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The map label for this gene is yccK [H]

Identifier: 226222722

GI number: 226222722

Start: 87860

End: 88843

Strand: Reverse

Name: yccK [H]

Synonym: Lm4b_00087

Alternate gene names: 226222722

Gene position: 88843-87860 (Counterclockwise)

Preceding gene: 226222739

Following gene: 226222721

Centisome position: 3.05

GC content: 41.97

Gene sequence:

>984_bases
ATGAAAAAGAGACAATTAGGAAACACTGGTTTAGTAACTTCAGAGCTTGGATTCGGCTGTATGGGACTCAATTATCACCG
GGGACCTGCGAAAGATAGAAAAGAAATGATTGAAGTCGTACGCACTGCAATGGATGCAGGGATTACGATGTTCGATACTG
CTGAAGTGTACGGACCTTATACTAATGAAGAACTTGTCGGAGAAGCTTTAGTTGGCAAAAGAAACCATGTTCAAATTGCA
ACAAAAGGTGGTTTTAAAATTAATGGTTTAAATAACGAAGTCGATAGCCGTCCAGAAAGCATCAAGGCCGCGGTTGAAGG
CTCTCTCAAACGGCTAAAAACGGATTACATTGATTTATATTACATTCATAGAATTGACCCCTCTATCCCAATTGAAGAGG
TTGCCGGAACCATTCAGAATTTAAAACAAGAAGGAAAAATTCTACACTGGGGACTTTCCGAAGCCAGCGCAAAGACAATA
CGCCGTGCTCATAAAGTAGAGCCACTAGCTGCTGTTGAAAATGAGTATTCCATCTGGTGGCGAGAAGCTGAAAAAGAAAT
ATTTCCGGTTTTAGAAGAACTTGGCATCGGGCTTGTCGCATACAGCCCACTAGGTCGCGGTTATTTAACTGGCAAATTGG
ATATAAATGCTAGCTTCAATGAAAACGACAACCGCGGTGGCTTACCAAGATTCCAAAAAGAAGCCATGGAAGCCAACCAA
GTACTACTCGCTTTTATGAAAGAAATAGCCGACGAGCAAAATGTCACAACGGCACAACTCGCCATCGCTTGGATACTTGA
CCAAAAACCTTGGATCGTGCCAATTCCCGGAACAACAAAACAAAGCAGAATTAAAGAAAATATCGCCTCCACGGACATTC
GTTTTGATGACGGAGCACGACAAAAAATAGCTGATGCTTTATCGCAGATTGAAATTGTTGGTGATAGATACTCAGCAGCT
GAAAATAAACGCATCGGAAAGTAG

Upstream 100 bases:

>100_bases
ATTAGTTACGCTTGACTTAAAGTTCACTTCAACTGATAAACTAAATACAACATCCTGATATTTCTAATTTAAAAATTTGG
TTTAAAAGGAGCATATTTTT

Downstream 100 bases:

>100_bases
GCATTTCCTATTCAAAATGGTATCCTTATGAAAAACACACAGAAGAGGTGATTAAATGGCTTTTTCTATCGGTGAATTTT
CCGAACTAGTAGGCATTCCC

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MKKRQLGNTGLVTSELGFGCMGLNYHRGPAKDRKEMIEVVRTAMDAGITMFDTAEVYGPYTNEELVGEALVGKRNHVQIA
TKGGFKINGLNNEVDSRPESIKAAVEGSLKRLKTDYIDLYYIHRIDPSIPIEEVAGTIQNLKQEGKILHWGLSEASAKTI
RRAHKVEPLAAVENEYSIWWREAEKEIFPVLEELGIGLVAYSPLGRGYLTGKLDINASFNENDNRGGLPRFQKEAMEANQ
VLLAFMKEIADEQNVTTAQLAIAWILDQKPWIVPIPGTTKQSRIKENIASTDIRFDDGARQKIADALSQIEIVGDRYSAA
ENKRIGK

Sequences:

>Translated_327_residues
MKKRQLGNTGLVTSELGFGCMGLNYHRGPAKDRKEMIEVVRTAMDAGITMFDTAEVYGPYTNEELVGEALVGKRNHVQIA
TKGGFKINGLNNEVDSRPESIKAAVEGSLKRLKTDYIDLYYIHRIDPSIPIEEVAGTIQNLKQEGKILHWGLSEASAKTI
RRAHKVEPLAAVENEYSIWWREAEKEIFPVLEELGIGLVAYSPLGRGYLTGKLDINASFNENDNRGGLPRFQKEAMEANQ
VLLAFMKEIADEQNVTTAQLAIAWILDQKPWIVPIPGTTKQSRIKENIASTDIRFDDGARQKIADALSQIEIVGDRYSAA
ENKRIGK
>Mature_327_residues
MKKRQLGNTGLVTSELGFGCMGLNYHRGPAKDRKEMIEVVRTAMDAGITMFDTAEVYGPYTNEELVGEALVGKRNHVQIA
TKGGFKINGLNNEVDSRPESIKAAVEGSLKRLKTDYIDLYYIHRIDPSIPIEEVAGTIQNLKQEGKILHWGLSEASAKTI
RRAHKVEPLAAVENEYSIWWREAEKEIFPVLEELGIGLVAYSPLGRGYLTGKLDINASFNENDNRGGLPRFQKEAMEANQ
VLLAFMKEIADEQNVTTAQLAIAWILDQKPWIVPIPGTTKQSRIKENIASTDIRFDDGARQKIADALSQIEIVGDRYSAA
ENKRIGK

