GI1788943, Length=869, Percent_Identity=47.5258918296893, Blast_Score=744, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=488, Percent_Identity=37.0901639344262, Blast_Score=295, Evalue=8e-81,
Organism=Saccharomyces cerevisiae, GI6320464, Length=706, Percent_Identity=48.5835694050992, Blast_Score=642, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=400, Percent_Identity=41.25, Blast_Score=296, Evalue=9e-81,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 91207; Mature: 91207

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFGRFTQRAQKVLALSQEEAMRLNHSNLGTEHILLGLVREGEGIAAKALYELGISSEKV
CCCCHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
QQEVEGLIGHGEKAVTTIQYTPRAKKVIELSMDEARKLGHTYVGTEHILLGLIREGEGVA
HHHHHHHHCCCCHHEEEEEECCCHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCHHH
ARVLSNLGISLNKARQQVLQLLGGGDATGAGRQTNTQATPTLDSLARDLTVIAREDNLDP
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEECCCCCC
VIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVRNEVPETLRGKRVMT
CCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCCEEEE
LDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNVILFIDELHTLIGAGGAEGAIDASNILK
EECCCEEECCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCHHHHCC
PPLARGELQCIGATTLDEYRKYIEKDAALERRFQPIKVDEPTVEESIQILHGLRDRYEAH
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HRVAITDEALEAAVRLSDRYISDRFLPDKAIDVIDESGSKVRLKSFTTPKNVKEMENNLS
CEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
DLKKEKDAAVQGQEFEKAASLRDKEQKLKKSLEETKANWQEKQGLDHSEVTEEIVAEVVA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
SWTGIPVAKLAETETNKLLNMEKLLHERVIGQDAAVKAVSLAVRRARAGLKDPKRPIGSF
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCE
IFLGPTGVGKTELARALAESMFGDEDSMIRIDMSEYMEKFSTARLVGAPPGYVGYEEGGQ
EEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHCEEECCCCCCCCCCCCCH
LTEKVRQKPYSVVLLDEIEKAHPDVFNMLLQVLDDGRLTDSKGRVVDFRNTVIIMTSNIG
HHHHHHHCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCCC
AQEMKQDKSMGFNVIDPLKDHKAMEHRVLQDLKQAFRPEFINRIDETIVFHSLQEKELKQ
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
IVTLLTAQLTKRLAERDIHVKLTEGAKSKIAKDGYDPEYGARPLKRAIQKEVEDMLSEEL
HHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LRGNIKVGDYVEIGVKDGKLEVRKKDAPKKKTTAKKVKTK
HHCCCCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MMFGRFTQRAQKVLALSQEEAMRLNHSNLGTEHILLGLVREGEGIAAKALYELGISSEKV
CCCCHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
QQEVEGLIGHGEKAVTTIQYTPRAKKVIELSMDEARKLGHTYVGTEHILLGLIREGEGVA
HHHHHHHHCCCCHHEEEEEECCCHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCHHH
ARVLSNLGISLNKARQQVLQLLGGGDATGAGRQTNTQATPTLDSLARDLTVIAREDNLDP
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEECCCCCC
VIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVRNEVPETLRGKRVMT
CCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCCEEEE
LDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNVILFIDELHTLIGAGGAEGAIDASNILK
EECCCEEECCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCHHHHCC
PPLARGELQCIGATTLDEYRKYIEKDAALERRFQPIKVDEPTVEESIQILHGLRDRYEAH
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HRVAITDEALEAAVRLSDRYISDRFLPDKAIDVIDESGSKVRLKSFTTPKNVKEMENNLS
CEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
DLKKEKDAAVQGQEFEKAASLRDKEQKLKKSLEETKANWQEKQGLDHSEVTEEIVAEVVA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
SWTGIPVAKLAETETNKLLNMEKLLHERVIGQDAAVKAVSLAVRRARAGLKDPKRPIGSF
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCE
IFLGPTGVGKTELARALAESMFGDEDSMIRIDMSEYMEKFSTARLVGAPPGYVGYEEGGQ
EEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHCEEECCCCCCCCCCCCCH
LTEKVRQKPYSVVLLDEIEKAHPDVFNMLLQVLDDGRLTDSKGRVVDFRNTVIIMTSNIG
HHHHHHHCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCCC
AQEMKQDKSMGFNVIDPLKDHKAMEHRVLQDLKQAFRPEFINRIDETIVFHSLQEKELKQ
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
IVTLLTAQLTKRLAERDIHVKLTEGAKSKIAKDGYDPEYGARPLKRAIQKEVEDMLSEEL
HHHHHHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LRGNIKVGDYVEIGVKDGKLEVRKKDAPKKKTTAKKVKTK
HHCCCCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8016066; 7584024; 9384377; 8195092 [H]