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The map label for this gene is galK [H]

Identifier: 225861647

GI number: 225861647

Start: 1683844

End: 1685022

Strand: Reverse

Name: galK [H]

Synonym: SPT_1770

Alternate gene names: 225861647

Gene position: 1685022-1683844 (Counterclockwise)

Preceding gene: 225861649

Following gene: 225861646

Centisome position: 79.78

GC content: 44.11

Gene sequence:

>1179_bases
ATGACACAACATCTTACTGCTGAAACTCTTCGCAAAGACTTTCTTGCTGTTTTTGGTCAAGAAGCAGACCAAACTTTCTT
TTCACCAGGTCGTATCAATTTGATTGGTGAACACACAGACTACAACGGTGGGCACGTTTTTCCTGCTGCTATTTCCTTGG
GAACTTACGGTGCAGCTCGTAAGCGTGACGACCAAGTCTTGCGTTTCTACTCAGCTAACTTTGAGGACAAGGGCATTATC
GAAGTGCCTCTCGCTGACCTCAAGTTTGAAAAAGAGCACAACTGGACCAATTATCCAAAAGGTGTCCTTCATTTCTTGCA
AGAAGCTGGGCACGTGATTGACAAAGGTTTTGATTTTTATGTTTATGGGAATATCCCAAATGGTGCTGGTTTGTCTTCTT
CAGCATCCTTGGAGCTCTTGACAGGAGTCGTGGCAGAGCATCTCTTTGATTTAAAACTAGAGCGTCTCGATTTGGTTAAA
ATCGGAAAACAAACAGAAAATAACTTTATCGGAGTAAATTCTGGCATTATGGACCAATTTGCTATTGGTATGGGGGCTGA
CCAACGTGCTATTTACTTAGATACCAATACTTTAGAATACGACTTGGTGCCACTTGATTTGAAGGACAATGTCGTTGTTA
TCATGAACACCAACAAACGCCGTGAATTGGCGGACTCTAAATACAATGAACGTCGTGCTGAGTGTGAAAAAGCAGTGGAA
GAATTGCAAGTTGCCTTGGATATTCAGACCCTGGGTGAATTGGACGAGTGGGCCGTTGACCAATATAGCTATCTGATTAA
AGATGAAAATCGTTTGAAACGTGCTCGCCATGCTGTGCTTGAAAACCAACGTACCCTTAAAGCTCAAGCAGCCCTTCAAG
CAGGTGATTTGGAAACATTTGGTCGTTTGATGAATGCGTCACACGTTTCTCTGGAGCGTGATTATGAAGTAACTGGTTTG
GAATTGGATACTCTTGTTCACACAGCTTGGGCACAAGAAGGAGTTCTCGGTGCTCGTATGACAGGGGCTGGTTTTGGTGG
CTGTGCCATTGCCTTGGTTCAAAAAGATACTGTTGAGGCCTTTAAGGAAGCTGTAGGCAAACACTACGAGGAAGTAGTTG
GATACGCTCCAAGCTTCTATATCGCTGAAGTTGCAGGTGGCACTCGCGTCCTTGACTAG

Upstream 100 bases:

>100_bases
TTTTAGTAAAAAGGATTGACCTTGGGAAATCCCTTGGATACAATAGAAGAAAACGATTACACGTTAAGGTGGCTTAACGG
ACAGTCAAAGGAGAAATCAT

Downstream 100 bases:

>100_bases
TCAAAAGGAGGCTCTATAGTGACCTTAGTAGATAAATTTGTAACACATGTAATTTCTGAAAGTTCATTTGAGGAAATGGA
TCGAATCTACCTGACCAACC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTQHLTAETLRKDFLAVFGQEADQTFFSPGRINLIGEHTDYNGGHVFPAAISLGTYGAARKRDDQVLRFYSANFEDKGII
EVPLADLKFEKEHNWTNYPKGVLHFLQEAGHVIDKGFDFYVYGNIPNGAGLSSSASLELLTGVVAEHLFDLKLERLDLVK
IGKQTENNFIGVNSGIMDQFAIGMGADQRAIYLDTNTLEYDLVPLDLKDNVVVIMNTNKRRELADSKYNERRAECEKAVE
ELQVALDIQTLGELDEWAVDQYSYLIKDENRLKRARHAVLENQRTLKAQAALQAGDLETFGRLMNASHVSLERDYEVTGL
ELDTLVHTAWAQEGVLGARMTGAGFGGCAIALVQKDTVEAFKEAVGKHYEEVVGYAPSFYIAEVAGGTRVLD

Sequences:

>Translated_392_residues
MTQHLTAETLRKDFLAVFGQEADQTFFSPGRINLIGEHTDYNGGHVFPAAISLGTYGAARKRDDQVLRFYSANFEDKGII
EVPLADLKFEKEHNWTNYPKGVLHFLQEAGHVIDKGFDFYVYGNIPNGAGLSSSASLELLTGVVAEHLFDLKLERLDLVK
IGKQTENNFIGVNSGIMDQFAIGMGADQRAIYLDTNTLEYDLVPLDLKDNVVVIMNTNKRRELADSKYNERRAECEKAVE
ELQVALDIQTLGELDEWAVDQYSYLIKDENRLKRARHAVLENQRTLKAQAALQAGDLETFGRLMNASHVSLERDYEVTGL
ELDTLVHTAWAQEGVLGARMTGAGFGGCAIALVQKDTVEAFKEAVGKHYEEVVGYAPSFYIAEVAGGTRVLD
>Mature_391_residues
TQHLTAETLRKDFLAVFGQEADQTFFSPGRINLIGEHTDYNGGHVFPAAISLGTYGAARKRDDQVLRFYSANFEDKGIIE
VPLADLKFEKEHNWTNYPKGVLHFLQEAGHVIDKGFDFYVYGNIPNGAGLSSSASLELLTGVVAEHLFDLKLERLDLVKI
GKQTENNFIGVNSGIMDQFAIGMGADQRAIYLDTNTLEYDLVPLDLKDNVVVIMNTNKRRELADSKYNERRAECEKAVEE
LQVALDIQTLGELDEWAVDQYSYLIKDENRLKRARHAVLENQRTLKAQAALQAGDLETFGRLMNASHVSLERDYEVTGLE
LDTLVHTAWAQEGVLGARMTGAGFGGCAIALVQKDTVEAFKEAVGKHYEEVVGYAPSFYIAEVAGGTRVLD

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=399, Percent_Identity=38.3458646616541, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4503897, Length=448, Percent_Identity=27.2321428571429, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI48527957, Length=439, Percent_Identity=27.3348519362187, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786972, Length=383, Percent_Identity=39.4255874673629, Blast_Score=255, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI71989053, Length=441, Percent_Identity=29.2517006802721, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319494, Length=268, Percent_Identity=27.9850746268657, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320212, Length=254, Percent_Identity=26.7716535433071, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24661292, Length=420, Percent_Identity=28.0952380952381, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI21355577, Length=420, Percent_Identity=28.0952380952381, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24661285, Length=420, Percent_Identity=28.0952380952381, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 43590; Mature: 43458

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHLTAETLRKDFLAVFGQEADQTFFSPGRINLIGEHTDYNGGHVFPAAISLGTYGAAR
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEHHHEECCCCCCCC
KRDDQVLRFYSANFEDKGIIEVPLADLKFEKEHNWTNYPKGVLHFLQEAGHVIDKGFDFY
CCHHHHHHHHHCCCCCCCEEEECHHHCEEECCCCCCCCCHHHHHHHHHCCHHHHCCCEEE
VYGNIPNGAGLSSSASLELLTGVVAEHLFDLKLERLDLVKIGKQTENNFIGVNSGIMDQF
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHH
AIGMGADQRAIYLDTNTLEYDLVPLDLKDNVVVIMNTNKRRELADSKYNERRAECEKAVE
HHCCCCCCEEEEEECCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
ELQVALDIQTLGELDEWAVDQYSYLIKDENRLKRARHAVLENQRTLKAQAALQAGDLETF
HHHHHHHHHHHCCHHHHHHHHHHHEECCHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHH
GRLMNASHVSLERDYEVTGLELDTLVHTAWAQEGVLGARMTGAGFGGCAIALVQKDTVEA
HHHHCCCCCEEECCCEECCEEHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEHHHHHH
FKEAVGKHYEEVVGYAPSFYIAEVAGGTRVLD
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
TQHLTAETLRKDFLAVFGQEADQTFFSPGRINLIGEHTDYNGGHVFPAAISLGTYGAAR
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEHHHEECCCCCCCC
KRDDQVLRFYSANFEDKGIIEVPLADLKFEKEHNWTNYPKGVLHFLQEAGHVIDKGFDFY
CCHHHHHHHHHCCCCCCCEEEECHHHCEEECCCCCCCCCHHHHHHHHHCCHHHHCCCEEE
VYGNIPNGAGLSSSASLELLTGVVAEHLFDLKLERLDLVKIGKQTENNFIGVNSGIMDQF
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHH
AIGMGADQRAIYLDTNTLEYDLVPLDLKDNVVVIMNTNKRRELADSKYNERRAECEKAVE
HHCCCCCCEEEEEECCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
ELQVALDIQTLGELDEWAVDQYSYLIKDENRLKRARHAVLENQRTLKAQAALQAGDLETF
HHHHHHHHHHHCCHHHHHHHHHHHEECCHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHH
GRLMNASHVSLERDYEVTGLELDTLVHTAWAQEGVLGARMTGAGFGGCAIALVQKDTVEA
HHHHCCCCCEEECCCEECCEEHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEHHHHHH
FKEAVGKHYEEVVGYAPSFYIAEVAGGTRVLD
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]