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=319, Percent_Identity=27.8996865203762, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4504825, Length=316, Percent_Identity=27.8481012658228, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI27436964, Length=311, Percent_Identity=27.9742765273312, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI27436971, Length=307, Percent_Identity=27.3615635179153, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI27436966, Length=311, Percent_Identity=27.6527331189711, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI27436962, Length=311, Percent_Identity=27.6527331189711, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI223718702, Length=205, Percent_Identity=33.1707317073171, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI41152114, Length=183, Percent_Identity=32.7868852459016, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI41327764, Length=200, Percent_Identity=31.5, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI223718708, Length=131, Percent_Identity=35.1145038167939, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788070, Length=316, Percent_Identity=33.5443037974684, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87081735, Length=308, Percent_Identity=29.8701298701299, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789375, Length=311, Percent_Identity=29.2604501607717, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787674, Length=291, Percent_Identity=26.4604810996564, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1789199, Length=358, Percent_Identity=27.0949720670391, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1788081, Length=287, Percent_Identity=27.5261324041812, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI48994888, Length=283, Percent_Identity=26.8551236749117, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17564128, Length=321, Percent_Identity=26.791277258567, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI212645785, Length=161, Percent_Identity=33.5403726708075, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17566692, Length=279, Percent_Identity=25.8064516129032, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6325384, Length=344, Percent_Identity=29.9418604651163, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6325169, Length=326, Percent_Identity=26.6871165644172, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323998, Length=282, Percent_Identity=26.9503546099291, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319958, Length=279, Percent_Identity=24.0143369175627, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322615, Length=240, Percent_Identity=25.8333333333333, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319951, Length=301, Percent_Identity=24.9169435215947, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320079, Length=268, Percent_Identity=24.6268656716418, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640980, Length=333, Percent_Identity=23.7237237237237, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45549126, Length=333, Percent_Identity=23.7237237237237, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24646155, Length=158, Percent_Identity=36.7088607594937, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646159, Length=168, Percent_Identity=31.547619047619, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644950, Length=290, Percent_Identity=24.4827586206897, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 36442; Mature: 36442

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRQLGNTGLVTSELGFGCMGLNYHRGPAKDRKEMIEVVRTAMDAGITMFDTAEVYGPY
CCCCCCCCCCCEECCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECHHHCCCC
TNEELVGEALVGKRNHVQIATKGGFKINGLNNEVDSRPESIKAAVEGSLKRLKTDYIDLY
CCHHHHHHHHHCCCCEEEEEECCCEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHEEEE
YIHRIDPSIPIEEVAGTIQNLKQEGKILHWGLSEASAKTIRRAHKVEPLAAVENEYSIWW
EEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCHHHHCCCHHHHH
REAEKEIFPVLEELGIGLVAYSPLGRGYLTGKLDINASFNENDNRGGLPRFQKEAMEANQ
HHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
VLLAFMKEIADEQNVTTAQLAIAWILDQKPWIVPIPGTTKQSRIKENIASTDIRFDDGAR
HHHHHHHHHCCCCCCHHHHHHEEEEECCCCEEEECCCCCHHHHHHHHHHHCCEEECCCHH
QKIADALSQIEIVGDRYSAAENKRIGK
HHHHHHHHHHHHHCCHHHHHCCCCCCC
>Mature Secondary Structure
MKKRQLGNTGLVTSELGFGCMGLNYHRGPAKDRKEMIEVVRTAMDAGITMFDTAEVYGPY
CCCCCCCCCCCEECCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECHHHCCCC
TNEELVGEALVGKRNHVQIATKGGFKINGLNNEVDSRPESIKAAVEGSLKRLKTDYIDLY
CCHHHHHHHHHCCCCEEEEEECCCEEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHEEEE
YIHRIDPSIPIEEVAGTIQNLKQEGKILHWGLSEASAKTIRRAHKVEPLAAVENEYSIWW
EEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCHHHHCCCHHHHH
REAEKEIFPVLEELGIGLVAYSPLGRGYLTGKLDINASFNENDNRGGLPRFQKEAMEANQ
HHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
VLLAFMKEIADEQNVTTAQLAIAWILDQKPWIVPIPGTTKQSRIKENIASTDIRFDDGAR
HHHHHHHHHCCCCCCHHHHHHEEEEECCCCEEEECCCCCHHHHHHHHHHHCCEEECCCHH
QKIADALSQIEIVGDRYSAAENKRIGK
HHHHHHHHHHHHHCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9106203 [H]