Click here to switch to the map view.

The map label for this gene is czcD [H]

Identifier: 225861651

GI number: 225861651

Start: 1687874

End: 1688764

Strand: Reverse

Name: czcD [H]

Synonym: SPT_1774

Alternate gene names: 225861651

Gene position: 1688764-1687874 (Counterclockwise)

Preceding gene: 225861653

Following gene: 225861650

Centisome position: 79.95

GC content: 40.18

Gene sequence:

>891_bases
ATGAAGGCAAAATATGCTGTTTGGGTGGCTTTTTTCTTAAATTTGACTTATGCCATTGTTGAGTTTATTGCAGGTGGAGT
ATTTGGTTCTAGCGCTGTTCTTGCTGACTCTGTGCATGACTTGGGAGATGTGATTGCAATTGGAATATCAGCTTTTCTAG
AAACAATCTCCAATCGTGAAGAAGACAATCAGTACACCTTGGGCTATAAGCGGTTTAGCCTACTAGGAGCCTTGGTAACA
GCTGTGATTCTCGTAACAGGCTCTGTTCTAGTCATTTTGGAAAATGTCACGAAGATTTTGCATCCGCAACCAGTCAATGA
TGAGGGGATTCTCTGGTTAGGAATTATTGCGATTACTATCAATCTGTTAGCGAGTCTGGTGGTTGGTAAGGGAAAGACAA
AGAATGAGTCTATTCTGAGTCTGCATTTTCTGGAAGATACGCTAGGGTGGGTAGCTGTTATCCTGATGGCGATTGTTCTT
CGATTTACGGACTGGTATATCCTAGATCCTCTTTTGTCCCTTGTCATTTCTTTCTTTATTCTTTCAAAAGCCCTTTCACG
TTTTTGGTCTACACTCAAGATTTTCTTGGATGCTGTGCCAGAAGGTCTTGATATCAAGCAAGTAAAGAGTGGCCTGGAAC
GATTGGACAATGTGGCCAGCCTTAATCAGCTTAATCTCTGGACTATGGATGCTTTGGAAAAAAATGCCATTGTCCATGTT
TGTCTAAAAGAAATGGAACATATGGAAACTTGTAAAGAGTCTATTCGAATTTTCCTAAAAGATTGTGGTTTTCAAAATAT
TACCATTGAAATTGATGCTGACCTAGAAACTCATCAAACCCATAAGCGAAAGGTGTGTGACTTGGAACGGAGTTATGAGC
ATCAACATTAG

Upstream 100 bases:

>100_bases
ATAAAGCTGACGTTTTGCTTCTATCCTTTCTTTGAGTTTTAGTGGATAATGATAATGAACAAGGTGTTCATAAACCTATT
ATAACAAAGGAATGAGAAAT

Downstream 100 bases:

>100_bases
AAAAAAGTGAAAAATACTTGGGTACTATCTTATTTGGAATAGAGTAATTTCTTTATTATTTAAATATTTCAAAAATTGGT
AAGAGAAGAGCATTGTATAA

Product: cation diffusion facilitator transporter - heavy metal transport

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDVIAIGISAFLETISNREEDNQYTLGYKRFSLLGALVT
AVILVTGSVLVILENVTKILHPQPVNDEGILWLGIIAITINLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVL
RFTDWYILDPLLSLVISFFILSKALSRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNVASLNQLNLWTMDALEKNAIVHV
CLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLETHQTHKRKVCDLERSYEHQH

Sequences:

>Translated_296_residues
MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDVIAIGISAFLETISNREEDNQYTLGYKRFSLLGALVT
AVILVTGSVLVILENVTKILHPQPVNDEGILWLGIIAITINLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVL
RFTDWYILDPLLSLVISFFILSKALSRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNVASLNQLNLWTMDALEKNAIVHV
CLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLETHQTHKRKVCDLERSYEHQH
>Mature_296_residues
MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDVIAIGISAFLETISNREEDNQYTLGYKRFSLLGALVT
AVILVTGSVLVILENVTKILHPQPVNDEGILWLGIIAITINLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVL
RFTDWYILDPLLSLVISFFILSKALSRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNVASLNQLNLWTMDALEKNAIVHV
CLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLETHQTHKRKVCDLERSYEHQH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=317, Percent_Identity=23.0283911671924, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI52352805, Length=288, Percent_Identity=25, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI289803013, Length=289, Percent_Identity=23.1833910034602, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI289803009, Length=289, Percent_Identity=23.1833910034602, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI289803007, Length=289, Percent_Identity=23.1833910034602, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI289803003, Length=289, Percent_Identity=23.1833910034602, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI64762489, Length=289, Percent_Identity=23.1833910034602, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786966, Length=269, Percent_Identity=26.7657992565056, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555794, Length=294, Percent_Identity=22.4489795918367, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17555796, Length=294, Percent_Identity=22.4489795918367, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193210990, Length=298, Percent_Identity=25.8389261744966, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI32564488, Length=302, Percent_Identity=21.8543046357616, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33145; Mature: 33145

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDVIAIGISAFLETISNRE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EDNQYTLGYKRFSLLGALVTAVILVTGSVLVILENVTKILHPQPVNDEGILWLGIIAITI
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
NLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVLRFTDWYILDPLLSLVISFFI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSKALSRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNVASLNQLNLWTMDALEKNAIVHV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
CLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLETHQTHKRKVCDLERSYEHQH
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDVIAIGISAFLETISNRE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EDNQYTLGYKRFSLLGALVTAVILVTGSVLVILENVTKILHPQPVNDEGILWLGIIAITI
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
NLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVLRFTDWYILDPLLSLVISFFI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSKALSRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNVASLNQLNLWTMDALEKNAIVHV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
CLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLETHQTHKRKVCDLERSYEHQH
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]